Liquid supplementing buffer device and biochemical analyzer

Abstract

The utility model relates to a fluid infusion buffer device and a biochemical analyzer. The fluid infusion buffer device comprises a fluid inlet pipeline, a fluid outlet end and a fluid buffer container, the liquid inlet pipeline is connected with the liquid outlet end, the liquid outlet end is located on the liquid buffer container, and liquid of the liquid inlet pipeline flows into the liquid buffer container through the liquid outlet end; the liquid outlet end is provided with a liquid outlet, and the liquid outlet area of the liquid outlet is set according to the inner diameter and flow of the liquid inlet pipeline. By optimizing the structure of the liquid outlet, liquid flowing into the liquid inlet pipeline is buffered, air generated due to the fact that inlet liquid impacts the liquid level is avoided, and air in the liquid can be eliminated through buffering, so that the effect of eliminating bubbles is achieved; the liquid outlet end can be arranged at any position on the liquid level, so that the limitation of the traditional technology on the length of the water inlet pipe is fundamentally eliminated, and the standardization and miniaturization of the product are favorably realized; liquid outlets do not need to be arranged according to the bubble area and the non-bubble area in a matched mode, filter screens do not need to be arranged for different liquid outlets, and standardization of products is further achieved.

Description

Technical Field

[0001] The present application relates to the field of fluid infusion, and in particular to a fluid infusion buffer device and a biochemical analyzer. Background Art

[0002] In the biochemical analyzer, pure water is mostly used to clean the sample needle and reaction cup. Due to the extremely high test speed of the biochemical analyzer, the cleaning frequency of the sample needle is very high, resulting in insufficient built-in cache pure water, which often needs to be supplemented by an external water source. Therefore, the pure water used for cleaning basically comes from an external water source. The pure water from the external water source enters the machine through the water inlet joint, pipeline, and valve on the biochemical analyzer for cache to meet the water demand for cleaning the biochemical analyzer.

[0003] Generally, the water pressure of the external water source is required to be between 50KPa and 400KPa, and the flow rate is between 40L (liter) / H (hour) and 120L / H. Under such flow and pressure, water entering the pure water buffer container is very likely to generate bubbles inside the container. The generated bubbles will enter the sample injection needle along the cleaning pipeline, causing the sample injection performance to be unqualified or interfering with the analysis results.

[0004] In order to reduce bubbles, the industry usually adopts the water inlet pipeline of the buffer container, which is placed below the replenishment liquid level of the container. As shown in Figure 1, the pure water in the external water source 110 enters the pure water buffer container 150 through the first pipeline 120, the solenoid valve 130 and the second pipeline 140 in sequence. In this way, when the liquid level drops to the replenishment liquid level 160, the control components related to the water inlet, such as the solenoid valve 130 of the water inlet, are opened to keep the water inlet below the liquid level of the pure water buffer container 150, so as to eliminate the bubbles 170 generated by the impact of the water inlet; at the same time, the gas dissolved in the pure water can also escape from the liquid in this way.

[0005] However, in actual use, this defoaming method requires strict control of the length of the water inlet pipe inside the buffer container. If the length is too short, the water inlet will be above the replenishing liquid level, causing pure water to directly impact the liquid level and form bubbles; if the length is too long, the bubbles in the pure water transported by the water inlet pipe will not be able to escape and enter the cleaning pipeline.

[0006] A Chinese patent document with application publication number CN115400460A discloses a bubble separation device and method, the bubble separation device comprises a container and a liquid inlet pipeline, a first liquid outlet pipeline and a second liquid outlet pipeline connected to the container, a liquid inlet and a first liquid outlet are provided at the bottom of the container, the liquid inlet is connected to the liquid inlet pipeline, the first liquid outlet is connected to the first liquid outlet pipeline, a second liquid outlet is provided at the top of the container, and the second liquid outlet is connected to the second liquid outlet pipeline; an expansion tube is provided in the container, the expansion tube has an inlet and an outlet, the inlet is connected to the liquid inlet, the outlet is arranged toward the second liquid outlet, the inner diameter of the outlet is larger than the inner diameter of the inlet, tiny bubbles in the reagent automatically float up and converge to the top of the container under the action of the expansion tube and its own buoyancy, the second liquid outlet pipeline discharges the reagent with tiny bubbles from the top of the container, and the first liquid outlet pipeline discharges the reagent without tiny bubbles after being acted by the expansion tube to the reaction and / or detection module for reaction, detection or cleaning, so as to ensure the accuracy of the detection result.

[0007] However, the technical solution disclosed in the patent document mainly divides the liquid in the tank into a bubble zone and a non-bubble zone, and then adapts different liquid outlets to eliminate the influence of bubbles on the test system, and does not involve optimization of the liquid inlet structure.

[0008] The Chinese patent document with the authorization announcement number CN211978805U discloses a liquid storage tank and a sample analyzer, wherein the liquid storage tank comprises: a tank body; the tank body comprises an upper tank body and a lower tank body, wherein the peripheral wall of the upper tank body is provided with a liquid inlet, and the peripheral wall of the lower tank body is provided with a liquid outlet; a filter assembly is provided inside the tank body, and the filter assembly connects the upper tank body and the lower tank body. In the above manner, the reagent can enter the tank body through the liquid inlet, and the filter assembly can filter the bubbles in the reagent in the upper tank body. At the same time, the liquid outlet is arranged at the lower part of the liquid storage tank. Since the bubbles float upward, the bubbles can be effectively prevented from entering the downstream of the liquid storage tank.

[0009] However, the technical solution disclosed in the patent document mainly adopts filter mesh filtration, which is essentially a multifunctional use of the device component and does not involve optimization of the liquid inlet structure. Utility Model Content

[0010] Based on this, it is necessary to provide a fluid infusion buffer device and a biochemical analyzer.

[0011] In one embodiment, a liquid replenishment buffer device includes a liquid inlet pipeline, a liquid outlet, and a liquid buffer container;

[0012] The liquid inlet pipeline is connected to the liquid outlet end, the liquid outlet end is located on the liquid cache container, and the liquid in the liquid inlet pipeline flows into the liquid cache container through the liquid outlet end;

[0013] The liquid outlet end is provided with a liquid outlet, and the liquid outlet area S of the liquid outlet is set according to the inner diameter D and flow rate Q of the liquid inlet pipeline.

[0014] The above-mentioned liquid replenishment buffer device, by optimizing the structure of the liquid outlet, on the one hand realizes a buffering function for the liquid including but not limited to pure water flowing into the liquid inlet pipeline, thereby avoiding the generation of air due to the impact of the incoming liquid on the liquid surface, and is also beneficial to eliminate the air contained in the liquid through buffering, thereby achieving the effect of eliminating bubbles; on the other hand, the liquid outlet end can be placed at any position on the liquid surface, fundamentally eliminating the limitation of traditional technology on the length of the water inlet pipe, which is beneficial to realize the standardization and miniaturization of the product; on the other hand, there is no need to set the liquid outlet according to the matching of the bubble area and the non-bubble area, nor is there a need to set filters for different liquid outlets, which is further beneficial to realize the standardization of the product.

[0015] In one embodiment, the liquid outlet area S≥π×(k×D)2, wherein k is the magnification factor and is set according to Q.

[0016] In one embodiment, when Q≤10L / H, k is a value between 1.1 and 2.0;

[0017] When 30L / H≤Q≤10L / H, k is a value between 2.0 and 4.0;

[0018] When 50L / H≤Q≤30L / H, k is a value between 4.0 and 8.0;

[0019] When 80L / H≤Q≤50L / H, k is a value between 8.0 and 12.0.

[0020] In one embodiment, the liquid outlet is located in the liquid buffer container; and / or,

[0021] The liquid outlet direction of the liquid outlet forms an angle with the gravity direction, and the angle is 60 degrees to 180 degrees.

[0022] In one embodiment, the liquid outlet end is provided with at least three holes as the liquid outlet.

[0023] In one embodiment, in the direction of gravity, the pores are distributed on the side and / or top of the liquid outlet.

[0024] In one embodiment, the number of the liquid outlets is at least two; or,

[0025] The liquid outlet end has an L-shaped cross section or a rectangular cross section; or,

[0026] The liquid replenishment buffer device also includes a connecting piece, and the liquid inlet pipeline or the liquid outlet end is arranged on the liquid cache container through the connecting piece.

[0027] In one embodiment, the liquid replenishment buffer device further includes a liquid inlet buffer, the liquid outlet is located in the liquid inlet buffer, and the liquid inlet buffer is located in the liquid cache container;

[0028] The liquid inlet buffer is provided with an opening for liquid discharge, so that the liquid flowing out of the liquid outlet end enters the liquid buffer container through the opening.

[0029] In one embodiment, the liquid outlet is located at the bottom of the liquid inlet buffer; or,

[0030] The opening is arranged at the top of the liquid inlet buffer or at a position adjacent to the top; or,

[0031] The bottom of the liquid inlet buffer is flush with the replenishing liquid level of the liquid cache container; or,

[0032] The top of the liquid inlet buffer is located above the replenishing liquid level and the bottom is located below the replenishing liquid level.

[0033] In one embodiment, a biochemical analyzer includes a cleaning pipeline, a cleaning tank, a sample addition needle and a fluid replenishment buffer device as described in any embodiment;

[0034] The liquid replenishment buffer device is connected to the cleaning tank through the cleaning pipeline, and the sample addition needle is in a state of being located in the cleaning tank for cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0036] FIG. 1 is a schematic diagram of the structure of a conventional biochemical analyzer implementing a buffer water replenishment method.

[0037] FIG. 2 is a schematic structural diagram of an embodiment of the fluid replenishment buffer device described in the present application.

[0038] FIG3 is a schematic structural diagram of another embodiment of the fluid replenishment buffer device described in the present application.

[0039] FIG. 4 is a schematic structural diagram of another embodiment of the fluid replenishment buffer device described in the present application.

[0040] FIG5 is a partial structural schematic diagram of another embodiment of the fluid replenishment buffer device described in the present application.

[0041] FIG6 is a partial structural schematic diagram of another embodiment of the fluid replenishment buffer device described in the present application.

[0042] FIG. 7 is a partial structural schematic diagram of another embodiment of the fluid replenishment buffer device described in the present application.

[0043] FIG8 is a schematic structural diagram of another embodiment of the fluid replenishment buffer device described in the present application.

[0044] FIG. 9 is a schematic diagram of an application of the embodiment shown in FIG. 8 .

[0045] FIG. 10 is a schematic structural diagram of an embodiment of a biochemical analyzer described in the present application.

[0046] Reference numerals:

[0047] External water source 110, first pipeline 120, solenoid valve 130, second pipeline 140, pure water buffer container 150, liquid replenishing level 160, bubbles 170;

[0048] Liquid replenishment buffer device 200, liquid inlet pipeline 210, liquid outlet end 220, liquid outlet 221, liquid outlet direction 222, angle 223, pore 224, liquid inlet buffer 230, opening 231, connector 240, liquid cache container 250, replenishing liquid level 260, liquid flow direction 300, gravity direction 400, cleaning pipeline 500, cleaning tank 600, sample addition needle 700, biochemical analyzer 800. DETAILED DESCRIPTION

[0049] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0050] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may also be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of this application are for illustrative purposes only and do not represent the only implementation method.

[0051] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0052] In the present application, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are in contact indirectly through an intermediate medium. Moreover, a first feature being “above”, “above”, or “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below”, or “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0053] Unless otherwise defined, all technical and scientific terms used in the specification of this application have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used in the specification of this application includes any and all combinations of one or more related listed items.

[0054] The present application discloses a fluid infusion buffer device and a biochemical analyzer, which include some or all of the technical features of the following embodiments; that is, the fluid infusion buffer device and the biochemical analyzer include some or all of the following structures. In one embodiment of the present application, a fluid infusion buffer device includes a liquid inlet pipeline, a liquid outlet end and a liquid cache container; the liquid inlet pipeline and the liquid outlet end are connected, the liquid outlet end is located on the liquid cache container, and the liquid in the liquid inlet pipeline flows into the liquid cache container through the liquid outlet end; the liquid outlet end is provided with a liquid outlet, and the liquid outlet area S of the liquid outlet is set according to the inner diameter D and flow rate Q of the liquid inlet pipeline. The above-mentioned liquid replenishment buffer device, by optimizing the structure of the liquid outlet, realizes the buffering function for the liquid including but not limited to pure water flowing into the liquid inlet pipeline, so as to avoid the generation of air due to the impact of the incoming liquid on the liquid surface, and is also conducive to eliminating the air contained in the liquid through buffering, thereby achieving the effect of eliminating bubbles; on the other hand, the liquid outlet end can be placed at any position on the liquid surface, which fundamentally eliminates the limitation of traditional technology on the length of the water inlet pipe, thereby facilitating the standardization and miniaturization of the product; on the other hand, there is no need to set the liquid outlet according to the matching of the bubble area and the non-bubble area, nor is there any need to set filters for different liquid outlets, which is further conducive to the standardization of the product.

[0055] The fluid infusion buffer device and the biochemical analyzer are described in detail below in conjunction with FIG. 2 to FIG. 10 .

[0056] In one embodiment, a fluid replenishment buffer device 200 is shown in Figure 2, which includes a liquid cache container 250, and also includes a connected liquid inlet pipeline 210 and a liquid outlet end 220, that is, the liquid inlet pipeline 210 is connected to the liquid outlet end 220 so that the replenished liquid can flow into the liquid outlet end 220 through the liquid inlet pipeline 210.

[0057] Generally, because the pressure of the external liquid inside the liquid inlet pipeline 210 is about 50KPa to 400KPa, and the flow rate is about 40L / H to 120L / H, if it flows directly from the liquid outlet 220 at the same pressure and flow rate, the kinetic energy of the replenished liquid will inevitably bring a large impact in the liquid buffer container 250, and the formation of bubbles is a high probability event, and the bubbles inside the replenished liquid still exist. Therefore, it is necessary to consider solving this technical problem.

[0058] Specifically, in each embodiment, the liquid outlet 220 is located on the liquid buffer container 250, and the liquid in the liquid inlet pipeline 210 flows into the liquid buffer container 250 through the liquid outlet 220; that is, the liquid flowing in from the liquid inlet pipeline 210 flows slowly through the liquid outlet 220, and then flows into the liquid buffer container 250. With such a structural design, the replenished liquid is first depressurized and defoamed by the liquid outlet 220 to reduce the kinetic energy of the replenished liquid, and then flows into the liquid buffer container 250, thereby reducing the impact in the liquid buffer container 250 and reducing the probability of forming bubbles. Therefore, the liquid outlet 220 can be placed at any position on the liquid surface, that is, the length of the liquid inlet pipeline 210 is basically not limited by the liquid surface, that is, the length of the liquid inlet pipeline 210 in the liquid buffer container 250 is basically not limited by the position or height of the replenishing liquid surface 260, thereby fundamentally eliminating the limitation of the length of the water inlet pipe in the traditional technology.

[0059] Taking into account the design requirements of reducing pressure and energy, in each embodiment, the liquid outlet end 220 is provided with a liquid outlet 221, and the liquid outlet area S of the liquid outlet 221 is set according to the inner diameter D and flow rate Q of the liquid inlet pipeline 210; it can be understood that in each embodiment, the liquid outlet area S of the liquid outlet 221 is larger than the pipeline flow area of ​​the liquid inlet pipeline 210, that is, the passing area. Such a structural design optimizes the structure of the liquid outlet 221, realizes a buffering function for the liquid flowing into the liquid inlet pipe 210, and reduces the pressure of the liquid flowing out of the liquid outlet 221. Since it is an optimized design for the area of ​​the liquid outlet 221, it can also be understood as reducing the pressure of the liquid flowing out of the liquid outlet 221, thereby eliminating the air contained in the liquid flowing into the liquid inlet pipe 210 to a certain extent, and since the pressure of the liquid is reduced, the generation of air due to the impact of the liquid on the liquid surface is avoided, thereby achieving the effect of eliminating bubbles; under this premise, the liquid outlet 220 can be placed at any position on the liquid surface, thereby fundamentally eliminating the limitation of the traditional technology on the length of the water inlet pipe, which is conducive to the standardization and miniaturization of the product; under this premise, further, there is no need to set the liquid outlet 221 according to the matching of the bubble area and the non-bubble area, nor is there any need to set a filter for different liquid outlets 221, which is conducive to the standardization of the product.

[0060] Further considering the design requirements of pressure reduction and energy reduction, in one embodiment, no additional restrictions are imposed on the shape and distribution of the liquid outlet 221, and it is only necessary to ensure the liquid outlet area S of the liquid outlet 221. In one embodiment, the liquid outlet area S ≥ π × k × D 2 , where k is the amplification factor, which is set according to Q. When the liquid outlet area S is larger than the inner diameter D of the liquid inlet pipeline 210 and the flow rate Q, the pressure of the liquid flowing into the liquid inlet pipeline 210 is effectively reduced, thereby facilitating the release of bubbles inside the liquid and preventing additional bubbles from being generated when the liquid flows into the liquid buffer container 250.

[0061] In order to define the liquid outlet 220 from the product structure, in one embodiment, when Q≤10L / H, k is a value between 1.1 and 2.0; when 30L / H≤Q≤10L / H, k is a value between 2.0 and 4.0; when 50L / H≤Q≤30L / H, k is a value between 4.0 and 8.0; when 80L / H≤Q≤50L / H, k is a value between 8.0 and 12.0. In one embodiment, when Q≤10L / H, k is 1.5; when 30L / H≤Q≤10L / H, k is 3; when 50L / H≤Q≤30L / H, k is 6; when 80L / H≤Q≤50L / H, k is 10. In one embodiment, when Q≤10L / H, k is 1.1; when 30L / H≤Q≤10L / H, k is 2.0; when 50L / H≤Q≤30L / H, k is 4.0; when 80L / H≤Q≤50L / H, k is 8.0. In one embodiment, when Q≤10L / H, k is 2.0; when 30L / H≤Q≤10L / H, k is 4.0; when 50L / H≤Q≤30L / H, k is 8.0; when 80L / H≤Q≤50L / H, k is 12.0. The rest of the embodiments are similar and will not be described in detail. Such a design is used to limit the liquid outlet area S of the liquid outlet 221, that is, to limit the structure of the liquid outlet 221, and its function is to effectively reduce the pressure of the liquid flowing into the liquid inlet pipeline 210 at the liquid outlet 221 to release the bubbles inside the liquid and avoid the generation of additional bubbles when flowing into the liquid buffer container 250.

[0062] The following example illustrates the relative positional relationship between the liquid outlet 220 and the liquid cache container 250. In one embodiment, as shown in FIG2 , the liquid outlet 220 is located in the liquid cache container 250. In this embodiment, the liquid outlet 220 is located above the replenishing liquid level 260 of the liquid cache container 250; in other embodiments, the liquid outlet 220 may also be located below the replenishing liquid level 260 of the liquid cache container 250. In other embodiments, the liquid outlet 220 may also be located on the liquid cache container 250; such a structural design is conducive to reducing the distance between the liquid outlet 220 and the liquid cache container 250, so as to reduce the pressure of the liquid flowing out of the liquid outlet 221, which is conducive to releasing the bubbles inside the liquid on the one hand, and avoiding the generation of additional bubbles when flowing into the liquid cache container 250 on the other hand; on the other hand, the liquid outlet 220 can be placed at any position on the liquid surface, fundamentally eliminating the limitation of traditional technology on the length of the water inlet pipe, which is conducive to achieving product standardization and miniaturization; under this premise, since there is no need to set the liquid outlet 221 according to the bubble area and the non-bubble area, there is no need to set a filter for different liquid outlets 221, which is further conducive to achieving the standardization of the liquid replenishment buffer device 200 product itself, as well as the standardization of related products using the liquid replenishment buffer device 200, such as a biochemical analyzer 800.

[0063] In one embodiment, the liquid outlet direction 222 of the liquid outlet 221 has an angle 223 with the gravity direction 400, and the angle 223 is 60 to 180 degrees. In the embodiment shown in FIG2 , the angle 223 is 90 degrees. In other embodiments, the angle 223 can be 60, 80, 110, 120, 150, 160 or 180 degrees. Such a structural design is conducive to adjusting the position of the liquid flowing out of the liquid outlet 221 and reducing the additional generation of bubbles when these liquids flow into the liquid buffer container 250. It can be understood that the main invention points of each embodiment of the present application are focused on eliminating the bubbles generated by rapid and large-scale fluid replenishment.

[0064] A plurality of liquid outlets 220 may also be provided. In one embodiment, the number of the liquid outlets 220 is at least two; in one embodiment, as shown in FIG2 , the liquid outlet 220 has an L-shaped cross section or a rectangular cross section. In this embodiment, the liquid replenishment buffer device 200 is provided with at least two liquid outlets 220, and each of the liquid outlets 220 is respectively connected to the liquid inlet pipeline 210, that is, each of the liquid outlets 220 is respectively connected to the liquid inlet pipeline 210; the total liquid outlet area S of each of the liquid outlets 221 is set according to the inner diameter D and flow rate Q of the liquid inlet pipeline 210, that is, the liquid outlet areas of all the liquid outlets 221 are summed up as the total liquid outlet area S; in one embodiment, as mentioned above, the total liquid outlet area S ≥ π×k×D 2, where k is the gain factor, which is set according to Q.

[0065] Alternatively, in one embodiment, the liquid replenishment buffer device 200 is shown in FIG. 3 , which is different from the embodiment shown in FIG. 2 in that each of the liquid outlets 220 is integrally provided, which can also be understood as only one liquid outlet 220 being provided.

[0066] In one embodiment, the liquid replenishment buffer device 200 is shown in FIG4 , which is different from the embodiment shown in FIG2 in that the liquid replenishment buffer device 200 further includes a connector 240, and the liquid inlet pipeline 210 is disposed on the liquid buffer container 250 through the connector 240. In other embodiments, the liquid outlet 220 can also be disposed on the liquid buffer container 250 through the connector 240. Such a design is conducive to the rapid and accurate disassembly and installation of the liquid inlet pipeline 210 and the liquid outlet 220.

[0067] In one embodiment, as shown in FIG5 , the liquid outlet 220 is provided with at least three pores 224 as the liquid outlet 221 . In this embodiment, the pores 224 are distributed on the side of the liquid outlet 220 .

[0068] In one embodiment, as shown in FIG. 6 or FIG. 7 , the liquid outlet 220 is also provided with at least three pores 224 as the liquid outlet 221. Different from the embodiment shown in FIG. 5 , in this embodiment, in the gravity direction 400, the pores 224 are distributed on the side and top of the liquid outlet 220. In other embodiments, the pores 224 may also be distributed only on the top of the liquid outlet 220.

[0069] In order to further avoid the generation of air due to the impact of the liquid on the liquid surface, in one embodiment, as shown in FIG8 , the liquid replenishment buffer device 200 further includes a liquid inlet buffer 230, the liquid outlet 220 is located in the liquid inlet buffer 230, and the liquid inlet buffer 230 is located in the liquid buffer container 250; the liquid inlet buffer 230 is provided with an opening 231 for liquid discharge, so that the liquid flowing out of the liquid outlet 220 enters the liquid buffer container 250 through the opening 231. In this embodiment, the opening 231 is arranged at the top of the liquid inlet buffer 230; in other embodiments, the opening 231 can also be arranged at a position adjacent to the top of the liquid inlet buffer 230. Such a structural design is conducive to allowing the liquid flowing out of the liquid inlet pipeline 210 and the liquid outlet 220 to enter the liquid buffer container 250 through the opening 231, thereby realizing the buffering function and avoiding the generation of air due to the impact of the liquid on the liquid surface.

[0070] In order to further avoid the generation of air due to the impact of the liquid on the liquid surface, in this embodiment, the bottom of the liquid inlet buffer 230 is flush with the replenishing liquid surface 260 of the liquid buffer container 250. In other embodiments, the top of the liquid inlet buffer 230 is located above the replenishing liquid surface 260 and the bottom is located below the replenishing liquid surface 260. In addition, in this embodiment, the liquid outlet 220 is located at the bottom of the liquid inlet buffer 230. Combined with Figure 9, such a design further realizes the buffering function for the liquid flowing into the liquid inlet pipeline 210, avoids the generation of air due to the impact of the liquid on the liquid surface, and is also conducive to eliminating the air in the liquid through buffering, thereby achieving the effect of eliminating bubbles.

[0071] In each embodiment, the liquid flowing into the liquid inlet pipeline 210 includes but is not limited to pure water, and other liquids can also be selected according to usage requirements. Exemplarily, the liquid includes deionized water, physiological saline, and organic solvents.

[0072] The following uses pure water as an example to illustrate the liquid replenishment buffer device 200. Specifically, the liquid inlet buffer 230 is a water inlet buffer, the liquid inlet pipeline 210 is the water inlet pipeline, and an opening 231 is provided on the top of the water inlet buffer; a protrusion is provided at the bottom of the inner cavity of the water inlet buffer as a liquid outlet 220, and small holes are provided around the liquid outlet 220, that is, on the side, as pores 224, for the pure water in the water inlet pipeline to flow out. The area of ​​the small hole protruding at the bottom is the effective area S of the liquid outlet 220, which can also be understood as the effective area S of the water inlet buffer. The effective area S of the water inlet buffer is determined by the flow rate Q and the inner diameter D of the water inlet pipeline, S≥π*k*D 2 Among them, k is the amplification factor, which is selected according to the flow rate Q: when Q≤10L / H, k=1.1~2.0; when 30L / H≤Q≤10L / H, k=2.0~4.0; when 50L / H≤Q≤30L / H, k=4.0~8.0; when 80L / H≤Q≤50L / H, k=8.0~12.0. In this way, the structure and size of the water outlet are optimized to eliminate bubbles.

[0073] When in use, connect the water inlet pipe, i.e. the water inlet pipeline, to the water inlet buffer to replenish water normally. The water inlet pipeline can be controlled by a solenoid valve and other equipment. Pure water enters the water inlet buffer through the water inlet pipeline; after being buffered once in the water inlet buffer, the flow rate is reduced, and the gas dissolved in the pure water is naturally released, thereby causing other gases in the water to escape; due to the reduced flow rate, the buffered water will not strongly impact the liquid surface, and thus no bubbles will be generated.

[0074] If necessary, it is also possible to consider omitting the setting of the water inlet buffer and directly changing it to a form of multiple joints connection, that is, directly adopting the design of connecting the liquid inlet pipeline 210 to the liquid outlet 220 to reduce the structural complexity of the water inlet buffer, and using a joint as the liquid outlet 220, the joint is L-shaped, that is, L-shaped, and the sum of the areas of the water outlets of the multiple joints is the effective area S of the water inlet buffer. When replenishing water, pure water is dispersed to multiple joints through the water inlet pipeline for buffering; after one buffering, the flow rate is reduced, and the gas dissolved in the pure water is naturally released, thereby allowing other gases in the water to escape; due to the reduced flow rate, the buffered water will not strongly impact the liquid surface, and thus no bubbles will be generated.

[0075] The water inlet buffer or liquid outlet end 220 can be placed at any position on the liquid surface, thereby fundamentally eliminating the limitation of the length of the water inlet pipe; and by optimizing the structure of the liquid outlet end 220, that is, the water outlet, a buffering function is achieved for the liquid in the liquid inlet pipeline 210, thereby achieving the purpose of eliminating bubbles.

[0076] In one embodiment, a biochemical analyzer 800 includes the rehydration buffer device 200 described in any embodiment. Such a design enables the rehydration buffer device 200 of the biochemical analyzer 800 to optimize the structure of the liquid outlet 221. On the one hand, it realizes a buffering function for the liquid, including but not limited to pure water, flowing into the liquid inlet pipeline 210, thereby avoiding the generation of air due to the impact of the liquid on the liquid surface, and is also conducive to eliminating the air in the liquid through buffering, thereby achieving the effect of eliminating bubbles; on the other hand, the liquid outlet 220 can be placed at any position on the liquid surface, fundamentally eliminating the limitation of the traditional technology on the length of the water inlet pipe, thereby facilitating the standardization and miniaturization of the product; on the other hand, there is no need to set the liquid outlet 221 according to the matching of the bubble area and the non-bubble area, nor is there any need to set a filter for different liquid outlets 221, which is further conducive to the standardization of the product.

[0077] In one embodiment, a biochemical analyzer 800 is shown in Figure 10, which includes a cleaning pipeline 500, a cleaning tank 600, a sample injection needle 700 and the fluid replenishment buffer device 200 described in any embodiment; the fluid replenishment buffer device 200 is connected to the cleaning tank 600 through the cleaning pipeline 500, and the sample injection needle 700 is in a state of being located in the cleaning tank 600 for cleaning. That is, the biochemical analyzer 800 includes a cleaning pipeline 500, a cleaning tank 600, a sample addition needle 700 and a fluid replenishment buffer device 200; the fluid replenishment buffer device 200 includes a liquid inlet pipeline 210, a liquid outlet 220 and a liquid buffer container 250; the liquid inlet pipeline 210 is connected to the liquid outlet 220, and the liquid outlet 220 is located on the liquid buffer container 250, and the liquid in the liquid inlet pipeline 210 flows into the liquid buffer container 250 through the liquid outlet 220; the liquid outlet 220 is provided with a liquid outlet 221, and the liquid outlet area S of the liquid outlet 221 is set according to the inner diameter D and flow rate Q of the liquid inlet pipeline 210. The rest of the embodiments are similar and will not be described in detail. It can be understood that the biochemical analyzer 800 has the advantages of the fluid replenishment buffer device 200 adopted, which will not be described in detail here.

[0078] It should be noted that other embodiments of the present application also include a fluid infusion buffer device and a biochemical analyzer that can be implemented by combining the technical features in the above embodiments.

[0079] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0080] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the scope of patent protection of the present application shall be subject to the attached claims.

Claims

1. A fluid replenishment buffer device (200), characterized in that: It comprises a liquid inlet pipeline (210), a liquid outlet (220) and a liquid buffer container (250); The liquid inlet pipeline (210) is connected to the liquid outlet end (220), the liquid outlet end (220) is located on the liquid cache container (250), and the liquid in the liquid inlet pipeline (210) flows into the liquid cache container (250) through the liquid outlet end (220); The liquid outlet end (220) is provided with a liquid outlet (221), and a liquid outlet area S of the liquid outlet (221) is set according to the inner diameter D and flow rate Q of the liquid inlet pipeline (210).

2. The fluid replenishment buffer device (200) according to claim 1, characterized in that: Liquid outlet area S ≥ π × (k × D) 2 , where k is the gain factor, which is set according to Q.

3. The fluid replenishment buffer device (200) according to claim 2, characterized in that: When Q≤10L / H, k is a value between 1.1 and 2.0; When 30L / H≤Q≤10L / H, k is a value between 2.0 and 4.0; When 50L / H≤Q≤30L / H, k is a value between 4.0 and 8.0; When 80L / H≤Q≤50L / H, k is a value between 8.0 and 12.

0.

4. The fluid replenishment buffer device (200) according to claim 1, characterized in that: The liquid outlet (220) is located in the liquid buffer container (250); and / or, The liquid outlet direction (222) of the liquid outlet (221) and the gravity direction (400) form an included angle (223), and the included angle (223) is 60 degrees to 180 degrees.

5. The fluid replenishment buffer device (200) according to claim 1, characterized in that: The liquid outlet end (220) is provided with at least three pores (224) serving as the liquid outlet (221).

6. The fluid replenishment buffer device (200) according to claim 5, characterized in that: In the gravity direction (400), the pores (224) are distributed on the side and / or top of the liquid outlet (220).

7. The fluid replenishment buffer device (200) according to claim 1, characterized in that: The number of the liquid outlet ends (220) is at least two; or, The liquid outlet end (220) has an L-shaped cross section or a rectangular cross section; or, The liquid replenishment buffer device (200) further comprises a connecting piece (240), and the liquid inlet pipeline (210) or the liquid outlet end (220) is arranged on the liquid buffer container (250) via the connecting piece (240).

8. The fluid replenishment buffer device (200) according to any one of claims 1 to 7, characterized in that: It also includes a liquid inlet buffer (230), the liquid outlet end (220) is located in the liquid inlet buffer (230), and the liquid inlet buffer (230) is located in the liquid cache container (250); The liquid inlet buffer (230) is provided with an opening (231) for discharging liquid, so that the liquid flowing out of the liquid outlet end (220) enters the liquid buffer container (250) through the opening (231).

9. The fluid replenishment buffer device (200) according to claim 8, characterized in that: The liquid outlet (220) is located at the bottom of the liquid inlet buffer (230); or, The opening (231) is disposed at the top of the liquid inlet buffer (230) or at a position adjacent to the top; or, The bottom of the liquid inlet buffer (230) is flush with the replenishing liquid surface (260) of the liquid cache container (250); or, The top of the liquid inlet buffer (230) is located above the replenishing liquid level (260) and the bottom is located below the replenishing liquid level (260).

10. A biochemical analyzer (800), characterized in that: It comprises a cleaning pipeline (500), a cleaning tank (600), a sample addition needle (700), and a fluid replenishment buffer device (200) as claimed in any one of claims 1 to 9; The liquid replenishment buffer device (200) is connected to the cleaning pool (600) via the cleaning pipeline (500), and the sample addition needle (700) is in a state of being located in the cleaning pool (600) for cleaning.

Images