Light path module and biochemical analyzer
By setting a partial optical path module in the storage space on the carrier disk of the biochemical analyzer, the problem of low handling accuracy of the carrier disk is solved, and effective light detection is achieved without affecting the handling accuracy of the carrier disk.
Patent Information
- Application Number
- CN202420633936.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-28
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2034-03-28
AI Technical Summary
The operating accuracy of existing biochemical analyzers is low, mainly due to the large volume of the light source, which requires the load disk to be larger to adapt to the light source, thereby reducing the operating accuracy.
An optical path module is designed, including a first light guide member and a second light guide member, which is partially arranged in the storage space of the carrier disk, and the light of the light source is emitted into the reaction unit through the reflective light path to form scattered light for reception by the detector.
This design avoids the excessive requirement of the light source for the disk size, ensures the handling accuracy of the disk, and realizes effective light detection of the reaction unit.
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Figure CN222671824U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to an optical path module and a biochemical analyzer. Background Art
[0002] Biochemical analyzers have the advantages of fast measurement speed, high accuracy and small reagent consumption, and are widely used in the medical field.
[0003] Existing biochemical analyzers are usually provided with a carrier plate, on which a number of reaction containers can be arranged and placed. Samples and reagents can be added to the reaction containers to react with each other to form a mixed solution. When the carrier plate is rotated, a light source is used to irradiate the mixed solution in the reaction container, and a photometer detects the transmitted light or scattered light of the reaction container. However, since the light source is usually a laser or a halogen lamp, the light source is large in size and occupies a large space, and the carrier plate needs to be made very large to accommodate the light source, resulting in reduced accuracy in the carrier plate manipulation. Utility Model Content
[0004] The utility model provides an optical path module and a biochemical analyzer, aiming to solve the problem of low plate control accuracy of the existing biochemical analyzer.
[0005] The utility model is implemented as follows: an optical path module is applied to a biochemical analyzer, the biochemical analyzer is provided with a rotatable carrier, and the optical path module comprises a first light guide and a second light guide;
[0006] The first light guide has a first light path channel and a second light path channel, and a first reflector arranged between the first light path channel and the second light path channel;
[0007] The second light guide member has a third light path channel and a fourth light path channel, and a second reflector member arranged between the third light path channel and the fourth light path channel;
[0008] The carrier plate has a first annular groove and a second annular groove arranged concentrically, the first annular groove is arranged on the periphery of the second annular groove, the first annular groove and the second annular groove are used to carry reaction units, the reaction units are used for mixing samples and reagents to react, and there is a receiving space between the reaction units on the first annular groove and the reaction units on the second annular groove;
[0009] The first light guide and the second light guide are both used to be partially arranged in the accommodation space;
[0010] The first reflector is used to reflect the light incident into the first optical path channel to the second optical path channel and then to the reaction unit of the first annular groove to form scattered light, so as to be received by the first detection element located at the periphery of the first annular groove;
[0011] The second reflector is used to reflect the light incident into the third optical path channel to the fourth optical path channel and then to the reaction unit of the second annular groove to form scattered light to be received by the second detection element located inside the second annular groove.
[0012] Furthermore, the optical path module further includes a third light guide and a fourth light guide;
[0013] The third light guide has a fifth light path and a third reflector, and the fourth light guide has a seventh light path and a fourth reflector;
[0014] The exit end of the fifth optical path channel corresponds to the first optical path channel, and the fifth optical path channel extends in the radial direction of the carrier and away from the center point of the carrier to form an incident end;
[0015] The third reflector is arranged at the exit end of the fifth optical path channel, and is used to reflect the light incident into the fifth optical path channel to the first optical path channel;
[0016] The exit end of the seventh optical path channel corresponds to the third optical path channel, and the seventh optical path channel extends in the radial direction of the carrier and in a direction close to the center point of the carrier to form an incident end;
[0017] The fourth reflector is disposed at the exit end of the seventh optical path channel, and is used for reflecting the light incident into the seventh optical path channel to the third optical path channel.
[0018] Furthermore, the second optical path channel, the fourth optical path channel, the first reflector and the second reflector are all arranged in the accommodating space, and an end of the first optical path channel close to the first reflector and an end of the third optical path channel close to the second reflector are both arranged in the accommodating space.
[0019] Furthermore, the optical path module further includes a fifth light guide and a sixth light guide;
[0020] The fifth light guide is located at the periphery of the first annular groove, and the sixth light guide is located at the inner periphery of the second annular groove;
[0021] The fifth light guide has a ninth optical path channel for connecting to the first detection element, the ninth optical path channel is arranged corresponding to the second optical path channel, and the extension direction of the ninth optical path channel forms a preset angle with the optical axis of the outgoing light of the second optical path channel;
[0022] The sixth light guide has a tenth optical path channel for connecting to the second detection element. The tenth optical path channel is arranged corresponding to the fourth optical path channel. The extension direction of the tenth optical path channel forms a preset angle with the optical axis of the outgoing light of the fourth optical path channel.
[0023] Furthermore, the ninth optical path channel gradually shifts upward from an end close to the second optical path channel to an end away from the second optical path channel, and the tenth optical path channel gradually shifts upward from an end close to the fourth optical path channel to an end away from the fourth optical path channel.
[0024] Furthermore, the preset angle includes 10 degrees to 30 degrees.
[0025] Furthermore, the fifth light guide is provided with a first reference light path channel corresponding to the second light path channel, and the sixth light guide is provided with a second reference light path channel corresponding to the fourth light path channel;
[0026] The first reference optical path channel is connected to the first reference detection component;
[0027] The second reference optical path channel is connected to the second reference detection component.
[0028] Furthermore, the diameters of the fifth optical path channel, the sixth optical path channel, the first optical path channel and the second optical path channel gradually decrease in sequence, and the diameters of the seventh optical path channel, the eighth optical path channel, the third optical path channel and the fourth optical path channel gradually decrease in sequence.
[0029] Furthermore, at least one first aperture is arranged in the first optical path channel and / or the fifth optical path channel, and at least one second aperture is arranged in the third optical path channel and / or the seventh optical path channel.
[0030] Furthermore, a first mounting groove and a second mounting groove are provided in the ninth optical path channel, the first mounting groove is used to install the first detection element, and the second mounting groove is used to install the first focusing lens;
[0031] A third mounting groove and a fourth mounting groove are arranged in the tenth optical path channel. The third mounting groove is used for mounting the second detection member, and the fourth mounting groove is used for mounting the second condensing lens.
[0032] In a second aspect, the present application also provides a biochemical analyzer, comprising:
[0033] The carrier plate is formed with a first annular groove and a second annular groove, the first annular groove and the second annular groove are concentrically arranged and the first annular groove is arranged on the periphery of the second annular groove, the first annular groove and the second annular groove are used to carry a reaction unit, and the reaction unit is used for mixing a sample with a reagent to react;
[0034] The detection assembly includes a first detection member disposed on the periphery of the first annular groove and a second detection member disposed on the inner periphery of the second annular groove; and
[0035] Such as the optical path module mentioned above.
[0036] The beneficial effect of the present application is that the optical path module of the present application includes a first light guide and a second light guide, and a first annular groove and a second annular groove are arranged on the carrier, wherein the first annular groove and the second annular groove are arranged concentrically, and the first annular groove is arranged on the periphery of the second annular groove, the first annular groove and the second annular groove are used to carry a reaction unit, and the reaction unit is used for mixing a sample with a reagent to react, and there is a accommodating space between the reaction unit on the first annular groove and the reaction unit on the second annular groove, and a first detection component is also arranged on the periphery of the first annular groove, and a second detection component is also arranged on the inner periphery of the second annular groove, and the first light guide and the second light guide are both partially arranged in the accommodating space The first light guide is connected to the first light source to guide the light of the first light source from the first optical path channel, and then reflect it through the first reflector and emit it from the second optical path channel to the reaction unit of the first annular groove to form scattered light, so as to be received by the first detection component. The second light guide is connected to the second light source to guide the light of the second light source from the third optical path channel, and then reflect it through the second reflector and emit it from the fourth optical path channel to the reaction unit of the second annular groove to form scattered light, so as to be received by the second detection component. Since the first light guide and the second light guide are both partially located in the accommodating space, the size of the carrier will not be too large, and the control accuracy of the carrier can be guaranteed. BRIEF DESCRIPTION OF THE DRAWINGS
[0037] Figure 1 It is a top view schematic diagram of a carrier plate of an embodiment of an optical path module provided by the present application;
[0038] Figure 2 It is a three-dimensional structural schematic diagram of an optical path module and a fixed plate in one embodiment of an optical path module provided by the present application;
[0039] Figure 3 It is a side view schematic diagram of an embodiment of an optical path module provided by the present application;
[0040] Figure 4 is along Figure 3 Schematic diagram of the cross-section structure of the AA line;
[0041] Figure 5 It is a structural schematic diagram of a single-reflection optical path module of an embodiment of an optical path module provided by the present application;
[0042] Figure 6 It is a schematic diagram of the structure of the optical path where the first light guide member of a single reflection of an optical path module provided by the present application is located;
[0043] Figure 7 is along Figure 6 Schematic cross-sectional view of the CC line;
[0044] Figure 8 It is a schematic diagram of the structure of the optical path where the second light guide member of a single reflection is located in an embodiment of an optical path module provided by the present application;
[0045] Fig. 9 is along Figure 8 Schematic cross-sectional view of the middle DD line;
[0046] Fig.10 is a bottom view schematic diagram of another embodiment of an optical path module provided by the present application;
[0047] Fig.11 This is a schematic structural diagram of an optical path module with two reflections in one embodiment of an optical path module provided by the present application;
[0048] Fig.12 It is a schematic diagram of the structure of the optical path where the first light guide member reflected twice in an embodiment of an optical path module provided by the present application;
[0049] Fig.13 is along Fig.12 Schematic cross-sectional view of line EE;
[0050] Fig.14 It is a schematic diagram of the structure of the optical path where the second light guide member reflected twice in an embodiment of an optical path module provided by the present application is located;
[0051] Fig.15 is along Fig.14 Schematic cross-sectional view of the FF line.
[0052] Wherein: 100, fixed disk; 110, disk plane; 120, disk outer annular surface; 130, disk inner annular surface; 200, carrier disk; 210, first annular groove; 220, second annular groove; 311, first light source; 312, second light source; 321, first detection element; 322, second detection element; 331, first focusing lens; 332, second focusing lens; 341, first aperture; 342, second aperture; 400, first light guide; 410, first light path channel; 420, second light path channel; 430, first reflector; 500, second light guide; 510, second light path channel; three optical path channels; 520, fourth optical path channel; 530, second reflector; 600, third light guide; 610, fifth optical path channel; 630, third reflector; 700, fourth light guide; 710, seventh optical path channel; 730, fourth reflector; 800, fifth light guide; 810, ninth optical path channel; 811, first mounting slot; 812, second mounting slot; 820, first reference optical path channel; 900, sixth light guide; 910, tenth optical path channel; 911, third mounting slot; 912, fourth mounting slot; 920, second reference optical path channel. DETAILED DESCRIPTION
[0053] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.
[0054] In the present application, since the first light guide member and the second light guide member are both partially located in the accommodating space, the size of the carrier plate will not be too large, and the control accuracy of the carrier plate can be guaranteed.
[0055] Embodiment 1
[0056] like Figures 1 to 15 As shown, this embodiment provides an optical path module, which is applied to a biochemical analyzer. The biochemical analyzer is provided with a rotatable carrier plate 200. The optical path module includes a first light guide 400 and a second light guide 500.
[0057] The first light guide member 400 has a first light path channel 410 and a second light path channel 420, and a first reflective member 430 disposed between the first light path channel 410 and the second light path channel 420;
[0058] The second light guide 500 has a third light path channel 510 and a fourth light path channel 520, and a second reflective member 530 disposed between the third light path channel 510 and the fourth light path channel 520;
[0059] The carrier plate 200 has a first annular groove 210 and a second annular groove 220 which are arranged concentrically. The first annular groove 210 is arranged at the periphery of the second annular groove 220. The first annular groove 210 and the second annular groove 220 are used to carry reaction units. The reaction units are used for mixing samples and reagents to react. There is a receiving space between the reaction units on the first annular groove 210 and the reaction units on the second annular groove 220.
[0060] The first light guide member 400 and the second light guide member 500 are both used to be partially disposed in the accommodation space;
[0061] The first reflector 430 is used to reflect the light incident into the first optical path channel 410 to the second optical path channel 420 and then to the reaction unit of the first annular groove 210 to form scattered light, so as to be received by the first detection element 321 located at the periphery of the first annular groove 210;
[0062] The second reflector 530 is used to reflect the light incident into the third optical channel 510 to the fourth optical channel 520 and then to the reaction unit of the second annular groove 220 to form scattered light to be received by the second detection element 322 located inside the second annular groove 220 .
[0063] During implementation, the optical path module provided by the present application is applied to a biochemical analyzer, which is used to measure chemical components in body fluids, including but not limited to blood, tissue fluid, etc.
[0064] In some embodiments, the biochemical analyzer has a carrier (not shown), a fixed disk 100 mounted on the carrier, and a drive motor (not shown) mounted on the carrier. The drive motor is connected to the carrier 200 for driving the carrier 200 to rotate.
[0065] The carrier plate 200 has a first annular groove 210 and a second annular groove 220 . The first annular groove 210 and the second annular groove 220 are concentrically arranged and the first annular groove 210 is arranged on the periphery of the second annular groove 220 . The first annular groove 210 and the second annular groove 220 are annular and are used to carry a plurality of reaction units arranged in a circle.
[0066] In some embodiments, the reaction unit can be a vessel that can be assembled and disassembled with the carrier plate 200. For example, the reaction unit can be a reaction cup. The carrier plate 200 is provided with slots one by one. The reaction cup can be inserted into the slots, and then the sample and reagent are added into the reaction cup so that the sample and reagent are mixed and reacted.
[0067] The first light guide 400 and the second light guide 500 are partially located in the accommodating space. During implementation, the first light guide 400 and the second light guide 500 are both arranged on the fixed plate 100 and partially extend into the accommodating space. The first light guide 400 is connected to the first light source 311, and the second light guide 500 is connected to the second light source 312.
[0068] In some embodiments, the first light source 311 and the second light source 312 refer to devices or components capable of emitting light, such as laser emitters, without limitation.
[0069] A first light path channel 410 and a second light path channel 420 are arranged in the first light guide member 400, the first light path channel 410 and the second light path channel 420 are connected, and a first reflective member 430 is arranged between the first light path channel 410 and the second light path channel 420, and a certain angle is formed between the first light path channel 410 and the second light path channel 420, for example, 60° to 90°, and preferably, the first light path channel 410 and the second light path channel 420 are perpendicular to each other.
[0070] The first optical path channel 410 is connected to the first light source 311, so that the light emitted by the first light source 311 passes through the first optical path channel 410 and is reflected by the first reflector 430 to the second optical path channel 420, and then emitted by the second optical path channel 420 to the reaction unit of the first annular groove 210 to form scattered light. In other words, the light emitted by the second optical path channel 420 is emitted from the inside of the first annular groove 210 to the outside of the first annular groove 210, so that it can be received by the first detection component 321 located on the periphery of the first annular groove 210, thereby realizing the scattered light detection function of the reaction unit on the first annular groove 210.
[0071] Similarly, a third optical path channel 510 and a fourth optical path channel 520 are arranged in the second light guide member 500, the third optical path channel 510 and the fourth optical path channel 520 are connected, and a second reflective member 530 is arranged between the third optical path channel 510 and the fourth optical path channel 520, and the third optical path channel 510 and the fourth optical path channel 520 form a certain angle, for example, 60° to 90°, and preferably, the third optical path channel 510 and the fourth optical path channel 520 are perpendicular to each other.
[0072] In some optional embodiments, when the angle between the first optical path channel 410 and the second optical path channel 420, or the angle between the first optical path channel 410 and the second optical path channel 420 is less than a specific angle value, for example, less than 70°, the second optical path channel 420 and the fourth optical path channel 520 are both disposed within the accommodating space, while the first reflector 430, the second reflector 530, the first optical path channel 410 and the third optical path channel 510 are all located outside the accommodating space.
[0073] In some optional embodiments, when the angle between the first optical path channel 410 and the second optical path channel 420, or the angle between the first optical path channel 410 and the second optical path channel 420 is equal to a specific angle value, the second optical path channel 420 and the fourth optical path channel 520 are both arranged in the accommodating space, the first reflector 430 and the second reflector 530 are at the edge of the accommodating space, and the first optical path channel 410 and the third optical path channel 510 are both located outside the accommodating space.
[0074] In some optional embodiments, when the angle between the first optical path channel 410 and the second optical path channel 420, or the angle between the first optical path channel 410 and the second optical path channel 420 is greater than a specific angle value, the second optical path channel 420, the fourth optical path channel 520, the first reflector 430 and the second reflector 530 are all arranged in the accommodating space, and an end of the first optical path channel 410 close to the first reflector 430 and an end of the third optical path channel 510 close to the second reflector 530 are both arranged in the accommodating space.
[0075] It should be noted that the above-mentioned specific angle can be 70°, 75° or 80°, which can be set according to actual conditions and is not limited.
[0076] The third optical path channel 510 is connected to the second light source 312, so that the light emitted by the second light source 312 passes through the third optical path channel 510 and is reflected by the second reflector 530 to the fourth optical path channel 520, and then emitted by the fourth optical path channel 520 to the reaction unit of the second annular groove 220 to form scattered light. In other words, the light emitted by the fourth optical path channel 520 is emitted from the outside of the second annular groove 220 to the inside of the second annular groove 220, so that it can be received by the second detection component 322 located inside the second annular groove 220, thereby realizing the light detection function of the reaction unit on the second annular groove 220.
[0077] In some embodiments, the first light guide 400 and the second light guide 500 may be distributed along the radial direction of the carrier 200. Since the first light guide 400 and the second light guide 500 may be designed to be very small, the distance between the first annular groove 210 and the second annular groove 220 can be effectively reduced, thereby reducing the diameter of the carrier 200. In other possible embodiments, such as Figure 2 Figure 5 Fig.10 and Fig.11 As shown, the first light guide 400 and the second light guide 500 may also at least partially overlap along the circumference of the carrier 200 in the accommodation space, thereby further reducing the distance between the first annular groove 210 and the second annular groove 220, making the carrier 200 smaller and easier to manipulate.
[0078] The optical path module of the present application includes a first light guide 400 and a second light guide 500, and a first concentric annular groove 210 and a second concentric annular groove 220 are provided on the carrier 200, wherein the first annular groove 210 is arranged on the periphery of the second annular groove 220, and the first annular groove 210 and the second annular groove 220 are used to carry a reaction unit, and the reaction unit is used for mixing a sample with a reagent to react, and there is a accommodating space between the reaction unit on the first annular groove 210 and the reaction unit on the second annular groove 220, and a first detection member 321 is also arranged on the periphery of the first annular groove 210, and a second detection member 322 is also arranged on the inner periphery of the second annular groove 220, and the first light guide 400 and the second light guide 500 are both used to be partially arranged in the accommodating space, and the first light guide 400 and the first light source 322 are arranged on the periphery of the first annular groove 210. 11 is connected to guide the light of the first light source 311 from the first optical path channel 410, and then reflect it through the first reflector 430 and emit it from the second optical path channel 420 to the reaction unit of the first annular groove 210 to form scattered light, so as to be received by the first detection component 321. The second light guide member 500 is connected to the second light source 312, so as to guide the light of the second light source 312 from the third optical path channel 510, and then reflect it through the second reflector 530 and emit it from the fourth optical path channel 520 to the reaction unit of the second annular groove 220 to form scattered light, so as to be received by the second detection component 322. Since the first light guide member 400 and the second light guide member 500 are both partially located in the accommodating space, the size of the carrier 200 will not be too large, and the control accuracy of the carrier 200 can be guaranteed.
[0079] In some embodiments, Figures 10 to 15 As shown, the optical path module provided by the present application further includes a third light guide 600 and a fourth light guide 700;
[0080] The third light guide 600 has a fifth light path channel 610 and a third reflector 630 , and the fourth light guide 700 has a seventh light path channel 710 and a fourth reflector 730 ;
[0081] The exit end of the fifth optical path channel 610 corresponds to the first optical path channel 410, and the fifth optical path channel 610 extends along the radial direction of the carrier plate 200 and away from the center point of the carrier plate 200 to form an incident end;
[0082] The third reflector 630 is disposed at the exit end of the fifth optical path channel 610 and is used to reflect the light incident into the fifth optical path channel 610 to the first optical path channel 410;
[0083] The exit end of the seventh optical path channel 710 corresponds to the third optical path channel 510, and the seventh optical path channel 710 extends along the radial direction of the carrier plate 200 and close to the center point of the carrier plate 200 to form an incident end;
[0084] The fourth reflector 730 is disposed at the exit end of the seventh optical path channel 710 , and is used to reflect the light incident into the seventh optical path channel 710 to the third optical path channel 510 .
[0085] During implementation, the fifth optical path channel 610 and the first optical path channel 410 form a certain angle. Similarly, the seventh optical path channel 710 and the third optical path channel 510 form a certain angle, for example, 60° to 90°. Preferably, the fifth optical path channel 610 and the first optical path channel 410 are perpendicular to each other, and the seventh optical path channel 710 and the third optical path channel 510 are perpendicular to each other.
[0086] In some embodiments, the incident end of the fifth optical path channel 610 is connected to the first light source 311, so that the light emitted by the first light source 311 passes through the fifth optical path channel 610, the third reflector 630, the first optical path channel 410, the first reflector 430, and the second optical path channel 420 in sequence and is emitted to the reaction unit of the first annular groove 210. Similarly, the incident end of the seventh optical path channel 710 is connected to the second light source 312, so that the light emitted by the second light source 312 passes through the seventh optical path channel 710, the fourth reflector 730, the third optical path channel 510, the second reflector 530, and the fourth optical path channel 520 in sequence and is emitted to the reaction unit of the second annular groove 220.
[0087] In some embodiments, the first light guide 400 and the third light guide 600 may be an integrated structure, and the second light guide 500 and the fourth light guide 700 may also be an integrated structure, which has a simple structure, is easy to install, and can effectively improve the structural strength of the light guide.
[0088] Since the incident end of the fifth optical path channel 610 extends in a direction away from the center point of the carrier plate 200, and the incident end of the seventh optical path channel 710 extends in a direction close to the center point of the carrier plate 200, the distance between the first light source 311 and the second light source 312 becomes larger, thereby reducing interference caused by the close distance between the light sources and improving the accuracy of light detection.
[0089] In some optional embodiments, the optical path module provided in the present application further includes a fifth light guide 800 and a sixth light guide 900;
[0090] The fifth light guide member 800 is located at the periphery of the first annular groove 210 , and the sixth light guide member 900 is located at the inner periphery of the second annular groove 220 ;
[0091] The fifth light guide 800 has a ninth optical path channel 810 for connecting to the first detection member 321. The ninth optical path channel 810 is arranged corresponding to the second optical path channel 420. The extension direction of the ninth optical path channel 810 forms a preset angle with the optical axis of the outgoing light of the second optical path channel 420.
[0092] The sixth light guide 900 has a tenth optical path channel 910 for connecting to the second detection element 322. The tenth optical path channel 910 is arranged corresponding to the fourth optical path channel 520. The extension direction of the tenth optical path channel 910 is arranged at a preset angle with the optical axis of the output light of the fourth optical path channel 520.
[0093] When implementing, Figure 2 As shown, the fixed disk 100 is surrounded by a disk plane 110, a disk outer annular surface 120 and a disk inner annular surface 130 to form an annular inner space, and the first annular groove 210 and the second annular groove 220 can be accommodated in the inner space and rotate along the annular inner space. The first light guide 400 and the second light guide 500 are arranged on the disk plane 110 and at least partially located in the accommodation space, the fifth light guide 800 is installed on the disk outer annular surface 120, that is, the fifth light guide 800 is located at the periphery of the first annular groove 210, and the sixth light guide 900 is installed on the disk inner annular surface 130, that is, the sixth light guide 900 is located at the inner periphery of the second annular groove 220.
[0094] The fifth light guide member 800 includes a ninth light path channel 810, one end of the ninth light path channel 810 is connected to the first detection member 321, the other end of the ninth light path channel 810 corresponds to the first annular groove 210 between the second light path channel 420, and the ninth light path channel 810 and the optical axis of the outgoing light of the second light path channel 420 are arranged at a preset angle, so that the light emitted by the second light path channel 420 is irradiated on the reaction unit of the first annular groove 210 to form scattered light, which can then enter the ninth light path channel 810, and then be guided by the ninth light path channel 810 to the first detection member 321, thereby realizing the light detection function of the reaction unit of the first annular groove 210.
[0095] The sixth light guide 900 has a tenth optical path channel 910, one end of the tenth optical path channel 910 is connected to the second detection element 322, the other end of the tenth optical path channel 910 corresponds to the second annular groove 220 between the fourth optical path channel 520, and the tenth optical path channel 910 and the optical axis of the outgoing light of the fourth optical path channel 520 are arranged at a preset angle, so that the light emitted by the fourth optical path channel 520 is irradiated on the reaction unit of the second annular groove 220 to form scattered light, which can enter the tenth optical path channel 910, and then be guided to the second detection element 322 by the tenth optical path channel 910, so as to realize the light detection function of the reaction unit of the second annular groove 220. By setting the ninth optical path channel 810 and the tenth optical path channel 910 to be inclined, the scattered light can be better guided, thereby improving the detection accuracy.
[0096] In some embodiments, the preset angle includes 10 degrees to 30 degrees, for example, the preset angle can be 15 degrees, 20 degrees or 25 degrees, etc., without limitation. The scattered light formed by the light irradiating the reaction unit is concentrated in the range of 10 degrees to 30 degrees with the incident light, that is, the scattered light in the range of 10 degrees to 30 degrees is stronger, thereby effectively improving the detection accuracy.
[0097] In some embodiments, the ninth optical path channel 810 gradually shifts upward from one end close to the second optical path channel 420 to one end away from the second optical path channel 420, and the tenth optical path channel 910 gradually shifts upward from one end close to the fourth optical path channel 520 to one end away from the fourth optical path channel 520.
[0098] During the detection process, reagents and samples need to be added to the reaction unit. When the amount of reagents and samples is large enough, the scattered light formed by the light irradiating the reaction unit can be regarded as a cone with the optical axis of the incident light as the axis. At this time, the ninth optical path channel 810 and the tenth optical path channel 910 can be located at any position of the conical surface of the cone. When the amount of reagents and samples is small, taking the second optical path channel 420 and the fourth optical path channel 520 being parallel to the horizontal plane as an example, the mixed liquid composed of reagents and samples is deposited at the bottom of the reaction unit. At this time, the scattered light formed by the light irradiating the reaction unit will be concentrated above the optical axis of the incident light. The ninth optical path channel 810 and the tenth optical path channel 910 adopt an upwardly tilted design, which is suitable for the case of less mixed liquid, and can effectively reduce the use and consumption of reagents and samples, thereby controlling costs.
[0099] In some optional embodiments, the fifth light guide 800 is provided with a first reference light path channel 820 corresponding to the second light path channel 420, and the sixth light guide 900 is provided with a second reference light path channel 920 corresponding to the fourth light path channel 520;
[0100] The first reference optical path channel 820 is connected to a first reference detection element (not shown);
[0101] The second reference optical path channel 920 is connected to a second reference detection component (not shown).
[0102] In implementation, the first reference optical path channel 820 can guide the scattered light formed after the second optical path channel 420 is emitted to the reaction unit to the first reference detection element, and the second reference optical path channel 920 can guide the scattered light formed after the fourth optical path channel 520 is emitted to the reaction unit to the second reference detection element. The reference detection element monitors the life and stability of the light source element, further improving the detection accuracy.
[0103] In some optional embodiments, the diameters of the fifth optical path channel 610, the sixth optical path channel, the first optical path channel 410, and the second optical path channel 420 gradually decrease, and the diameters of the seventh optical path channel 710, the eighth optical path channel, the third optical path channel 510, and the fourth optical path channel 520 gradually decrease. By gradually shrinking the optical path channels, the light is gathered and focused, which can effectively improve the detection accuracy.
[0104] In some possible embodiments, each optical path channel may also be designed to have a gradually decreasing diameter. For example, the diameter of the first optical path channel 410 gradually decreases from the incident end to the exit end, or the diameter of the first optical path channel 410 decreases in sections from the incident end to the exit end.
[0105] In some optional embodiments, at least one first aperture 341 is disposed in the first optical path channel 410 and / or the fifth optical path channel 610 , and at least one second aperture 342 is disposed in the third optical path channel 510 and / or the seventh optical path channel 710 .
[0106] During implementation, the aperture is in the shape of a ring with a hole in the center, which can block stray light at the edge and only allow light from the center to pass through, which can further improve detection accuracy.
[0107] In some optional embodiments, a first mounting groove 811 and a second mounting groove 812 are provided in the ninth optical path channel 810, the first mounting groove 811 is used to install the first detection member 321, and the second mounting groove 812 is used to install the first condensing lens 331;
[0108] A third mounting groove 911 and a fourth mounting groove 912 are provided in the tenth optical path channel 910 . The third mounting groove 911 is used for mounting the second detection member 322 , and the fourth mounting groove 912 is used for mounting the second condensing lens 332 .
[0109] During implementation, the first mounting groove 811, the second mounting groove 812, the third mounting groove 911 and the fourth mounting groove 912 are all groove-shaped, the optical probe part of the first detection component 321 can be embedded in the first mounting groove 811, and the optical probe part of the second detection component 322 can be embedded in the third mounting groove 911, and the first focusing lens 331 and the second focusing lens 332 can play a focusing role, so that the light can be more concentrated on the optical probe of the detection component, thereby improving the detection accuracy.
[0110] In some embodiments, the focusing lens can be a single-sided convex lens or a double-sided convex lens, as long as it can achieve a focusing effect, without limitation.
[0111] Embodiment 2
[0112] In some optional embodiments, the present application also provides a biochemical analyzer, comprising:
[0113] The carrier plate 200 is formed with a first annular groove 210 and a second annular groove 220, the first annular groove 210 and the second annular groove 220 are concentrically arranged and the first annular groove 210 is arranged on the periphery of the second annular groove 220, the first annular groove 210 and the second annular groove 220 are used to carry a reaction unit, and the reaction unit is used for mixing a sample with a reagent to react;
[0114] The detection assembly includes a first detection member 321 disposed on the periphery of the first annular groove 210 and a second detection member 322 disposed on the inner periphery of the second annular groove 220 ; and the optical path module as described above.
[0115] Those skilled in the art can clearly understand that, for the convenience and brevity of description, the structure and implementation principle of the biochemical analyzer described above can refer to the corresponding structure and implementation principle in the aforementioned embodiment 1, and will not be repeated here.
[0116] In some embodiments, the biochemical analyzer provided in the present application also includes a carrier, and the above-mentioned optical path module is installed on the carrier. The carrier can also be provided with a sample placement position (not shown in the figure), a reagent placement position (not shown in the figure) and a manipulator (not shown in the figure), wherein the sample placement position is used to place and store samples, the reagent placement position is used to place and store reagents, and the manipulator is used to add samples and reagents into the reaction unit, and then drive the carrier 200 to rotate by a driving motor for detection.
[0117] The optical path module of the present application includes a first light guide 400 and a second light guide 500, and the carrier 200 has a concentric first annular groove 210 and a second annular groove 220, wherein the first annular groove 210 is arranged on the periphery of the second annular groove 220, and the first annular groove 210 and the second annular groove 220 are used to carry a reaction unit, and the reaction unit is used for mixing a sample with a reagent to react, and there is a accommodating space between the reaction unit on the first annular groove 210 and the reaction unit on the second annular groove 220, and a first detection member 321 is also arranged on the periphery of the first annular groove 210, and a second detection member 322 is also arranged on the inner periphery of the second annular groove 220, and the first light guide 400 and the second light guide 500 are both used to be partially arranged in the accommodating space, and the first light guide 400 is connected to the first light source 311 to transmit the first The light of the light source 311 is introduced from the first optical path channel 410, reflected by the first reflector 430, and emitted from the second optical path channel 420 to the reaction unit of the first annular groove 210 to form scattered light, which is received by the first detection component 321. The second light guide component 500 is connected to the second light source 312 to introduce the light of the second light source 312 from the third optical path channel 510, and then reflect by the second reflector 530 and emit from the fourth optical path channel 520 to the reaction unit of the second annular groove 220 to form scattered light, which is received by the second detection component 322. Since the first light guide component 400 and the second light guide component 500 are both partially located in the area between the first annular groove 210 and the second annular groove 220, the size of the carrier 200 will not be too large, and the difficulty of operating the carrier 200 can be effectively reduced.
[0118] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.
Claims
1. An optical path module, applied to a biochemical analyzer, wherein the biochemical analyzer is provided with a rotatable carrier plate, characterized in that: The optical path module comprises a first light guide and a second light guide; The first light guide has a first light path channel and a second light path channel, and a first reflective member arranged between the first light path channel and the second light path channel; The second light guide member has a third light path channel and a fourth light path channel, and a second reflector member arranged between the third light path channel and the fourth light path channel; The carrier plate has a first annular groove and a second annular groove arranged concentrically, wherein the first annular groove is arranged at the periphery of the second annular groove, the first annular groove and the second annular groove are used to carry reaction units, and the reaction units are used for mixing samples and reagents to react, and there is a receiving space between the reaction units on the first annular groove and the reaction units on the second annular groove; The first light guide member and the second light guide member are both used to be partially disposed in the accommodation space; The first reflector is used to reflect the light incident into the first optical path channel to the second optical path channel and then to the reaction unit of the first annular groove to form scattered light, so as to be received by the first detection element located at the periphery of the first annular groove; The second reflector is used to reflect the light incident into the third optical path channel to the fourth optical path channel and then emit it to the reaction unit of the second annular groove to form scattered light to be received by the second detection element located inside the second annular groove.
2. The optical path module according to claim 1, characterized in that: The optical path module further includes a third light guide and a fourth light guide; The third light guide has a fifth light path and a third reflector, and the fourth light guide has a seventh light path and a fourth reflector; The exit end of the fifth optical path channel corresponds to the first optical path channel, and the fifth optical path channel extends along the radial direction of the carrier and away from the center point of the carrier to form an incident end; The third reflector is disposed at the exit end of the fifth optical path channel, and is used to reflect the light incident into the fifth optical path channel to the first optical path channel; The exit end of the seventh optical path channel corresponds to the third optical path channel, and the seventh optical path channel extends along the radial direction of the carrier and in a direction close to the center point of the carrier to form an incident end; The fourth reflector is disposed at the exit end of the seventh optical path channel, and is used to reflect the light incident on the seventh optical path channel to the third optical path channel.
3. The optical path module according to claim 1, characterized in that: The second optical path channel, the fourth optical path channel, the first reflector and the second reflector are all arranged in the accommodating space, and an end of the first optical path channel close to the first reflector and an end of the third optical path channel close to the second reflector are both arranged in the accommodating space.
4. The optical path module according to claim 1, characterized in that: The optical path module further includes a fifth light guide and a sixth light guide; The fifth light guide is located at the periphery of the first annular groove, and the sixth light guide is located at the inner periphery of the second annular groove; The fifth light guide has a ninth optical path channel for connecting to the first detection element, the ninth optical path channel is arranged corresponding to the second optical path channel, and the extension direction of the ninth optical path channel forms a preset angle with the optical axis of the outgoing light of the second optical path channel; The sixth light guide has a tenth optical path channel for connecting to the second detection element. The tenth optical path channel is arranged corresponding to the fourth optical path channel. The extension direction of the tenth optical path channel forms the preset angle with the optical axis of the output light of the fourth optical path channel.
5. The optical path module according to claim 4, characterized in that: The ninth optical path channel gradually shifts upward from an end close to the second optical path channel to an end away from the second optical path channel, and the tenth optical path channel gradually shifts upward from an end close to the fourth optical path channel to an end away from the fourth optical path channel.
6. The optical path module according to claim 4 or 5, characterized in that: The preset angle includes 10 degrees to 30 degrees.
7. The optical path module according to claim 4, characterized in that: The fifth light guide is provided with a first reference light path channel corresponding to the second light path channel, and the sixth light guide is provided with a second reference light path channel corresponding to the fourth light path channel; The first reference optical path channel is used to connect with a first reference detection component; The second reference optical path channel is used to connect to a second reference detection component.
8. The optical path module as claimed in claim 2, characterized in that: The diameters of the fifth optical path channel, the first optical path channel, and the second optical path channel gradually decrease in sequence, and the diameters of the seventh optical path channel, the third optical path channel, and the fourth optical path channel gradually decrease in sequence.
9. The optical path module according to claim 2 or 8, characterized in that: At least one first aperture is arranged in the first optical path channel and / or the fifth optical path channel, and at least one second aperture is arranged in the third optical path channel and / or the seventh optical path channel.
10. The optical path module according to claim 4, characterized in that: The ninth optical path channel is provided with a first mounting groove and a second mounting groove, the first mounting groove is used to mount the first detection element, and the second mounting groove is used to mount the first condensing lens; A third mounting groove and a fourth mounting groove are provided in the tenth optical path channel, the third mounting groove is used for mounting the second detection member, and the fourth mounting groove is used for mounting the second focusing lens.
11. A biochemical analyzer, characterized in that: include: A carrier plate, wherein the carrier plate is formed with a first annular groove and a second annular groove, wherein the first annular groove and the second annular groove are concentrically arranged and the first annular groove is arranged on the periphery of the second annular groove, and the first annular groove and the second annular groove are used to carry a reaction unit, and the reaction unit is used for mixing a sample with a reagent to react; The detection assembly comprises a first detection member arranged at the periphery of the first annular groove and a second detection member arranged at the inner periphery of the second annular groove; as well as The optical path module according to any one of claims 1 to 10.