Manual propeller for inner ear gene therapy

Abstract

The utility model relates to the technical field of medical instruments, and provides a manual thruster for inner ear gene therapy, which comprises a shell, a first pivot point, a second handle, a second pivot point, a first through hole and a second through hole, the first pivot point and the second handle are arranged at the near end, and the second pivot point and the first through hole are arranged at the far end. The transmission part penetrates through the first through hole and is in sliding fit with the first through hole; one side of the response body is in rotating fit with the second pivot point, and the other side of the response body is in rotating and sliding fit with the far end of the transmission part; one end of the driving body is provided with a first handle matched with the second handle, the middle of the driving body is rotationally matched with the first pivot point, and the other end of the driving body is rotationally and slidably matched with the near end of the transmission part. The first handle and the second handle can be manually adjusted so as to control the response body to drive the injection catheter to rotate, the accuracy of an operation approach and the controllability of round window injection are improved, and the round window injection device has the advantages of being easy to operate, low in cost and capable of being repeatedly used.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, and in particular to a manual propeller for inner ear gene therapy. Background Art

[0002] According to statistics, there are as many as 26 million patients with congenital deafness in the world. In my country, about 30,000 newborns are born with deafness each year, of which 60% are related to genetic factors, which seriously damage children's hearing, speech and intellectual development, but there is currently no effective treatment in clinical practice. In recent years, with the innovation and development of biomedical technology, biological treatment methods for hereditary deafness have been deeply explored. The most popular methods include promoting hair cell regeneration, stem cell transplantation and gene therapy. Among them, gene therapy is considered to be one of the most promising and ideal strategies for curing hereditary deafness. Gene therapy introduces normal genes or therapeutic genes into target cells to compensate or correct defective genes, thereby fundamentally improving hearing and making the restored hearing closer to the state of natural sound.

[0003] In addition to the actual clinical needs, gene therapy for deafness also benefits from the unique structure of the inner ear. The inner ear is a relatively accessible but closed and fluid-filled space. Its blood-labyrinth barrier allows drugs injected into the cochlea to maintain high concentrations in the target organ while minimizing systemic distribution, reducing toxicity to non-target organs and tissues.

[0004] At present, the injection approach with the lowest risk of trauma and postoperative complications (vertigo, total deafness, etc.) is the round window membrane introduction surgical route. The main difficulty of the round window injection approach is the lack of stable and controllable tools for precise virus introduction. In order to meet the accuracy of the surgical approach and improve the stability and controllability of the round window injection, it is urgent to construct a propulsion device for inner ear gene therapy to address the shortcomings of existing technologies. Utility Model Content

[0005] In view of the defects in the prior art, the purpose of the utility model is to provide a manual propeller for inner ear gene therapy.

[0006] According to the utility model, a manual propeller for inner ear gene therapy is provided, comprising:

[0007] The housing has a first pivot point and a second handle both disposed at the proximal end, a second pivot point disposed at the distal end, and a first through hole and a second through hole disposed inside;

[0008] A transmission member, passing through the first through hole and slidingly engaging with the first through hole;

[0009] The responding body has one side rotatingly matched with the second pivot point and the other side rotatingly and slidingly matched with the distal end of the transmission member; the second through hole is used to guide the injection catheter into the interior of the housing and enter the interior of the responding body from the rear end of the responding body and extend to the front end of the responding body;

[0010] A driving body, one end of which has a first handle matching the second handle, the middle part of which is rotationally matched with the first pivot point, and the other end of which is rotationally and slidingly matched with the proximal end of the transmission member. When the first handle and the second handle are tightened or loosened by hand force, the driving body can rotate around the first pivot point and then pull or push the transmission member to drive the response body to rotate around the second pivot point, thereby driving the injection catheter to rotate synchronously.

[0011] Preferably, the rotation and sliding structure at the proximal end of the transmission member comprises a first sliding member and a first rotating member, wherein the end of the first rotating member extends into the interior of the first sliding member or penetrates the first sliding member and can rotate and / or slide relative to the first sliding member;

[0012] The rotating and sliding structure at the distal end of the transmission member includes a second sliding member and a second rotating member, wherein the end of the second rotating member extends into the interior of the second sliding member or penetrates the second sliding member and can rotate and / or slide relative to the second sliding member.

[0013] Preferably, a waist-shaped hole is provided on the first sliding member, and the first rotating member is a rotating shaft structure;

[0014] The second sliding member is provided with a waist-shaped hole, and the second rotating member is a rotating shaft structure.

[0015] Preferably, the first sliding member is fixed on the driving body, and the second sliding member is fixed on the responding body.

[0016] Preferably, the first sliding member is fixed on the transmission member, and the second sliding member is fixed on the response body.

[0017] Preferably, the first sliding member is fixed on the driving body, and the second sliding member is fixed on the transmission member.

[0018] Preferably, the first sliding member is fixed on the transmission member, and the second sliding member is fixed on the transmission member.

[0019] Preferably, the transmission member is a rod-shaped, plate-shaped or steel wire structure.

[0020] Preferably, a catheter port is provided on the shell, the catheter port forms a port of the second through-hole, and the catheter port is used to guide the injection catheter into the second through-hole.

[0021] Preferably, stainless steel is used; the shell is an integral structure or a split structure.

[0022] Compared with the prior art, the utility model has the following beneficial effects:

[0023] The utility model can manually adjust the relative angle between the first handle and the second handle to drive the transmission member to drive the response body to rotate around the axis, thereby controlling the response body to drive the injection catheter to rotate, thereby achieving direction adjustment, improving the accuracy of the surgical approach and the controllability of the round window injection, and has the advantages of simple operation, low cost, and repeated use. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Other features, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings:

[0025] Figure 1 It is a schematic diagram of the structure of the utility model;

[0026] Figure 2 It is a schematic diagram of the cross-sectional structure of the utility model;

[0027] Figure 3 It is a structural schematic diagram of Example 2;

[0028] Figure 4 It is a structural schematic diagram of Example 3;

[0029] Figure 5 It is a schematic diagram of the structure of the connection between the transmission body and the response body in Example 2 or 3;

[0030] Figure 6 It is a structural schematic diagram of Example 4;

[0031] Figure 7 This is a schematic diagram of the structure of Example 5.

[0032] The figure shows:

[0033] Driver 1

[0034] First handle 101

[0035] Transmission parts 2

[0036] Response body 3

[0037] First pivot point 4

[0038] First sliding member 5

[0039] First rotating member 6

[0040] Sliding pair 7

[0041] The second rotating member 8

[0042] Second sliding member 9

[0043] Second pivot point 10

[0044] Injection catheter 11

[0045] Housing 12

[0046] Second handle 121

[0047] Catheter port 13 DETAILED DESCRIPTION

[0048] The utility model is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the utility model, but do not limit the utility model in any form. It should be pointed out that for those of ordinary skill in the art, several changes and improvements can be made without departing from the concept of the utility model. These all belong to the protection scope of the utility model.

[0049] Embodiment 1:

[0050] The utility model provides a manual propeller for inner ear gene therapy, which is preferably made of stainless steel. Figure 1 , Figure 2 As shown, it includes a driving body 1, a transmission member 2, a responding body 3 and a shell 12. The shell 12 serves as a supporting structure of the entire manual propeller. The proximal end of the shell 12 is provided with a first pivot point 4 and a second handle 121, and the distal end is provided with a second pivot point 10. The interior of the shell 12 is provided with a first through hole and a second through hole. The transmission member 2 passes through the first through hole. Under the drive of an external force, the transmission member 2 can slide with the first through hole; one side of the responding body 3 is rotationally matched with the second pivot point 10, and the other side is rotationally and slideably matched with the distal end of the transmission member 2 so that the front end of the responding body 3 The direction can be adjusted; the second perforation is used to guide the injection catheter 11 to enter the interior of the shell 12 and enter the interior of the responding body 3 from the rear end of the responding body 3 and extend to the front end of the responding body 3. When in use, a catheter port 13 is provided on the shell 12, and the catheter port 13 forms the port of the second perforation. The catheter port 13 is used to guide the injection catheter 11 to enter the second perforation. The inner diameter of the catheter port 13 can be designed to be slightly larger than the inner diameter of the second perforation, preferably in a trumpet shape, so that the injection catheter 11 can be inserted into the second perforation more quickly, thereby improving assembly efficiency. After the manual pusher in the utility model is used, the injection catheter 11 can be pulled out through the catheter port 13, and after disinfection and sterilization, it can be used again, thereby reducing the use cost of surgical instruments.

[0051] Furthermore, one end of the driver 1 has a first handle 101 matching the second handle 121. The first handle 101 and the second handle 121 together form the force-applying end of the manual propeller. The first handle 101 and the second handle 121 can be closed or separated by holding the hand. The middle part of the driver 1 rotates with the first pivot point 4 to become the support point for the driver 1 to complete the rotation. The other end of the driver 1 rotates and slides with the proximal end of the transmission member 2. When the first handle 101 and the second handle 121 are tightened or loosened by hand, the driver 1 can rotate around the first pivot point 4 and then pull or push the transmission member 2. At this time, the transmission member 2 slides in the first perforation and forms a sliding pair 7 with the shell 12. The precise matching of the sliding pair 7 makes the transmission member 2 have no radial displacement in the reciprocating motion, thereby improving the stability of the transmission. The movement of the transmission member 2 in the axial direction drives the response body 3 to rotate around the second pivot point 10, thereby driving the injection catheter 11 to rotate synchronously. While adjusting the direction of the response body 3, the direction of the injection catheter 11 can also be adjusted, thereby achieving the drug administration requirements.

[0052] It should be noted that both the first pivot point 4 and the second pivot point 10 can adopt a hinge structure to achieve the function of rotational cooperation, for example, the hinge function is achieved by the cooperation of a rotating shaft and a hole.

[0053] Specifically, the rotation and sliding structure at the proximal end of the transmission member 2 includes a first sliding member 5 and a first rotating member 6, the end of the first rotating member 6 extends to the interior of the first sliding member 5 or passes through the first sliding member 5 and can rotate and / or slide relative to the first sliding member 5; the rotation and sliding structure at the distal end of the transmission member 2 includes a second sliding member 9 and a second rotating member 8, the end of the second rotating member 8 extends to the interior of the second sliding member 9 or passes through the second sliding member 9 and can rotate and / or slide relative to the second sliding member 9, wherein the first sliding member 5 and the second sliding member 9 are both provided with waist-shaped holes, which can be blind holes or through holes, and the first rotating member 6 and the second rotating member 8 are both rotating shaft structures. When the driving body 1 rotates around the first pivot point 4, the motion trajectory of the driving body 1 close to the end of the transmission member 2 is an arc. Therefore, the motion coordination relationship with the proximal end of the transmission member 2 can be achieved by setting a rotation and sliding method. Similarly, when the responding body 3 rotates around the second pivot point 10, the motion trajectory of the end of the responding body 3 away from the second pivot point 10 is also an arc, and the motion coordination relationship with the far end of the transmission member 2 can only be achieved through rotation and sliding.

[0054] The transmission member 2 can adopt a variety of structural forms, such as a rod-shaped, plate-shaped or steel wire structure. The steel wire structure can be made of a material with high rigidity to avoid deformation that affects the driving accuracy. A steel wire bundle made of multiple strands of steel wire can also be used to improve the driving effect. The housing 12 can adopt an integrated structure or a split structure, which can be flexibly designed according to actual conditions. When the housing 12 is designed as a split structure, a detachable effect is achieved, which is convenient for storage and occupies a small space.

[0055] The utility model designs the manual propeller into a structural form in which the transmission member 2 pushes or pulls the responding body 3 to rotate, which greatly increases the rotation angle range of the responding body 3 and improves the versatility of the device.

[0056] Specifically, the responding body 3 has a third perforation inside that matches the injection catheter 11. The third perforation should be designed to match the size of the injection catheter 11, which can not only meet the requirements of easy assembly, but also drive the injection catheter 11 to rotate synchronously when the responding body 3 rotates, thereby increasing the accuracy of the position adjustment of the injection catheter 11. In addition, the inlet end of the third perforation on the responding body 3 should correspond to the position of the outlet end of the second perforation, so that the injection catheter 11 can smoothly transition from the second perforation to the third perforation, thereby increasing the practicality of the device.

[0057] Embodiment 2:

[0058] This embodiment is a preferred example of embodiment 1. The first sliding member 5 and the second sliding member 9 are both provided with waist-shaped holes. Figure 3 As shown, the first sliding member 5 is fixed on the driving body 1, the second sliding member 9 is fixed on the responding body 3, the first rotating member 6 and the second rotating member 8 are both rotating shafts, and the two rotating shafts are respectively fixed on the two ends of the transmission member 2.

[0059] like Figure 5 As shown, a hinged joint is provided at the far end of the transmission member 2. On the one hand, the hinged joint can limit the retracted position of the transmission member 2. On the other hand, a rotating shaft is provided on the hinged joint. The rotating shaft serves as the second rotating member 8. The second sliding member 9 is a waist-shaped through hole and is an integrally formed structure with the responding body 3. The rotating shaft passes through the waist-shaped through hole so that the rotating shaft and the waist-shaped through hole form a rotating and sliding matching relationship during the rotation of the responding body 3.

[0060] The responder 3 in this embodiment is made of stainless steel and has a narrow front end and a wide rear end. Its size can be flexibly designed according to the needs of the operation.

[0061] Embodiment 3:

[0062] The difference between this embodiment and embodiment 2 is that the first sliding member 5 is fixed to the proximal end of the transmission member 2. Figure 4 As shown, the first rotating member 6 is fixed on the driving body 1 .

[0063] Embodiment 4:

[0064] The difference between this embodiment and embodiment 2 is that the second sliding member 9 is fixed at the distal end of the transmission member 2. Figure 6 As shown, the second rotating member 8 is fixed on the responding body 3 .

[0065] Embodiment 5:

[0066] The difference between this embodiment and embodiment 2 is that the first sliding member 5 is fixed to the proximal end of the transmission member 2. Figure 7 As shown, the second sliding member 9 is fixed on the distal end of the transmission member 2 , the second rotating member 8 is fixed on the responding body 3 , and the first rotating member 6 is fixed on the driving body 1 .

[0067] The operating principle of the utility model is as follows:

[0068] First: cut and lift the external auditory canal flap under an otoscope or microscope, enter the tympanic cavity, and directly observe the round window niche and round window membrane;

[0069] Secondly, the prepared virus or drug is introduced into the injection catheter 11, and then the injection catheter 11 is extended from the catheter port 13 and passes through the second perforation to the third perforation;

[0070] Once again, the responding body 3 of the manual propeller is operated to go deep into the tympanic cavity from the external auditory canal, and the first handle 101 and the second handle 121 are held by the hand and the relative angle between the two is adjusted, so that the direction of the responding body 3 can be adjusted by driving the responding body 3 to rotate around the second pivot point 10, so that the responding body 3 reaches the surface of the round window membrane;

[0071] Finally, the length of the injection catheter 11 is adjusted to puncture and enter the round window membrane, and the first handle 101 and the second handle 121 are fixed to achieve the introduction of the virus or drug into the inner ear through the injection catheter 11.

[0072] In the description of the present application, it should be understood that the terms "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0073] The above describes the specific embodiments of the present invention. It should be understood that the present invention is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essence of the present invention. In the absence of conflict, the embodiments of the present application and the features in the embodiments can be combined with each other at will.

Claims

1. A manual propeller for inner ear gene therapy, characterized in that: include: The housing (12) has a first pivot point (4) and a second handle (121) both arranged at the proximal end, a second pivot point (10) arranged at the distal end, and a first through hole and a second through hole arranged inside. A transmission member (2), passing through the first through hole and slidingly engaging with the first through hole; The responding body (3) has one side that is rotationally matched with the second pivot point (10) and the other side that is rotationally and slidingly matched with the distal end of the transmission member (2); the second through hole is used to guide the injection catheter (11) to enter the interior of the housing (12) and enter the interior of the responding body (3) from the rear end of the responding body (3) and extend to the front end of the responding body (3); A driving body (1) has a first handle (101) at one end that matches the second handle (121), a middle portion that is rotationally matched with the first pivot point (4), and the other end that is rotationally and slidably matched with the proximal end of the transmission member (2). When the first handle (101) and the second handle (121) are tightened or loosened by hand force, the driving body (1) can rotate around the first pivot point (4) and then pull or push the transmission member (2) to drive the response body (3) to rotate around the second pivot point (10), thereby driving the injection catheter (11) to rotate synchronously.

2. The manual propeller for inner ear gene therapy according to claim 1, characterized in that: The rotating and sliding structure at the proximal end of the transmission member (2) comprises a first sliding member (5) and a first rotating member (6), wherein the end of the first rotating member (6) extends into the interior of the first sliding member (5) or penetrates the first sliding member (5) and is capable of rotating and / or sliding relative to the first sliding member (5); The rotating and sliding structure at the far end of the transmission member (2) comprises a second sliding member (9) and a second rotating member (8), wherein the end of the second rotating member (8) extends into the interior of the second sliding member (9) or penetrates the second sliding member (9) and is capable of rotating and / or sliding relative to the second sliding member (9).

3. The manual propeller for inner ear gene therapy according to claim 2, characterized in that: The first sliding member (5) is provided with a waist-shaped hole, and the first rotating member (6) is a rotating shaft structure; The second sliding member (9) is provided with a waist-shaped hole, and the second rotating member (8) is a rotating shaft structure.

4. The manual propeller for inner ear gene therapy according to claim 2 or 3, characterized in that: The first sliding member (5) is fixed on the driving body (1), and the second sliding member (9) is fixed on the responding body (3).

5. The manual propeller for inner ear gene therapy according to claim 2 or 3, characterized in that: The first sliding member (5) is fixed on the transmission member (2), and the second sliding member (9) is fixed on the response body (3).

6. The manual propeller for inner ear gene therapy according to claim 2 or 3, characterized in that: The first sliding member (5) is fixed on the driving body (1), and the second sliding member (9) is fixed on the transmission member (2).

7. The manual propeller for inner ear gene therapy according to claim 2 or 3, characterized in that: The first sliding member (5) is fixed on the transmission member (2), and the second sliding member (9) is fixed on the transmission member (2).

8. The manual propeller for inner ear gene therapy according to claim 1, characterized in that: The transmission member (2) is in the shape of a rod, a plate or a steel wire.

9. The manual propeller for inner ear gene therapy according to claim 1, characterized in that: The shell (12) is provided with a catheter port (13), the catheter port (13) forming a port of the second through hole, and the catheter port (13) is used to guide the injection catheter (11) into the second through hole.

10. The manual propeller for inner ear gene therapy according to claim 1, characterized in that: The material is stainless steel; the shell (12) is an integral structure or a split structure.

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