Flexible plasma equipment for treating skin soft tissue infection

Abstract

The utility model discloses flexible plasma equipment for treating skin soft tissue infection, and particularly relates to the field of flexible plasma equipment. Comprising a polyimide film, a plurality of electrodes are distributed on the polyimide film in an array mode, all the electrodes are connected with a power source in parallel through electric wires, a rubber plate adheres to one side of the polyimide film, and a plurality of connecting holes are formed in the upper side and the lower side of the rubber plate. The upper side and the lower side of the upper end of the rubber plate are rotationally connected with connecting blocks, the connecting blocks are in threaded connection with limiting bolts, and the limiting bolts are matched with the connecting holes. By adopting the technical scheme of the utility model, the problems of drug resistance and increased treatment difficulty caused by the fact that the existing skin soft tissue infection is mainly treated by antibiotics are solved, and the treatment effect of the skin soft tissue infection is improved.

Description

Technical Field

[0001] The utility model relates to the field of flexible plasma equipment, in particular to a flexible plasma equipment for treating skin and soft tissue infection. Background Art

[0002] Skin and soft tissue infection refers to inflammatory diseases caused by pathogenic bacteria such as Staphylococcus aureus and hemolytic streptococci invading the epidermis, dermis and subcutaneous tissue. It includes folliculitis, furuncle, carbuncle, lymphangitis, acute cellulitis, burn wound infection, postoperative incision infection and bedsore infection, etc. The main manifestations are redness, swelling and pain of the skin. In severe cases, it can cause systemic necrotizing infection and even death.

[0003] There are the following difficulties in the diagnosis and treatment of skin and soft tissue infections: first, it is sometimes difficult to distinguish skin and soft tissue infectious diseases from non-infectious inflammatory skin diseases. Second, it is necessary to further identify the pathogens through pathogen culture and drug sensitivity tests and give targeted treatment, so professional laboratory equipment and testing personnel are needed. Finally, in terms of treatment, the main treatment for skin and soft tissue infections is antibiotic treatment. However, the abuse of antibiotics in recent years has led to an increase in drug-resistant strains and multidrug resistance of drug-resistant bacteria, making it more difficult to treat. Therefore, we urgently need to find a non-antibiotic therapy with a broad treatment spectrum for skin and soft tissue infections. Utility Model Content

[0004] The utility model aims to provide a flexible plasma device for treating skin and soft tissue infections, which solves the problem that the existing skin and soft tissue infections are mainly treated with antibiotics, resulting in drug resistance and increased difficulty in treatment.

[0005] In order to achieve the above-mentioned purpose, the technical solution of the utility model is as follows: a flexible plasma device for treating skin and soft tissue infections, comprising a polyimide film, on which a plurality of electrodes are distributed in an array, all of which are connected in parallel with a power supply through electrical conductors, a rubber plate is adhered to one side of the polyimide film, a plurality of connection holes are provided on the upper and lower sides of the rubber plate, and connection blocks are rotatably connected on the upper and lower sides of the upper end of the rubber plate, and a limit bolt is threadedly connected to the connection block, and the limit bolt cooperates with the connection hole.

[0006] The principle and effect of the technical solution are as follows: by rolling the polyimide film and the rubber sheet outside the area to be treated, and then rotating the connecting block to position the limit bolt directly above the corresponding connecting hole, and then screwing the limit bolt so that the bottom of the limit bolt is located in the connecting hole, the position of the end of the rubber sheet is fixed by means of the limit bolt and the connecting hole, and the device is fixed to the affected part of the patient by means of the rolling force generated by the polyimide film and the rubber sheet, and at the same time, the flexible structure makes the device suitable for soft tissue treatment of different parts of the patient.

[0007] Furthermore, a first support rod is provided on the polyimide film, the first support rod and the rubber plate are arranged on both sides of the polyimide film, and the thickness of the first support rod is greater than the thickness of the electrode.

[0008] Furthermore, a horizontally arranged flexible guide rail is adhered to the polyimide film, and a second support rod located on the right side of the first support rod is slidably connected to the flexible guide rail.

[0009] Through the above arrangement, by sliding the second support rod between two corresponding adjacent columns of electrodes, the first support rod and the second support rod are used to keep the skin and the electrodes separated, thereby ensuring the safety of treatment during the operation of the device.

[0010] Furthermore, the first support rod is provided with an L-shaped air passage, the air passage connects the end of the first support rod with the side of the first support rod facing the electrode, and the air passage is connected to a high-pressure argon gas bottle via a hose.

[0011] Through the above settings, argon gas has stable properties and lacks stable compound forms between argon gas and other elements. Compared with the instability of air discharge, argon gas discharge can form a more stable, larger and more uniform plasma, thereby improving the treatment effect. Compared with other rare gases, argon gas is less expensive. At the same time, compared with gases such as nitrogen or oxygen, argon gas has a relatively low thermal conductivity, and is more suitable as a plasma gas under such conditions.

[0012] Furthermore, a plurality of elastic bands are arranged at intervals on one side of the rubber plate.

[0013] Through the above arrangement, the end position of the rubber sheet after rolling can be kept fixed by means of the elastic band, thereby improving the stability of the present solution.

[0014] Compared with the prior art, this solution has the following beneficial effects:

[0015] 1. This program is suitable for skin and soft tissue infections such as erysipelas and other common sites (lower limbs, etc.), providing sufficient treatment area (≥30cm 2) to improve the efficacy. At the same time, with the help of active particles, ultraviolet radiation and other active substances in the plasma, it can penetrate through the skin pores to act on the skin soft tissue, directly acting on the tissue depth ≥ 2mm, which can meet the common clinical treatment needs of skin and soft tissue infections.

[0016] 2. Compared with traditional antibiotic therapy, this device has the advantages of portability, high therapeutic efficacy, shortened treatment course, low cost, not easy to produce drug resistance, high safety, and no pollution, which improves the practicality of the device and the compliance of treatment.

[0017] 3. This solution can also act on skin and soft tissue damage areas that have not yet been infected, kill pathogens on the surface, and effectively prevent possible skin and soft tissue infections.

[0018] 4. When treating skin and soft tissue wound infections, this device can not only control the infection but also promote wound healing. However, plasma can effectively promote wound healing by promoting epithelial cell proliferation, promoting fibroblast proliferation and differentiation, inducing dermal fibroblast proliferation, and regulating inflammatory response.

[0019] 5. This scheme does not conflict with conventional antibiotic therapy and can be carried out simultaneously to achieve a two-pronged approach. Plasma can improve the bactericidal effect of antibiotics, which is mainly related to the mechanism that plasma destroys the outer cell layer, improves the penetration of antibiotics into cells, and promotes the inhibitory effect of antibiotics on quorum sensing (QS) signal molecules. Therefore, this device can be combined with conventional treatment to effectively improve the efficacy and shorten the course of treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a front view of a flexible plasma device for treating skin and soft tissue infections in the utility model;

[0021] Figure 2 It is a top view of a flexible plasma device for treating skin and soft tissue infection in the utility model, in which a high-pressure argon gas bottle is removed;

[0022] Figure 3 This is a graph showing the changes in the average survival rates of Staphylococcus aureus and hemolytic Streptococcus after treatment with the flexible plasma device. DETAILED DESCRIPTION

[0023] The utility model is further described in detail below through specific implementation methods:

[0024] The figure marks in the drawings of the specification include: polyimide film 1, electrode 2, rubber plate 3, power box 4, elastic band 5, connecting hole 6, fixing rod 7, connecting block 8, limiting bolt 9, first support rod 10, flexible guide rail 11, second support rod 12, high-pressure argon gas cylinder 13.

[0025] Example

[0026] like Figures 1 to 3 As shown, a flexible plasma device for treating skin and soft tissue infection comprises a polyimide film 1, a plurality of electrodes 2 are distributed in an array on the front side of the polyimide film 1, all the electrodes 2 are connected in parallel with a power supply through an electric conductor, and the power supply is fixedly arranged on the right rear side of a rubber plate 3 through a power supply box 4. A rubber plate 3 is adhered to the rear side of the polyimide film 1, and a plurality of elastic bands 5 are adhered to the rear side of the rubber plate 3 at intervals. A plurality of connection holes 6 distributed at intervals are provided on the upper and lower sides of the rubber plate 3, and a fixing rod 7 is provided on the upper and lower sides of the right end of the rubber plate 3. The free end of each fixing rod 7 is rotatably connected to a connection block 8, and a threaded hole is provided on the free end of the connection block 8, and a limit bolt 9 is threadedly connected to the threaded hole, and the limit bolt 9 cooperates with the connection hole 6, that is, the outer diameter of the threaded end of the limit bolt 9 is slightly smaller than the diameter of the connection hole 6.

[0027] A first support rod 10 is also adhered to the left end of the front side of the polyimide film 1. The first support rod 10 and the rubber plate 3 are arranged on the front and rear sides of the polyimide film 1. The thickness of the first support rod 10 is greater than the thickness of the electrode 2. A flexible guide rail 11 located on the upper side of the polyimide film 1 and arranged horizontally is adhered to the right side of the first support rod 10. A second support rod 12 located on the right side of the first support rod 10 is slidably connected to the flexible guide rail 11. The first support rod 10 is provided with an L-shaped airway, which connects the top of the first support rod 10 with the center of the right side wall of the first support rod 10. The airway is connected to a high-pressure argon gas cylinder 13 located outside the rubber plate 3 through a hose. In this embodiment, the right side wall of the first support rod 10 and the left side wall of the second support rod 12 are both arc-shaped, which is conducive to increasing the contact area between the first support rod 10 and the patient's skin, thereby reducing the pressure.

[0028] The working process of this technical solution:

[0029] Before use, slide the second support rod 12 between the two predetermined columns of electrodes 2 according to the width of the infected area. During the sliding process of the second support rod 12, the second support rod 12 can be pulled outward to avoid the electrodes 2. Then, the first support rod 10 and the second support rod 12 in the device are respectively pressed against the two sides outside the infected area of ​​the patient's skin and soft tissue, and then the polyimide film 1 and the rubber sheet 3 are rolled on the infected area. When the right side of the rubber sheet 3 is located behind the left end of the rubber sheet 3, the rolled state of the polyimide film 1 and the rubber sheet 3 can be maintained with the help of the corresponding elastic band 5. After the polyimide film 1 and the rubber sheet 3 are rolled to the predetermined position, rotate the connection block 8 and screw the limit bolt 9 into the corresponding connection hole 6, thereby realizing the positioning and fixing work of the device.

[0030] When in use, firstly, a certain amount of argon gas is introduced into the infected area by using a high-pressure argon gas cylinder 13, a hose and an airway, and then the electrode 2 is energized by a power supply control, and the argon gas between the polyimide film 1 and the electrode 2 is ionized by the mechanism of dielectric barrier discharge, thereby generating plasma including ROS, RNS, ultraviolet rays, metastable particles, pH, charged particles and electric fields, etc., and using plasma to act on the skin soft tissue to produce a therapeutic effect. In this embodiment, the power supply outputs a microsecond pulse voltage when working, and the voltage amplitude of the power supply is 1-5kV and the frequency is 5-20kHz. The single use time of the flexible plasma device is 3min.

[0031] In this embodiment, argon is stable in nature, and there is a lack of stable compound forms between argon and other elements. Compared with the instability of air discharge, argon discharge can form a more stable, larger, and more uniform plasma, thereby improving the therapeutic effect; compared with other rare gases, argon is less expensive. At the same time, compared with gases such as nitrogen or oxygen, argon has a relatively low thermal conductivity, and is also more suitable as a plasma gas under such conditions. When the high-pressure argon cylinder 13 cannot be replenished in time after use, it can be ionized directly through the air. This method is relatively more convenient and easy to obtain, and is suitable for outdoor or non-hospital places where special gases are not easy to obtain, and can reduce costs.

[0032] Experimental test analysis:

[0033] Preliminary in vitro experiments were conducted to evaluate the in vitro antibacterial activity of the device using Staphylococcus aureus and hemolytic Streptococcus, common pathogens of clinical skin and soft tissue infections.

[0034] The experimental method is as follows:

[0035] 1. Prepare solid culture medium:

[0036] (1) adding tryptone, yeast extract, agar, and sodium chloride into deionized water in proportion and mixing;

[0037] (2) High temperature sterilization for 30 minutes;

[0038] (3) Cool and solidify the sterilized culture medium for later use.

[0039] 2. Treatment of flexible low-temperature plasma equipment and bacterial culture count

[0040] (1) Take 1 ml of the initial bacterial solution and add it to a sterile test tube. Dilute it repeatedly and add the dilution to the solid culture medium. Set up 3 plates for each dilution. Place it in a 37°C incubator for 24-48 hours and select the plates with a colony count between 30 and 300 for counting.

[0041] (2) Take 1 ml of the initial bacterial solution and add it to 6 sterile culture dishes, and irradiate them with flexible low-temperature plasma for 30 s, 60 s, 90 s, 120 s, 150 s, and 180 s.

[0042] (3) Dilute, culture and count the treated bacterial solution (same method as before)

[0043] 3. Calculate bacterial survival rate according to the following formula

[0044] Bacterial survival rate = N / Nc×100% (N: the number of colonies in the bacterial suspension after treatment for a certain period of time; Nc: the number of colonies in the initial bacterial suspension before treatment).

[0045] The experimental results are as follows Figure 3 As shown, Figure 3 (a) is the change chart of the average survival rate of Staphylococcus aureus. Figure 3 (b) The change of average survival rate of hemolytic streptococci. Figure 3 It can be seen that:

[0046] 1. The initial bacterial concentration is 7.0log10 CFU / mL.

[0047] 2. After exposure to the flexible plasma device, the number of Staphylococcus aureus and Streptococcus decreased, and the bactericidal effect was dose-dependent with the treatment time.

[0048] 3. After 180 seconds of treatment, Staphylococcus aureus and hemolytic Streptococcus were almost killed.

[0049] 4. This flexible plasma device has a good in vitro bactericidal effect on common pathogens of clinical skin and soft tissue infections.

[0050] The above are only embodiments of the present invention, and the common knowledge such as the known specific structure and / or characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several deformations and improvements can be made without departing from the structure of the present invention, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A flexible plasma device for treating skin and soft tissue infections, characterized in that: The invention comprises a polyimide film, on which a plurality of electrodes are distributed in an array, all of which are connected in parallel with a power source through electrical conductors, a rubber plate is adhered to one side of the polyimide film, a plurality of connection holes are provided on the upper and lower sides of the rubber plate, and connection blocks are rotatably connected on the upper and lower sides of the upper end of the rubber plate, and a limit bolt is threadedly connected to the connection block, and the limit bolt matches the connection hole.

2. A flexible plasma device for treating skin and soft tissue infections according to claim 1, characterized in that: A first support rod is also provided on the polyimide film. The first support rod and the rubber plate are arranged on both sides of the polyimide film. The thickness of the first support rod is greater than the thickness of the electrode.

3. A flexible plasma device for treating skin and soft tissue infections according to claim 2, characterized in that: A horizontally arranged flexible guide rail is also adhered to the polyimide film, and a second support rod located on the right side of the first support rod is slidably connected to the flexible guide rail.

4. A flexible plasma device for treating skin and soft tissue infections according to claim 3, characterized in that: The first support rod is provided with an L-shaped air passage, which connects the end of the first support rod with the side of the first support rod facing the electrode, and a high-pressure argon gas bottle is connected to the air passage through a hose.

5. A flexible plasma device for treating skin and soft tissue infections according to any one of claims 1 to 4, characterized in that: A plurality of elastic bands are arranged at intervals on one side of the rubber plate.

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