Component for in-vitro construction and cartilage transplantation of autologous bone marrow mesenchymal stem cells

Abstract

The utility model discloses a cartilage transplantation component for in-vitro construction of autologous bone marrow mesenchymal stem cells, which relates to the technical field of orthopedic medical instruments and comprises a guide part and a drilling implant, the guide part is matched with the drilling implant for use, and a guide structure matched with the drilling implant for use is arranged on the guide part. The drilling implant comprises a punching part, a cartilage pushing-in part and a reaming part. Through the cooperative use of the guide piece and the drilling implant, the in-vitro construction of the cartilage transplantation assembly by the BMSCs is realized. Due to the design of the guide part, the drilling implant can be used for drilling, reaming and implanting at a cartilage defect part, and meanwhile, chronic tissues are protected, so that the operation is simpler, more convenient and more accurate. The drilling implant comprises a punching part, a cartilage pushing-in part and a reaming part, each part has a specific function, and different operation requirements can be met. By means of the technical scheme, the success rate and stability of cartilage transplantation operation can be effectively improved, and better guarantee is provided for rehabilitation of patients.

Description

Technical Field

[0001] The utility model relates to the technical field of orthopedic medical instruments, in particular to a component for in vitro construction of cartilage transplantation by autologous bone marrow mesenchymal stem cells. Background Art

[0002] In daily life, many people often suffer from articular cartilage damage due to unscientific exercise methods; if the cartilage damage is not treated and repaired in time, it will cause certain harm to the body; usually, the repair method should be selected according to the degree of cartilage damage; when the cartilage damage defect is serious, surgical treatment is required; artificial transplantation, by making an incision at the damaged part, and then combining the body's own bone tissue with artificial bone, can effectively achieve the effect of promoting generation, which will improve the growth rate of bones and achieve the effect of repair;

[0003] At present, cartilage transplantation is one of the commonly used methods for treating cartilage lesions. Traditional cartilage transplantation usually uses autologous cartilage transplantation or transplantation of other cartilage, but these methods have a series of problems, such as damage to the donor area and easy deformity after transplantation. In order to overcome these problems, researchers began to apply stem cells to the field of cartilage transplantation, hoping to achieve cartilage regeneration and repair through stem cell engineering technology. Among them, autologous bone marrow mesenchymal stem cells (BMSCs) are widely used in the field of cartilage transplantation, with mature in vitro expansion technology and good regeneration ability. However, the current BMSCs carrier performance is limited, the surgical operation is difficult, and the unstable effect after transplantation still exists.

[0004] Therefore, in order to solve the above problems, we proposed a component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells. Utility Model Content

[0005] The utility model aims to provide a component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells, so as to solve the problems raised by the above-mentioned background technology.

[0006] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0007] A component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells comprises a guide and a drilling implant. The guide is used in conjunction with the drilling implant. A guiding structure used in conjunction with the drilling implant is arranged on the guide. The drilling implant comprises a punch, a cartilage pusher and a hole expander.

[0008] As a preferred technical solution of the utility model, the guide member includes a handle and a guide tube, a handle is provided at one end of the guide tube, and the end of the guide tube is flush with the side wall of one end of the handle, a limiting cover is provided at the upper part of the handle, and a fixed cover is provided at the lower part, a serration is provided at the bottom end of the guide tube, and an elliptical hole is opened on the bottom side wall, and a scale is provided on the side wall next to the elliptical hole.

[0009] As a preferred technical solution of the utility model, the punching member includes a first cross bar, a first vertical bar and a flat-head drill bit. The side wall of the first cross bar is welded to one end of the first vertical bar at 90 degrees, and the flat-head drill bit is arranged on the end of the first vertical bar away from the first cross bar.

[0010] As a preferred technical solution of the utility model, the cartilage pushing piece includes a second cross bar, a second vertical bar and a cylindrical head. The side wall of the second cross bar is welded to one end of the second vertical bar at 90 degrees, and the cylindrical head is arranged on one end of the second vertical bar away from the second cross bar.

[0011] As a preferred technical solution of the utility model, the hole expanding member includes a third cross bar, a third vertical bar and a triangular conical head. The side wall of the third cross bar is welded to one end of the third vertical bar at 90 degrees, and the triangular conical head is arranged on one end of the third vertical bar away from the third cross bar.

[0012] As a preferred technical solution of the utility model, the guide tube is used in conjunction with the first vertical rod, the second vertical rod and the third vertical rod, and the first vertical rod, the second vertical rod and the third vertical rod have the same length, the length of the guide tube is smaller than the length of the first vertical rod, the second vertical rod and the third vertical rod, and the top side walls of the first vertical rod, the second vertical rod and the third vertical rod are all provided with threads.

[0013] As a preferred technical solution of the present invention, the guide member and the drilling implant are both made of 304 or 316 stainless steel.

[0014] As a preferred technical solution of the present invention, the handle is columnar, and its outer wall is provided with anti-slip convex or concave patterns.

[0015] As a preferred technical solution of the utility model, the diameter of the cylindrical head is equal to the diameter of the second vertical rod.

[0016] As a preferred technical solution of the present utility model, the first cross bar, the second cross bar and the third cross bar have the same size specifications.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] The utility model realizes the construction of cartilage transplant components by BMSCs in vitro through the coordinated use of a guide and a drilling implant. The design of the guide enables the drilling implant to punch, expand, and implant in the cartilage defect site while protecting chronic tissue, making the operation easier and more accurate. The drilling implant includes a punch, a cartilage pusher, and an expansion member, each of which has a specific function to meet different operational requirements. Through this technical solution, the success rate and stability of cartilage transplant surgery can be effectively improved, providing better protection for the patient's recovery. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A schematic diagram of the structure of a guide component for constructing a cartilage transplantation component in vitro using autologous bone marrow mesenchymal stem cells provided by the utility model;

[0020] Figure 2 A schematic diagram of the structure of a drilling implant component for constructing a cartilage transplantation component in vitro with autologous bone marrow mesenchymal stem cells provided by the utility model;

[0021] Figure 3 A schematic diagram of the structure of a punching piece of a component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells provided by the utility model;

[0022] Figure 4 A schematic diagram of the structure of a cartilage pusher of a component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells provided by the utility model;

[0023] Figure 5 The utility model provides a schematic structural diagram of a hole expansion component for a component used for in vitro construction of cartilage transplantation using autologous bone marrow mesenchymal stem cells.

[0024] In the figure:

[0025] 1. Guide; 11. Handle; 12. Guide tube; 13. Limit cover; 14. Fixed cover;

[0026] 2. Drilling implants;

[0027] 23. Punching member; 21. Hole expanding member; 22. Pushing member;

[0028] 211, first horizontal bar; 212, first vertical bar; 213, flat drill bit;

[0029] 221, second horizontal bar; 222, second vertical bar; 223, cylindrical head;

[0030] 231. The third horizontal bar; 232. The third vertical bar; 233. The triangular cone head. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0032] Example:

[0033] The solution provided by the embodiment of the utility model is: a component for constructing cartilage transplantation with autologous bone marrow mesenchymal stem cells in vitro, please refer to Figure 1-Figure 2 As shown, it includes a guide 1 and a drilling implant 2. The guide 1 is used in conjunction with the drilling implant 2. A guiding structure used in conjunction with the drilling implant 2 is provided on the guide 1. The drilling implant 2 includes a hole expanding member 21, a cartilage pushing member 22 and a punching member 23.

[0034] The guide 1 is used to guide the drilling implant 2 to reach an accurate position.

[0035] Specific reference Figure 1 As shown, the guide member 1 includes a handle 11, a guide tube 12, a limit cover 13 and a fixed cover 14. The handle 11 is provided at one end of the guide tube 12, and the end of the guide tube 12 is flush with the side wall of one end of the handle 11. The setting of the handle 11 is convenient for medical personnel to operate by hand, and the guide tube 12 provides a direction and position guidance function for the subsequent expansion member 21, cartilage pusher 22 and punching member 23; the limit cover 13 is provided at the upper part of the handle 11, and the fixed cover 14 is provided at the lower part. The bottom end of the guide tube 12 is provided with saw teeth, and a rectangular hole is opened on the bottom side wall, and a scale is provided on the side wall next to the rectangular hole. The fixed cover 14 is used to fix the guide tube 12, and the limit rod 13 is used to limit the insertion length of the drilling implant 2.

[0036] Specific reference Figure 3 As shown, the hole reamer 21 includes a first cross bar 211, a first vertical bar 212 and a flat-head drill bit 213. The side wall of the first cross bar 211 is welded to one end of the first vertical bar 212 at 90 degrees, and the flat-head drill bit 213 is arranged on the end of the first vertical bar 212 away from the first cross bar 211. The hole reamer 21 is used to expand the hole at the position where cartilage needs to be implanted. The design of the first cross bar 211 is convenient for medical workers to hold and operate;

[0037] Specific reference Figure 4As shown, the cartilage pushing member 22 includes a second cross bar 221, a second vertical bar 222 and a cylindrical head 223. The side wall of the second cross bar 221 is welded to one end of the second vertical bar 222 at 90 degrees. The cylindrical head 223 is arranged on the second vertical bar 222 at an end away from the second cross bar 221. The cartilage pushing member 22 pushes the cartilage tissue placed in the guide member 1 to the target position. The coordinated use of the cylindrical head 223 and the guide tube 12 can deliver the cartilage tissue to the target position more quickly.

[0038] Specific reference Figure 5 As shown, the punching member 23 includes a third cross bar 231, a third vertical bar 232 and a triangular cone head 233. The side wall of the third cross bar 231 is welded to one end of the third vertical bar 232 at 90 degrees. The triangular cone head 233 is arranged on the end of the third vertical bar 232 away from the third cross bar 231. The punching member 23 is designed to punch holes for implanting cartilage tissue. The rotation of the triangular cone head 233 can quickly expand the holes for implanting cartilage tissue.

[0039] The guide tube 12 is used in conjunction with the first vertical rod 212, the second vertical rod 222 and the third vertical rod 232, and the first vertical rod 212, the second vertical rod 222 and the third vertical rod 232 have the same length. The length of the guide tube 12 is smaller than the length of the first vertical rod 212, the second vertical rod 222 and the third vertical rod 232, and the top side walls of the first vertical rod 212 and the second vertical rod 222 are both provided with threads.

[0040] The guide 1 and the drilling implant 2 are both made of 304 or 316 stainless steel. 304 or 316 stainless steel is safer and more corrosion-resistant.

[0041] The handle 11 is columnar, and its outer wall is provided with anti-skid convex or concave patterns. The design of the convex or concave patterns can make the medical worker hold it more stably.

[0042] The diameter of the cylindrical head 223 is equal to the diameter of the second vertical rod 222 .

[0043] The first cross bar 211 , the second cross bar 221 and the third cross bar 231 have the same size and specifications, which facilitates storage and operation.

[0044] When in use, under arthroscopy, first place the guide tube 12 of the guide member 1 at the site where cartilage needs to be transplanted;

[0045] Then put in the punching member 23, and punch the hole to the depth limit position;

[0046] Then the hole is further expanded to a suitable depth using the expansion member 21;

[0047] Finally, the transplanted cartilage is placed in the guide tube 12 and pushed in with the cartilage pusher 22 until it is flush with the surrounding cartilage.

[0048] The contents not described in detail in this specification belong to the prior art known to professional and technical personnel in the field. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for technical personnel in the field to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells, comprising a guide (1) and a drilling implant (2), characterized in that: The guide member (1) is used in conjunction with a drilling implant (2); a guide structure for use in conjunction with the drilling implant (2) is provided on the guide member (1); the drilling implant (2) comprises a hole expanding member (21), a cartilage pushing member (22) and a punching member (23).

2. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 1, characterized in that: The guide member (1) comprises a handle (11), a guide tube (12), a limit cover (13) and a fixed cover (14); one end of the guide tube (12) is provided with the handle (11), and the end of the guide tube (12) is flush with the side wall of one end of the handle (11); the upper part of the handle (11) is provided with the limit cover (13), and the lower part is provided with the fixed cover (14); the bottom end of the guide tube (12) is provided with saw teeth, and the bottom side wall is provided with a rectangular hole, and the side wall next to the rectangular hole is provided with a scale.

3. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 1, characterized in that: The hole expanding member (21) comprises a first cross bar (211), a first vertical bar (212) and a flat-head drill bit (213); a side wall of the first cross bar (211) is welded to one end of the first vertical bar (212) at a 90-degree angle; and the flat-head drill bit (213) is arranged on one end of the first vertical bar (212) away from the first cross bar (211).

4. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 1, characterized in that: The cartilage pushing member (22) comprises a second cross bar (221), a second vertical bar (222) and a cylindrical head (223); the side wall of the second cross bar (221) is welded to one end of the second vertical bar (222) at 90 degrees; and the cylindrical head (223) is arranged on one end of the second vertical bar (222) away from the second cross bar (221).

5. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 1, characterized in that: The punching member (23) comprises a third crossbar (231), a third vertical bar (232) and a triangular cone head (233); a side wall of the third crossbar (231) is welded to one end of the third vertical bar (232) at 90 degrees; and the triangular cone head (233) is arranged on one end of the third vertical bar (232) away from the third crossbar (231).

6. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 2, characterized in that: The guide tube (12) is used in conjunction with the first vertical rod (212), the second vertical rod (222) and the third vertical rod (232), and the first vertical rod (212), the second vertical rod (222) and the third vertical rod (232) have the same length, the length of the guide tube (12) is smaller than the length of the first vertical rod (212), the second vertical rod (222) and the third vertical rod (232), and the top side walls of the first vertical rod (212) and the second vertical rod (222) are both provided with threads.

7. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 2, characterized in that: The guide member (1) and the drilling implant member (2) are both made of 304 or 316 stainless steel.

8. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 2, characterized in that: The handle (11) is columnar, and its outer wall is provided with anti-slip convex or concave patterns.

9. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 4, characterized in that: The diameter of the cylindrical head (223) is equal to the diameter of the second vertical rod (222).

10. The component for constructing cartilage transplantation in vitro with autologous bone marrow mesenchymal stem cells according to claim 3, characterized in that: The first crossbar (211), the second crossbar (221) and the third crossbar (231) have the same size specifications.

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