Flexible multi-mode ablation catheter with vacuum tube compensation structure

Abstract

The embodiment of the utility model provides a flexible multi-mode ablation catheter with a vacuum tube compensation structure, and the catheter comprises a front end structure which comprises a needle head; the far end of the flexible pipeline is connected with the needle head, and the flexible pipeline sequentially wraps a vacuum forming layer, a first air return pipeline and an air inlet pipeline from outside to inside in the radial direction; the far end of the air return chamber is communicated with the first air return pipeline, and the near end of the air return chamber is communicated with the second air return pipeline; a first vacuum chamber having a distal end in communication with the vacuum forming layer; the vacuum tube compensation structure comprises a pipeline connecting structure, the pipeline connecting structure is provided with a second vacuum chamber communicated with the first vacuum chamber, the air inlet pipeline penetrates through the vacuum chambers and the air return chamber, and the air inlet pipeline and the second air return pipeline are arranged in the second vacuum chamber in a penetrating mode independently. According to the flexible multi-mode ablation catheter, a concentric structure of the pipeline is converted into a structure that the first vacuum chamber surrounds the second air return pipeline and the air inlet pipeline, and then the parallel tubular structure is converted through the rear end connector, so that the high vacuum degree can be formed.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of medical device technology, and in particular to a flexible multimodal ablation catheter with a vacuum tube compensation structure. Background Art

[0002] The incidence of malignant tumors is increasing year by year, posing a growing threat to human health. Traditional treatment methods such as surgery, radiotherapy, chemotherapy and other technologies are becoming more and more mature, but they will inevitably cause varying degrees of damage to the normal functions of the body, and the success rate of treatment still needs to be improved. With the development of science and technology, especially the advancement of medical imaging technologies such as magnetic resonance imaging and ultrasound imaging, minimally invasive surgeries such as cryotherapy and heating ablation therapy for tumors have made great progress and are becoming more and more popular, but they still have their own shortcomings.

[0003] Multimodal thermal physical therapy for tumors can not only overcome the shortcomings of single cold and single heat therapy, but also improve the cure rate of tumors, while protecting normal tissues from damage. It has become a hot topic in the research of thermal physical therapy for tumors. Through the precise control and regulation of the local thermal physical effects of malignant tumors, multimodal thermal physical therapy can not only effectively treat in situ tumors, but also relieve the immunosuppression of malignant tumors on the body, and induce and enhance the body's anti-tumor immune response, thereby effectively inhibiting distant metastasis.

[0004] Chinese invention patent CN202210774481.6 discloses a multimodal ablation probe and control system, which is inserted into the target lesion through percutaneous puncture, and then sequentially applies freezing and radiofrequency energy to the tumor tissue to achieve multimodal ablation treatment. However, for tumors in some special locations, such as those near natural cavities such as the respiratory tract, esophagus, and urethra, it is difficult for the probe to enter the tumor through percutaneous puncture without causing trauma to the tissue in the cavity, and once the wall of the above-mentioned cavity is penetrated, the result is often fatal. Therefore, the development of a flexible multimodal ablation needle and control system, which can smoothly reach the target tumor through the natural cavity and implement multimodal treatment, will significantly reduce tissue initiation, improve surgical efficiency, and is of great significance in the treatment of cavity tumors.

[0005] The main difference between the flexible multimodal ablation needle system and the traditional multimodal ablation needle system (percutaneous puncture) is that the flexible multimodal ablation needle has a longer tube (about 1m) entering the human body, and the outer tube material is usually a flexible polymer material with a high deflation coefficient under vacuum conditions. Therefore, if the conventional probe is used to pre-make the vacuum tube, it will be difficult to maintain the high vacuum degree of the flexible probe needle tube for a long time. In addition, the vacuum cavity formed between the inner and outer vacuum tubes of the flexible multimodal ablation needle is very thin (about 0.15mm). When the ablation needle bends in the preset laparoscope, the inner and outer vacuum tubes will contact each other due to the different bending radii of the inner and outer vacuum tubes, resulting in vacuum failure at the contact point, affecting the operation. Utility Model Content

[0006] In view of the above problems, the present application provides a flexible multi-modal ablation catheter to overcome the above problems or at least partially solve the above problems.

[0007] An embodiment of the present application provides a flexible multimodal ablation catheter, which includes: a front end structure, including: a needle; a flexible pipeline, the distal end of which is connected to the needle, and the flexible pipeline radially covers a vacuum-forming layer, a first return air pipeline and an air inlet pipeline in sequence from the outside to the inside; a vacuum tube compensation structure, which includes: a pipeline conversion structure, which has: a return air chamber, the distal end of which is connected to the first return air pipeline, and the proximal end of which is connected to the second return air pipeline; a first vacuum chamber, the distal end of which is connected to the vacuum-forming layer; a pipeline connection structure, which has a second vacuum chamber connected to the first vacuum chamber, the air inlet pipeline runs through the vacuum chamber and the return air chamber, and is independently arranged in the second vacuum chamber from the second return air pipeline.

[0008] Optionally, the flexible multimodal ablation catheter further comprises a rear end connector having three independent conversion pipelines respectively connected to the air inlet pipeline, the second air return pipeline and the second vacuum chamber.

[0009] Optionally, the rear end connector is also connected to a gas generating device, a gas recovery device and a vacuum forming device, respectively. The gas generating device, the gas recovery device and the vacuum forming device are connected to the air inlet pipeline, the second air return pipeline and the second vacuum chamber via the rear end connector, respectively. When the vacuum forming device is working, the vacuum forming layer, the vacuum chamber and the second vacuum chamber form a vacuum.

[0010] Optionally, a base is provided at the proximal end of the first vacuum chamber, the base is connected to the vacuum chamber and the return air chamber respectively, and the second vacuum chamber and the second return air pipeline are connected to the first vacuum chamber and the return air chamber respectively via the base, and the air inlet pipeline runs through the base.

[0011] Optionally, the second return air pipeline is connected to the return air chamber through a transition pipeline provided on the base, and the transition pipeline includes a first pipe portion and a second pipe portion extending axially, and a third pipe portion extending radially, and the third pipe portion is respectively connected to the first pipe portion and the second pipe portion.

[0012] Optionally, the flexible multimodal ablation catheter further comprises: a compensation component, the compensation component is provided with an adjustment member, and the adjustment member is axially slidably disposed between the flexible pipeline and the vacuum chamber.

[0013] Optionally, the vacuum chamber has a shell, the adjusting member axially passes through the shell and extends to the inside of the shell, the distal end of the adjusting member is slidably and sealingly connected to the flexible pipeline, and the adjusting member can slide axially relative to the shell.

[0014] Optionally, the compensation component further comprises a fastener disposed on the housing, and the fastener can fix the adjusting member in the radial direction to limit the axial movement of the adjusting member.

[0015] Optionally, a limiting structure is provided between the adjusting member and the housing, and the limiting structure has a planar structure for limiting the axial rotation of the adjusting member.

[0016] Optionally, a stopper is provided at the proximal end of the adjusting member, and a radial length of the stopper is greater than a radial length of the proximal end of the shell.

[0017] It can be seen from the above technical scheme that the vacuum-forming layer, the first return air line and the air inlet line of the flexible multimodal ablation catheter in the embodiment of the present application are converted into a concentric structure of the pipelines so that the first vacuum chamber surrounds the second return air line and the air inlet line, and at the same time the vacuum-forming layer is expanded to the second vacuum chamber with a larger space, thereby realizing the vacuum extraction technology inside the first vacuum chamber and the second vacuum chamber, and then converting the parallel tubular structure through the rear end joint, so that the air paths are separated and do not interfere with each other, and the formation of a high vacuum degree can be achieved.

[0018] This patent adopts real-time vacuum extraction technology during surgery to achieve the vacuum structure of the flexible multimodal ablation needle. In addition, this patent also sets a vacuum compensation structure for the vacuum layer. When the pipeline is bent, the vacuum compensation structure can effectively compensate for the displacement difference between the inner and outer tubes caused by the different bending radius. When the ablation needle is positioned, it is locked by the locking device to form an effective sealing structure to realize the subsequent vacuum process. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the embodiments of the present application. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0020] Figure 1 is a schematic diagram of a flexible multimodal ablation catheter of the present application;

[0021] Figure 2 It is a cross-sectional view of an embodiment of a pipeline conversion structure of the present application;

[0022] Figure 3 is a partially enlarged cross-sectional view of an embodiment of a vacuum compensation structure of the present application;

[0023] Figure 4 is a cross-sectional view of an embodiment of a needle portion of the present application;

[0024] Figure 5 is a front view of an embodiment of the base of the present application facing the distal end;

[0025] Figure 6-7 They are Figure 4 The cross-sectional view of the base along the GG and HH directions shown;

[0026] Figure 8 is a front view of an embodiment of the base of the present application facing the proximal end;

[0027] Fig. 9 is a three-dimensional perspective view of the base of the present application;

[0028] Fig. 10A It is a rear view of the far end of a rear end connector of a pipeline conversion structure of the present application;

[0029] Fig. 10B is along Fig. 10A A cross-sectional view of the rear end joint in the GG direction shown;

[0030] Fig. 10C It is a front view of the far end of a rear end connector of a pipeline conversion structure of the present application;

[0031] Fig. 10D is along Fig. 10C A cross-sectional view of the rear end joint in the HH direction shown;

[0032] Fig.10E It is a three-dimensional perspective view of the far end of a rear end connector of a pipeline conversion structure of the present application.

[0033] Component number

[0034] 10: flexible multimodal ablation catheter; 101: needle; 102: flexible pipeline; 103: vacuum forming layer; 104: first return air pipeline; 105: air inlet pipeline; 106: exhaust hole; 108: first vacuum chamber; 109: second vacuum chamber; 110: return air chamber; 111: base; 112: transfer pipeline; 1121: first tube part; 1122: second tube part; 1123: third tube part; 114: rear end joint; 118: pipeline conversion structure; 119: second return air pipeline; 123: adjusting member; 124: housing; 126: fastener; 127: limiting structure; 128: stopper; 129: sealing ring. DETAILED DESCRIPTION

[0035] In order to enable those skilled in the art to better understand the technical solutions in the embodiments of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments in the embodiments of the present application should fall within the scope of protection of the embodiments of the present application.

[0036] The “distal end” and “front end” mentioned herein refer to the left end of the flexible multimodal ablation catheter shown in the figure; the “proximal end” and “rear end” mentioned herein refer to the right end of the flexible multimodal ablation catheter shown in the figure.

[0037] The specific implementation of the embodiment of the present application is further explained below in conjunction with the accompanying drawings of the embodiment of the present application.

[0038] See also Figures 1 to 10E In a specific implementation of the present application, a flexible multimodal ablation catheter 10 is provided, comprising: a front end structure, comprising: a needle 101; a flexible pipeline, the distal end of which is connected to the needle 101, and the flexible pipeline radially covers a vacuum-forming layer 103, a first return air pipeline 104, and an air inlet pipeline 105 in sequence from the outside to the inside; a vacuum tube compensation structure, which comprises: a pipeline conversion structure 118, which has: a return air chamber 110, the distal end of which is connected to the first return air chamber 110; The return air pipeline 104 is connected, and the proximal end of the return air chamber 110 is connected to the second return air pipeline 119; the first vacuum chamber 108, and the distal end of the first vacuum chamber 108 is connected to the vacuum forming layer 103; the pipeline connection structure has a second vacuum chamber 109 connected to the first vacuum chamber 108, the air inlet pipeline 105 runs through the vacuum chamber and the return air chamber 110, and is independently arranged in the second vacuum chamber 109 with the second return air pipeline 119.

[0039] The needle 101 may be connected to the distal end of the air intake pipeline 105 , and the air intake pipeline 105 may be provided with a plurality of exhaust holes 106 to connect the air intake pipeline 105 with the first air return pipeline 104 .

[0040] Optionally, the flexible multimodal ablation catheter 10 further includes a rear end connector 114 , and the rear end connector 114 has three independent conversion pipelines, which are respectively connected to the air inlet pipeline 105 , the second air return pipeline 119 and the second vacuum chamber 109 .

[0041] Optionally, the rear end connector 114 is also connected to a gas generating device, a gas recovery device and a vacuum forming device, respectively. The gas generating device, the gas recovery device and the vacuum forming device are connected to the air inlet pipe 105, the second air return pipe 119 and the second vacuum chamber 109 via the rear end connector 114, respectively. When the vacuum forming device is working, the vacuum forming layer 103, the vacuum chamber and the second vacuum chamber 109 form a vacuum.

[0042] Optionally, a base 111 is provided at the proximal end of the first vacuum chamber 108, and the base 111 is connected to the vacuum chamber and the return air chamber 110 respectively, and the second vacuum chamber 109 and the second return air pipeline 119 are connected to the first vacuum chamber 108 and the return air chamber 110 respectively via the base 111, and the air inlet pipeline 105 runs through the base 111.

[0043] Optionally, the second return air pipeline 119 is connected to the return air chamber 110 through a transfer pipeline 112 provided on the base 111, and the transfer pipeline 112 includes a first tube portion 1121 and a second tube portion 1122 extending axially, and a third tube portion 1123 extending radially, and the third tube portion 1123 is connected to the first tube portion 1121 and the second tube portion 1122 respectively.

[0044] Optionally, the flexible multimodal ablation catheter 10 further includes: a compensation component, the compensation component is provided with an adjustment member 123, and the adjustment member 123 is axially slidably disposed between the flexible pipeline 102 and the vacuum chamber.

[0045] Optionally, the vacuum chamber has a shell 124 , the adjusting member 123 axially passes through the shell 124 and extends into the shell 124 , the distal end of the adjusting member 123 is slidably and sealingly connected to the flexible pipe 102 , and the adjusting member 123 can slide axially relative to the shell 124 .

[0046] Optionally, the compensation assembly further includes a fastener 126 disposed on the housing 124, and the fastener 126 can fix the adjusting member 123 in the radial direction to limit the axial movement of the adjusting member 123. The fastener 126 can be a nut, and the housing 124 can be provided with a screw.

[0047] Optionally, a limiting structure 127 is provided between the adjusting member 123 and the housing 124 , and the limiting structure 127 has a planar structure and is used to limit the adjusting member 123 from rotating along the axial direction.

[0048] Optionally, a stopper 128 is provided at the proximal end of the adjusting member 123 , and a radial length of the stopper 128 is greater than a radial length of the proximal end of the housing 124 .

[0049] The vacuum compensation structure includes: a vacuum forming layer 103, which is sandwiched between the flexible pipeline 102 and the vacuum inner tube (the first return air pipeline 104); a transition structure, which has: a first vacuum chamber 108, the distal end of the first vacuum chamber 108 is connected to the vacuum forming layer 103, and the proximal end of the first vacuum chamber 108 is connected to the second vacuum chamber 109; a compensation component, the compensation component is provided with an adjustment member 123, and the adjustment member 123 can be axially slidably arranged between the flexible pipeline 102 and the first vacuum chamber 108.

[0050] In one embodiment, the vacuum compensation structure also includes: a return air chamber 110, the distal end of the return air chamber 110 is connected to the first return air pipeline 104, and the proximal end of the return air chamber 110 is connected to the second return air pipeline 119; an air intake pipeline 105, which runs through the first vacuum chamber 108 and the return air chamber 110, and the air intake pipeline 105 includes a first part and a second part, the vacuum forming layer 103, the first return air pipeline 104 and the first part of the air intake pipeline 105 are sequentially arranged from the outside to the inside in the radial direction, the second return air pipeline 119 and the second part of the air intake pipeline 105 are independent of each other and the first vacuum chamber 108 is covered on the outer periphery of the second return air pipeline 119 and the second part of the air intake pipeline 105.

[0051] In one embodiment, the first vacuum chamber 108 has a shell 124, the adjusting member 123 axially passes through the shell 124 and extends into the shell 124, the distal end of the adjusting member 123 is slidably and sealingly connected to the flexible pipe 102, and the adjusting member 123 can slide axially relative to the shell 124.

[0052] In one embodiment, the compensation assembly further includes a fastener 126 disposed on the housing 124, and the fastener 126 can fix the adjusting member 123 in the radial direction to limit the axial movement of the adjusting member 123. The fastener 126 can be a locking nut, and the sealing connection between the adjusting member 123 and the vacuum housing 124 is achieved by tightening the locking nut.

[0053] In one embodiment, a limiting structure 127 is provided between the adjusting member 123 and the shell 124. The limiting structure 127 has a planar structure. The contact portion of the shell 124 with the limiting structure 127 can be a plane or an arc surface. Thus, the limiting structure 127 can limit the axial rotation of the adjusting member 123.

[0054] In one embodiment, a stopper 128 is disposed at the proximal end of the adjusting member 123 , and a radial length of the stopper 128 is greater than a radial length of the proximal end of the housing 124 .

[0055] In one embodiment, a sealing ring 129 is provided on the stop member 128, and a groove can be provided at the front end of the stop member 128, and the sealing ring 129 is clamped in the groove. When the adjustment member 123 moves axially to the far end of the outer shell 124, the sealing ring 129 forms a seal between the stop member 128 and the outer shell 124.

[0056] In one embodiment, a base 111 is provided at the proximal end of the vacuum compensation structure, and the base 111 is connected to the first vacuum chamber 108 and the return air chamber 110 respectively, and the second vacuum chamber 109 and the second return air pipeline 119 are connected to the first vacuum chamber 108 and the return air chamber 110 respectively via the base 111, and the air inlet pipeline 105 runs through the base 111.

[0057] In one embodiment, the second return air pipe 119 is connected to the return air chamber 110 through a transfer pipe 112 provided on the base 111, and the transfer pipe 112 includes a first pipe portion 1121 and a second pipe portion 1122 extending axially, and a third pipe portion 1123 extending radially, and the third pipe portion 1123 is connected to the first pipe portion 1121 and the second pipe portion 1122 respectively.

[0058] In one embodiment, the second vacuum chamber 109 is connected to a vacuum forming device. When the vacuum forming device is in operation, the vacuum forming layer 103, the first vacuum chamber 108 and the second vacuum chamber 109 are vacuumed.

[0059] When the flexible pipe 102 is not bent, there is an axial gap (1 to 3 mm) between the sealing ring 129 and the vacuum shell 124. When the flexible pipe 102 moves and bends in the endoscope cavity, due to the displacement difference between the flexible pipe 102 and the vacuum inner tube, the axial gap between the sealing ring 129 and the vacuum shell 124 gradually decreases, and the sealing ring 129 fits the inner side of the vacuum shell 124; when the flexible pipe 102 is placed, the sealing adjustment piece 123 and the vacuum shell 124 are sealed by the locking nut.

[0060] The flexible pipe 102 can be made of a flexible pipe with good lubricity and insulation. The material of the flexible pipe 102 can be a polymer material such as PTFE, Nylon, PEBAX, etc. The outer diameter of the flexible pipe 102 can be between 1mm and 4mm, and the length can be between 100mm and 3000mm. The material of the air intake pipe 105 can be metal, such as stainless steel 304, 316L, brass, copper, etc. The material of the first return air pipe 104 and the second return air pipe 119 can be PTFE, Nylon, PEBAX, etc.

[0061] In one embodiment, the vacuum forming layer 103 is sandwiched between the flexible pipeline 102 and the vacuum inner tube, and the flexible pipeline 102 is closed and connected to the distal end of the vacuum inner tube. The vacuum compensation structure also includes a needle 101 connected to the distal end of the flexible pipeline 102, and the first return air pipeline 104 is connected to the first part of the air inlet pipeline 105.

[0062] In one embodiment, the first portion is connected to the needle 101, and at least one through hole is disposed at a distal end of the first portion.

[0063] In one embodiment, a temperature measuring device is provided in the first air return line 104, and the temperature measuring device is in contact with the needle 101; the needle 101 is connected to a radio frequency circuit, and the radio frequency circuit is also electrically connected to the host to transmit the energy generated by the host to the needle 101. The temperature measuring device can be a thermocouple or other temperature measuring devices.

[0064] The second vacuum chamber 109 can be connected to a rear end connector 114, which has three independent conversion pipelines, which are connected to the air intake pipeline 105, the second air return pipeline 119 and the second vacuum chamber 109 respectively. The rear end connector 114 is also connected to the gas generating device, the gas recovery device and the vacuum forming device respectively. The gas generating device, the gas recovery device and the vacuum forming device are connected to the air intake pipeline 105, the second air return pipeline 119 and the second vacuum chamber 109 via the rear end connector 114 respectively. When the vacuum forming device is working, the vacuum forming layer 103, the first vacuum chamber 108 and the second vacuum chamber 109 form a vacuum. The connector is also connected to the host electrical signal, which is used for the thermocouple to collect temperature signals and transmit radio frequency signals respectively. The electrical signal connection part realizes contact connection through a spring ejector structure. One end of the radio frequency signal transmission line is connected to the air intake pipeline 105, and the radio frequency signal is transmitted to the needle 101 through the air intake pipeline 105.

[0065] In one embodiment, a hollow handle may be further provided outside the first vacuum chamber 108 , and the handle covers the first vacuum chamber 108 from the outside.

[0066] The main difference between the flexible multimodal ablation needle in the embodiment of the present application and the traditional multimodal ablation needle (percutaneous puncture type) is that the pipeline of the flexible multimodal ablation needle entering the human body is longer (about 1m), and the outer tube material is usually a flexible polymer material with a high degassing coefficient under vacuum conditions. Therefore, if a conventional probe is used to pre-make a vacuum tube, the high vacuum degree of the flexible probe needle tube will be difficult to maintain for a long time.

[0067] During the operation, the endoscope first passes through the natural cavity of the human body (oral cavity, anus, urethra, etc.), and enters and finds the lesion with the help of the endoscope's own light source and imaging system. Then the flexible ablation catheter enters through the instrument channel of the endoscope until the lesion tissue is located for surgical treatment, thus solving the technical problem that the metal hard rod of the probe cannot bend and enter the natural cavity and can only enter through needle puncture. It avoids skin damage and bleeding caused by puncture.

[0068] The working modes of existing probes are all single freezing or radio frequency modes, which are difficult to achieve the freezing requirements of precise control and rapid pre-cooling of multimodal ablation. Due to different patients and different lesion organs, the location of the lesion will also be different. For example, if the lesion location is more demanding, the difficulty of the operation will be increased, the time of the operation will be prolonged, and the success rate of the operation will be reduced. The endoscope can enter the demanding lesion location from the natural cavity of the human body through the bending angle of the front end. The flexible multimodal ablation needle uses the internal channel of the endoscope to enter and finally reach the lesion location through its own bending for surgical treatment. The probe can only perform destructive puncture on the tissue, and once the wall of the cavity is penetrated, the result is often fatal.

[0069] The vacuum forming layer 103, the first vacuum chamber 108 and the second vacuum chamber 109 form a vacuum layer structure. The vacuum forming device can evacuate the vacuum layer structure in real time. When the vacuum degree of the vacuum layer structure reaches the required requirement, the multimodal ablation catheter starts the transmission work. During the entire working period of the flexible multimodal ablation needle, the vacuum forming device always keeps working to ensure the maintenance of the vacuum degree of the vacuum layer structure. When the flexible multimodal ablation needle finishes working, the vacuum forming device also stops working.

[0070] When the multimodal ablation catheter is working during surgery, the cryogenic medium will reach the needle through the air inlet line 105 to perform cryoablation on the tumor tissue. If frosting occurs on other parts of the ablation catheter except the needle, the liquid nitrogen cooling capacity will be lost, so that the temperature at the needle cannot reach the cryotherapy temperature, and other frosted parts will damage the normal tissues in the human body cavity, so the vacuum layer is indispensable. The real-time vacuum pumping technology ensures the maintenance of the vacuum degree of the vacuum layer during the operation, improves the success rate of the operation, and the vacuum layer plays an insulating role when the ablation needle is working. At present, the vacuum layer of the probe is mostly pre-processed, rather than real-time suction. If the vacuum layer leaks or the vacuum degree decreases before use, it will cause damage to the patient and the instrument. The connection method between the second vacuum chamber 109 and the vacuum forming device can be a VCR joint sealing connection, or it can be connected and sealed by a metal lead-out tube and a latex tube. The connection method is not limited as long as it can play a sealing role.

[0071] The vacuum forming layer 103, the first air return line 104 and the air intake line 105 are converted from the concentric structure of the lines into the first vacuum chamber 108 surrounding the second air return line 119 and the air intake line 105, and at the same time the vacuum forming layer 103 is expanded to the second vacuum chamber 109 with a larger space, so that the vacuum pumping technology is realized inside the first vacuum chamber 108 and the second vacuum chamber 109, and then converted into a parallel tubular structure through the rear end joint 114, so that each gas path is separated and does not interfere with each other, and the formation of a high vacuum degree can be achieved.

[0072] The multimodal ablation catheter has two working modes: cryoablation mode and radiofrequency ablation mode. During treatment, the rapid temperature change from local freezing to sub-high temperature causes the tumor tissue to simultaneously withstand drastic changes in temperature and stress in a short period of time, effectively achieving in situ fragmentation of tumor cells and tumor microvessels, and maximally releasing tumor antigens, immune-related factors, and a large number of danger signals; then, through the continuous warming effect of radiofrequency heating, the body's anti-tumor immune response is further stimulated, thereby achieving the purpose of inhibiting the recurrence and metastasis of solid tumors. In the single cryoablation mode, tumor cells are mechanically destroyed by deep freezing to form ice crystals, which can release a large number of tumor antigens. However, tumor cells in the sub-low temperature zone at the edge of cryoablation are mainly apoptotic, which can cause immunosuppression. In the single radiofrequency ablation mode, the edge warm area may mobilize the body to have an endogenous immune response during the ablation process, but due to the lack of sufficient tumor-related factors and antigen release, its immunoregulatory effect is weak. The thermocouple can reach the needle 101 position through the vacuum formation layer 103 or through the first return air pipeline 104. There is no restriction on the arrival method, as long as the radiofrequency ablation function can be achieved. Identification resistors are installed inside the freezing line connector and the radio frequency line 116 connector connected to the host. When the ablation needle is connected to the host, the host can identify whether it is inserted in place. When it is not inserted in place or missed, an alarm will be prompted.

[0073] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the embodiments of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A flexible multimodal ablation catheter with a vacuum tube compensation structure, characterized in that: The flexible multimodal ablation catheter comprises: The front-end structure includes: Needles; A flexible pipeline, the distal end of which is connected to the needle, and the flexible pipeline radially covers the vacuum-forming layer, the first air return pipeline and the air intake pipeline in sequence from the outside to the inside; The vacuum tube compensation structure comprises: The pipeline conversion structure has: A return air chamber, wherein the distal end of the return air chamber is communicated with the first return air pipeline, and the proximal end of the return air chamber is communicated with the second return air pipeline; a first vacuum chamber, the distal end of which is in communication with the vacuum-forming layer; The pipeline connection structure has a second vacuum chamber connected to the first vacuum chamber, the air inlet pipeline runs through the vacuum chamber and the air return chamber, and is independently arranged in the second vacuum chamber with the second air return pipeline.

2. The flexible multimodal ablation catheter according to claim 1, characterized in that: The flexible multi-modal ablation catheter also includes a rear end connector, which has three independent conversion pipelines, which are respectively connected to the air inlet pipeline, the second air return pipeline and the second vacuum chamber.

3. The flexible multimodal ablation catheter according to claim 2, characterized in that: The rear end connector is also respectively connected to a gas generating device, a gas recovery device and a vacuum forming device. The gas generating device, the gas recovery device and the vacuum forming device are respectively connected to the air inlet pipeline, the second air return pipeline and the second vacuum chamber via the rear end connector. When the vacuum forming device is working, the vacuum forming layer, the vacuum chamber and the second vacuum chamber form a vacuum.

4. The flexible multimodal ablation catheter according to claim 1, characterized in that: A base is provided at the proximal end of the first vacuum chamber, and the base is connected to the first vacuum chamber and the return air chamber respectively, and the second vacuum chamber and the second return air pipeline are connected to the first vacuum chamber and the return air chamber respectively via the base, and the air inlet pipeline runs through the base.

5. The flexible multimodal ablation catheter according to claim 4, characterized in that: The second return air pipeline is connected to the return air chamber through a transfer pipeline arranged on the base. The transfer pipeline includes a first pipe portion and a second pipe portion extending axially, and a third pipe portion extending radially. The third pipe portion is connected to the first pipe portion and the second pipe portion respectively.

6. The flexible multimodal ablation catheter according to claim 1, characterized in that: The flexible multi-modal ablation catheter further comprises: a compensation component, wherein the compensation component is provided with an adjustment member, and the adjustment member is axially slidably arranged between the flexible pipeline and the vacuum chamber.

7. The flexible multimodal ablation catheter according to claim 6, characterized in that: The vacuum chamber has a shell, the adjusting member axially passes through the shell and extends to the inside of the shell, the distal end of the adjusting member is slidably and sealingly connected with the flexible pipeline, and the adjusting member can slide relative to the shell along the axial direction.

8. The flexible multimodal ablation catheter according to claim 7, characterized in that: The compensation component also includes a fastener disposed on the housing, and the fastener can fix the adjusting member in the radial direction to limit the axial movement of the adjusting member.

9. The flexible multimodal ablation catheter according to claim 7, characterized in that: A limiting structure is provided between the adjusting member and the housing. The limiting structure has a planar structure and is used to limit the adjusting member from rotating along the axial direction.

10. The flexible multimodal ablation catheter according to claim 7, characterized in that: A stopper is disposed at the proximal end of the adjusting member, and a radial length of the stopper is greater than a radial length of the proximal end of the housing.

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