A high performance liquid chromatography column filling tank

Abstract

The present application relates to the technical field of liquid chromatography column filling tanks, and in particular to a high-performance liquid chromatography column filling tank, which includes a substrate, a mounting seat fixedly installed in the middle of the substrate, and a tank body fixedly installed on the inner side of the mounting seat. The present application can easily add materials to the tank body through the feeding mechanism. After starting the second motor, the stirring auger makes the solution tumble, thereby improving the stirring and mixing efficiency. At the same time, the second motor drives the rotating shaft to rotate, driving the upper scraper and the lower scraper to rotate, evenly cleaning the inner wall of the tank body to avoid the adhesion of high-viscosity solutions. When cleaning, the cleaning liquid is added, and the scraper assists in stirring to improve the cleaning efficiency. After the stirring is completed, the solenoid valve is opened to discharge the material; when cleaning, the side solenoid valve is opened to discharge the cleaning liquid, so as to realize the diversion of the cleaning liquid and the mobile phase and avoid mis-discharge. The device is cleverly designed and easy to operate, greatly improving the stirring, mixing and cleaning efficiency, and meeting different usage requirements.

Description

Technical Field

[0001] The present application relates to the technical field of liquid chromatography column filling tanks, and in particular to a high performance liquid chromatography column filling tank. Background Art

[0002] At present, the chromatographic column is the core component in chromatographic analysis, and its main function is to separate the mixture. In gas chromatography, the diameter of the chromatographic column is several millimeters, which is filled with solid adsorbent or liquid solvent, which is called the stationary phase. Corresponding to the stationary phase is a mobile phase, which has different affinities with each component in the sample. When the carrier gas carries the sample through the chromatographic column continuously, the components with large affinity move slowly in the chromatographic column, while the components with small affinity move quickly. By detecting the separated components through the detector, the qualitative and quantitative analysis results can be obtained. The system of the HPLC column is composed of several parts such as a liquid reservoir, a pump, an injector, a chromatographic column, a detector, and a recorder. The mobile phase in the liquid reservoir is pumped into the system by a high-pressure pump, and the sample solution enters the mobile phase through the injector and is carried into the chromatographic column (stationary phase) by the mobile phase. Since the components in the sample solution have different distribution coefficients in the two phases, when they move relative to each other in the two phases, after repeated adsorption and desorption distribution processes, the components have large differences in movement speed and are separated into single components that flow out of the column in turn. When passing through the detector, the sample concentration is converted into an electrical signal and transmitted to the recorder, and the data is printed out in the form of a graph.

[0003] The existing homogenization tank for loading high performance liquid chromatography columns has a high viscosity of slurry that adheres to the inner wall of the tank and is not easy to discharge. The structure of most tanks is not easy to disassemble. After use, the inner wall of the tank is not easy to clean, which makes it inconvenient to use next time.

[0004] Through searching, the Chinese patent with the Chinese patent announcement number "CN218917294U" discloses a filling device for a homogenization tank for filling a high-performance liquid chromatography column, which includes a bracket, a tank body on the top of the bracket and a feeding pipe on the right side of the tank body, a water pipe is provided on the top of the tank body, a solenoid valve is connected to the bottom end of the bracket, a chromatographic column tube is connected to the bottom end of the solenoid valve, a cleaning mechanism is provided on the left side of the tank body, and a stirring mechanism is provided inside the tank body; the utility model injects water into the tank body again after the sample solution is filled, drives the motor to rotate the paddle again through the rotating shaft, and dissolves the residue on the inner wall of the tank body in water through the scraper, drives the plunger to move upward through the cylinder in the cleaning mechanism, extracts the air of the piston cylinder to make its inside become negative pressure, and makes the waste liquid automatically flow into the piston cylinder and then discharge outward, so as to facilitate automatic cleaning of the tank body, and solves the problem of inconvenient disassembly of the tank body structure in the prior art.

[0005] With respect to the above-mentioned related technologies, the utility model inventor found the following defects:

[0006] Although the above-mentioned device has a certain cleaning function, during its specific application, its internal cleaning structure cannot completely cover the inside of the tank body for scraping. There are gaps during the scraping of the overall scraper, and it cannot completely cover the bottom, top and sides of the tank body. The overall cleaning efficiency is poor. In addition, during the loading and unloading process, spiral conveying is used to assist loading, and the auger structure in the spiral conveying equipment obviously lacks a cleaning structure, which is inconvenient for cleaning. At the same time, during its use, the vertical auger is difficult to transport liquid mobile phases. During loading, the liquid will flow downward, and the overall loading efficiency is low. At the same time, the liquid is also easy to overflow. Obviously, the above-mentioned equipment has certain defects, so it needs to be improved. Utility Model Content

[0007] In order to improve the overall operational convenience of the device, the present application provides a high performance liquid chromatography column filling tank.

[0008] The present application provides a high-performance liquid chromatography column filling tank, which adopts the following technical scheme: it comprises a base plate, a mounting seat is fixedly installed in the middle of the base plate, a tank body is fixedly installed on the inner side of the mounting seat, a driving mechanism is fixedly installed in the middle of the rear side of the base plate, a stirring mechanism is fixedly installed on the top of the driving mechanism, and the bottom of the stirring mechanism extends inside the tank body, a feeding mechanism is fixedly installed in the middle of one side of the base plate, the output end of the feeding mechanism is connected to the upper end of the tank body, a discharge hopper is fixedly installed at the bottom of the tank body, a discharge pipe is fixedly installed at the bottom of the discharge hopper, a solenoid valve is fixedly installed at the bottom and one side of the discharge pipe, a chromatographic column tube is fixedly installed at the bottom of the solenoid valve at the bottom of the discharge pipe, and a liquid discharge pipe is fixedly installed at the outer end of the solenoid valve on one side of the discharge pipe;

[0009] The driving mechanism comprises a guide rail, the guide rail is fixedly installed in the middle of the back side of the substrate, a mounting frame is fixedly installed on the top of the guide rail, a driving assembly is fixedly installed on the back side of the mounting frame, a sliding rod is slidably connected inside the guide rail, the top of the sliding rod is fixedly connected to the top of the stirring mechanism, and the output end of the driving assembly is meshedly connected to the sliding rod;

[0010] The feeding mechanism includes a side rail, which is fixedly installed in the middle of one side of the base plate, a third motor is fixedly installed on the inner bottom of the side rail, a screw rod is fixedly installed on the output end of the third motor, the screw rod is rotatably connected to the inside of the side rail, a slide plate is threadedly connected to the outer surface of the screw rod, and a feeding assembly is fixedly installed on the outer end of the slide plate.

[0011] Optionally, the driving assembly includes a first motor and a bar groove, the bar groove is opened on the back side of the sliding rod, the first motor is fixedly installed in the middle of one side of the mounting frame, the output end of the first motor passes through the mounting frame and is fixedly installed with a transmission gear, and a rack is fixedly installed inside the bar groove, and the rack and the transmission gear are meshingly connected.

[0012] Optionally, support plates are fixedly mounted on both sides of the bottom of the base plate, and mounting plates are fixedly mounted on the outer ends of the support plates.

[0013] Optionally, mounting holes are provided at both ends of the mounting plate, and the mounting holes are configured as countersunk holes.

[0014] Optionally, the stirring mechanism includes a fixed block, which is fixedly installed on the top of the sliding rod, a top cover is fixedly installed on the bottom of the fixed block, a second motor is fixedly installed in the middle of the top of the top cover, and an output end of the second motor passes through the top cover and is fixedly installed with a stirring assembly.

[0015] Optionally, the stirring assembly includes a rotating shaft, which is fixedly mounted on the output end of the second motor, an upper scraper is fixedly mounted at equal intervals on the outer surface of the rotating shaft, a lower scraper is fixedly mounted at equal intervals on the lower end of the outer surface of the rotating shaft, the overall cross-sectional shape of the lower scraper is an isosceles trapezoid, the outer inclined surface of the lower scraper is fit-connected to the inner wall inclined surface of the discharge hopper, and the outer side and top of the upper scraper are respectively fit-connected to the inner wall of the tank body and the bottom of the top cover.

[0016] Optionally, a stirring auger is fixedly mounted on the outer surface of the rotating shaft, and the stirring auger is arranged on the inner side of the upper scraper and the lower scraper, and the lower end of the stirring auger is also arranged to be conical.

[0017] Optionally, the loading assembly includes a side frame and a threaded interface, the side frame is fixedly mounted on the outer upper end of the skateboard, a placement seat is fixedly mounted on the outer side of the side frame, a placement groove is opened in the inner middle part of the placement seat, a loading barrel is inserted into the placement groove, a regulating valve is fixedly mounted on the bottom of the loading barrel, a hose is fixedly mounted on the output end of the regulating valve, the threaded interface is fixedly mounted on the upper end of one side of the tank body, the output end of the threaded interface is connected to the interior of the tank body, and the outer end of the hose is connected to the inner upper end of the tank body through the threaded interface.

[0018] In summary, this application includes the following beneficial technical effects:

[0019] 1. This equipment realizes the convenience of adding materials by setting a stirring mechanism. After starting the second motor, the stirring auger starts to rotate, causing the solution in the tank to roll up and down, significantly improving the stirring and mixing efficiency. At the same time, the second motor is located on the top of the top cover, driving the shaft to rotate, thereby driving the upper scraper and the lower scraper to rotate. The upper scraper fits the inner wall of the tank and the bottom of the top cover, and the lower scraper fits the bottom of the tank and the bottom of the discharge hopper, so as to achieve uniform scraping and cleaning of any position in the tank, effectively preventing the adhesion of high-viscosity solutions. When cleaning, only cleaning liquid needs to be added, and the upper scraper and the lower scraper assist in stirring to improve the cleaning efficiency and uniformity. After stirring, the material is discharged through the solenoid valve at the bottom of the discharge pipe. When cleaning, the side solenoid valve discharges the cleaning liquid to achieve diversion and discharge of the cleaning liquid and the mobile phase liquid to avoid mis-discharge. This equipment is cleverly designed and easy to operate, greatly improving the stirring, mixing and cleaning efficiency, and meeting different usage requirements.

[0020] 2. By setting up a driving mechanism, the equipment can be easily cleaned and repaired after cleaning. Start the first motor, the transmission gear will rotate accordingly, meshing with the rack, and driving the slide bar to slide in the guide rail. This design allows the fixed block to move up quickly, driving the top cover to detach from the tank body, thereby easily pulling out the stirring mechanism. After the stirring mechanism is fully exposed, the user can conveniently perform deep cleaning and maintenance, which not only simplifies the cleaning process, but also improves the convenience of equipment maintenance and improves the overall operation efficiency. The equipment is cleverly designed and highly practical, bringing great convenience to users.

[0021] 3. By setting up a feeding mechanism, this equipment realizes convenient material transportation and cleaning and maintenance. The hose is connected by a threaded interface. After the material is added to the loading barrel, the third motor is started to drive the screw to rotate, and the slide plate slides up, so that the loading barrel is higher than the threaded interface, and the material flows into the tank body through the hose adaptively. When cleaning, the screw rod is driven in the reverse direction to retract the slide plate into the side rail, the hose is removed and the loading barrel is taken out for cleaning. Compared with traditional bolt-type transportation, this design is not only more convenient to clean and maintain, but also lower in cost, simpler and more efficient to operate. In addition, the feeding mechanism has a compact structure, occupies little space, and is suitable for various scenarios. This equipment improves the convenience and efficiency of the overall operation by optimizing the feeding mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure in the embodiment of the present application;

[0023] Figure 2 It is a structural schematic diagram of the feeding mechanism in the descending state in the embodiment of the present application;

[0024] Figure 3 It is a structural schematic diagram of the feeding mechanism in the embodiment of the present application in the rising state;

[0025] Figure 4is a schematic diagram of the structure of the rear view in the embodiment of the present application;

[0026] Figure 5 It is a structural schematic diagram of the feeding mechanism in the embodiment of the present application;

[0027] Figure 6 It is a schematic diagram of the overall structure of the stirring mechanism in the embodiment of the present application;

[0028] Figure 7 is a schematic diagram of the structure of the stirring mechanism in an embodiment of the present application when viewed from above;

[0029] Figure 8 In the embodiment of this application Figure 4 A is an enlarged structural diagram of FIG.

[0030] Figure numerals: 1, base plate; 2, mounting seat; 3, tank body; 4, driving mechanism; 41, guide rail; 42, mounting frame; 43, driving assembly; 431, first motor; 432, strip groove; 433, transmission gear; 434, rack; 44, slide bar; 5, discharge hopper; 6, feeding mechanism; 61, side rail; 62, third motor; 63, screw rod; 64, slide plate; 65, feeding assembly; 651, side frame; 652, threaded interface; 65 3. Placement seat; 654. Placement slot; 655. Loading barrel; 656. Regulating valve; 657. Hose; 7. Stirring mechanism; 71. Fixed block; 72. Top cover; 73. Second motor; 74. Stirring assembly; 741. Rotating shaft; 742. Upper scraper; 743. Lower scraper; 744. Stirring auger; 8. Discharge pipe; 9. Solenoid valve; 10. Chromatographic column tube; 11. Drain pipe; 12. Support plate; 13. Mounting plate; 14. Mounting hole. DETAILED DESCRIPTION

[0031] The following is combined with Figure 1-8 This application is described in further detail.

[0032] The present application embodiment discloses a high performance liquid chromatography column filling tank. Figure 1As shown, it includes a substrate 1, a mounting seat 2 is fixedly installed in the middle of the substrate 1, a tank body 3 is fixedly installed on the inner side of the mounting seat 2, a driving mechanism 4 is fixedly installed in the middle of the rear side of the substrate 1, a stirring mechanism 7 is fixedly installed on the top of the driving mechanism 4, and the bottom of the stirring mechanism 7 extends inside the tank body 3, a feeding mechanism 6 is fixedly installed in the middle of one side of the substrate 1, and the output end of the feeding mechanism 6 is connected to the upper end of the tank body 3, a discharge hopper 5 is fixedly installed at the bottom of the tank body 3, a discharge pipe 8 is fixedly installed at the bottom of the discharge hopper 5, and a solenoid valve 9 is fixedly installed at the bottom and one side of the discharge pipe 8, and a chromatographic column tube 10 is fixedly installed at the bottom of the solenoid valve 9 at the bottom of the discharge pipe 8 , a discharge pipe 11 is fixedly installed on the outer end of the solenoid valve 9 on one side of the discharge pipe 8. The base plate 1 serves as the supporting structure of the entire equipment and stably carries other components. The mounting seat 2 is responsible for fixing the tank body 3 to ensure its stability during operation. The driving mechanism 4 is located in the middle of the rear side of the base plate 1. The stirring mechanism 7 can be controlled by the driving mechanism 4. The driving mechanism 4 can accurately control the lifting and lowering of the stirring mechanism 7, so that the stirring mechanism 7 can easily enter or exit the tank body 3, which is convenient for material stirring and tank body 3 cleaning. The stirring mechanism 7 is the core part of the filling tank, and its bottom extends into the interior of the tank body 3. The stirring mechanism 7 can be driven by the driving mechanism 4. In order to carry out efficient stirring operation in the tank body 3, the uniform mixing of the materials is promoted. At the same time, the design of the stirring mechanism 7 also takes into account the convenience of cleaning, and the inside of the tank body 3 can be easily cleaned to avoid the influence of residues on subsequent experiments. The feeding mechanism 6 is located in the middle of one side of the substrate 1, and its output end is connected with the upper end of the tank body 3. Through the feeding mechanism 6, the material to be processed can be easily added to the tank body 3 to achieve rapid feeding. This design reduces the tediousness of manual operation and improves work efficiency. A discharge hopper 5 and a discharge pipe 8 are provided at the bottom of the tank body 3. The discharge pipe 8 is equipped with an electromagnetic valve 9. When the material in the tank body 3 needs to be discharged, it can be controlled The discharge pipe 8 is connected to the chromatographic column tube 10 at the bottom of the solenoid valve 9, so that the stirred material can be directly transported to the chromatographic column for analysis. At the same time, the outer end of the solenoid valve 9 on one side of the discharge pipe 8 is connected to the discharge pipe 11 for discharging cleaning liquid or other liquids, thereby realizing the diversion of cleaning liquid and mobile phase and avoiding the situation of misdischarge. The design scheme of this high-performance liquid chromatography column filling tank fully considers the needs of multiple links such as stirring and mixing, feeding, discharging and cleaning. Through the coordinated work of various components, efficient and convenient experimental operation is realized. This equipment has broad prospects in the application of chemistry, biology and other fields.

[0033] Please refer to Figure 3The driving mechanism 4 includes a guide rail 41, which is fixedly installed in the middle of the back side of the substrate 1. A mounting frame 42 is fixedly installed on the top of the guide rail 41, and a driving component 43 is fixedly installed on the back side of the mounting frame 42. A sliding rod 44 is slidably connected inside the guide rail 41. The top of the sliding rod 44 is fixedly connected to the top of the stirring mechanism 7. The output end of the driving component 43 is meshed with the sliding rod 44. The guide rail 41 is fixedly installed in the middle of the back side of the substrate 1, providing a stable and accurate sliding path for the sliding rod 44. The mounting frame 42 is firmly fixed on the top of the guide rail 41 for supporting and fixing the driving component 43. The driving component 43 is installed on the back side of the mounting frame 42, and its output end is meshed with the sliding rod 44. Through the operation of the driving component 43, the sliding rod 44 can be driven, thereby controlling the lifting and lowering of the stirring mechanism 7. The sliding rod 44 is fixedly connected to the top of the stirring mechanism 7. When the driving component 43 is in motion, the sliding rod 44 can be driven. When the component 43 is working, the slide bar 44 will slide up and down along the guide of the guide rail 41, driving the stirring mechanism 7 to perform corresponding lifting and lowering movements. This design allows the stirring mechanism 7 to easily enter the tank body 3 for stirring operations, and quickly exit after the stirring is completed, which is convenient for subsequent cleaning work. In addition, the design of the driving mechanism 4 also takes into account the convenience and stability of operation. By accurately controlling the operation of the driving component 43, the lifting and lowering speed and position of the stirring mechanism 7 can be accurately adjusted to ensure efficient stirring and cleaning processes. At the same time, the sliding connection between the guide rail 41 and the slide bar 44 uses high-quality wear-resistant materials to ensure the smoothness and durability of sliding. This driving mechanism 4 is reasonably designed and fully functional, and can efficiently and stably control the lifting and lowering movement of the stirring mechanism 7, providing strong support for the stirring and cleaning operations of the high-performance liquid chromatography column filling tank.

[0034] Please refer to Figure 3The driving assembly 43 includes a first motor 431 and a strip groove 432. The strip groove 432 is opened on the back of the slide bar 44. The first motor 431 is fixedly installed in the middle of one side of the mounting frame 42. The output end of the first motor 431 passes through the mounting frame 42 and is fixedly installed with a transmission gear 433. The interior of the strip groove 432 is fixedly installed with a rack 434. The rack 434 and the transmission gear 433 are meshed and connected. The first motor 431 is fixedly installed in the middle of one side of the mounting frame 42. It is the power of the driving assembly 43. When the motor is started, its output end will start to rotate and drive the transmission gear 433 connected thereto to rotate together. The transmission gear 433 is installed at the output end of the first motor 431. It passes through the mounting frame 42 and is meshed with the rack 434. This meshing connection ensures a close fit between the transmission gear 433 and the rack 434, so that the power of the motor can be efficiently transmitted to the rack 434. The rack 434 is fixedly installed inside the strip groove 432, and the strip groove 432 is opened. The rack 434 is arranged on the back side of the slide bar 44, and is designed so that it can mesh with the transmission gear 433, thereby converting the rotational motion of the motor into the linear motion of the slide bar 44. When the first motor 431 is started, the transmission gear 433 begins to rotate, and through the meshing action with the rack 434, the rack 434 is pushed to move up and down in the strip groove 432. Since the rack 434 and the slide bar 44 are fixedly connected, the slide bar 44 will also slide up and down accordingly. This design not only realizes the lifting and lowering control of the stirring mechanism 7, but also ensures the smoothness and accuracy of the movement. In addition, the driving component 43 also has the advantages of simple structure, easy operation, and high reliability. By adjusting the speed and direction of the motor, the lifting speed and direction of the stirring mechanism 7 can be accurately controlled to meet different experimental requirements. This driving component 43 realizes accurate control of the lifting and lowering motion of the stirring mechanism 7 through motor drive and gear rack 434 transmission, which provides a strong guarantee for the efficient operation of the high-performance liquid chromatography column filling tank.

[0035] Please refer to Figure 1, support plates 12 are fixedly installed on both sides of the bottom of the substrate 1, and mounting plates 13 are fixedly installed on the outer ends of the support plates 12. The mounting plates 13 are fixedly installed on the outer ends of the support plates 12. This design allows the entire device to be easily installed and fixed on a laboratory bench or other work platform. The mounting plate 13 usually has sufficient area and strength to withstand the weight of the device itself and the vibration and impact that may occur during use. In addition, mounting holes 14 are usually provided on the mounting plate 13. These mounting holes 14 can be conveniently bolted to the laboratory bench or other fixed structures to ensure the safe fixation of the equipment. The mounting holes 14 are designed to be countersunk holes, so that the bolt heads after installation can be sunk into the holes, avoiding the impact on the appearance and use of the equipment. The design of the support plate 12 and the mounting plate 13 provides a stable and reliable installation foundation for the high-performance liquid chromatography column filling tank, ensuring the stability and safety of the equipment during operation. At the same time, this design also makes the installation and maintenance of the equipment more convenient.

[0036] Please refer to Figure 2 , mounting holes 14 are provided at both ends of the mounting plate 13, and the mounting holes 14 are set as countersunk holes. In order to ensure the firmness and stability of the installation, mounting holes 14 are provided at both ends of the mounting plate 13, and these mounting holes 14 are specially designed as countersunk holes. The characteristic of the countersunk hole is that its hole mouth part has a larger diameter, while the depth of the hole gradually decreases and finally matches the rod of the bolt or screw. This design allows the mounting plate 13 to be tightly connected to the laboratory bench or other fixed structure using bolts or screws during installation, and at the same time, the head of the bolt or screw can be completely sunk into the hole and will not protrude from the surface of the mounting plate 13. The benefits of using countersunk holes as mounting holes 14 are obvious. First, it avoids the head of the bolt or screw protruding from the surface of the mounting plate 13, thereby ensuring the neatness and beauty of the appearance of the equipment. Secondly, the countersunk hole design can reduce the friction and collision caused by the contact between the head of the bolt or screw and external objects, which helps to extend the service life of the equipment. Finally, this design can also reduce the shaking or loosening of the equipment caused by improper installation to a certain extent, thereby improving the stability and safety of the equipment.

[0037] Please refer to Figure 6The stirring mechanism 7 includes a fixed block 71, which is fixedly installed on the top of the sliding rod 44. A top cover 72 is fixedly installed on the bottom of the fixed block 71. A second motor 73 is fixedly installed in the middle of the top of the top cover 72. The output end of the second motor 73 passes through the top cover 72 and is fixedly installed with a stirring assembly 74. The stirring mechanism 7 is a key part in the high-performance liquid chromatography column filling tank. Its main function is to achieve stirring and mixing of the materials in the tank body 3 to ensure the uniformity of the materials and the adequacy of the reaction. The stirring mechanism 7 includes key components such as a fixed block 71, a top cover 72, a second motor 73 and a stirring assembly 74, which work together to complete the stirring task. The fixed block 71, as a supporting structure of the stirring mechanism 7, is firmly fixedly installed on the top of the sliding rod 44, which ensures the stability of the stirring mechanism 7 during the lifting process and avoids operational errors or equipment damage caused by shaking or vibration. The top cover 72 is located at the bottom of the fixed block 71. It not only plays a role of sealing and protection, but also serves as an installation base for the second motor 73. The design of the top cover 72 takes into account the cooperation with the tank body 3 to ensure that there will be no interference or friction with the inside of the tank body 3 during the stirring process. The second motor 73 is the power source of the entire stirring mechanism 7. It is fixedly installed in the middle position of the top of the top cover 72. When the motor is started, its output end will begin to rotate, driving the stirring component 74 connected to it to perform stirring operations. This design enables the stirring mechanism 7 to work independently, which is convenient for precise control of the stirring speed and stirring time. The stirring component 74 is the core part of the stirring mechanism 7, which is directly involved in the stirring process. The stirring component 74 is driven by the second motor 73 to rotate to fully stir the material in the tank body 3. Its design takes into account factors such as stirring effect, stirring uniformity and material characteristics to ensure the efficiency and reliability of the stirring process. This stirring mechanism 7 is reasonably designed and fully functional, can achieve uniform stirring of the material in the tank body 3, improve reaction efficiency and the accuracy of experimental results, and at the same time, it has a compact structure and is easy to operate.

[0038] Please refer to Figure 6The stirring assembly 74 includes a rotating shaft 741, which is fixedly mounted on the output end of the second motor 73. An upper scraper 742 is fixedly mounted at equal intervals on the outer surface of the rotating shaft 741. A lower scraper 743 is fixedly mounted at equal intervals on the lower end of the outer surface of the rotating shaft 741. The overall cross-sectional shape of the lower scraper 743 is an isosceles trapezoid. The outer inclined surface of the lower scraper 743 is fitted and connected to the inner wall inclined surface of the discharge hopper 5. The outer side and the top of the upper scraper 742 are respectively fitted and connected to the inner wall of the tank body 3 and the bottom of the top cover 72. The rotating shaft 741 As the power transmission component of the stirring assembly 74, it is fixedly installed at the output end of the second motor 73. When the motor is started, the rotating shaft 741 rotates accordingly, driving the stirring component installed thereon to perform stirring operation. This design ensures the efficient transmission of stirring power and provides a stable and reliable power source for the stirring operation. The upper scraper 742 is fixedly installed at an equal interval on the upper outer surface of the rotating shaft 741. During the stirring process, the upper scraper 742 rotates with the rotation of the rotating shaft 741, and its outer side is closely fitted with the inner wall of the tank body 3. The top is fitted with the bottom of the top cover 72. This design enables the upper scraper 742 to effectively scrape off the material attached to the inner wall of the tank body 3, preventing the accumulation and waste of materials, and improving the uniformity of stirring. The lower scraper 743 is also fixedly installed at equal intervals on the lower part of the outer surface of the rotating shaft 741, and its overall cross-sectional shape is an isosceles trapezoid. This design enables the outer inclined surface of the lower scraper 743 to fit closely with the inner wall inclined surface of the discharge hopper 5. During the stirring process, the lower scraper 743 rotates with the rotation of the rotating shaft 741, which can not only The stirring assembly 74 is designed to effectively scrape off the material attached to the inner wall of the discharge hopper 5 and guide the material to flow toward the discharge port, thereby accelerating the discharge process of the material. The design of the stirring assembly 74 fully considers the uniformity of stirring and the fluidity of the material. Through the coordinated use of the upper scraper 742 and the lower scraper 743, the inner wall of the tank body 3 and the inner wall of the discharge hopper 5 can be fully scraped to avoid material residue and waste. At the same time, the rotational motion of the stirring assembly 74 can also promote the uniform mixing of the material in the tank body 3 and improve the stirring efficiency and reaction effect.

[0039] Please refer to Figure 6The outer surface of the rotating shaft 741 is fixedly installed with a stirring auger 744, which is arranged on the inner side of the upper scraper 742 and the lower scraper 743. The lower end of the stirring auger 744 is also set to a cone shape. The stirring auger 744 is located on the inner side of the upper scraper 742 and the lower scraper 743. The spiral shape design can effectively push and mix the materials. When the rotating shaft 741 rotates, the stirring auger 744 rotates accordingly, pushing the materials from the bottom of the tank body 3 upward, and at the same time making the materials form a rotating flow in the tank body 3, thereby achieving uniform mixing of the materials. It is worth mentioning that the lower end of the stirring auger 744 is specially designed to be conical. This design makes the stirring auger 7 When 44 contacts the inner wall of the discharge hopper 5, it can guide the material to flow to the discharge port more smoothly, reducing material residue and blockage. At the same time, the conical design can also reduce the friction between the stirring auger 744 and the inner wall of the discharge hopper 5 to a certain extent, thereby improving the durability and service life of the equipment. The addition of the stirring auger 744 and the conical design of its lower end not only enhance the stirring effect of the stirring mechanism 7 and improve the mixing uniformity of the material, but also optimize the flow path of the material and reduce material residue and waste. This design makes the HPLC column filling tank more efficient and reliable in stirring and mixing, thus providing a strong guarantee for the smooth progress of experiments and production.

[0040] Please refer to Figure 5 The feeding mechanism 6 includes a side rail 61, which is fixedly installed in the middle of one side of the substrate 1. A third motor 62 is fixedly installed at the bottom of the side rail 61. A screw rod 63 is fixedly installed at the output end of the third motor 62. The screw rod 63 is rotatably connected to the inside of the side rail 61. A slide plate 64 is threadedly connected to the outer surface of the screw rod 63. A feeding assembly 65 is fixedly installed at the outer end of the slide plate 64. The side rail 61, as a supporting and guiding component of the feeding mechanism 6, is fixedly installed in the middle of one side of the substrate 1. It ensures the stability and accuracy of the slide plate 64 during movement and avoids the occurrence of vibrations or deviations. In case of feeding failure, the third motor 62, as the power source of the feeding mechanism 6, is installed at the inner bottom of the side rail 61. When the motor is started, the screw rod 63 driven by its output end begins to rotate. The screw rod 63 is connected to the inside of the side rail 61 by rotation, and the rotational motion of the motor is converted into the linear motion of the slide plate 64. The slide plate 64 is connected to the outer surface of the screw rod 63 by threads. When the screw rod 63 rotates, the slide plate 64 will move in a straight line along the direction of the screw rod 63. This design enables the slide plate 64 to be accurately moved to the specified position under the drive of the motor, thereby realizing precise control of the feeding component 65.

[0041] Please refer to Figure 6The feeding assembly 65 includes a side frame 651 and a threaded interface 652. The side frame 651 is fixedly installed on the upper end of the outer side of the slide plate 64. A placement seat 653 is fixedly installed on the outer side of the side frame 651. A placement groove 654 is opened in the middle of the inner side of the placement seat 653. A feeding barrel 655 is inserted into the placement groove 654. A regulating valve 656 is fixedly installed at the bottom of the feeding barrel 655. A hose 657 is fixedly installed at the output end of the regulating valve 656. The threaded interface 652 is fixedly installed on the upper end of one side of the tank body 3. The output end of the threaded interface 652 is connected to the interior of the tank body 3. The outer end of the hose 657 is connected to the upper end of the tank body 3 through the threaded interface 652. The side frame 651 serves as a supporting structure for the loading assembly 65 and is fixedly mounted on the upper end of the outer side of the slide 64. It not only provides a stable mounting base for the placement seat 653, but also ensures the stability of the loading assembly 65 during movement. The placement seat 653 is fixedly mounted on the outer side of the side frame 651, and the placement groove 654 opened in the middle of the inner side is used to place the loading barrel 655. This design allows the loading barrel 655 to be easily inserted and removed, and is convenient for replacement and cleaning. The loading barrel 655 serves as a component for storing and conveying materials, and a regulating valve 656 is fixedly mounted on the bottom thereof. The conveying speed and flow rate of the material can be controlled by adjusting the opening and closing degree of the regulating valve 656. , to achieve precise control of the feeding process, a hose 657 is fixedly installed at the output end of the regulating valve 656. The hose 657 has a certain flexibility and can be easily bent and stretched to adapt to different installation positions and angles. The other end of the hose 657 is connected to the inside of the tank body 3 through a threaded interface 652 to ensure that the material can smoothly enter the tank body 3. The threaded interface 652 is fixedly installed on the upper end of one side of the tank body 3. Its design takes into account the tightness and sealing of the connection. Through the threaded connection, a reliable connection is formed between the hose 657 and the tank body 3, avoiding leakage and waste of materials during transportation. During work, the user only needs to The barrel 655 is placed in the placement groove 654 of the placement seat 653, and the material delivery speed and flow rate are controlled by the regulating valve 656. Then the feeding mechanism 6 is started, and the slide 64 drives the loading assembly 65 to move to a suitable position. At this time, the hose 657 is connected to the inside of the tank body 3 through the threaded interface 652. The material enters the inside of the tank body 3 through the hose 657 under the action of gravity or pressure. This loading assembly 65 is reasonably designed and easy to operate. It can realize efficient and accurate delivery of materials, and provides a strong guarantee for the efficient operation of the high-performance liquid chromatography column filling tank. At the same time, it has a compact structure and is easy to clean and maintain, which improves the practicability and durability of the equipment.

[0042] The implementation principle of a high performance liquid chromatography column filling tank in the embodiment of the present application is as follows: the device is provided with a stirring mechanism 7, so that during use of the device, materials can be added into the interior of the tank body 3 through the feeding mechanism 6, and at this time, the second motor 73 is started to run, and the second motor 73 drives the stirring auger 744 to rotate, and the stirring auger 744 can drive the solution inside the tank body 3 to roll up and down, which can promote the overall stirring and mixing efficiency of the device to be high, can improve the overall stirring and mixing efficiency of the device, can improve the mixing and stirring efficiency of the overall materials of the device, and at the same time, the second motor 73 is located at the top of the top cover 72 to drive and operate, that is, the second motor 73 drives the rotating shaft 741 to rotate, and the rotation of the rotating shaft 741 can drive the upper scraper 742 and the lower scraper 743 to rotate, and the upper scraper 742 fits the inside of the tank body 3 and the bottom of the top cover 72, and the lower scraper 743 fits the tank The bottom of the tank body 3 and the bottom of the discharge hopper 5 are driven by the rotating shaft 741 to rotate the upper scraper 742 and the lower scraper 743. The upper scraper 742 and the lower scraper 743 can evenly scrape and clean any position in the tank body 3, which can avoid the high-viscosity solution from adhering to the inside of the tank body 3. During this cleaning process, it is only necessary to add the cleaning liquid into the inside of the tank body 3, and the upper scraper 742 and the lower scraper 743 are used to assist in stirring and mixing, which can improve the cleaning efficiency and uniformity of the inside of the tank body 3 of the equipment. After the material is stirred and mixed, the solenoid valve 9 at the bottom of the discharge pipe 8 is opened to discharge the material. When the cleaning liquid needs to be discharged during cleaning, the solenoid valve 9 on the displacement side can be opened to discharge the cleaning liquid. The cleaning liquid and the mobile phase liquid are discharged in separate flows, which can avoid the situation where the material is discharged into the mobile phase when cleaning is required, and it is convenient to quickly discharge the mobile phase liquid or the cleaning liquid.

[0043] By setting the driving mechanism 4, during the use of the device, when the cleaning of the device is completed, the first motor 431 can be started to run, and the first motor 431 can be used to drive the transmission gear 433 to rotate, and the transmission gear 433 and the rack 434 are meshed and connected. At this time, the driving gear contacts the rack 434, which can cause the slide bar 44 to slide inside the guide rail 41, and can assist in adjusting the up and down displacement of the slide bar 44, so that the device can quickly pull the fixed block 71 up, causing the fixed block 71 to drive the top cover 72 to separate from the interior of the tank body 3, and can quickly pull the stirring mechanism 7 out of the interior of the tank body 3. At this time, the stirring mechanism 7 is pulled out and the tank body 3 is opened, and the stirring mechanism 7 is exposed to the outside as a whole, so that the device can conveniently clean and repair the entire device, and can further improve the convenience of further cleaning and maintenance of the entire device on the basis of easy cleaning, and can improve the convenience of overall operation and use of the device.

[0044] By setting up the feeding mechanism 6, during the use of the device, the hose 657 is first connected through the threaded interface 652, so that the hose 657 and the upper end of the tank body 3 are connected, and then the material is added to the interior of the upper barrel 655. At this time, by starting the third motor 62 to run, the third motor 62 is used to drive the screw rod 63 to rotate, and the screw rod 63 is located inside the side rail 61 and rotates, which can drive the slide plate 64 inside the side rail 61 to slide up and down. At this time, the slide plate 64 moves upward to drive the height of the upper barrel 655 to be higher than the threaded interface 652. At this time, the material inside the upper barrel 655 can pass through The hose 657 and the threaded interface 652 adaptively convey the flow to the interior of the tank body 3. When cleaning and maintenance are required, it is only necessary to start the third motor 62 to reversely drive the screw 63 to drive the slide 64 to retract into the inside of the side rail 61. At this time, the threaded interface 652 is loosened to remove the hose 657, and then the loading barrel 655 placed in the placement groove 654 is taken out and disassembled, which is convenient for cleaning and maintenance of the loading barrel 655 and the hose 657. Compared with the design of bolt-type conveying in the prior art, it can be seen that the overall cleaning and maintenance of the device is more convenient, the overall application cost is lower, the operation is simple and the efficiency is high.

[0045] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A high performance liquid chromatography column filling tank, characterized in that: The invention comprises a base plate (1), a mounting seat (2) is fixedly mounted in the middle of the base plate (1), a tank body (3) is fixedly mounted on the inner side of the mounting seat (2), a driving mechanism (4) is fixedly mounted in the middle of the rear side of the base plate (1), a stirring mechanism (7) is fixedly mounted on the top of the driving mechanism (4), the bottom of the stirring mechanism (7) extends into the interior of the tank body (3), a feeding mechanism (6) is fixedly mounted in the middle of one side of the base plate (1), the output end of the feeding mechanism (6) is connected to the upper end of the tank body (3), a discharge hopper (5) is fixedly mounted at the bottom of the tank body (3), a discharge pipe (8) is fixedly mounted at the bottom of the discharge hopper (5), a solenoid valve (9) is fixedly mounted at the bottom and one side of the discharge pipe (8), a chromatographic column tube (10) is fixedly mounted at the bottom of the solenoid valve (9) at the bottom of the discharge pipe (8), and a liquid discharge pipe (11) is fixedly mounted at the outer end of the solenoid valve (9) on one side of the discharge pipe (8); The driving mechanism (4) comprises a guide rail (41), the guide rail (41) is fixedly mounted in the middle of the back side of the substrate (1), a mounting frame (42) is fixedly mounted on the top of the guide rail (41), a driving component (43) is fixedly mounted on the back side of the mounting frame (42), a sliding rod (44) is slidably connected inside the guide rail (41), the top of the sliding rod (44) is fixedly connected to the top of the stirring mechanism (7), and the output end of the driving component (43) is meshingly connected to the sliding rod (44); The feeding mechanism (6) comprises a side rail (61), the side rail (61) is fixedly mounted on the middle part of one side of the base plate (1), a third motor (62) is fixedly mounted on the inner bottom of the side rail (61), a screw rod (63) is fixedly mounted on the output end of the third motor (62), the screw rod (63) is rotatably connected to the inside of the side rail (61), a slide plate (64) is threadedly connected to the outer surface of the screw rod (63), and a feeding assembly (65) is fixedly mounted on the outer end of the slide plate (64).

2. A high performance liquid chromatography column filling tank according to claim 1, characterized in that: The driving assembly (43) comprises a first motor (431) and a strip groove (432), wherein the strip groove (432) is provided on the back of the slide bar (44), the first motor (431) is fixedly mounted on the middle part of one side of the mounting frame (42), the output end of the first motor (431) passes through the mounting frame (42) and is fixedly mounted with a transmission gear (433), a rack (434) is fixedly mounted inside the strip groove (432), and the rack (434) and the transmission gear (433) are meshingly connected.

3. The high performance liquid chromatography column filling tank according to claim 1, characterized in that: Support plates (12) are fixedly mounted on both sides of the bottom of the base plate (1), and mounting plates (13) are fixedly mounted on the outer ends of the support plates (12).

4. A high performance liquid chromatography column filling tank according to claim 3, characterized in that: Both ends of the mounting plate (13) are provided with mounting holes (14), and the mounting holes (14) are configured as countersunk holes.

5. The high performance liquid chromatography column filling tank according to claim 1, characterized in that: The stirring mechanism (7) comprises a fixed block (71), wherein the fixed block (71) is fixedly mounted on the top of the sliding rod (44), a top cover (72) is fixedly mounted on the bottom of the fixed block (71), a second motor (73) is fixedly mounted in the middle of the top of the top cover (72), and a stirring assembly (74) is fixedly mounted on the output end of the second motor (73) passing through the top cover (72).

6. The high performance liquid chromatography column filling tank according to claim 5, characterized in that: The stirring assembly (74) comprises a rotating shaft (741), wherein the rotating shaft (741) is fixedly mounted on the output end of the second motor (73), an upper scraper (742) is fixedly mounted at equal intervals on the outer surface of the rotating shaft (741), and a lower scraper (743) is fixedly mounted at equal intervals on the lower end of the outer surface of the rotating shaft (741), wherein the overall cross-sectional shape of the lower scraper (743) is an isosceles trapezoid, the outer inclined surface of the lower scraper (743) is fitted and connected to the inner wall inclined surface of the discharge hopper (5), and the outer side and the top of the upper scraper (742) are respectively fitted and connected to the inner wall of the tank body (3) and the bottom of the top cover (72).

7. A high performance liquid chromatography column filling tank according to claim 6, characterized in that: A stirring auger (744) is fixedly mounted on the outer surface of the rotating shaft (741). The stirring auger (744) is arranged on the inner side of the upper scraper (742) and the lower scraper (743). The lower end of the stirring auger (744) is also arranged in a conical shape.

8. The high performance liquid chromatography column filling tank according to claim 1, characterized in that: The loading assembly (65) comprises a side frame (651) and a threaded interface (652), wherein the side frame (651) is fixedly mounted on the outer upper end of the slide plate (64), a placement seat (653) is fixedly mounted on the outer side of the side frame (651), a placement groove (654) is provided in the inner middle part of the placement seat (653), a loading barrel (655) is inserted into the placement groove (654), a regulating valve (656) is fixedly mounted on the bottom of the loading barrel (655), a hose (657) is fixedly mounted on the output end of the regulating valve (656), the threaded interface (652) is fixedly mounted on the upper end of one side of the tank body (3), the output end of the threaded interface (652) is connected to the interior of the tank body (3), and the outer end of the hose (657) is connected to the inner upper end of the tank body (3) through the threaded interface (652).

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