Micro-fluidic chip and micro-fluidic equipment

Abstract

The utility model provides a micro-fluidic chip and micro-fluidic equipment. The micro-fluidic chip comprises a chip main body, the chip main body is provided with a main body flow channel and at least one flow guide channel, and the main body flow channel is constructed to have at least one function of mixing, detecting, separating, generating liquid drops and generating bubbles; the at least one first connecting part is provided with a first flow channel, one end of the flow guide channel is communicated with one end of the main body flow channel, and the other end of the flow guide channel is communicated with the first flow channel; and the second connecting part is provided with a second flow channel, the second flow channel is communicated with the other end of the main body flow channel, and the second connecting part, the first connecting part and the chip main body are integrally formed. According to the technical scheme, the problems that in the prior art, the pressure resistance of a micro-fluidic chip is poor, and the connection mode of the micro-fluidic chip and an external pipeline is not standard are solved.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluidics, and in particular to a microfluidics chip and a microfluidics device. Background Art

[0002] Microfluidics is a technology that precisely manipulates microfluids (from femtoliters to microliters) in micro-nanoscale space. Its basic feature and greatest advantage is that it can flexibly combine or integrate multiple unit technologies on a microchip. It has been applied to various fields such as physics, biology, chemistry and medicine. Therefore, the processing and production of microfluidic chips, and how to effectively connect the accessories of the microfluidic system, such as connecting tubes, adapters and microfluidic chip interfaces in a simple, reliable and standard way without any leakage, are the basis and key to ensure the completion of microfluidic experiments.

[0003] At present, microfluidic chips are mainly divided into two categories: hard chips and soft chips. Soft chips mainly refer to polymer PDMS (polydimethylsiloxane) chips, and hard chips include PMMA (polymethyl methacrylate) chips, PC (polycarbonate) chips, COC (cyclic olefin copolymer) chips, glass chips, silicon substrate chips and resin chips. Different material chips have different processing techniques. Soft PDMS chips are generally processed and manufactured by soft lithography plus plasma treatment bonding; for different types of hard chips, lithography and etching technology, hot pressing, molding, injection molding, LIGA, laser ablation and 3D printing technology can be used. There are also different connection methods for different types of chips. For soft chips, for example, holes are punched on the surface of the PDMS chip and then directly connected to a steel needle or a connecting tube. If the thickness of the PDMS chip is not enough, glue is generally needed to further reinforce the PDMS chip and the steel needle or the connecting tube. For hard chips, standard threaded joints are generally glued to the inlet and outlet of the chip with glue, and then the corresponding joints and connecting tubes are threadedly connected, or chip fixtures and rubber rings are additionally used for auxiliary sealing and connection, but the chip fixture needs to be selected according to the specific chip specifications used. Through the above connection method, the connecting tube can be connected to the chip, and the liquid can flow to the inside of the chip through the connecting tube. Since the pressure limit of the soft chip is generally 0.25 MPa, and the pressure limit of the hard chip is generally 0.25-0.3 MPa, when the liquid in the connecting tube exceeds the pressure limit, it is easy to be washed away by the liquid at the connection between the connecting tube and the chip, which will cause leakage. Utility Model Content

[0004] The main purpose of the utility model is to provide a microfluidic chip and a microfluidic device to solve the problems of poor pressure resistance of the microfluidic chip in the prior art and non-standard connection mode with external pipelines.

[0005] In order to achieve the above-mentioned purpose, the utility model provides a microfluidic chip, which includes a chip body, a main flow channel and at least one guide channel are provided on the chip body, and the main flow channel is constructed to have at least one function of mixing, detecting, separating, generating droplets and generating bubbles; at least one first connecting part, a first flow channel is provided on the first connecting part, one end of the guide channel is connected to one end of the main flow channel, and the other end of the guide channel is connected to the first flow channel; a second connecting part, a second flow channel is provided on the second connecting part, and the second flow channel is connected to the other end of the main flow channel, and the second connecting part, the first connecting part and the chip body are integrally formed.

[0006] Furthermore, the flow guide channel includes a first hole segment and a second hole segment which are connected and arranged at an angle, the first hole segment is connected to the first flow channel, and the second hole segment is connected to the main flow channel.

[0007] Furthermore, there are two guide channels and two first connecting parts, the two guide channels are connected to the two first connecting parts respectively, and the two guide channels are connected to the main flow channel.

[0008] Furthermore, the main flow channel includes a main flow channel and two branch flow channels, one end of the main flow channel is connected to the two branch flow channels, the two branch flow channels are respectively connected to two guide channels, and the other end of the main flow channel is connected to the second flow channel, wherein the two branch flow channels are arranged at an angle.

[0009] Furthermore, the main flow channel includes a plurality of S-shaped flow channels connected in sequence, or the main flow channel is a Tesla valve flow channel.

[0010] Further, at least one of the chip body, the first connection portion and the second connection portion is made of a transparent material.

[0011] According to another aspect of the utility model, the utility model provides a microfluidic device, which includes: at least one first pipeline assembly; a second pipeline assembly; and the above-mentioned microfluidic chip, the first pipeline assembly is correspondingly connected to the first connecting part, and the second pipeline assembly is correspondingly connected to the second connecting part.

[0012] Furthermore, the first pipeline assembly includes: a first pipeline; a first connecting piece; and a second connecting piece, one end of the first pipeline is connected to the first connecting portion via the second connecting piece, and the other end of the first pipeline is connected to one end of the first connecting piece.

[0013] Furthermore, when there are two first connecting parts, there are two first pipeline assemblies, and the microfluidic device also includes a first infusion part and a second infusion part, and the outlet of the first infusion part and the outlet of the second infusion part are respectively connected to the two first connecting parts, and the two second connecting parts are correspondingly connected to the two first connecting parts.

[0014] Furthermore, the second pipeline assembly includes: a second pipeline; a third connecting piece; a fourth connecting piece, one end of the second pipeline is connected to the fourth connecting piece, and the other end of the second pipeline is connected to one end of the third connecting piece. The second pipeline assembly also includes a flow meter, which is connected to the other end of the third connecting piece.

[0015] By applying the technical solution of the utility model, the liquid flows from at least one first flow channel through at least one guide channel to the main flow channel, and the liquid performs the functions of mixing, detecting, separating, generating droplets and generating bubbles in the main flow channel. After the liquid is processed in the main flow channel, the liquid flows from the main flow channel to the second flow channel. Compared with the prior art, in this embodiment, the second connecting part, the first connecting part, the guide channel and the main flow channel are integrally formed, and the integrally formed setting can avoid the use of gluing or punching to connect the microfluidic chip and the connecting tube. In this way, the pressure resistance and sealing of the entire microfluidic chip can be improved, and the risk of leakage is reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The drawings constituting part of the present application are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation on the present invention. In the drawings:

[0017] Figure 1 A schematic structural diagram of an embodiment of a microfluidic chip of the utility model is shown;

[0018] Figure 2 A schematic structural diagram of an embodiment of the microfluidic device of the utility model is shown.

[0019] The above drawings include the following reference numerals:

[0020] 10. First connection part; 11. First infusion part; 12. Second infusion part; 13. Flow meter; 20. Diversion channel; 201. First hole section; 202. Second hole section; 30. Main flow channel; 40. Chip body; 41. Second connection piece; 50. First pipeline; 51. Second pipeline; 60. Fourth connection piece; 70. First connection piece; 80. Third connection piece; 90. Second connection part. DETAILED DESCRIPTION

[0021] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present utility model will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0022] like Figure 1As shown, an embodiment of the utility model provides a microfluidic chip. The microfluidic chip includes a chip body 40, on which a main flow channel 30 and at least one guide channel 20 are provided, and the main flow channel 30 is configured to have at least one function of mixing, detecting, separating, generating droplets and generating bubbles; at least one first connecting part 10, on which a first flow channel is provided, one end of the guide channel 20 is connected to one end of the main flow channel 30, and the other end of the guide channel 20 is connected to the first flow channel; a second connecting part 90, on which a second flow channel is provided, and the second flow channel is connected to the other end of the main flow channel 30, and the second connecting part 90, the first connecting part 10 and the chip body 40 are integrally formed.

[0023] In the above technical scheme, the liquid flows from at least one first flow channel through at least one guide channel 20 to the main flow channel 30, and the liquid performs the functions of mixing, detecting, separating, generating droplets and generating bubbles in the main flow channel 30. After the liquid is processed in the main flow channel 30, the liquid flows from the main flow channel 30 to the second flow channel. Compared with the prior art, in this embodiment, the second connecting part 90, the first connecting part 10 and the chip body 40 are integrally formed, and the integrally formed setting can avoid the use of gluing or punching to connect the microfluidic chip and the connecting tube. In this way, the pressure resistance and sealing of the entire microfluidic chip can be improved, and the risk of leakage is reduced.

[0024] Specifically, in the embodiment of the present invention, the first connection part 10 and the second connection part 90 on the microfluidic chip are designed to be of standard size and shape, so that they can match with universal pipe connectors, thereby avoiding the problem of non-standard connection with external pipes.

[0025] Furthermore, in the embodiment of the utility model, the one-piece molding setting means that the first connecting part 10, the second connecting part 90 and the chip body 40 are formed in the same manufacturing process without additional gluing or mechanical connection steps. In this way, the number of interfaces and connection points between different components can be reduced. These interfaces and connection points are often the main source of leakage. The one-piece molding setting eliminates these potential leakage points, thereby improving the sealing and pressure resistance of the entire microfluidic chip.

[0026] Specifically, in the embodiment of the utility model, when the surface of the PDMS chip is punched, additional punching work and alignment equipment are required. When the PDMS chip is connected using an adhesive joint, a long time of waiting for the adhesive to cure is required during the bonding process. This increases the complexity of making the chip and connecting the pipelines. In this embodiment, by integrally forming the second connecting part 90, the first connecting part 10 and the chip body 40, it is possible to avoid waiting for a long time of waiting for the adhesive to cure during the bonding process. This can reduce the complexity of the production of the microfluidic chip.

[0027] Specifically, in the embodiment of the present invention, the first connecting portion 10 and the second connecting portion 90 are cylindrical in shape, and the length is generally 1-10 cm.

[0028] Specifically, in the embodiment of the present invention, the function of the main flow channel 30 is not limited to mixing, detecting, separating, generating droplets and generating bubbles, and the main flow channel 30 can also be designed according to the specific function to be achieved.

[0029] like Figure 1 As shown, in the embodiment of the utility model, the guide channel 20 includes a first hole segment 201 and a second hole segment 202 which are connected and arranged at an angle, the first hole segment 201 is connected to the first flow channel, and the second hole segment 202 is connected to the main flow channel 30.

[0030] In the above technical solution, the liquid enters the main flow channel 30 from the first flow channel through the first hole segment 201 and the second hole segment 202. The liquid performs the functions of mixing, detecting, separating, generating droplets and generating bubbles in the main flow channel 30. After the liquid is processed in the main flow channel 30, the liquid flows from the main flow channel 30 to the second flow channel.

[0031] Specifically, in the embodiment of the utility model, the length range of the guide channel 20 is relatively wide, the length range of the guide channel 20 is 0.1-100mm, and the function of the guide channel 20 is to connect the main flow channel 30 and the first connecting part 10, and stably guide the fluid to enter or flow out of the main functional flow channel.

[0032] In one embodiment, the guiding channel 20 may be curved or have other specific shapes.

[0033] like Figure 1 As shown, in the embodiment of the present invention, there are two guide channels 20 and two first connecting parts 10 . The two guide channels 20 are connected to the two first connecting parts 10 respectively, and the two guide channels 20 are connected to the main flow channel 30 .

[0034] In the above technical solution, in one application scenario, the liquid enters the main flow channel 30 through the two guide channels 20 from the two first connection parts 10 respectively, and performs the functions of mixing, detecting, generating droplets and generating bubbles in the main flow channel 30. After the liquid is processed in the main flow channel 30, the liquid flows from the main flow channel 30 to the second flow channel; in another application scenario, the liquid can also enter the main flow channel 30 from the second connection part 90 and perform the separation function in the main flow channel 30. After the liquid is processed in the main flow channel 30, the separated liquid flows to the two first connection parts 10 through the two guide channels 20 respectively.

[0035] Specifically, in an embodiment of the utility model, the number of the guide channels 20 can also be one or several, the number of the first connecting parts 10 can be one or more, multiple guide channels 20 are correspondingly connected to multiple first connecting parts 10, and multiple guide channels 20 are connected to the main flow channel 30, and several guide channels 20 can be arranged axially symmetrically along a straight line in the microfluidic chip, can be centrally symmetrical or have a high-order rotationally symmetrical point group structure along a certain point of the microfluidic chip, or can be arranged in an asymmetric structure.

[0036] like Figure 1 As shown, in the embodiment of the present invention, at least one of the chip body 40 , the first connecting portion 10 and the second connecting portion 90 is made of a transparent material.

[0037] Through the above settings, phenomena such as fluid flow, reaction changes and particle movement during the experiment can be observed directly under a microscope, thereby enhancing the intuitiveness and accuracy of the experiment.

[0038] Specifically, in the embodiments of the present invention, the microfluidic chip is made of a transparent material that is resistant to a variety of organic solvents. Biological or chemical reactions can be performed inside the microfluidic chip, and the fluid flow inside the microfluidic chip can be directly observed under a microscope. The material can be one of PMMA, PDMS, glass and resin.

[0039] In one embodiment, at least one of the chip body 40 , the first connection part 10 , and the second connection part 90 is made of a translucent material.

[0040] Embodiment 1

[0041] like Figure 1 As shown, in the first embodiment of the present invention, the main flow channel 30 includes a main flow channel and two branch flow channels, one end of the main flow channel is connected to the two branch flow channels, the two branch flow channels are connected to the two guide channels 20 respectively, and the other end of the main flow channel is connected to the second flow channel, wherein the two branch flow channels are arranged at an angle.

[0042] In the above technical solution, in one application scenario, the liquid can enter the two branch channels through the two guide channels 20 from the two first connecting parts 10 respectively, and perform the functions of detection, droplet generation or bubble generation in the main channel. After the liquid is processed in the main channel 30, the liquid flows from the main channel to the second channel; in another application scenario, the liquid enters the main channel from the second connecting part 90 and performs the separation function in the main channel. After the liquid is processed in the main channel, the separated liquid flows from the two branch channels through the two guide channels 20 to the two first connecting parts 10 respectively.

[0043] Specifically, in the first embodiment of the present invention, the structure of the main flow channel 30 for performing the separation function can be a microfluidic filter for cell separation and sorting, such as a weir-type, column-type or cross-flow filter, etc.; the structure of the main flow channel 30 for performing the separation function can also be a groove, linear or herringbone structure, etc. for separation based on the size, deformation ability and density of cells or particles.

[0044] Specifically, in the first embodiment of the utility model, the structure of the main flow channel 30 for performing the function of generating droplets is T-shaped or Y-shaped. When the angle between the two branch flow channels is less than 180°, the structure of the main flow channel 30 is Y-shaped. When the angle between the two branch flow channels is equal to 180°, the structure of the main flow channel 30 is T-shaped.

[0045] In one embodiment, the structure of the main flow channel 30 for performing the function of generating droplets can also be a flow focusing type or a cross type.

[0046] Embodiment 2

[0047] The difference between the second embodiment and the first embodiment is that the main flow channel 30 has different functions, such as Figure 1 As shown, the main flow channel 30 includes a plurality of S-shaped flow channels connected in sequence, or the main flow channel 30 is a Tesla valve flow channel.

[0048] Through the above arrangement, the liquid enters the main flow channel 30 from the first connection part 10 through the guide channel 20, performs the mixing function in the main flow channel 30, and after the liquid is processed in the main flow channel 30, the liquid flows from the main flow channel 30 to the second flow channel.

[0049] Specifically, in the second embodiment of the present invention, the structure of the main flow channel 30 for performing the mixing function can also be serpentine.

[0050] Specifically, in the second embodiment of the present invention, the structures of the S-shaped flow channel and the Tesla valve flow channel can refer to the prior art and will not be described in detail here.

[0051] The other structures of the second embodiment are the same as those of the first embodiment and will not be described again here.

[0052] like Figure 1 and Figure 2 As shown, an embodiment of the utility model provides a microfluidic device, the microfluidic device includes: at least one first pipeline assembly; a second pipeline assembly; and the above-mentioned microfluidic chip, the first pipeline assembly is correspondingly connected to the first connecting part 10, and the second pipeline assembly is correspondingly connected to the second connecting part 90.

[0053] In the above technical solution, the compatibility and interchangeability of the microfluidic chip with various external devices (for example, pumps, pressure gauges or detectors, etc.) are ensured by connecting the first pipeline assembly to the first connecting part 10, and connecting the second pipeline assembly to the second connecting part 90, which not only simplifies the assembly and configuration of the microfluidic device, but also increases the flexibility and application range of the microfluidic device.

[0054] Preferably, in an embodiment of the present utility model, there are two first pipeline assemblies.

[0055] like Figure 1 and Figure 2 As shown, in an embodiment of the utility model, the first pipeline assembly includes a first pipeline 50; a first connecting member 70; and a second connecting member 41, one end of the first pipeline 50 is connected to the first connecting portion 10 via the second connecting member 41, and the other end of the first pipeline 50 is connected to one end of the first connecting member 70.

[0056] In the above technical solution, the first pipeline 50 is connected to the first connecting part 10 through the second connecting member 41, and is connected to the external device through the first connecting member 70. This design simplifies the assembly process of the microfluidic device and enhances the compatibility of the device with other standard microfluidic accessories. The operator can quickly replace or maintain the pipeline components, making the assembly method more convenient.

[0057] Specifically, in the embodiment of the utility model, the second connecting member 41 is a ferrule joint, and the interior of the ferrule joint has a first flow channel, and the first flow channel is used to connect the first flow channel and the interior of the first pipeline 50. The ferrule joint is generally set to standard sizes such as 1 / 16 inch, 1 / 8 inch, 3 / 16 inch, φ3, φ6 or φ8. The material of the ferrule joint can be one of 304 / 316 stainless steel, PEEK (polyetheretherketone) and PTFE (polytetrafluoroethylene). The function of the ferrule joint is to connect to an external device such as a pump or a syringe, and then transport the fluid to be reacted or detected to the microfluidic chip to achieve the corresponding function.

[0058] Specifically, in the embodiment of the present invention, the material of the first pipeline 50 can be one of PEEK (polyetheretherketone) tube, PTFE (polytetrafluoroethylene) Teflon tube, Tygon (polyethylene) tube, FEP (fluorinated ethylene propylene) tube, ETFE (ethylene tetrafluoroethylene) tube and PP (polypropylene) tube.

[0059] like Figure 2 As shown, in an embodiment of the utility model, when there are two first connecting parts 10, there are two first pipeline assemblies, and the microfluidic device also includes a first infusion part 11 and a second infusion part 12, and the outlet of the first infusion part 11 and the outlet of the second infusion part 12 are respectively connected to the two first connecting parts 70, and the two second connecting parts 41 are respectively connected to the two first connecting parts 10.

[0060] In the above technical solution, the liquid in the first infusion part 11 and the liquid in the second infusion part 12 flow into the two first connecting parts 10 respectively through the two first pipeline components, and flow into the main flow channel 30 through the two guide channels 20, and perform the functions of mixing, detecting, generating droplets and generating bubbles in the main flow channel 30. After the liquid is processed in the main flow channel 30, the liquid flows from the main flow channel 30 to the second flow channel.

[0061] Specifically, in the embodiment of the utility model, the first connecting piece 70 connected to the first infusion part 11 is a quick connector, the first infusion part 11 is a plunger pump, the plunger pump has an inlet and an outlet, and the interior of the quick connector has a second flow channel, one end of the second flow channel is connected to the first pipeline 50, and the other end of the second flow channel is connected to the outlet of the plunger pump. The specific structure of the plunger pump and the quick connector can refer to the prior art and will not be repeated here.

[0062] Specifically, in the embodiment of the utility model, the first connecting piece 70 connected to the second infusion part 12 is a Luer connector, the second infusion part 12 is a syringe, the syringe has a liquid outlet, and the interior of the Luer connector has a third flow channel, one end of the third flow channel is connected to the first pipeline 50, and the other end of the third flow channel is connected to the liquid outlet. The specific structure of the syringe and the Luer connector can refer to the prior art and will not be repeated here.

[0063] like Figure 2 As shown, in an embodiment of the utility model, the second pipeline assembly includes a second pipeline 51; a third connecting piece 80; and a fourth connecting piece 60, one end of the second pipeline 51 is connected to the fourth connecting piece 60, and the other end of the second pipeline 51 is connected to one end of the third connecting piece 80, and the second pipeline assembly also includes a flow meter 13, which is connected to the other end of the third connecting piece 80.

[0064] In the above technical solution, the processed fluid passes through the main flow channel 30 , the second connecting portion 90 and the second pipeline 51 , and the third connecting piece 80 to reach the flow meter 13 . The flow meter 13 is used to measure the flow rate of the fluid flowing through the second pipeline 51 .

[0065] Specifically, in the embodiment of the utility model, the third connecting member 80 is a 1 / 4-28 threaded joint, and the third connecting member 80 has a fourth flow channel inside. One end of the fourth flow channel is connected to the flow meter 13 by a threaded connection, and the other end of the fourth flow channel is connected to the fourth connecting member 60. The fourth connecting member 60 is a ferrule joint. The specific structure of the 1 / 4-28 threaded joint can refer to the prior art and will not be repeated here.

[0066] Specifically, in an embodiment of the utility model, if it is necessary to measure the pressure of a microfluidic device, a locked Luer connector is installed at one end of the first pipeline 50, which is connected to a pressure gauge via a Luer connection, and the other end of the first pipeline 50 is connected to the second connector 41. In this way, the pressure of the microfluidic device can be measured.

[0067] Specifically, in the embodiment of the utility model, when making a microfluidic chip, an integrated molding scheme or a strengthened bonding connection scheme can be selected. Among them, the integrated molding scheme can use the surface projection micro-stereolithography 3D printing technology to achieve ultra-high precision micro-scale 3D printing, which can be used for rapid prototyping of complex three-dimensional microfluidic structures. Its material can be a variety of resin materials such as high-precision resin, high-strength resin or high-temperature resistant resin, without additional bonding; the strengthened bonding scheme can select thermal bonding, surface modification bonding or ultrasonic bonding, etc., and the bonding of the molded microfluidic chip is more solid and pressure-resistant, without the need for screw fastening, and the commonly used materials are PMMA, PDMS or glass. The microfluidic chip under this production scheme can achieve acid and alkali resistance and a variety of organic solvents, and can realize the functions of various physical, biological or chemical related reactions in the main flow channel 30 of the microfluidic chip. And the microfluidic chip needs to be transparent or translucent material, and the flow of fluid inside the chip can be observed under the microscope bright field, dark field, fluorescence of different wavelengths and intensities, which is convenient for researchers to record experimental phenomena instantly and accurately and make in-depth research and analysis.

[0068] Specifically, in the embodiments of the present invention, the microfluidic chip manufacturing and microfluidic equipment of the present invention can solve the problems of poor pressure resistance of traditional PDMS microfluidic chips, multiple ways of connecting with external pipelines, and non-standard connection schemes. By adopting / designing a special microfluidic chip structure and microfluidic equipment, the problems of microfluidic chips not being able to withstand pressure and lacking standard interfaces with external pipelines are solved to a certain extent, and the flow of fluid in the chip can be directly observed under a microscope, which provides convenience for the industrial application and communication of microfluidic chips.

[0069] Specifically, in the embodiment of the utility model, after the first connecting part 10 is connected to one end of the second connecting member 41, the other end of the second connecting member 41 is threadedly connected to the Hamilton 10 mL syringe by the first connecting member 70 through the first pipeline 50, and the outer pipeline is tightened by the reverse blade ring provided by the joint, and the syringe is placed on the Harvard syringe pump to push the syringe at a speed of 30 mL / h, and the first connecting part 10 and the microfluidic chip are leak-free. After the second connecting part 90 is connected to one end of the fourth connecting member 60, the other end of the fourth connecting member 60 is connected to the third connecting member 80 through the second pipeline 51, and the third connecting member 80 is connected to the flow meter 13. After the outer pipeline is tightened by the reverse blade ring provided by the joint, the fluid is pushed at a speed of 30 mL / h by the syringe pump, and the second connecting part 90 is leak-free, and the flow meter reading range fluctuates within 30±0.5 mL / h, indicating that the connection is tight everywhere and the flow meter 13 reading is accurate.

[0070] From the above description, it can be seen that the above-mentioned embodiments of the utility model achieve the following technical effects: the liquid flows from at least one first flow channel through at least one guide channel to the main flow channel, and the liquid performs the functions of mixing, detecting, separating, generating droplets and generating bubbles in the main flow channel. After the liquid is processed in the main flow channel, the liquid flows from the main flow channel to the second flow channel. Compared with the prior art, in this embodiment, the second connecting part, the first connecting part and the chip body are integrally formed, and the integrally formed setting can avoid the use of gluing or punching to connect the microfluidic chip and the connecting tube. In this way, the pressure resistance and sealing of the entire microfluidic chip can be improved, and the risk of leakage is reduced.

[0071] The above description is only the preferred embodiment of the utility model, and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A microfluidic chip, characterized in that: include: A chip body (40), wherein the chip body (40) is provided with a main flow channel (30) and at least one flow guide channel (20), wherein the main flow channel (30) is configured to have at least one function of mixing, detecting, separating, generating droplets, and generating bubbles; at least one first connection portion (10), the first connection portion (10) being provided with a first flow channel, one end of the flow guide channel (20) being connected to one end of the main flow channel (30), and the other end of the flow guide channel (20) being connected to the first flow channel; A second connecting portion (90), wherein the second connecting portion (90) is provided with a second flow channel, the second flow channel is connected to the other end of the main flow channel (30), and the second connecting portion (90), the first connecting portion (10) and the chip main body (40) are integrally formed.

2. The microfluidic chip according to claim 1, characterized in that: The flow guide channel (20) comprises a first hole section (201) and a second hole section (202) which are connected and arranged at an angle, the first hole section (201) being connected to the first flow channel, and the second hole section (202) being connected to the main flow channel (30).

3. The microfluidic chip according to claim 1, characterized in that: There are two guide channels (20), there are two first connection parts (10), the two guide channels (20) are correspondingly connected to the two first connection parts (10), and the two guide channels (20) are both connected to the main flow channel (30).

4. The microfluidic chip according to claim 3, characterized in that: The main flow channel (30) comprises a main flow channel and two branch flow channels, one end of the main flow channel is connected to the two branch flow channels, the two branch flow channels are respectively connected to two corresponding guide channels (20), and the other end of the main flow channel is connected to the second flow channel, wherein the two branch flow channels are arranged at an angle.

5. The microfluidic chip according to any one of claims 1 to 3, characterized in that: The main flow channel (30) comprises a plurality of S-shaped flow channels that are connected in sequence, or the main flow channel (30) is a Tesla valve flow channel.

6. The microfluidic chip according to any one of claims 1 to 4, characterized in that: At least one of the chip body (40), the first connection portion (10) and the second connection portion (90) is made of a transparent material.

7. A microfluidic device, characterized in that: include: at least one first pipe assembly; a second pipeline assembly; And the microfluidic chip according to any one of claims 1 to 4, wherein the first pipeline assembly is connected to the first connecting portion (10) correspondingly, and the second pipeline assembly is connected to the second connecting portion (90) correspondingly.

8. The microfluidic device according to claim 7, characterized in that: The first pipeline assembly comprises: First pipeline (50); A first connecting member (70); A second connecting piece (41), wherein one end of the first pipeline (50) is connected to the first connecting portion (10) via the second connecting piece (41), and the other end of the first pipeline (50) is connected to one end of the first connecting piece (70).

9. The microfluidic device according to claim 8, characterized in that: When there are two first connecting parts (10), there are two first pipeline assemblies, and the microfluidic device further comprises a first infusion part (11) and a second infusion part (12), wherein an outlet of the first infusion part (11) and an outlet of the second infusion part (12) are respectively connected to two corresponding first connecting members (70), and two second connecting members (41) are respectively connected to two corresponding first connecting parts (10).

10. The microfluidic device according to claim 7, characterized in that: The second pipeline assembly comprises: Second pipeline (51); A third connecting member (80); a fourth connecting piece (60), one end of the second pipeline (51) being connected to the fourth connecting piece (60), the other end of the second pipeline (51) being connected to one end of the third connecting piece (80), the second pipeline assembly further comprising a flow meter (13), the flow meter (13) being connected to the other end of the third connecting piece (80).

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