Biopharmaceutical two-in-one reaction kettle

Abstract

The utility model belongs to the technical field of biopharmacy, and particularly relates to a biopharmacy two-in-one reaction kettle which comprises a kettle body, and the inner side wall of the kettle body is rotatably connected with a transmission shaft. A spiral structure can increase the turbulence degree of the materials, the stirring effect is good, a transmission shaft drives a mounting plate to rotate through a supporting rod, so that a scraping plate scrapes along the inner wall of the kettle body, the materials are prevented from adhering to blocks, the scraping plate is prevented from being abraded after being used for a long time, and the scraping plate can be always attached to the inner wall of the kettle body through a spring; when the kettle body needs to be cleaned, a valve is opened to discharge materials from a discharging pipe, a transmission shaft drives a material pushing plate to scrape along the bottom of the kettle body, the discharging effect is improved, high-pressure water is sprayed to the inner wall through a rotary cleaning ball, a second motor is started to control a hose to release, the rotary cleaning ball descends, the water consumption is reduced, and the cleaning effect is improved; the device can fully stir and scrape, is not easy to stick, is convenient for automatically cleaning residues, and saves time and labor.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, in particular to a two-in-one biopharmaceutical reactor. Background Art

[0002] In recent years, due to the rapid increase in human demand for biological products such as growth hormone, interferon, monoclonal antibodies, vaccines and interleukins, cell culture through large-scale in vitro culture technology is an effective method for producing biological products. Bioreactors refer to equipment that uses living cells or enzymes as biocatalysts to provide a suitable environment for cell proliferation or biochemical reactions. It is a key equipment in the large-scale animal cell culture process. The most common biopharmaceutical reaction device is a reactor. Since biopharmaceuticals are often made by stirring and mixing liquid medicines, in order to ensure the reaction temperature of the liquid medicine in the reactor, a heating device will be added to heat and regulate the temperature in the reactor to accelerate the reaction;

[0003] During the heating reaction, some existing reactors are prone to local overheating due to uneven stirring, and the heating tubes on the reactor wall are easily heated. After long-term use, a layer of paste will be produced. In order to avoid affecting the quality of subsequent drugs, it is necessary to manually clean the residues in the reactor frequently, which is time-consuming and laborious. Therefore, a two-in-one biopharmaceutical reactor is proposed. Utility Model Content

[0004] The purpose of the utility model is to provide a two-in-one biopharmaceutical reactor to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a two-in-one biopharmaceutical reactor, comprising a reactor body, the inner side wall of the reactor body is rotatably connected to a transmission shaft, a first motor is installed on the upper surface of the reactor body, the output end of the first motor is fixedly connected to the upper end of the transmission shaft, the outer side wall of the transmission shaft is fixedly connected to a uniformly distributed support rod, the outer side wall of the support rod is fixedly connected to a pair of spiral strips, the end of the support rod away from the transmission shaft is fixedly connected to a mounting plate, and the inner side wall of the mounting plate is slidably connected to uniformly distributed sliding rods The end of the sliding rod away from the transmission shaft is fixedly connected with a scraper, the outer wall of the scraper is fixedly connected with a spring between the outer wall of the mounting plate, the outer wall of the kettle body is fixedly connected with a heating pipe, the upper surface of the kettle body is connected with a feeding pipe, the upper surface of the kettle body is installed with a tube winder, the inner wall of the tube winder is wound with a hose, the outer wall of the hose is slidably connected to the inner wall of the kettle body, the upper end of the hose passes through the left side wall of the tube winder, the lower end of the hose is installed with a rotating cleaning ball, and the right side wall of the tube winder is installed with a second motor.

[0006] As a further preferred embodiment of the technical solution: an end of the sliding rod away from the scraper is fixedly connected with an anti-slip block.

[0007] As a further preferred embodiment of the present technical solution: the outer wall of the kettle body is fixedly connected with an insulation sleeve, the upper end of the heating tube is connected with a liquid inlet pipe, the lower end of the heating tube is connected with a liquid outlet pipe, and the outer walls of the liquid inlet pipe and the liquid outlet pipe pass through the inner wall of the insulation sleeve.

[0008] As a further preferred embodiment of the technical solution: the lower surface of the kettle body is connected to a discharge pipe, and a valve is installed on the outer side wall of the discharge pipe.

[0009] As a further preferred embodiment of the present technical solution: the lower surface of the kettle body is fixedly connected with evenly distributed supporting legs.

[0010] As a further preferred embodiment of the present technical solution: a push plate is installed on the lower side of the outer side wall of the transmission shaft.

[0011] Compared with the prior art, the beneficial effects of the utility model are:

[0012] When the utility model is used, heat-conducting oil is injected into the heating tube to heat the material and accelerate the reaction. The first motor is started to drive the transmission shaft, so that the spiral strip stirs the material. The spiral structure can increase the turbulence of the material and has a good stirring effect. The transmission shaft drives the mounting plate to rotate through the support rod, so that the scraper is scraped along the inner wall of the kettle body to prevent the material from sticking and agglomerating. The scraper is worn out after long-term use. The spring can keep the scraper always in contact with the inner wall of the kettle body, and the scraping effect is good. When the kettle body needs to be cleaned, the valve is opened to discharge the material from the discharge pipe, and the transmission shaft drives the push plate to scrape along the bottom of the kettle body to improve the discharge effect. The high-pressure water is sprayed toward the inner wall by the rotating cleaning ball, and the second motor is started to control the hose to release the pipe, so that the rotating cleaning ball is lowered, which reduces the water consumption and improves the cleaning effect. It can fully stir and scrape, is not easy to stick, is convenient for automatic cleaning of residues, and saves time and effort. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a front structural schematic diagram of the utility model;

[0014] Figure 2 It is a cross-sectional structural schematic diagram of the transmission shaft, support rod and spiral strip in the utility model;

[0015] Figure 3 This is a schematic diagram of the structure of the heating pipe, the discharge pipe and the valve in the utility model;

[0016] Figure 4 This is a schematic diagram of the structure of the slide bar, scraper and spring in the utility model;

[0017] Figure 5 It is a schematic structural diagram of the pipe winding device, the hose and the rotating cleaning ball in the utility model.

[0018] In the figure: 1. kettle body; 2. transmission shaft; 3. first motor; 4. support rod; 5. spiral strip; 6. mounting plate; 7. slide rod; 8. scraper; 9. spring; 10. heating tube; 11. feed tube; 12. tube winder; 13. hose; 14. rotating cleaning ball; 15. second motor; 16. anti-slip block; 17. insulation cover; 18. liquid inlet pipe; 19. liquid outlet pipe; 20. outlet pipe; 21. valve; 22. support leg; 23. push plate. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Examples of the embodiments are shown in the drawings, where the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below with reference to the drawings are exemplary and are only used to explain the present application, and cannot be understood as limitations on the present application. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0020] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "install", "connect", "connect", and "set" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0021] See also Figure 1-5The utility model provides a technical solution: a biopharmaceutical two-in-one reactor, comprising a reactor body 1, the inner side wall of the reactor body 1 is rotatably connected to a transmission shaft 2, a first motor 3 is installed on the upper surface of the reactor body 1, the output end of the first motor 3 is fixedly connected to the upper end of the transmission shaft 2, the outer side wall of the transmission shaft 2 is fixedly connected to a uniformly distributed support rod 4, the outer side wall of the support rod 4 is fixedly connected to a pair of spiral strips 5, the end of the support rod 4 away from the transmission shaft 2 is fixedly connected to a mounting plate 6, and the inner side wall of the mounting plate 6 is slidably connected to a uniformly distributed The sliding rod 7 of the cloth, the end of the sliding rod 7 away from the transmission shaft 2 is fixedly connected with a scraper 8, the outer wall of the scraper 8 and the outer wall of the mounting plate 6 are fixedly connected with a spring 9, the outer wall of the kettle body 1 is fixedly connected with a heating pipe 10, the upper surface of the kettle body 1 is connected with a feeding pipe 11, the upper surface of the kettle body 1 is installed with a pipe winding device 12, the inner wall of the pipe winding device 12 is wound with a hose 13, the outer wall of the hose 13 is slidably connected to the inner wall of the kettle body 1, the upper end of the hose 13 passes through the left side wall of the pipe winding device 12, and the lower end of the hose 13 is installed with a rotating cleaning The second motor 15 is installed on the right side wall of the washing ball 14 and the pipe winding device 12; when in use, the material is injected into the kettle body 1 through the feed pipe 11, and the heat transfer oil is injected into the heating pipe 10 to heat the material and accelerate the reaction. The first motor 3 is started to drive the transmission shaft 2 to rotate, so that the spiral strip 5 stirs the material. The spiral structure can increase the turbulence of the material, improve the heat transfer efficiency, and have a good stirring effect. The transmission shaft 2 drives the mounting plate 6 to rotate through the support rod 4, so that the scraper 8 scrapes along the inner wall of the kettle body 1 to prevent the material from sticking. The scraper 8 will be abraded after long-term use. The spring 9 can keep the scraper 8 always in contact with the inner wall of the kettle body 1, and the scraping effect is good. When the kettle body 1 needs to be cleaned, the upper end of the hose 13 is connected to the external water source, and the high-pressure water is sprayed to the inner wall by the rotating cleaning ball 14. The second motor 15 is started to control the hose 13 to release the tube, so that the rotating cleaning ball 14 descends, reducing the water consumption and improving the cleaning effect. A two-in-one biopharmaceutical reactor is formed, which can fully stir and scrape, is not easy to stick, is convenient for automatic cleaning of residues, and saves time and effort.

[0022] In this embodiment, specifically: one end of the slide bar 7 away from the scraper plate 8 is fixedly connected with an anti-dropping block 16 ; the anti-dropping block 16 prevents the slide bar 7 from detaching from the mounting plate 6 .

[0023] In this embodiment, specifically: the outer wall of the kettle body 1 is fixedly connected with an insulation sleeve 17, the upper end of the heating tube 10 is connected with a liquid inlet pipe 18, and the lower end of the heating tube 10 is connected with a liquid outlet pipe 19, and the outer walls of the liquid inlet pipe 18 and the liquid outlet pipe 19 pass through the inner wall of the insulation sleeve 17; the heat transfer oil is injected into the heating tube 10 through the liquid inlet pipe 18, and the insulation sleeve 17 can reduce temperature loss and improve the heating effect.

[0024] In this embodiment, specifically: the lower surface of the kettle body 1 is connected with a discharge pipe 20 , and a valve 21 is installed on the outer wall of the discharge pipe 20 ; when the valve 21 is opened, the mixed material is discharged through the discharge pipe 20 .

[0025] In this embodiment, specifically: the lower surface of the kettle body 1 is fixedly connected with evenly distributed supporting legs 22 ; the supporting legs 22 are used to support and fix the kettle body 1 .

[0026] In this embodiment, specifically: a push plate 23 is installed on the lower side of the outer wall of the transmission shaft 2; the transmission shaft 2 drives the push plate 23 to scrape along the bottom of the kettle body 1, thereby reducing the probability of material sticking and improving the discharge effect.

[0027] The working principle of the utility model is as follows: when in use, the material is injected into the kettle body 1 through the feed pipe 11, the heat transfer oil is injected into the heating pipe 10 to heat the material and accelerate the reaction, the first motor 3 is started to drive the transmission shaft 2 to rotate, so that the spiral strip 5 stirs the material, the spiral structure can increase the turbulence of the material, improve the heat transfer efficiency, and have a good stirring effect, the transmission shaft 2 drives the mounting plate 6 to rotate through the support rod 4, so that the scraper 8 is scraped along the inner wall of the kettle body 1 to prevent the material from sticking and agglomerating, the scraper 8 is worn after being used for a long time, and the spring 9 can keep the scraper 8 always in close contact with the inner wall of the kettle body 1 The wall has a good scraping effect. The transmission shaft 2 drives the push plate 23 to scrape along the bottom of the kettle body 1, which reduces the probability of material sticking and improves the discharge effect. When the kettle body 1 needs to be cleaned, the valve 21 is opened to discharge the material from the discharge pipe 20, and the upper end of the hose 13 is connected to an external water source. The high-pressure water is sprayed to the inner wall by rotating the cleaning ball 14, and the second motor 15 is started to control the hose 13 to release the tube, so that the rotating cleaning ball 14 descends, reducing the water consumption and improving the cleaning effect. A two-in-one biopharmaceutical reactor is formed, which can be fully stirred and scraped, is not easy to stick, is convenient for automatic cleaning of residues, and saves time and effort.

[0028] In the present invention, the rotating cleaning ball 14 can be a HWS rotating cleaning ball of CYCO, model HWS-20.

[0029] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A two-in-one biopharmaceutical reactor, comprising a reactor body (1), characterized in that: The inner side wall of the kettle body (1) is rotatably connected to a transmission shaft (2); a first motor (3) is installed on the upper surface of the kettle body (1); an output end of the first motor (3) is fixedly connected to the upper end of the transmission shaft (2); an outer side wall of the transmission shaft (2) is fixedly connected to evenly distributed support rods (4); an outer side wall of the support rod (4) is fixedly connected to a pair of spiral strips (5); an end of the support rod (4) away from the transmission shaft (2) is fixedly connected to a mounting plate (6); an inner side wall of the mounting plate (6) is slidably connected to evenly distributed sliding rods (7); an end of the sliding rod (7) away from the transmission shaft (2) is fixedly connected to a scraper (8); the scraper A spring (9) is fixedly connected between the outer wall of the kettle body (8) and the outer wall of the mounting plate (6); a heating tube (10) is fixedly connected to the outer wall of the kettle body (1); the upper surface of the kettle body (1) is connected to a feeding tube (11); a tube winding device (12) is installed on the upper surface of the kettle body (1); a hose (13) is wound around the inner wall of the tube winding device (12); the outer wall of the hose (13) is slidably connected to the inner wall of the kettle body (1); the upper end of the hose (13) passes through the left side wall of the tube winding device (12); a rotating cleaning ball (14) is installed at the lower end of the hose (13); and a second motor (15) is installed on the right side wall of the tube winding device (12).

2. A biopharmaceutical two-in-one reactor according to claim 1, characterized in that: An anti-slip block (16) is fixedly connected to one end of the slide rod (7) away from the scraper (8).

3. A biopharmaceutical two-in-one reactor according to claim 1, characterized in that: The outer wall of the kettle body (1) is fixedly connected to a heat preservation sleeve (17); the upper end of the heating tube (10) is connected to a liquid inlet pipe (18); the lower end of the heating tube (10) is connected to a liquid outlet pipe (19); and the outer walls of the liquid inlet pipe (18) and the liquid outlet pipe (19) pass through the inner wall of the heat preservation sleeve (17).

4. A two-in-one biopharmaceutical reactor according to claim 1, characterized in that: The lower surface of the kettle body (1) is connected to a discharge pipe (20), and a valve (21) is installed on the outer side wall of the discharge pipe (20).

5. The two-in-one biopharmaceutical reactor according to claim 1, characterized in that: The lower surface of the kettle body (1) is fixedly connected with evenly distributed supporting legs (22).

6. The two-in-one biopharmaceutical reactor according to claim 1, characterized in that: A push plate (23) is installed on the lower side of the outer side wall of the transmission shaft (2).

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