Multi-type medicine preparation device

Abstract

The utility model discloses a device for preparing various medicines. The device comprises an unwinding system, a bottom film, a coating system, an oven system, a plurality of feeding systems and a plurality of winding systems, the multiple feeding systems provide different coating liquid medicine, after a layer of medicine film is formed on a bottom film through coating of the coating system, the bottom film and the medicine film are fed into the oven system to be baked, the baked bottom film and the baked medicine film are placed in one winding system to be wound, the operation is repeated, and the multi-layer oral dissolving film can be prepared. In addition, at least one other winding system is further connected with the other unwinding system, an upper film used for preparing the transdermal patch is arranged on the other unwinding system, and the transdermal patch is obtained by compounding the bottom film coated with the layer of liquid medicine and the upper film through the other winding system and then winding. The preparation of various medicines is realized on one preparation device, the preparation efficiency of the medicines is improved, and the preparation cost of the medicines is reduced.

Description

Technical Field

[0001] The utility model relates to the field of medicine preparation devices, in particular to a multi-type medicine preparation device. Background Art

[0002] Among the routes of drug administration, oral administration is one of the most convenient, cost-effective and popular routes of administration. With the development of science and medical technology, the forms of drugs have also developed in various forms. Orodispersible film is a relatively new dosage form. The drug liquid is processed into a thin layer of drug film, which can quickly disintegrate or dissolve in the tongue or mouth, making it easier for patients to swallow. It is suitable for the administration of drugs to the elderly, children and other groups with swallowing difficulties. However, some drugs need to release their efficacy slowly in the patient's body. Traditional orodispersible film tablets have a single-layer structure, which melts in the mouth, and the drug is directly absorbed, and the drug takes a relatively short time to exert its efficacy. If the requirements for slow drug release are to be met, a double-layer orodispersible film needs to be developed to meet the above situation.

[0003] In addition, a transdermal patch is a medical device that delivers drugs into the body through the skin. It uses the skin's natural barrier and meridian system to gradually release drugs through the skin into the blood circulation to achieve the purpose of treating diseases. The use of transdermal patches involves many aspects, including Chinese medicine transdermal technology and fentanyl transdermal patches. Both transdermal patches and double-layer orodispersible films are currently commonly used drug preparations. They are widely used in clinical practice according to different treatment needs and drug administration requirements.

[0004] In the prior art, there is only a process for preparing a single-layer orodispersible film. When multiple drugs need to be prepared, they need to be prepared together with other preparations, which results in high preparation costs. Therefore, there is an urgent need for a multi-class drug preparation device and process to solve the problem of preparing a double-layer orodispersible film and a transdermal patch at the same time, reduce preparation costs, and improve preparation efficiency. Utility Model Content

[0005] The purpose of the utility model is to provide a multi-type medicine preparation device, which can realize the preparation of multiple types of medicines on one preparation device and reduce the cost of medicine preparation.

[0006] In order to solve the above technical problems, the utility model provides a multi-type drug preparation device, including: an unwinding system, a base film, a coating system, an oven system, multiple feeding systems and multiple winding systems;

[0007] The coating system includes a precision slide, a scraper, a coating roller and a coating pressure roller;

[0008] The base film is installed on the unwinding system; the unwinding system is connected to the coating roller, and the coating roller is connected to the coating pressure roller;

[0009] A plurality of the feeding systems are connected to the coating roller; the scraper is arranged on the precision slide, and is adjusted by the precision slide to coat the liquid medicine onto the surface of the base film; an adjustable gap is arranged between the scraper and the coating roller;

[0010] The winding system comprises: a winding roller and a winding roller pressure roller;

[0011] The coating roller is connected to the oven system, the oven system is connected to the plurality of winding rollers, and the winding roller is connected to the winding roller pressure roller;

[0012] At least one of the reeling systems is also connected to another unreeling system.

[0013] Furthermore, the oven system includes an oven, a fan, a heating pipe, an air outlet pipe and an air return pipe;

[0014] The fan is connected to the heating tube, the heating tube is connected to the air outlet duct, the air outlet duct is connected to the inside of the oven, and the return air duct connects the inside and the outside of the oven.

[0015] Furthermore, a stop bar is provided inside the oven system.

[0016] Furthermore, the oven system is stacked to include an upper oven system and a lower oven system.

[0017] Further, the feeding system includes a buffer tank, a liquid medicine and a pump;

[0018] The buffer tank is connected to the pump, the pump is installed in the drug liquid pipe, and the pump is used to transfer the drug liquid from the buffer tank to the coating system through the drug liquid pipe.

[0019] Furthermore, the pump is a gear pump or a peristaltic pump.

[0020] Further, the unwinding system includes an unwinding roller or an upper film unwinding roll;

[0021] The unwinding roller is connected to the coating roller; the upper film unwinding roller is connected to the winding roller.

[0022] Furthermore, it also includes: a plurality of static electricity eliminators, which are respectively arranged between the unwinding roller and the coating roller and between the winding roller and the coating roller.

[0023] Furthermore, it also includes: a deviation correcting machine, a film closing roller and a film closing pressure roller;

[0024] The deviation correcting machine is connected to the film-closing roller, the film-closing roller is connected to the plurality of winding rollers, and the film-closing roller is also connected to the film-closing pressing roller.

[0025] Further, it includes a first feeding system and a second feeding system, a first winding system and a second winding system;

[0026] The first feeding system and the second feeding system are respectively connected to the coating roller;

[0027] The first winding system and the second winding system are connected to the film combining rollers respectively.

[0028] Compared with the prior art, the utility model has at least the following beneficial effects:

[0029] In this embodiment, multiple feeding systems are provided to provide different coating liquids. After a layer of drug film is formed on the base film by the coating system, it is sent to the oven system for baking. The baked base film and drug film are placed in one of the winding systems for winding, and then the base film coated with a layer of drug film is placed in the unwinding system. After another feeding system coats the base film with a second layer of drug liquid, the base film is sent to the oven system for baking. The base film and the two layers of drug film are wound up by one of the winding systems. The above operation is repeated to prepare a multi-layer oral dissolving film. In addition, at least one winding system is also connected to another unwinding system. The other unwinding system is provided with an upper film for preparing a transdermal patch. The base film coated with a layer of drug liquid is compounded with the upper film by another winding system and then rolled up to obtain a transdermal patch. The preparation of multiple drugs is realized, the preparation efficiency of drugs is improved, and the preparation cost of drugs is reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 This is a schematic diagram of a device for preparing multiple types of medicines in one embodiment of the utility model;

[0031] Figure 2 It is a partial schematic diagram of an oven in one embodiment of the utility model. DETAILED DESCRIPTION

[0032] The following will be described in more detail with reference to the schematic diagram of a multi-class drug preparation device of the present invention, wherein the preferred embodiment of the present invention is shown, and it should be understood that the present invention described herein can be modified by a person skilled in the art, while still achieving the advantageous effects of the present invention. Therefore, the following description should be understood as being widely known to a person skilled in the art, and not as a limitation to the present invention.

[0033] The present invention is described in more detail in the following paragraphs by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer according to the following description. It should be noted that the accompanying drawings are in very simplified form and in non-precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention.

[0034] The present invention provides a device for preparing multiple types of medicines. Figure 1 As shown, it includes an unwinding system, a base film, a coating system, an oven system 6, multiple feeding systems and multiple winding systems.

[0035] The coating system comprises a precision slide 2 , a scraper 22 , a coating roller 3 and a coating pressure roller 4 .

[0036] The base film is installed on the unwinding system; the unwinding system is connected to the coating roller 3.

[0037] The multiple feeding systems are connected to the coating roller 3, and the coating roller 3 is connected to the coating pressure roller 4; the scraper 22 is arranged on the precision slide 2, and is adjusted by the precision slide 2 to apply the liquid medicine to the surface of the base film; an adjustable gap is provided between the scraper 22 and the coating roller 3.

[0038] The winding system comprises: a winding roller and a winding roller pressure roller.

[0039] The coating roller 3 is connected to the oven system 6, the oven system 6 is connected to a plurality of winding rollers, and the winding rollers are connected to the winding roller pressure rollers.

[0040] At least one of the reeling systems is also connected to another unreeling system.

[0041] In a specific example, the film unwinding system includes an unwinding roller 1 and an upper film unwinding roller 1 , wherein the unwinding roller 1 is used to place the bottom film, and the upper film unwinding roller 1 is used to place the upper film for preparing the transdermal patch.

[0042] In this example, the scraper 22 is controlled to move by the precision slide 2, and the precision slide 2 is used to adjust the gap between the scraper 22 and the coating roller 3, so that the scraper 22 can achieve accurate coating, and the coating roller 3 can evenly coat the coating on the base film. They are usually driven by a motor, and the scraper 22 moves along a linear track according to a preset program and speed, driving the scraper 22 and the coating roller 3 to coat the base film on the unwinding roller 1. The coating pressure roller 4 is used to adjust the coating pressure so that the coating firmly adheres to the base film.

[0043] In this example, the oven system 6 is used to bake and air-dry the base film with the coating.

[0044] In this example, after the base film is dried in the oven, the base film is returned to the winding roller for winding.

[0045] The following will take the preparation of a double-layer orally dissolving film and a transdermal patch as an example to illustrate the preparation process.

[0046] In a specific example, it includes a first feeding system and a second feeding system, a first winding system and a second winding system, the first winding system includes a first winding roller 10 and a first winding roller pressure roller 11, and the second winding system includes a second winding roller 12 and a second winding roller pressure roller 13.

[0047] The first feeding system and the second feeding system are connected to the coating roller 3 respectively.

[0048] The first winding system and the second winding system are connected to the film combining roller 8 respectively.

[0049] In a specific example, if a double-layer oral dissolving film is required to be prepared, the first feeding system provides a first layer of coating for the oral dissolving film, and the bottom film forms a first layer of medicine film after the first coating by the coating system, passes through the oven system 6 and then rotates to the first winding roller 10, and the first winding roller 10 and the first winding roller pressure roller 11 wind up the bottom film, at this time, the first layer of oral dissolving film is formed; the first layer of oral dissolving film is placed on the unwinding roller 1, and the second feeding system provides a second layer of coating for the bottom film, and the bottom film passes through the coating system for the second coating to form a second layer of medicine film, and the bottom film passes through the oven system 6 and then rotates to the first winding roller 10, and the first winding roller 10 and the first winding roller pressure roller 11 wind up the bottom film again, at this time, a double-layer oral dissolving film is formed. It can be understood that the composite oral dissolving film in this embodiment can be a double-layer oral dissolving film, and can also be three or more layers according to actual production needs.

[0050] In another specific example, if a transdermal patch needs to be prepared, only the first feeding system or the second feeding system needs to be used, or other feeding systems can be used to provide a first layer of coating. After the base film is coated for the first time by the coating system, a layer of drug film is formed, which passes through the oven system 6 and then rotates back to the second winding system, and is compounded with the upper film released from the upper film unwinding roller 1 in the second winding system and then wound up.

[0051] Specifically, according to the medicine to be prepared, winding rollers with different tensions, different materials, and different temperature controls are selected to roll up the orally dissolving film and the transdermal patch.

[0052] In summary, in this embodiment, different coating liquids are provided through multiple feeding systems. After a layer of drug film is formed on the base film by the coating system, it is sent to the oven system 6 for baking. The baked base film and drug film are placed in one of the winding systems for winding, and then the base film coated with a layer of drug film is placed in the unwinding system. After another feeding system coats the base film with a second layer of drug liquid, the base film is sent to the oven system 6 for baking. The base film and the two layers of drug film are wound up by one of the winding systems. The above operation is repeated to prepare a multi-layer oral dissolving film. In addition, at least one winding system is also connected to another unwinding system, and the other unwinding system is provided with an upper film for preparing a transdermal patch. The base film coated with a layer of drug liquid is compounded with the upper film by another winding system and then rolled up to obtain a transdermal patch. The preparation of multiple drugs is realized, the preparation efficiency of drugs is improved, and the preparation cost of drugs is reduced.

[0053] For further information, please refer to Figure 2 The oven system 6 includes an oven, a fan 20 , a heating tube 21 , an air outlet duct 14 and an air return duct 15 .

[0054] Specifically, the fan 20 is connected to the heating tube 21, the heating tube 21 is connected to the air outlet duct 14, the air outlet duct 14 is connected to the heating cavity inside the oven, and the return air duct 15 is connected to the heating cavity inside the oven and the outside of the oven.

[0055] Preferably, the oven system 6 is provided with gear bars inside.

[0056] By configuring the oven system 6, clean air is sent to the heating tube 21 by the fan 20 for heating, and then enters the oven through the air outlet pipe 14. The hot air in the oven is discharged from the oven through the return air pipe 15 with the water vapor in the medicine solution, thus forming a heating cycle.

[0057] In this example, the oven system 6 has an upper layer and a lower layer. After the bottom film passes through the upper layer of the oven system 6 with the drug solution, it returns to the lower layer of the oven system 6, and then returns from the lower layer of the oven to the winding system.

[0058] Specifically, the feeding system includes a liquid medicine pipe 18 , a buffer tank 19 and a pump 14 .

[0059] The buffer tank 19 is used to store the liquid medicine. The pump 14 is installed in the liquid medicine pipe 18. The liquid medicine is drawn out from the buffer tank 19 and transmitted to the coating system through the liquid medicine pipe 18.

[0060] In a specific example, the pump 14 may be a gear pump 14 or other pumps 14, such as a peristaltic pump 14, etc. For this, those skilled in the art may make their own selection according to the needs of actual application.

[0061] It is understandable that those skilled in the art can select the types of liquid medicines stored in the plurality of buffer tanks 19 according to actual needs.

[0062] Furthermore, the multi-type drug preparation device also includes: a deflection corrector 5, a film closing roller 7, and a film closing pressure roller 8. The deflection corrector 5 detects the edge of the base film to make the edge more neat, and the mold closing roller 7 and the mold closing pressure roller 8 provide a certain tension to the base film to improve the flatness of the film surface. The deflection corrector 5 is connected to the film closing roller 7, and the film closing roller 7 is connected to the multiple winding rollers, and the film closing roller 7 is also connected to the film closing pressure roller 8. After the base film is baked in the oven, it passes through the deflection corrector 5 and the mold closing roller 7 in sequence and is input into the winding system.

[0063] Furthermore, the multi-type drug preparation device further comprises a plurality of static eliminators, which are respectively arranged between the unwinding roller 1 and the coating roller 3 and between the winding roller and the coating roller 3 .

[0064] In this example, the static eliminator includes a front static eliminator 16 and a rear static eliminator 17. After the static eliminator is powered on, it releases positive and negative charged ions to neutralize the static electricity on the base film, so that the base film is not affected by static adsorption when winding and unwinding, and keeps the base film from adsorbing free dust, so that the winding is more neat. In a specific example, the front static eliminator 16 eliminates static electricity on the base film before the liquid is applied, and the rear static eliminator 17 eliminates static electricity on the base film before the base film is wound.

[0065] The positive and negative charged ions are released by the static electricity remover to neutralize the static electricity on the base film, so that the base film is not affected by static electricity adsorption when it is wound and unwound, and the base film is kept free of adsorption of free dust. The winding is made more neat by setting the deviation correcting machine 5, the film closing roller 7, and the mold closing roller 8.

[0066] In summary, the utility model provides a multi-type drug preparation device, including a reeling system, a base film, a coating system, an oven system 6, multiple feeding systems and multiple reeling systems. The structure is simple and reasonable, and different drugs can be prepared to meet supply needs. A precision slide 2 is provided in the coating system to adjust the gap between the scraper 22 and the coating roller 3, which can control the thickness of the applied drug solution, that is, the thickness of the prepared orodispersible film can be controlled, and can adapt to different needs in actual application scenarios. In addition, the specific setting of the oven system 6 of the utility model also enables the drug solution to be quickly baked and air-dried, and avoids interfering with the work of other systems or causing product contamination during the drying process.

[0067] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A device for preparing multiple types of drugs, characterized in that: include: Unwinding system, base film, coating system, oven system, multiple feeding systems and multiple winding systems; The coating system includes a precision slide, a scraper, a coating roller and a coating pressure roller; The base film is installed on the unwinding system; the unwinding system is connected to the coating roller, and the coating roller is connected to the coating pressure roller; A plurality of the feeding systems are connected to the coating roller, the scraper is arranged on the precision slide, and is adjusted by the precision slide to coat the liquid medicine onto the surface of the base film; an adjustable gap is arranged between the scraper and the coating roller; The winding system comprises: a winding roller and a winding roller pressure roller; The coating roller is connected to the oven system, the oven system is connected to the plurality of winding rollers, and the winding roller is connected to the winding roller pressure roller; At least one reeling system is connected to another unreeling system.

2. The multi-type drug preparation device according to claim 1, characterized in that: The oven system comprises an oven, a fan, a heating pipe, an air outlet pipe and an air return pipe; The fan is connected to the heating tube, the heating tube is connected to the air outlet duct, the air outlet duct is connected to the inside of the oven, and the return air duct connects the inside and the outside of the oven.

3. The multi-type drug preparation device according to claim 1, characterized in that: The oven system is provided with a stop bar inside.

4. The multi-type drug preparation device according to claim 1, characterized in that: The oven system is stacked and includes an upper oven system and a lower oven system.

5. The multi-type drug preparation device according to claim 1, characterized in that: The feeding system includes a buffer tank, a liquid medicine pipe and a pump; The buffer tank is connected to the pump, and the pump is installed in the liquid medicine pipe. The pump guides the liquid medicine out of the buffer tank and transmits the liquid medicine to the coating roller through the liquid medicine pipe.

6. The multi-type drug preparation device according to claim 5, characterized in that: The pump is a gear pump or a peristaltic pump.

7. The multi-type drug preparation device according to claim 1, characterized in that: The unwinding system comprises an unwinding roller or an upper film unwinding roller; The unwinding roller is connected to the coating roller; the upper film unwinding roller is connected to the winding roller.

8. The multi-type drug preparation device according to claim 7, characterized in that: Also includes: A plurality of static eliminators are respectively arranged between the unwinding roller and the coating roller and between the winding roller and the coating roller.

9. The multi-type drug preparation device according to claim 1, characterized in that: Also includes: Deviation correction machine, film closing roller and film closing pressure roller; The deviation correcting machine is connected to the film-closing roller, the film-closing roller is connected to the plurality of winding rollers, and the film-closing roller is also connected to the film-closing pressing roller.

10. The multi-type drug preparation device according to claim 9, characterized in that: It includes a first feeding system and a second feeding system, a first winding system and a second winding system; The first feeding system and the second feeding system are respectively connected to the coating roller; The first winding system and the second winding system are connected to the film combining rollers respectively.

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