Reagent card shell
By arranging a check structure on the overflow tank of the reagent cartridge and designing multiple overflow tanks and sampling holes, the problem of sample overflow and backflow in the detection reagent card is solved, and the samples are evenly distributed and fixed, which is suitable for multiplex detection. Reagent card.
Patent Information
- Application Number
- CN202420804064.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-17
- Publication Date
- 2025-01-21
- Estimated Expiration
- 2034-04-17
AI Technical Summary
The existing detection reagent cards have problems with the sample being easily overflowed and refluxed when detecting samples, especially the multi-link detection reagent cards cannot be effectively distributed equally or the loading volume of each test strip is allocated as needed.
A reagent cartridge is designed, including a first shell and a second shell, which are set on the overflow tank through a non-return structure (such as a capillary groove) to prevent the backflow of liquid samples and pass through multiple overflow tanks and injection holes. The design ensures even distribution and fixation of samples.
It effectively prevents the backflow of liquid samples, ensures uniform distribution and fixation of samples, solves the problem of sample overflow and backflow in existing detection reagent cards, and at the same time realizes the rapid replacement of test strips and the concept of environmental protection.
Smart Images
Figure CN222379705U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of medical liquid testing products, and in particular to a reagent cartridge. Background Art
[0002] Lateral flow chromatography technology usually uses test reagent cards to detect whether a sample contains a certain substance. Test reagent cards have many applications in life or the medical industry, such as qualitative or quantitative detection of target analytes through blood test reagent cards, urine test reagent cards or other biological sample test reagent cards. However, existing test reagent cards have the problem of easy sample overflow and backflow when testing samples, and multi-test reagent cards also have the problem of being unable to evenly distribute or distribute the sample amount of each test strip according to needs. Utility Model Content
[0003] The present application aims to solve at least one of the above technical problems in the prior art to a certain extent. To this end, the present application provides a reagent cartridge that can effectively solve the problem of easy sample backflow in the existing detection reagent cartridge when detecting a sample.
[0004] According to the reagent cartridge described in the embodiment of the present application, it includes a first shell and a second shell, and the first shell and the second shell are matched to form a cavity for fixing a test paper. The surface of the first shell is provided with a sample receiving portion, an overflow groove, a window and at least one injection hole, the sample receiving portion is connected to the injection hole through the overflow groove, and the injection hole is connected to the cavity, wherein at least a portion of the overflow groove is provided with a non-return structure, and the window is used to display the result area of the test paper located in the cavity.
[0005] According to the reagent cartridge described in the embodiment of the present application, the non-return structure is a capillary groove, and the ratio of the width of the capillary groove to the width of the overflow groove is in the range of 0.2:1 to 0.5:1.
[0006] According to the reagent cartridge described in the embodiment of the present application, the length of the capillary groove is less than 1 / 3 of the total length of the overflow groove.
[0007] According to the reagent cartridge described in the embodiment of the present application, the number of the injection holes is greater than or equal to 2, the number of the overflow slots is the same as the number of the injection holes, and the lengths of all the overflow slots are the same.
[0008] According to the reagent cartridge described in the embodiment of the present application, a separator is provided between two adjacent overflow grooves.
[0009] According to the reagent cartridge described in the embodiment of the present application, a stepped groove is provided on one side of the second shell, a first clamping portion is provided in the stepped groove, a second clamping portion is provided at a position of the first shell corresponding to the first clamping portion, and after the first shell is embedded in the stepped groove, the second clamping portion is connected to the first clamping portion.
[0010] According to the reagent cartridge described in the embodiment of the present application, the first shell protrudes toward one side of the second shell to form the second snap-fitting portion, a plurality of second snap-fitting portions are provided, and the second snap-fitting portions are arranged in an array on both sides of the first shell, and the first snap-fitting portion includes two symmetrically arranged limiting portions, and a slot for inserting the second snap-fitting portion is formed between the two limiting portions.
[0011] According to the reagent cartridge described in the embodiment of the present application, a notch communicating with the stepped groove is provided at one end of the second shell, and a convex portion is configured at a position of the first shell corresponding to the notch.
[0012] According to the reagent cartridge described in the embodiment of the present application, a placement groove for positioning the test paper is provided in the second shell, and a pre-tightening portion for pressing against the test paper is provided at a position of the first shell corresponding to the placement groove.
[0013] According to the reagent cartridge described in the embodiment of the present application, the surface of the first shell is provided with an interception portion that surrounds the sample receiving portion, the overflow groove, and the injection hole.
[0014] According to the reagent cartridge described in the embodiment of the present application, a sample loading protection piece is provided on the surface of the first shell, and the sample loading protection piece at least covers the areas where the sample receiving part, the overflow groove, and the injection hole are located. The sample loading protection piece also includes a sample squeezing structure, and the sample squeezing structure is connected to the sample receiving part.
[0015] The above reagent cartridge has at least the following beneficial effects: when the reagent cartridge of the present application is used, the corresponding test paper is placed in the second shell, and then the first shell and the second shell are matched and closed to fix the test paper in the cavity formed by the first shell and the second shell. The liquid sample is distributed by the sample receiving part and then diverted to the injection hole through the overflow groove, and then enters the test paper fixed in the cavity through the injection hole for detection. The test result area of the test paper can be observed from the window set on the first shell, which is convenient for observation. In addition, since a check structure is provided in the overflow groove, the liquid sample can be effectively prevented from flowing back. The entire reagent cartridge has a simple structure and can effectively solve the problem that the sample is easy to flow back when the existing detection reagent card is used to detect the sample. At the same time, because the first shell and the second shell are detachable, the test paper can also be replaced conveniently and quickly, realizing the concept of environmental protection. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] The present application is further described below with reference to the accompanying drawings and embodiments;
[0017] Figure 1 The structure of the reagent cartridge with two overflow grooves in the embodiment of the present application is shown in FIG. Figure 1 ;
[0018] Figure 2 The structure of the reagent cartridge with two overflow grooves in the embodiment of the present application is shown in FIG. Figure 2 ;
[0019] Figure 3 is a schematic structural diagram of a reagent cartridge with three overflow grooves according to an embodiment of the present application;
[0020] Figure 4 It is a schematic structural diagram of a reagent cartridge having an overflow groove according to an embodiment of the present application;
[0021] Figure 5 is a structural schematic diagram of the first shell in an embodiment of the present application;
[0022] Figure 6 This is a schematic diagram of the structure of the second housing in the embodiment of the present application. Figure 1 ;
[0023] Figure 7 This is a schematic diagram of the structure of the second housing in the embodiment of the present application. Figure 2 ;
[0024] Figure 8 1 is a schematic structural diagram of a reagent cartridge with a sample adding protection member in an embodiment of the present application;
[0025] Fig. 9 It is a structural schematic diagram of the sample adding protection component in an embodiment of the present application. DETAILED DESCRIPTION
[0026] This section will describe in detail the specific embodiments of the present application. The preferred embodiments of the present application are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present application, but it cannot be understood as a limitation on the scope of protection of the present application.
[0027] In the description of the present application, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.
[0028] In the description of this application, "several" means one or more, "more" means more than two, "greater than", "less than", "exceed", etc. are understood to exclude the number itself, and "above", "below", "within", etc. are understood to include the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.
[0029] In the description of this application, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in this application based on the specific content of the technical solution.
[0030] Lateral flow assay is a technique that detects target substances in samples based on specific binding of antigens and antibodies or hybridization reactions between nucleic acid probes and targeted nucleic acids under the action of capillary chromatography. Depending on the object being detected, lateral flow chromatography can be divided into immunochromatography and nucleic acid chromatography. Lateral flow chromatography usually uses a test reagent card to detect whether a sample contains a certain substance. Test reagent cards have many applications in life or the medical industry, such as qualitative or quantitative detection of target analytes through blood test reagent cards, urine test reagent cards or other biological sample test reagent cards. However, existing test reagent cards have the problem of easy sample reflux when detecting samples.
[0031] Reference Figures 1 to 4 The present application provides a novel reagent cartridge, specifically comprising a first shell 100 and a second shell 200. The first shell 100 is embedded in the second shell 200 to form a cavity for fixing a test paper. The same surface of the first shell 100 is provided with a sample receiving portion 110, an overflow groove 120, a window 140 and at least one injection hole 130. The sample receiving portion 110 is connected to the injection hole 130 through the overflow groove 120, and the injection hole 130 is connected to the cavity, wherein at least a portion of the overflow groove 120 is provided with a non-return structure, and the window 140 is used to display the result area of the test paper located in the cavity.
[0032] When the above reagent cartridge is used, the corresponding test paper is placed in the second shell 200, which has a cavity, and the cavity is open. Then, the first shell 100 is inserted into the second shell 200 from the side of the cavity opening and the cavity is covered, so that the test paper is fixed in the cavity formed by the first shell 100 and the second shell 200. Then, the liquid sample obtained by the sampler is placed in the sample receiving portion 110 for squeezing. The reagent liquid squeezed in the sample receiving portion 110 is diverted to the injection hole 130 through the overflow groove 120, and then the injection hole 130 is used to inject the reagent liquid into the sample receiving portion 110. 30 The liquid sample is introduced into the test paper fixed in the cavity for detection. The test result area of the test paper can be observed through the window 140 set on the first shell 100, which makes it convenient to observe the test result. In addition, since the overflow groove 120 is provided with a non-return structure, it can effectively prevent the liquid sample from flowing back. The entire reagent card shell structure is simple, which can effectively solve the problem of easy sample backflow in the existing detection reagent card when detecting the sample. At the same time, since the first shell 100 and the second shell 200 are embedded in each other, the test paper can also be replaced conveniently and quickly.
[0033] In some other embodiments, the first shell 100 and the second shell 200 can be matched in a sliding manner, the second shell 200 is provided with a slide rail groove, the first shell 100 is inserted from the side, and the second shell 200 is slidably covered to form a cavity.
[0034] In the embodiment of the present application, the check structure is a capillary groove 121, and the ratio of the width of the capillary groove 121 to the width of the overflow groove 120 is 0.2:1 to 0.5:1, for example, the ratio may be 0.2:1, 0.25:1, 0.3:1, 0.35:1, 0.4:1, 0.45:1 or 0.5:1. The width of the capillary groove 121 is smaller than the width of the overflow groove 120, and the surface tension of the capillary groove 121 is utilized to effectively inhibit the backflow of the liquid sample. The length of the capillary groove 121 is less than 1 / 3 of the total length of the overflow groove 120. If the capillary groove 121 is too long, it is easy to affect the flow of the liquid sample and thus slow down the speed of the test paper test. It is a better choice to control the length of the capillary groove 121 to be less than 1 / 3 of the total length of the overflow groove 120.
[0035] like Figure 4As shown, the present application provides a reagent cartridge with only one overflow groove 120, and there is only one corresponding injection hole 130, and the cavity is also used to fix only one test paper. In some embodiments, the number of injection holes 130 can be greater than or equal to 2, and the number of overflow grooves 120 and injection holes 130 is the same, that is, there are as many overflow grooves 120 as there are injection holes 130, and all overflow grooves 120 have the same length. The same length of all overflow grooves 120 can ensure that the liquid path of the liquid sample flowing to each injection hole 130 is of equal length, so that the reagent liquid at the sample receiving portion 110 can be evenly distributed to each injection hole 130, and the capillary groove 121 provided on each overflow groove 120 can avoid the situation where the amount of sample flowing into each injection hole 130 is different due to the backflow of the reagent liquid, such as Figure 3 As shown, the present application provides a reagent cartridge having three overflow grooves 120 .
[0036] It should be noted that the present application can distribute the sample amount flowing to each test paper through multiple overflow grooves 120; the capillary groove 121 can prevent the sample from flowing back to other overflow grooves 120 after the sample flows back, which can well solve the problem of sample backflow existing in the existing detection reagent card, and solve the problem of uneven sample flow in the multi-link reagent card. Furthermore, the equal length of the liquid path of the overflow groove 120 is also very important, which involves the fluid resistance along the way, system resistance and uniformity. The equal length liquid path design can well achieve the purpose of smooth liquid path and non-interference.
[0037] In some other embodiments, when the number of overflow slots 120 is greater than 2, a partition 160 is disposed between two adjacent overflow slots 120 to prevent the reagent solution in the overflow slot 120 from overflowing excessively and flowing into the adjacent overflow slot 120 .
[0038] In some other embodiments, the surface of the first shell 100 does not protrude from the surface of the second shell 200, so that the entire reagent cartridge looks more integrated and beautiful, and feels better when used. Figures 1 to 4 As shown, the surface of the first shell 100 is provided with an intercepting portion 150 which surrounds the sample receiving portion 110, the overflow groove 120 and the injection hole 130. The reagent liquid distribution portion is circled by the intercepting portion 150 to prevent excessive reagent liquid from flowing directly from the window 140 to the test paper.
[0039] In some other embodiments, such as Figures 1 to 4 As shown, the hole wall of the injection hole 130 is a slope, and the inclination angle of the slope is preferably 30° to 45°. The slope at a certain angle can well control the flow rate of the reagent solution. Compared with the vertical hole wall, the slope can better ensure the stability and uniformity of the rate at which the liquid sample flows into the test paper.
[0040] like Figure 6 and Figure 7 As shown, a stepped groove 210 is provided on one side of the second housing 200, and a first engaging portion is provided in the stepped groove 210. Specifically, one side of the second housing 200 is hollowed out, and the hollowed-out portion is hollowed out for a second time to form the stepped groove 210, and the engaging portion is provided at the bottom of the second hollowing out. Figure 5 As shown, the second snap-fitting portion 101 is provided at the position of the first shell 100 corresponding to the first snap-fitting portion. After the first shell 100 is embedded in the stepped groove 210, the second snap-fitting portion 101 is plugged and connected to the first snap-fitting portion. Through the mutual cooperation between the first snap-fitting portion and the second snap-fitting portion 101, the first shell 100 and the second shell 200 are connected into one, and the connection is convenient.
[0041] Further, such as Figure 5 As shown, one side of the first shell 100 protrudes toward the second shell 200 to form a second engaging portion 101. A plurality of second engaging portions 101 are provided, and the second engaging portions 101 are arranged in an array on both sides of the same side of the first shell 100. Figure 6 and Figure 7 As shown, the first engaging portion includes two symmetrically arranged limiting portions 220, and a slot for inserting the second engaging portion 101 is formed between the two limiting portions 220, and the width of the slot is 0.15 to 0.35 mm smaller than the width of the second engaging portion 101. The slot plays a role in both positioning and clamping the second engaging portion 101. The width of the slot is 0.15 to 0.35 mm smaller than the width of the second engaging portion 101, which can provide sufficient clamping force to clamp the second engaging portion 101. In addition, the first shell 100 and the second shell 200 in the embodiment of the present application are both manufactured integrally by injection molding, so the slot formed by the two limiting portions 220 has the ability to deform and can clamp the second engaging portion 101.
[0042] In some other preferred embodiments, a placement groove for positioning the test paper is provided in the second housing 200, and a pre-tightening portion for pressing the test paper is provided at a position corresponding to the placement groove in the first housing 100. Figure 6 and Figure 7 As shown, a plurality of groups of first limiting ends are formed in the cavity of the second shell 200, and a group of first limiting ends includes limiting blocks 230 arranged opposite to each other. At least two groups of first limiting ends and one second limiting end 250 constitute the above-mentioned placement groove, and a support bar 260 for supporting the middle part of the test paper is arranged in the middle of the formed placement groove. The number of placement grooves corresponds to the number of sample inlets 130. When the test paper is placed in the placement groove, the upper end of one end of the test paper is aligned with the sample inlet 130, and the middle position of the test paper is aligned with the window 140. Further, as shown in FIG. Figure 5As shown, the pre-tightening portion includes a first clamping block 104 and a second clamping block 105. After the first shell 100 is engaged in the stepped groove 210 of the second shell 200, the first clamping block 104 and the second clamping block 105 respectively press against the two ends of the test paper placed in the placement groove, and the test paper is clamped and fixed through the cooperation between the placement groove and the pre-tightening portion.
[0043] In other preferred embodiments, Figure 6 and Figure 7 As shown, one end of the second housing 200 is provided with a notch 211 connected to the stepped groove 210. Figure 1 and Figure 5 It can be understood that the first shell 100 is provided with a convex portion 170 at the position corresponding to the notch 211. After the first shell 100 is engaged with the second shell 200, the convex portion 170 is stuck in the notch 211. The setting of the convex portion 170 and the notch 211 not only plays a fool-proof role, but also facilitates the user to quickly take the first shell 100 out of the second shell 200 through the convex portion 170, so as to facilitate the replacement of the test paper. Figure 5 As shown, the first shell 100 has a first positioning end 102 and a second positioning end 103 on one side of the second locking portion 101 away from the protrusion 170, and the second shell 200 is provided with a groove 240 for the first positioning end 102 to move. Before the first shell 100 is embedded in the second shell 200, the second positioning end 103 is against the wall of the internal cavity of the second shell 200, and then the first shell 100 is slowly embedded in the second shell 200, which is convenient to assemble and not easy to be installed incorrectly.
[0044] In other preferred embodiments, Figure 8 and Fig. 9 As shown, a sample adding protection part 300 is arranged on the surface of the first shell 100, and the sample adding protection part 300 includes a cylindrical structure 320 and a flat structure 310. The cylindrical structure 320 contains a sample squeezing structure inside, and the sample squeezing structure can be used to squeeze the sampling cotton to release the liquid sample, and the sample squeezing structure is connected to the sample receiving part 110; the flat structure 310 covers the area where the sample receiving part 110, the overflow groove 120, and the sampling hole 130 are located, and is used to protect the sample from external contamination.
[0045] The embodiments of the present application are described in detail above in conjunction with the accompanying drawings, but the present application is not limited to the above embodiments, and various changes can be made within the knowledge scope of ordinary technicians in the technical field without departing from the purpose of the present application.
Claims
1. A reagent jam, characterized in that: The invention comprises a first shell (100) and a second shell (200), wherein the first shell (100) and the second shell (200) cooperate to form a cavity for fixing a test paper, and the surface of the first shell (100) is provided with a sample receiving portion (110), an overflow groove (120), a window (140) and at least one injection hole (130), wherein the sample receiving portion (110) is connected to the injection hole (130) through the overflow groove (120), and the injection hole (130) is connected to the cavity, wherein at least a portion of the overflow groove (120) is provided with a non-return structure, and the window (140) is used to display a result area of the test paper located in the cavity.
2. The reagent cartridge according to claim 1, characterized in that: The non-return structure is a capillary groove (121), and the ratio of the width of the capillary groove (121) to the width of the overflow groove (120) is in the range of 0.2:1 to 0.5:
1.
3. The reagent cartridge according to claim 2, characterized in that: The length of the capillary groove (121) is less than 1 / 3 of the total length of the overflow groove (120).
4. The reagent cartridge according to claim 1, 2 or 3, characterized in that: The number of the injection holes (130) is greater than or equal to 2, the number of the overflow grooves (120) is the same as the number of the injection holes (130), and the lengths of all the overflow grooves (120) are the same.
5. The reagent cartridge according to claim 4, characterized in that: A separator (160) is provided between two adjacent overflow grooves (120).
6. The reagent cartridge according to claim 1, 2 or 3, characterized in that: A stepped groove (210) is provided on one side of the second shell (200), a first clamping portion is provided in the stepped groove (210), a second clamping portion (101) is provided at a position of the first shell (100) corresponding to the first clamping portion, and after the first shell (100) is embedded in the stepped groove (210), the second clamping portion (101) is connected to the first clamping portion.
7. The reagent cartridge according to claim 6, characterized in that: One side of the first shell (100) protrudes toward the second shell (200) to form the second engaging portion (101); a plurality of the second engaging portions (101) are provided, and the second engaging portions (101) are arranged in an array on both sides of the first shell (100); the first engaging portion comprises two symmetrically arranged limiting portions (220); a slot for inserting the second engaging portion (101) is formed between the two limiting portions (220).
8. The reagent cartridge according to claim 6, characterized in that: One end of the second shell (200) is provided with a notch (211) communicating with the stepped groove (210), and the first shell (100) is provided with a convex portion (170) at a position corresponding to the notch (211).
9. The reagent cartridge according to claim 1, 2 or 3, characterized in that: A placement groove for positioning the test paper is provided in the second housing (200), and a pre-tightening portion for pressing against the test paper is provided at a position of the first housing (100) corresponding to the placement groove.
10. The reagent cartridge according to claim 1, 2 or 3, characterized in that: The surface of the first shell (100) is provided with an intercepting portion (150) which surrounds the sample receiving portion (110), the overflow groove (120) and the injection hole (130); and / or the surface of the first shell (100) is provided with a sample adding protection member (300), the sample adding protection member (300) at least covers the areas where the sample receiving portion (110), the overflow groove (120) and the injection hole (130) are located, and the sample adding protection member (300) also includes a sample squeezing structure, and the sample squeezing structure is connected to the sample receiving portion (110).