AAV packaging titer detection kit

Abstract

The utility model relates to the technical field of biology, in particular to an AAV package titer detection kit which comprises a kit body and a kit cover arranged above the kit body, fasteners are fixedly installed at the left end and the right end of the kit body respectively, an elastic compression spring is arranged at one end of each fastener in an embedded mode, a locking rod is arranged on the outer side of each elastic compression spring in a sleeved mode, and the locking rod is connected with the kit body. A pull ring is arranged at the left end of the locking rod, a sealing groove and a placement groove are formed in the surface of the top of the box body, a sealing strip is arranged at the bottom end in the sealing groove, a plurality of reagent grooves are formed in the surface of the top of the placement groove, and positioning clamping mechanisms are arranged in the reagent grooves. A sealing ring block is fixedly mounted on the surface of the bottom of the box cover, through the arrangement of the AAV package titer detection kit, by utilizing the structural design in the positioning clamping mechanism, the purpose of stably clamping a reagent tube is achieved, the stability of the reagent tube is improved, and the placement effect of the kit is ensured.

Description

Technical Field

[0001] The utility model relates to the field of biotechnology, in particular to an AAV packaging titer detection kit. Background Art

[0002] The AAV Packaging Titer Kit is used to quantify genome-containing viral particles in supernatants from cell-based bioproduction systems.

[0003] A currently used AAV packaging titer detection kit has a reagent slot in which the reagent tube is in direct contact. This contact method does not provide a good clamping effect. Therefore, when the kit is moved, the reagent tube is easily shaken, which affects the placement of the kit and is not conducive to subsequent use. At the same time, the kit and the lid are mostly not sealed, so that the air outside the kit can contact the reagent tube, which affects the storage effect of the reagent tube.

[0004] In summary, the utility model solves the problems in the above-mentioned background technology by designing an AAV packaging titer detection kit. Utility Model Content

[0005] The purpose of the utility model is to provide an AAV packaging titer detection kit to solve the problems raised in the above background technology.

[0006] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0007] An AAV packaging titer detection kit comprises a box body and a box cover arranged above the box body, wherein fasteners are fixedly installed at both left and right ends of the box body, an elastic compression spring is embedded at one end of the fastener, a locking rod is sleeved on the outer side of the elastic compression spring, a pull ring is arranged at the left end of the locking rod, a sealing groove and a placement groove are respectively opened on the top surface of the box body, a sealing strip is arranged at the inner bottom end of the sealing groove, a plurality of reagent grooves are opened on the top surface of the placement groove, a positioning clamping mechanism is arranged inside the reagent groove, and a sealing ring block is fixedly installed on the bottom surface of the box cover;

[0008] The positioning and clamping mechanism includes a mounting ring arranged inside the reagent tank, a clamping ring seat is arranged on the inner side of the mounting ring, a mounting cavity is opened inside the clamping ring seat, a supporting compression spring and a positioning plate are respectively arranged inside the mounting cavity, and a rubber clamping ball is fixedly installed on one side of the positioning plate.

[0009] As a preferred solution of the utility model, the cross-section of the sealing groove is an annular structure, and it matches the sealing ring block.

[0010] As a preferred solution of the utility model, the top surface of the sealing strip is in sealing contact with the bottom surface of the sealing ring block.

[0011] As a preferred solution of the utility model, locking holes are opened on the left and right side surfaces of the sealing ring block, and the right end of the locking rod sequentially fits through the left side of the fastener and the left side surface of the box body and extends to the inside of the sealing groove, and is plugged into the socket.

[0012] As a preferred solution of the utility model, the top surface of the mounting ring is flush with the bottom inner wall of the placement groove.

[0013] As a preferred solution of the utility model, the installation cavities are distributed in an annular shape and at equal distances with respect to the inner center of the clamping ring seat.

[0014] As a preferred solution of the utility model, the outer surface of the positioning plate slides in contact with the inner wall of the installation cavity, and the side surface of the rubber clamping ball away from the positioning plate penetrates the inner wall of the installation cavity and extends outward.

[0015] Compared with the prior art, the beneficial effects of the utility model are:

[0016] 1. In the utility model, an AAV packaging titer detection kit is provided, and the structural design in the positioning and clamping mechanism is utilized to realize the elastic support of the positioning plate 305 by the supporting compression spring, so that the positioning plate drives the rubber clamping ball to be close to the reagent tube, thereby achieving the purpose of firmly clamping the reagent tube, improving the stability of the reagent tube, and ensuring the placement effect of the kit.

[0017] 2. In the utility model, an AAV packaging titer detection kit is provided, and the structural design of the sealing ring block, the sealing groove, the sealing strip, the fastener, the elastic compression spring, the locking rod and the pull ring is utilized to realize the clamping connection between the locking rod and the socket, so that the sealing ring block is in contact with the sealing strip, thereby achieving the purpose of sealing the interior of the kit, preventing external air from entering the interior of the kit, and improving the storage effect of the kit. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0019] Figure 2 It is a structural schematic diagram of the box body of the utility model;

[0020] Figure 3 For the utility model Figure 2 A schematic diagram of the enlarged structure of point A;

[0021] Figure 4 It is a schematic diagram of the partial decomposition structure of the kit of the utility model;

[0022] Figure 5 It is a schematic cross-sectional structure diagram of the positioning and clamping mechanism of the utility model.

[0023] In the figure: 1. box body; 101. fastener; 102. elastic compression spring; 103. locking rod; 104. pull ring; 105. sealing groove; 1051. sealing strip; 106. placement groove; 107. reagent tank; 2. box cover; 201. sealing ring block; 3. positioning clamping mechanism; 301. mounting ring; 302. clamping ring seat; 302. clamping ring seat; 303. mounting cavity; 304. supporting compression spring; 305. positioning plate; 306. rubber clamping ball. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0025] To facilitate the understanding of the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings, and several embodiments of the present invention are given. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0026] It should be noted that when an element is referred to as being "fixed on" another element, it may be directly on the other element or there may also be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used in this article are for illustrative purposes only.

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field of the present invention. The terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used in this article includes any and all combinations of one or more related listed items.

[0028] For examples, see Figure 1-5 , the utility model provides a technical solution:

[0029] An AAV packaging titer detection kit comprises a box body 1 and a box cover 2 arranged above the box body 1, fasteners 101 are fixedly installed on both left and right ends of the box body 1, an elastic compression spring 102 is embedded in one end of the fastener 101, a locking rod 103 is sleeved on the outer side of the elastic compression spring 102, a pull ring 104 is arranged on the left end of the locking rod 103, a sealing groove 105 and a placement groove 106 are respectively opened on the top surface of the box body 1, a sealing strip 1051 is arranged on the inner bottom end of the sealing groove 105, a plurality of reagent grooves 107 are opened on the top surface of the placement groove 106, a positioning clamping mechanism 3 is arranged inside the reagent groove 107, and a sealing ring block 201 is fixedly installed on the bottom surface of the box cover 2;

[0030] Specifically, the cross-section of the sealing groove 105 is annular, and it matches the sealing ring block 201. The top surface of the sealing strip 1051 is in sealing contact with the bottom surface of the sealing ring block 201. The left and right surfaces of the sealing ring block 201 are provided with locking holes. The right end of the locking rod 103 sequentially fits through the left side of the fastener 101 and the left side surface of the box body 1 and extends to the inside of the sealing groove 105, and is plugged into the jack.

[0031] In the present embodiment, the sealing groove 105 is mainly used to contact the sealing ring block 201, and the elastic compression spring 102 is mainly used to provide an elastic force for the locking rod 103, so that the locking rod 103 moves toward the sealing groove 105 and contacts the socket, thereby achieving the function of fixing the box cover 2, wherein the sealing strip 1051 is mainly used to come into sealing contact with the sealing ring block 201, thereby ensuring the sealing effect between the box cover 2 and the box body 1, and meeting the storage requirements of the reagent tubes.

[0032] In this embodiment, please refer to Figure 2 and Figure 5 The positioning and clamping mechanism 3 includes a mounting ring 301 disposed inside the reagent tank 107, a clamping ring seat 302 is disposed inside the mounting ring 301, a mounting cavity 303 is provided inside the clamping ring seat 302, a supporting compression spring 304 and a positioning plate 305 are respectively disposed inside the mounting cavity 303, and a rubber clamping ball 306 is fixedly mounted on one side of the positioning plate 305;

[0033] Specifically, the top surface of the mounting ring 301 is flush with the inner wall of the bottom end of the placement groove 106, the mounting cavity 303 is distributed in a circular shape with equal distances about the inner center of the clamping ring seat 302, the outer surface of the positioning plate 305 slides in contact with the inner wall of the mounting cavity 303, and the surface of the rubber clamping ball 306 on one side away from the positioning plate 305 penetrates the inner wall of the mounting cavity 303 and extends outward;

[0034] In this embodiment, the supporting compression spring 304 is mainly used to elastically support the positioning plate 305, and the fitting arrangement of the positioning plate 305 and the mounting cavity 303 ensures the stability of the positioning plate 305 during movement, thereby achieving a tight fit between the rubber clamping ball 306 and the reagent tube, thereby meeting the positioning and clamping requirements of the reagent tube.

[0035] The working process of the utility model is as follows: when using an AAV packaging titer detection kit, the kit is first placed in the required position, and then the reagent tube is placed, and the reagent tube is moved to gradually approach the reagent tank 107. During the approaching process, the reagent tube contacts the rubber clamping ball 306, and the rubber clamping ball 306 drives the positioning plate 305 to move, and the positioning plate 305 slides along the inner wall of the installation cavity 303 and squeezes the supporting compression spring 304, and the squeezed supporting compression spring 304 generates an elastic force, which can drive the rubber clamping ball 306 and the reagent tank 107 to move. The outer surface of the tube is in close contact, thereby completing the positioning and clamping of the reagent tube and improving the stability between the reagent tube and the reagent tank 107. Finally, the box cover 2 is moved to make the sealing ring block 201 close to the sealing groove 105 until the sealing ring block 201 contacts the sealing strip 1051. At this time, the socket and the locking rod 103 are in the same straight line, and the elastic compression spring 102 in a stretched state gradually shrinks and drives the locking rod 103 to move through the pull ring 104, and then the locking rod 103 is in contact with the socket, thereby completing the sealing installation of the box cover 2, facilitating the storage of reagent tubes and meeting the needs of users.

[0036] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An AAV packaging titer detection kit, comprising a box body (1) and a box cover (2) arranged above the box body (1), characterized in that: The left and right ends of the box body (1) are fixedly installed with fasteners (101), one end of the fastener (101) is embedded with an elastic compression spring (102), the outer side of the elastic compression spring (102) is sleeved with a locking rod (103), the left end of the locking rod (103) is provided with a pull ring (104), the top surface of the box body (1) is respectively provided with a sealing groove (105) and a placement groove (106), the inner bottom end of the sealing groove (105) is provided with a sealing strip (1051), the top surface of the placement groove (106) is provided with a plurality of reagent grooves (107), the interior of the reagent groove (107) is provided with a positioning clamping mechanism (3), and the bottom surface of the box cover (2) is fixedly installed with a sealing ring block (201); The positioning clamping mechanism (3) comprises a mounting ring (301) arranged inside the reagent tank (107), a clamping ring seat (302) being arranged on the inner side of the mounting ring (301), a mounting cavity (303) being provided inside the clamping ring seat (302), a supporting compression spring (304) and a positioning plate (305) being respectively arranged inside the mounting cavity (303), and a rubber clamping ball (306) being fixedly mounted on one side of the positioning plate (305).

2. An AAV packaging titer detection kit according to claim 1, characterized in that: The cross-sectional shape of the sealing groove (105) is an annular structure, and matches the sealing ring block (201).

3. An AAV packaging titer detection kit according to claim 1, characterized in that: The top surface of the sealing strip (1051) is in sealing contact with the bottom surface of the sealing ring block (201).

4. The AAV packaging titer detection kit according to claim 1, characterized in that: The left and right surfaces of the sealing ring block (201) are provided with locking holes, and the right end of the locking rod (103) is fitted through the left side of the fastener (101) and the left side surface of the box body (1) in sequence and extends to the inside of the sealing groove (105), and is plugged into the socket.

5. The AAV packaging titer detection kit according to claim 1, characterized in that: The top surface of the mounting ring (301) is flush with the bottom inner wall of the placement groove (106).

6. The AAV packaging titer detection kit according to claim 1, characterized in that: The mounting cavities (303) are distributed in an annular manner and at equal distances with respect to the inner center of the clamping ring seat (302).

7. The AAV packaging titer detection kit according to claim 1, characterized in that: The outer surface of the positioning plate (305) slides in contact with the inner wall of the installation cavity (303), and the surface of the rubber clamping ball (306) on one side away from the positioning plate (305) penetrates the inner wall of the installation cavity (303) and extends outward.

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