Liquid leakage detection circuit of medicine storage device, medicine storage device and medicine injection equipment

Abstract

According to the liquid leakage detection circuit of the medicine storage device, the medicine storage device and the medicine injection equipment provided by the utility model, the first electrode and the second electrode are arranged on the medicine storage bottle in a penetrating manner, so that one ends, positioned in the medicine storage bottle, of the first electrode and the second electrode are in contact with the liquid in the medicine storage bottle; the first resistance detection circuit is used for detecting the resistance value of the equivalent resistance of the liquid between the two electrodes, the detected resistance value is sent to the controller, and the controller can quickly judge whether the liquid in the medicine storage bottle leaks or not based on the resistance value. And the signal output port outputs a control signal for controlling the medicine storage device to stop pumping the liquid medicine.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to a medicine storage device leakage detection circuit capable of measuring leakage, a medicine storage device and medicine injection equipment. Background Art

[0002] As a component of the infusion pump, the drug reservoir solves the problem of storing liquid medicine after the infusion pump is worn on the user for a long time. The current pumping schemes of infusion pumps with drug reservoirs can be divided into: (1) mechanical push injection: the main body of the drug reservoir is divided into a liquid medicine storage chamber and a liquid medicine push chamber, and the liquid medicine push screw moves the push block in the push chamber to pump the liquid in the storage chamber; (2) hydraulic push injection: the main body of the drug reservoir is divided into a liquid medicine storage chamber and a hydraulic chamber, and the liquid medicine push is achieved by pushing the hydraulic liquid to move the push piston to move the liquid medicine in the liquid medicine storage chamber for pumping.

[0003] The current medicine storage devices that use hydraulic liquid to push have the problem of hydraulic liquid leakage due to piston damage or piston tilt. When the hydraulic liquid leaks, the hydraulic liquid and the medicine liquid leak into each other, and there is a risk of contaminating the medicine liquid, diluting the medicine liquid, or even denaturing the medicine liquid. If these medicine liquids are injected into the human body, they will seriously affect the user's health. Utility Model Content

[0004] In view of this, the embodiments of the utility model provide a drug reservoir leakage detection circuit, a drug reservoir and a drug injection device, so as to quickly detect the mixing of hydraulic fluid and drug liquid caused by the piston of the drug reservoir being damaged or tilted.

[0005] To achieve the above purpose, the present invention provides the following technical solutions:

[0006] A medicine storage device leakage detection circuit, comprising:

[0007] A first electrode and a second electrode, wherein one end of the first electrode and the second electrode are inserted into the medicine storage bottle;

[0008] a first resistance detection circuit, the first resistance detection circuit being used to measure an equivalent resistance of a liquid between the first electrode and the second electrode;

[0009] The controller has a signal output port and a signal input port, wherein the signal input port is used to be connected to the output end of the first resistance detection circuit, and the signal output port is used to output a control signal for controlling the drug storage device to stop pumping the drug solution.

[0010] Optionally, in the above-mentioned medicine storage device leakage detection circuit, the first resistance detection circuit includes:

[0011] A first operational amplifier, wherein a first input terminal of the first operational amplifier is connected to the first electrode, a second input terminal of the first operational amplifier is connected to the second electrode, and an output terminal of the first operational amplifier serves as an output terminal of the first resistance detection circuit.

[0012] Optionally, in the above-mentioned medicine storage device leakage detection circuit, one end of the first electrode and the second electrode are inserted into the medicine liquid cavity of the medicine storage bottle, and the medicine liquid is stored in the medicine liquid cavity.

[0013] Optionally, in the above-mentioned medicine storage device leakage detection circuit, one end of the first electrode is inserted into the medicine liquid cavity of the medicine storage bottle, and the medicine liquid cavity is used to store the medicine liquid;

[0014] One end of the second electrode is inserted into the hydraulic cavity of the medicine storage bottle, and the hydraulic cavity is used to store hydraulic fluid.

[0015] Optionally, in the above-mentioned medicine storage device leakage detection circuit, one end of the first electrode and the second electrode are inserted into the hydraulic cavity of the medicine storage bottle, and the hydraulic cavity is used to store hydraulic fluid.

[0016] Optionally, the above-mentioned drug storage device leakage detection circuit further includes:

[0017] A third electrode and a fourth electrode, one end of each of the third electrode and the fourth electrode being inserted into the medicine liquid cavity of the medicine storage bottle;

[0018] a second resistance detection circuit, the second resistance detection circuit being used to measure an equivalent resistance of the liquid between the third electrode and the fourth electrode;

[0019] The signal input port of the controller is also used to be connected to the output end of the second resistance detection circuit.

[0020] Optionally, in the above-mentioned medicine storage device leakage detection circuit, the first resistance detection circuit includes:

[0021] a second operational amplifier, wherein a first input terminal of the second operational amplifier is connected to the first electrode, a second input terminal of the second operational amplifier is connected to an output terminal of the second operational amplifier, and an output terminal of the second operational amplifier serves as an output terminal of the first resistance detection circuit;

[0022] The second electrode is connected to a voltage source.

[0023] A medicine reservoir comprises the first electrode and the second electrode in any one of the above-mentioned medicine reservoir leakage detection circuits.

[0024] Optionally, in the above-mentioned drug storage device, a drug storage bottle of the drug storage device is provided with a drug adding port, a drug outlet and an infusion needle quick interface, and the drug adding port, the drug outlet and the infusion needle quick interface are connected with the drug liquid cavity;

[0025] A piston is disposed in the medicine storage bottle and is used to isolate the medicine liquid chamber and the hydraulic chamber.

[0026] A drug injection device comprises a drug reservoir, a volumetric pump and a liquid storage bag, and also comprises: a liquid leakage detection circuit of the drug reservoir as described in any one of the above.

[0027] The above-mentioned scheme provided by the embodiment of the utility model is to penetrate the first electrode and the second electrode on the medicine storage bottle so that one end of the first electrode and the second electrode located inside the medicine storage bottle is in contact with the liquid inside the medicine storage bottle, and the resistance value of the equivalent resistance of the liquid between the two electrodes is measured by the first resistance detection circuit, and the detected resistance value is sent to the controller. The controller can quickly determine whether there is leakage of the liquid in the medicine storage bottle based on the resistance value. When the controller determines that the medicine storage bottle is leaking, the signal output port outputs a control signal that controls the medicine storage device to stop pumping the medicine liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0029] Figure 1 It is a structural schematic diagram of a liquid leakage detection circuit of a medicine storage device disclosed in an embodiment of the present application;

[0030] Figure 2 This is a schematic diagram of the leakage detection process;

[0031] Figure 3 A schematic diagram of the circuit structure of the resistance detection circuit disclosed in the embodiment of the present application;

[0032] Figure 4 A schematic diagram of the circuit structure of a resistance detection circuit disclosed in another embodiment of the present application;

[0033] Figure 5 A schematic diagram of the arrangement of electrodes disclosed in the embodiments of the present application;

[0034] Figure 6 A schematic diagram of an arrangement of electrodes disclosed in another embodiment of the present application;

[0035] Figure 7A schematic diagram of an arrangement of electrodes disclosed in another embodiment of the present application;

[0036] Figure 8 A schematic diagram of an arrangement of electrodes disclosed in another embodiment of the present application;

[0037] 1. First electrode; 2. Second electrode; 3. First resistance detection circuit; 4. Controller; 5. Dosing port; 6. Discharge port; 7. Quick connector for infusion needle; 8. Drug storage bottle; 9. Piston; 10. Liquid discharge pipeline; 11. Bottom cover of liquid storage bottle; 12. Exhaust port; 13. Drug liquid chamber; 14. Hydraulic chamber; 15. Volumetric pump; 16. Liquid inlet pipeline; 17. Dosing port; 18. Liquid storage bag; 19. Third electrode; 20. Fourth electrode. DETAILED DESCRIPTION

[0038] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0039] Considering that the existing medicine storage device only has the function of storing liquid medicine and cannot detect the aforementioned leakage risk, this application adds two electrodes that penetrate the medicine storage bottle on the basis of the existing solution. One end of the electrode is located inside the medicine storage bottle, and the end is in contact with the liquid in the medicine storage bottle. The equivalent resistance of the liquid between the two electrodes can be detected by the resistance detection circuit. By the change of the equivalent resistance value, it can be determined whether there is a leakage problem in the medicine storage bottle. When the detection unit detects leakage, the medicine storage device can be stopped from continuing to pump the liquid medicine, thereby eliminating the possibility of diluted or denatured liquid medicine entering the human body.

[0040] For details, see Figure 1 The drug storage device leakage detection circuit disclosed in the embodiment of the present application may include:

[0041] A first electrode 1, a second electrode 2, a first resistance detection circuit 3 and a controller 4;

[0042] One end of the first electrode 1 and the second electrode 2 is inserted into the medicine storage bottle 8, that is, the first electrode 1 and the second electrode 2 pass through the medicine storage bottle 8, one end of the first electrode 1 and the second electrode 2 is located inside the medicine storage bottle 8 and in contact with the liquid inside the medicine storage bottle 8, and the other end of the first electrode 1 and the second electrode 2 is located outside the medicine storage bottle 8;

[0043] The first resistance detection circuit 3 is used to measure the equivalent resistance of the liquid between the first electrode 1 and the second electrode 2. The specific structure of the first resistance detection circuit 3 can be a resistance value measurement circuit of any structure in the prior art. The user can select a suitable first resistance detection circuit 3 according to the design requirements;

[0044] The controller 4 can be an MCU, and the controller 4 has a signal output port and a signal input port, the signal input port is used to be connected to the output end of the first resistance detection circuit 3, and the signal output port is used to output a control signal for controlling the medicine storage device to stop pumping the medicine liquid. The controller 4 can judge whether the medicine storage bottle 8 has leakage based on the output result of the first resistance detection circuit 3 through an internal comparison circuit. If leakage occurs, the signal output port of the controller 4 outputs a control signal, and the control signal is used to control the medicine storage device to stop pumping the medicine liquid. In this process, the comparison circuit can judge whether the medicine storage bottle 8 has leakage based on the comparison result by comparing the output result of the first resistance detection circuit 3 with a preset value. Its principle and process are both conventional comparison processes, for example, the technical solutions in the patents disclosed in the patent publication numbers CN205747515U and CN116223574A can be referred to. This application does not involve the improvement of the control logic of the controller 4. The implementation logic and implementation circuit of the controller 4 are well-known solutions for those skilled in the art, or are easily conceivable by those skilled in the art.

[0045] In the technical solution disclosed in the above embodiment, the first electrode 1 and the second electrode 2 are penetrated through the medicine storage bottle 8 so that one end of the first electrode 1 and the second electrode 2 located inside the medicine storage bottle 8 is in contact with the liquid inside the medicine storage bottle 8, and the resistance value of the equivalent resistance of the liquid between the two electrodes is measured by the first resistance detection circuit 3, and the detected resistance value is sent to the controller 4. When the controller 4 determines that the medicine storage bottle 8 is leaking based on the detected resistance value, the signal output port of the controller outputs a control signal that controls the medicine storage device to stop pumping the medicine solution.

[0046] See also Figure 2 The working state of the resistance detection circuit disclosed in this embodiment can be controlled by the controller 4. When it is necessary to determine whether the medicine storage bottle 8 is leaking, the controller 4 can send a detection instruction to the resistance detection circuit. After obtaining the detection instruction, the resistance detection circuit measures the resistance value of the equivalent resistance of the liquid between its two corresponding electrodes and feeds back the measurement result to the controller 4.

[0047] This embodiment discloses a specific structure of a first resistance detection circuit 3. In the technical solution disclosed in this embodiment, the first resistance detection circuit 3 can be implemented by using a first operational amplifier U2. Figure 3 The first resistance detection circuit 3 may include a first operational amplifier U2 and a peripheral circuit, wherein a first input terminal of the first operational amplifier U2 is connected to the first electrode 1, a second input terminal of the first operational amplifier U2 is connected to the second electrode 2, and an output terminal of the first operational amplifier U2 serves as an output terminal of the first resistance detection circuit 3. Figure 3 In the embodiment, the resistor Rs3 is the equivalent resistance of the liquid between the first electrode 1 and the second electrode 2, the Iin is the current on the liquid between the first electrode 1 and the second electrode 2, the resistor Ry21 is arranged between the first electrode 1 and the first input terminal of the first operational amplifier U2, one end of the resistor Ry22 is grounded, and the other end is connected to the first input terminal of the first operational amplifier U2, the resistor Ry23 is arranged between the second electrode 2 and the second input terminal of the first operational amplifier U2, the resistor Ry24 is arranged between the second input terminal and the output terminal of the first operational amplifier U2, the resistor Ry21, the resistor Ry22, the resistor Ry23 and the resistor Ry24 constitute a differential circuit, and the output signal of the differential circuit passes through the filter circuit constituted by the resistor R21 and the capacitor C21 and is sent to the controller 4. In this embodiment, the controller 4 may be configured with an ADC conversion circuit, and the output signal of the first resistance detection circuit 3 may be converted into a digital signal through the ADC conversion circuit. Figure 3 Usam in is the measurement result of the first resistance detection circuit 3.

[0048] This embodiment also discloses a specific structure of the first resistance detection circuit 3. In the technical solution disclosed in this embodiment, the first resistance detection circuit 3 can be implemented by using a second operational amplifier U1. Figure 4 The first input terminal of the second operational amplifier U1 is connected to the first electrode 1, the second input terminal of the second operational amplifier U1 is connected to the output terminal of the second operational amplifier U1, the output terminal of the second operational amplifier U1 serves as the output terminal of the first resistance detection circuit 3, and the second electrode 2 is connected to a voltage source. Figure 4In the embodiment, the resistor Rs1 is the equivalent resistance of the liquid between the first electrode 1 and the second electrode 2, the resistor Rs2 is the equivalent resistance of the liquid in the liquid storage bottle that is not between the first electrode and the second electrode 2, the Vin is the output voltage of the voltage source connected to the second electrode 2, the resistor Ry11 is arranged between the first electrode 1 and the first input terminal of the first operational amplifier U2, the capacitor C11 is arranged with one end grounded and the other end connected to the first input terminal of the second operational amplifier U1, the resistor Ry11 and the capacitor C11 constitute an RC filter circuit, the output of the second operational amplifier U1 passes through the filter circuit constituted by the resistor R11 and the capacitor C11, and is sent to the controller 4. In this embodiment, the controller 4 may also be configured with an ADC conversion circuit, and the output signal of the first resistance detection circuit 3 may be converted into a digital signal through the ADC conversion circuit. Figure 4 Usam in is the measurement result of the first resistance detection circuit 3.

[0049] In the above embodiment, the types of the first operational amplifier U2 and the second operational amplifier U1 can be selected according to user needs. For example, in the technical solution disclosed in this embodiment, the first operational amplifier U2 and the second operational amplifier U1 can be implemented by rail-to-rail operational amplifiers (Rail-to-Rail Operational Amplifier) ​​or low offset voltage operational amplifiers (Low Offset Voltage Operational Amplifier).

[0050] In the technical solution disclosed in this embodiment, the positions of the first electrode 1 and the second electrode 2 can be set according to user needs, as long as the first electrode 1 and the second electrode 2 can be in contact with the liquid in the medicine storage bottle 8. The liquid in contact with the first electrode 1 and the second electrode 2 can be a medicine liquid or a hydraulic liquid. The hydraulic liquid can be pure water, antifreeze liquid or other antifreeze liquids. The types of the liquid (medicine liquid or hydraulic liquid) in contact with the first electrode 1 and the second electrode 2 can be the same or different.

[0051] For example, see Figure 5 The first electrode 1 and the second electrode 2 can be inserted into the hydraulic chamber 14 of the drug storage bottle 8 together, see Figure 6 The first electrode 1 and the second electrode 2 can be inserted into the liquid chamber 13 of the drug storage bottle 8 together, see Figure 7 One of the first electrode 1 and the second electrode 2 is inserted into the hydraulic chamber 14 of the medicine storage bottle 8, and the other electrode is inserted into the liquid chamber 13 of the medicine storage bottle 8.

[0052] Furthermore, when leakage occurs in the liquid storage bottle, it may be that the liquid medicine penetrates into the hydraulic chamber 14, or it may be that the hydraulic fluid penetrates into the liquid medicine chamber 13. At this time, the equivalent resistance value of the uncontaminated liquid medicine or hydraulic fluid does not change. Therefore, if the first electrode 1 and the second electrode 2 are set in the hydraulic chamber 14 or the liquid medicine chamber 13 alone, in some cases, no leakage phenomenon can be detected. Therefore, in order to ensure the reliability of the measurement result, see Figure 8 In the technical solution disclosed in this embodiment, the medicine reservoir leakage detection circuit may include, in addition to the first electrode 1 and the second electrode 2, a third electrode 19 and a fourth electrode 20, and a second resistance detection circuit corresponding to the third electrode 19 and the fourth electrode 20, and the function and circuit design of the second resistance detection circuit are the same as those of the first resistance detection circuit 3. The role and function of the third electrode 19 are the same as those of the first electrode 1, and the role and function of the fourth electrode 20 are the same as those of the second electrode 2, except that the second resistance detection circuit is used to measure the equivalent resistance of the liquid between the third electrode 19 and the fourth electrode 20. When the first electrode 1, the second electrode 2, the third electrode 19 and the fourth electrode 20 are simultaneously provided in the medicine reservoir leakage detection circuit, in order to prevent mutual interference when measuring resistance, the two groups of electrodes may be respectively provided at the medicine liquid chamber 13 and the hydraulic chamber 14, for example, Figure 8 As shown, one end of the first electrode 1 and the second electrode 2 can be inserted into the hydraulic chamber 14 of the medicine storage bottle 8, and one end of the third electrode 19 and the fourth electrode 20 can be inserted into the liquid chamber 13 of the medicine storage bottle 8. At this time, two groups of sampling results are measured by the first resistance detection circuit 3 and the second resistance detection circuit, and whether the medicine storage bottle 8 is leaking is judged based on the two groups of sampling results, thereby ensuring the reliability of the detection results.

[0053] Corresponding to the above-mentioned drug storage device leakage detection circuit, the present application also discloses a drug storage device, see Figure 5 , Figure 6 , Figure 7 , Figure 8 The medicine reservoir includes the first electrode 1 and the second electrode 2 in the medicine reservoir leakage detection circuit described in any one of the above items, and of course can also include the third electrode 19 and the fourth electrode 20 mentioned above. At this time, the first electrode 1, the second electrode 2, the third electrode 19 and the fourth electrode 20 are fixed on the medicine storage bottle 8 of the medicine reservoir as part of the medicine reservoir.

[0054] See also Figure 5 , Figure 6 , Figure 7 , Figure 8The medicine storage bottle 8 of the medicine storage device is provided with: a medicine adding port 5; a medicine outlet 6; an infusion needle quick interface 7; a medicine storage bottle 8; a piston 9; a liquid outlet pipeline 10; a liquid storage bottle bottom cover 11; and an exhaust port 12. The medicine adding port 5; the medicine outlet 6; and the infusion needle quick interface 7 are connected to the medicine liquid chamber 13; the piston 9 is arranged in the medicine storage bottle 8 to isolate the medicine liquid chamber 13 from the hydraulic chamber 14. The exhaust port 12 is connected to the hydraulic chamber 14. In this embodiment, the electrode and the liquid outlet pipeline 10 arranged at the position of the hydraulic chamber 14 can be fixed by the liquid storage bottle bottom cover 11.

[0055] Corresponding to the above-mentioned drug storage device leakage detection circuit, the present application also discloses a drug injection device, see Figure 1 , Figure 5 , Figure 6 , Figure 7 , Figure 8 The drug injection device includes a drug reservoir, a volumetric pump 15, a liquid bag 18 and a drug reservoir leakage detection circuit as described in any one of the above. The volumetric pump 15 is connected to the hydraulic chamber 14 of the liquid storage bottle 8 through a liquid outlet pipeline 10, and the liquid storage bag 18 is connected to the liquid inlet of the volumetric pump 15 through a liquid inlet pipeline 16. The liquid storage bag 18 is provided with a liquid filling port 17.

[0056] In order to verify the effect, the applicant also conducted an effect verification on the feasibility of the technical solution disclosed in this application in the laboratory. The verification results are shown in Table 1:

[0057]

[0058] Table 1

[0059] In Table 1, pure water is hydraulic fluid, insulin is liquid medicine, and 3ml+0.2ml insulin is the mixed liquid caused by leakage. As can be seen from Table 1, the resistance values ​​of pure water before leakage measured by this scheme are 1.72MΩ, 1.66MΩ and 1.76MΩ respectively, the resistance values ​​of insulin before leakage are 0.52MΩ, 0.48MΩ and 0.58MΩ respectively, and the resistance values ​​of the mixed liquid after pure water and insulin are mixed according to 3ml pure water + 0.2ml insulin are 0.74MΩ, 0.72MΩ and 0.77MΩ respectively. It can be seen that after leakage occurs, the resistance value of the liquid in the liquid chamber 13 or the hydraulic chamber 14 will change greatly, and the change can be easily detected. It can be seen that the above scheme disclosed in this application is feasible and has high feasibility.

[0060] It should also be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variants thereof are intended to cover non-exclusive inclusions, and also include other elements not explicitly listed, or also include elements inherent to such articles or equipment. In the absence of further restrictions, the elements defined by the statement "comprises a ..." do not exclude the presence of other identical elements in the articles or equipment that include the elements.

[0061] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

[0062] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A medicine storage device leakage detection circuit, characterized in that: include: A first electrode and a second electrode, wherein one end of the first electrode and the second electrode are inserted into the medicine storage bottle; a first resistance detection circuit, the first resistance detection circuit being used to measure an equivalent resistance of a liquid between the first electrode and the second electrode; The controller has a signal output port and a signal input port, wherein the signal input port is used to be connected to the output end of the first resistance detection circuit, and the signal output port is used to output a control signal for controlling the drug storage device to stop pumping the drug solution.

2. The drug storage device leakage detection circuit according to claim 1, characterized in that: One end of the first electrode and the second electrode is inserted into the medicine liquid cavity of the medicine storage bottle, and the medicine liquid cavity stores medicine liquid.

3. The drug storage device leakage detection circuit according to claim 1, characterized in that: One end of the first electrode is inserted into the medicine liquid cavity of the medicine storage bottle, and the medicine liquid cavity is used to store medicine liquid; One end of the second electrode is inserted into the hydraulic cavity of the medicine storage bottle, and the hydraulic cavity is used to store hydraulic fluid.

4. The drug storage device leakage detection circuit according to claim 1, characterized in that: One end of the first electrode and the second electrode is inserted into the hydraulic cavity of the medicine storage bottle, and the hydraulic cavity is used to store hydraulic fluid.

5. The drug storage device leakage detection circuit according to claim 4, characterized in that: Also includes: A third electrode and a fourth electrode, one end of each of the third electrode and the fourth electrode being inserted into the medicine liquid cavity of the medicine storage bottle; a second resistance detection circuit, the second resistance detection circuit being used to measure an equivalent resistance of the liquid between the third electrode and the fourth electrode; The signal input port of the controller is also used to be connected to the output end of the second resistance detection circuit.

6. The drug storage device leakage detection circuit according to claim 1, characterized in that: The first resistance detection circuit comprises: A first operational amplifier, wherein a first input terminal of the first operational amplifier is connected to the first electrode, a second input terminal of the first operational amplifier is connected to the second electrode, and an output terminal of the first operational amplifier serves as an output terminal of the first resistance detection circuit.

7. The drug storage device leakage detection circuit according to claim 1, characterized in that: The first resistance detection circuit comprises: a second operational amplifier, wherein a first input terminal of the second operational amplifier is connected to the first electrode, a second input terminal of the second operational amplifier is connected to an output terminal of the second operational amplifier, and an output terminal of the second operational amplifier serves as an output terminal of the first resistance detection circuit; The second electrode is connected to a voltage source.

8. A medicine storage device, characterized in that: include: The first electrode and the second electrode in the medicine reservoir leakage detection circuit according to any one of claims 1 to 7.

9. The drug storage device according to claim 8, characterized in that: The medicine storage bottle of the medicine storage device is provided with a medicine adding port, a medicine outlet and a quick interface for an infusion needle, and the medicine adding port, the medicine outlet and the quick interface for an infusion needle are connected with the medicine liquid cavity; A piston is disposed in the medicine storage bottle and is used to isolate the medicine liquid chamber and the hydraulic chamber.

10. A drug injection device, comprising a drug reservoir, a volumetric pump and a liquid storage bag, characterized in that: Also includes: A medicine reservoir leakage detection circuit as described in any one of claims 1 to 7.

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