Static mixer

Abstract

The utility model discloses a static mixer which comprises an inlet end, a mixing unit and an outlet end, and the inlet end is communicated with the outlet end through the mixing unit; the mixing unit comprises an inner-layer pipe and an outer-layer pipe, the inner-layer pipe is arranged in the outer-layer pipe in a penetrating mode, the inner-layer pipe is provided with a special-shaped mixing cavity, the inlet end is in transition communication with the special-shaped mixing cavity through a chamfer, and the inner diameter of the inlet end is larger than the diameter of the special-shaped mixing cavity; the special-shaped mixing cavity is an uneven inner cavity, and the structure of the inner cavity is in regular symmetry, irregular distribution or special-shaped unevenness. The static mixer disclosed by the utility model has no power requirement, is convenient to clean, is not easy to remain, is not easy to rust and has smaller influence on the activity of a protein solution.

Description

Technical Field

[0001] The utility model relates to a static mixer and belongs to the technical field of static mixers. Background Art

[0002] In the downstream separation and purification process of biopharmaceuticals, such as the chromatography process, it is often necessary to dilute or mix multiple solutions online, including protein solutions, high salt or high chloride solutions.

[0003] Existing liquid-liquid mixing methods, such as SK-shaped static mixers, use independent mixing elements that are cut and installed in pipelines. Mixing elements are usually made of stainless steel, which is prone to rust when circulating high-salt or high-chloride solutions. Mixing elements usually have a rigid structure and are not convenient for direct installation into elbows. Mixing elements need to be cut before entering the pipeline, and the cutting size is difficult to control very accurately, resulting in active displacement of the blade mixer inside the pipeline. The inner wall of the pipeline is easily scratched during the installation of the mixing element. The mixing element adopts an irregular spiral structure, which is not conducive to cleaning, and the shear force of the spiral structure may affect the activity of certain protein solutions;

[0004] There are also some existing liquid-liquid mixing methods, such as dynamic stirring tanks, which include stirring drives, stirring tanks, stirring blades and stirring seals. The stirring drive requires additional control and power. The stirring volume of the stirring tank is large, and there is a lot of residual solution. Excessive residual solution in the previous link affects the quality of the solution in the next link. The stirring shear force of the stirring blade may affect the activity of some protein solutions. The stirring seal requires additional lubrication and maintenance. The material receiving parts are usually made of stainless steel, which is easy to rust when circulating high-salt or high-chloride solutions.

[0005] Therefore, there is an urgent need for a static mixer that has no power requirements, is easy to clean, does not easily leave residue, is not easy to rust, and has little effect on the activity of the protein solution. Utility Model Content

[0006] The technical problem to be solved by the utility model is that most of the existing liquid-liquid mixing devices are prone to rust and inconvenient to clean, and most of them use spiral structures or stirring blades for stirring, which requires additional stirring drive and will affect the activity of certain protein solutions.

[0007] In order to solve the above technical problems, the utility model provides a static mixer, which has no power requirement, is easy to clean, does not easily leave residue, is not easy to rust, and has little effect on the activity of protein solution.

[0008] In order to achieve the above technical objectives and the above technical effects, this application is implemented through the following technical solutions:

[0009] A static mixer comprises an inlet end, a mixing unit and an outlet end, wherein the inlet end and the outlet end are connected through the mixing unit; the mixing unit comprises an inner tube and an outer tube, wherein the inner tube is inserted into the outer tube, and the inner tube is provided with a special-shaped mixing cavity; the inlet end and the special-shaped mixing cavity are connected through a chamfer transition, and the inner diameter of the inlet end is larger than the diameter of the special-shaped mixing cavity.

[0010] Preferably, the irregular mixing cavity is an uneven inner cavity, and the inner cavity structure is regularly symmetrical, irregularly distributed or irregularly uneven.

[0011] Furthermore, the cross-section of the special-shaped mixing cavity is distributed in a regular arc shape.

[0012] Preferably, the inner wall of the special-shaped mixing chamber is a tube wall spiral structure.

[0013] Preferably, the inner wall of the special-shaped mixing chamber is a tube wall protrusion type structure.

[0014] Preferably, the mixing unit is linear, U-shaped, S-shaped or L-shaped.

[0015] Preferably, the inlet end, the outlet end and the mixing unit are tubes made of polymer material or stainless steel material.

[0016] Preferably, the inlet end and the outlet end are joints matching the special-shaped mixing cavity in the inner tube.

[0017] The static mixer provided by the utility model has the following advantages:

[0018] 1. When the utility model is used, a static mixing method is adopted without additional power. The special-shaped mixing cavity is a uniform regular or irregular special-shaped distribution inner cavity structure, and the design of the blade-free structure reduces the influence of shear force on the liquid.

[0019] 2. When the utility model is in use, there is no blade structure and no power is required. Through the special-shaped structure design of the mixing cavity, the liquid can undergo regular movements such as diversion, confluence and rotation in the mixing unit to form a mixing effect. At the same time, the bladeless structure design is easy to clean, avoiding the risk of blade structure retention and meeting the pharmaceutical cleaning requirements required by biopharmaceutical processes.

[0020] 3. When the utility model is used, the mixing unit is an uneven inner cavity, and the inner cavity structure can be regularly symmetrical, irregularly distributed, and irregularly shaped. The mixing unit part is not limited to a straight line, and can be S-shaped. The mixing unit can be made of a flexible material, and can also be directly formed into an S-shape or a U-shape, so that the installation connection form of the mixer in the system can be bent and folded, and flexibly connected across the plane, which can better meet the actual application environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the structure of a static mixer according to an embodiment of the utility model;

[0022] Figure 2 for Figure 1 Schematic diagram of the AA section structure;

[0023] Figure 3 for Figure 1 Schematic diagram of the structure of the middle BB section;

[0024] Figure 4 for Figure 1 Schematic diagram of the CC cross-section structure;

[0025] Figure 5 This is a schematic structural diagram of a mixing unit with an irregular inner cavity according to a first embodiment of the utility model;

[0026] Figure 6 This is a schematic diagram of the static mixer structure of the S-type mixing unit structure of the embodiment of the utility model;

[0027] Figure 7 for Figure 6 Schematic diagram of the structure of the middle DD section;

[0028] Figure 8 This is a schematic cross-sectional structure diagram of the second embodiment of the utility model, in which the inner wall of the special-shaped mixing chamber is a tube wall spiral structure;

[0029] Fig. 9 This is a schematic cross-sectional structure diagram of a third embodiment of the utility model in which the inner wall of the special-shaped mixing chamber is a tube wall protrusion type structure;

[0030] Fig.10 Simulation analysis of the flow trajectory of the mixed liquid in the static mixer of the utility model Figure 1 ;

[0031] Fig.11 Simulation analysis of the flow trajectory of the mixed liquid in the static mixer of the utility model Figure 2 ;

[0032] Fig.12 Simulation analysis of the flow trajectory of the mixed liquid in the static mixer of the utility model Figure 3 ;

[0033] In the figure:

[0034] 1-inlet end; 2-mixing unit; 21-inner tube; 211-special-shaped mixing cavity; 22-outer tube; 3-outlet end. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present utility model, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technical personnel in the field without creative work are within the scope of protection of the present utility model.

[0036] Embodiment 1:

[0037] Reference Figure 1-Figure 4 A static mixer comprises an inlet end 1, a mixing unit 2 and an outlet end 3, wherein the inlet end 1 and the outlet end 3 are connected through the mixing unit 2, wherein the inlet end 1, the mixing unit 2 and the outlet end 3 are preferably circular tubes, wherein the mixing unit 2 comprises an inner tube 21 and an outer tube 22, wherein the inner tube 21 is integrally formed in the outer tube 22, wherein a special-shaped mixing cavity 211 is integrally formed in the inner tube 21 through a mold, wherein the special-shaped mixing cavity 211 can smoothly transition the end surface vortex caused by the change of the cavity structure of the material liquid, wherein the inlet end 1 and the special-shaped mixing cavity 211 are connected through a chamfer transition, wherein the inlet end 1 The inner diameter is larger than the diameter of the special-shaped mixing chamber 211. In this embodiment, the inlet end 1 and the outlet end 3 are structures that match the special-shaped mixing chamber 211. The preferred form is a chuck joint. The connection method between the inlet end 1 and the outlet end 3 and the outer tube 22 can be welding, one-piece molding or threaded connection. The material of the inlet end 1, the inner tube 21, the outer tube 22 and the outlet end 3 can be the same material or different materials, which can be stainless steel, PP, silicone, PEEK, etc., to avoid corrosion, rust, ion precipitation, and increase the ability to tolerate high-salt or high-chloride ion fluid materials.

[0038] Reference Figure 3 and Figure 5 In a further embodiment, the irregular mixing cavity 211 may be an uneven inner cavity, and the inner cavity structure is regularly symmetrical, irregularly distributed or irregularly uneven. Preferably, the irregular mixing cavity 211 is an irregular regular cavity with a regular arc-shaped distribution in cross section. When the two solutions flow into the irregular mixing cavity 211 through the inlet end 1, due to the change in the caliber, the inlet fluid generates pressure, and the two solutions enter the irregular mixing cavity 211, and movements such as diversion, confluence, and rotation occur. The volume changes in the two cavities cause the liquid to collide and split. After flowing through the mixing unit 2, the inner cavity structure design of the inner tube 21 is uniformly and regularly distributed in the arc shape, and the liquid is displaced. Under the action of pressure, the liquid deflects and moves regularly in the mixing unit 2, so that the liquid is divided, displaced, and reunited in a regular and repeated manner to achieve mixing of different liquids.

[0039] Furthermore, the two solutions enter the mixing unit from the inlet port 1 for mixing. During the movement, the inlet port 1 and the inner tube 21 produce irregular regular structural changes in the inner cavity, and the fluid morphology produces a state change of laminar flow-end flow-laminar flow. The mixed substance flows in the cavity of the inlet port 1 in a laminar flow, and different fluids are divided-shifted-reunited in the cavity in a regular and repeated manner to achieve mixing. In the mixing unit 2, due to the setting of its irregular regular cavity structure, the liquid generates vortices, and under the action of shear force, the fine parts of the fluid are further divided and remixed. The setting of the irregular specification inner cavity of the mixing unit 2 enables the mixed fluid to repeatedly achieve regular and repeated division-shifting-reuniting in the entire channel to achieve mixing.

[0040] Reference Figure 6 and Figure 7 The mixing unit 2 is not limited to a straight line, but can be S-shaped. The mixing unit 2 can be made of a flexible material, or can be directly formed into an S-shape or a U-shape, so that the installation connection form of the mixer in the system can be bent and folded, and can be flexibly connected across the plane, which can better meet the actual application environment.

[0041] Reference Figure 8-Figure 10 Through simulation analysis of the trajectory of the mixed liquid in the static mixer, it can be seen that after the liquid passes through the mixing unit 2, the flow trajectory undergoes obvious deflection changes. The actual effect is that it can promote the movement of the fine parts of the fluid, and the division and remixing of the fine parts can be achieved to achieve mixing of the liquid.

[0042] The cross section of the special-shaped mixing chamber 211 is distributed in a standard arc shape. After the fluid enters the mixing unit 2, the speed remains consistent, avoiding the low flow rate area caused by the spiral distribution of blades in the traditional pipeline static mixer causing the fluid to flow into the mixing unit 2, thereby reducing the impact of shear force on the feed liquid.

[0043] Embodiment 2:

[0044] The difference between this embodiment and the first embodiment is that the inner wall of the special-shaped mixing cavity 211 is a spiral structure of the tube wall. When in use, the liquid entering the special-shaped mixing cavity 211 undergoes a flipping motion through the spiral structure of the tube wall to achieve mixing.

[0045] Embodiment three:

[0046] The difference between this embodiment and the first and second embodiments is that the inner wall of the special-shaped mixing cavity 211 is a tube wall protrusion type structure. When in use, the liquid entering the special-shaped mixing cavity 211 passes through the tube wall spiral structure, and when it hits the protrusion type inner wall, a dispersion-combination process occurs to achieve mixing.

[0047] The above is only a preferred embodiment of the utility model, and is not any formal or substantial limitation of the utility model. It should be pointed out that ordinary technicians in this technical field can make some improvements and supplements without departing from the utility model, and these improvements and supplements should also be regarded as the protection scope of the utility model. Any technician familiar with this profession can make some changes, modifications and equivalent changes made by using the technical content disclosed above without departing from the spirit and scope of the utility model, which are all equivalent embodiments of the utility model; at the same time, any changes, modifications and evolutions of any equivalent changes made to the above embodiments based on the essential technology of the utility model are still within the scope of the technical solution of the utility model.

Claims

1. A static mixer, characterized in that: The invention comprises an inlet end (1), a mixing unit (2) and an outlet end (3), wherein the inlet end (1) and the outlet end (3) are connected via the mixing unit (2); the mixing unit (2) comprises an inner tube (21) and an outer tube (22), wherein the inner tube (21) is inserted into the outer tube (22), and the inner tube (21) is provided with a special-shaped mixing cavity (211); the inlet end (1) and the special-shaped mixing cavity (211) are connected via a chamfer transition, and the inner diameter of the inlet end (1) is larger than the diameter of the special-shaped mixing cavity (211).

2. A static mixer as claimed in claim 1, characterized in that: The special-shaped mixing cavity (211) is an uneven inner cavity, and the inner cavity structure is regularly symmetrical, irregularly distributed or has special-shaped unevenness.

3. A static mixer as claimed in claim 2, characterized in that: The cross section of the special-shaped mixing cavity (211) is distributed in a regular arc shape.

4. A static mixer as claimed in claim 1, characterized in that: The inner wall of the special-shaped mixing cavity (211) is a tube wall spiral structure.

5. A static mixer as claimed in claim 1, characterized in that: The inner wall of the special-shaped mixing cavity (211) is a tube wall protrusion type structure.

6. A static mixer as claimed in claim 1, characterized in that: The mixing unit (2) is linear, U-shaped, S-shaped or L-shaped.

7. A static mixer as claimed in claim 1, characterized in that: The inlet end (1), the outlet end (3) and the mixing unit (2) are tubes made of polymer material or stainless steel material.

8. A static mixer as claimed in claim 1, characterized in that: The inlet end (1) and the outlet end (3) are joints that match the special-shaped mixing cavity (211) in the inner tube (21).

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