An ion source device

Abstract

The present application belongs to the technical field of mass spectrometers, and relates to an ion source device. The ion source device comprises: an ion source chamber, provided with a first waste discharge channel; an interface assembly, connected to the ion source chamber, and arranged in a second waste discharge channel connected to the first waste discharge channel; a waste discharge assembly, comprising a venturi seat connected to the interface assembly, a third waste discharge channel is provided in the venturi seat, and the third waste discharge channel comprises an intake section, a throat section and an exhaust section connected in sequence, and the calibers of the intake section and the exhaust section are gradually reduced in the direction toward the throat section; a suction port is formed on the side wall of the throat section, and the suction port is connected to the second waste discharge channel. The present application can prevent waste samples and solvent vapors from causing corrosive damage to the mass spectrometer, effectively remove water vapor and turbulent airflow in the ion source chamber, and improve the stability and service life of the mass spectrometer; and the distance from the waste samples and solvent vapors generated by the ion source chamber to the exhaust section is short, so that the structure of the ion source device is compact and simple.

Description

Technical Field

[0001] The present application relates to the technical field of mass spectrometers, and more specifically, to an ion source device. Background Art

[0002] A mass spectrometer, also known as a mass spectrometer, is an instrument used to separate and detect different isotopes. It is a type of instrument that separates and detects the composition of substances according to the mass differences of atoms, molecules or molecular fragments of the substance based on the principle that charged particles can be deflected in an electromagnetic field. Among them, electrospray ionization (ESI) is a soft ionization technology that converts liquid ions into gaseous ions. It is particularly suitable for the analysis of polar molecules and biomacromolecules.

[0003] In mass spectrometers, the electrospray ion source plays a vital role, which can produce high-sensitivity detection; however, the charged droplets in the electrospray ion source may have a negative impact on the performance of the mass spectrometer. These charged droplets may hit the ion optical elements or mass analyzer, triggering ion pulses, thereby generating interfering spike signals in the mass spectrum. The spike signals not only affect the accuracy of ion detection, but also shorten the life of the detector.

[0004] In addition, due to the evaporation of the solvent, a certain amount of solvent and a large amount of water vapor will remain in the ion source. When these gases enter the vacuum area of ​​the mass spectrometer, they will cool rapidly due to the free jet expansion. In this process, polar molecules may combine with sample ion clusters to form ion clusters, further affecting the sensitivity of the mass spectrometer. In addition, the charged droplets and the airflow they form will also affect the stability of the air pressure in the ion source cavity. Based on this, it is necessary to develop a waste exhaust structure to timely and effectively remove the charged droplets generated when the electrospray ion source of the mass spectrometer is working. Utility Model Content

[0005] The embodiment of the present application provides an ion source device for solving the problem of discharging charged droplets generated when the electrospray ion source is working in the prior art.

[0006] In order to solve the above technical problems, the present application provides an ion source device, which adopts the following technical solution:

[0007] An ion source device, comprising:

[0008] An ion source chamber is provided with a first row of waste channels;

[0009] an interface assembly connected to the ion source chamber and disposed in a second waste discharge channel communicating with the first waste discharge channel;

[0010] A waste discharge assembly comprises a venturi seat connected to the interface assembly, a third waste discharge channel is provided in the venturi seat, the third waste discharge channel comprises an air intake section, a throat section and an exhaust section which are connected in sequence, the calibers of the air intake section and the exhaust section are gradually reduced in the direction toward the throat section; a suction port is formed on the side wall of the throat section, and the suction port is connected to the second waste discharge channel.

[0011] Furthermore, the first waste discharge channel includes a collecting section, a connecting section and a discharge section which are connected in sequence, the collecting section is connected to the ion source chamber, the discharge section is connected to the second waste discharge channel, the aperture of the collecting section gradually decreases in the direction toward the connecting section, and the discharge section is inclined in the direction toward the second waste discharge channel.

[0012] Furthermore, the second waste discharge channel and the suction port are both arranged to be inclined in a direction away from the ion source chamber.

[0013] Further, the discharge section includes a first oblique section and a second oblique section that are connected in sequence, the first oblique section is connected to the connecting section, and the second oblique section is connected to the second waste discharge channel;

[0014] The ion source chamber includes a shell and a discharge seat arranged on the shell, the discharge seat is provided with an exhaust port connected to the shell, the collecting section and the first inclined section are opened on the discharge seat, the collecting section is connected to the exhaust port, and the second inclined section is opened on the shell.

[0015] Furthermore, the ion source chamber also includes an injection assembly and a heating assembly disposed on the shell, and the discharge seat is located below the injection assembly.

[0016] Furthermore, a first sealing member is provided at a connection between the discharge seat and the shell, at a connection between the shell and the interface assembly, and at a connection between the interface assembly and the Venturi seat.

[0017] Furthermore, the interface assembly includes a connecting seat, a step seat and a metal cone, the connecting seat is connected to the shell, the step seat is arranged on the connecting seat, and the metal cone is sleeved on the step seat and located in the shell; an ion entrance hole is opened at the top of the metal cone, the step seat has a first through hole passing through both sides, and the connecting seat has a second through hole passing through both sides, and the ion entrance hole, the first through hole and the second through hole are located on the same axis.

[0018] Furthermore, the ion source device also includes a fixed handle and a fixed seat, the fixed seat is arranged on the connecting seat, the fixed handle includes a connecting rod and a baffle, the connecting rod passes through the shell and is connected to the fixed seat, and the baffle abuts against the shell.

[0019] Furthermore, a second sealing member is provided at the connection between the connecting seat and the step seat.

[0020] Furthermore, the exhaust assembly also includes an air intake pipe and an exhaust pipe, the air intake pipe is connected to the air intake section, and the exhaust pipe is connected to the exhaust section.

[0021] Compared with the prior art, the embodiment of the present application has the following beneficial effects: the ion source device utilizes the Venturi negative pressure effect generated when blowing air into the air inlet section of the Venturi seat to complete the suction and discharge of the waste sample and solvent vapor generated in the ion source chamber, thereby avoiding corrosive damage to the mass spectrometer, effectively eliminating water vapor and turbulent airflow in the electrospray ion source chamber, and improving the stability and service life of the mass spectrometer. In addition, the distance from the waste sample and solvent vapor generated in the ion source chamber to the exhaust section is short, making the structure of the ion source device compact and simple, reducing costs on the basis of effective waste discharge, so as to facilitate industrialization and cost control. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the scheme of the present application, a brief introduction is given below to the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0023] Figure 1 is a three-dimensional diagram of an ion source device provided in an embodiment of the present application;

[0024] Figure 2 yes Figure 1 A top view of

[0025] Figure 3 yes Figure 2 Sectional view at AA in the middle;

[0026] Figure 4 yes Figure 3 The enlarged view of point B in the middle;

[0027] Figure 5 yes Figure 1 An exploded view of one perspective;

[0028] Figure 6 yes Figure 1 Exploded image from another perspective;

[0029] Figure 7 yes Figure 1 Side view of the Chinese churidarium;

[0030] Figure 8 yes Figure 7Cross-sectional view at CC.

[0031] Figure numerals: 1, ion source chamber; 11, first waste discharge channel; 111, collecting section; 112, connecting section; 113, discharge section; 1131, first oblique section; 1132, second oblique section; 12, shell; 13, discharge seat; 131, exhaust port; 14, injection assembly; 15, heating assembly; 2, interface assembly; 21, second waste discharge channel; 22, connecting seat; 221, second through hole; 23, step seat; 231, first through hole; 24, metal cone; 241, ion entrance hole; 3, waste discharge assembly; 31, venturi seat; 32, third waste discharge channel; 321, air inlet section; 322, throat section; 323, exhaust section; 324, suction port; 33, air inlet pipe; 34, exhaust pipe; 4, first sealing member; 5, fixed handle; 51, connecting rod; 52, baffle; 6, fixed seat; 7, second sealing member. DETAILED DESCRIPTION

[0032] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by technicians in the technical field of this application; the terms used in the specification of the application herein are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" and any variations thereof in the specification and claims of this application and the above-mentioned drawings are intended to cover non-exclusive inclusions. The terms "first", "second", etc. in the specification and claims of this application or the above-mentioned drawings are used to distinguish different objects, not to describe a specific order.

[0033] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0034] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings.

[0035] The present application embodiment provides an ion source device, such as Figures 1 to 8As shown, the ion source device includes: an ion source chamber 1, an interface component 2 and a waste discharge component 3; the ion source chamber 1 is provided with a first waste discharge channel 11; the interface component 2 is connected to the ion source chamber 1, and is arranged in a second waste discharge channel 21 connected to the first waste discharge channel 11; the waste discharge component 3 includes a Venturi seat 31 connected to the interface component 2, and a third waste discharge channel 32 is opened in the Venturi seat 31, and the third waste discharge channel 32 includes an air intake section 321, a throat section 322 and an exhaust section 323 connected in sequence, and the calibers of the air intake section 321 and the exhaust section 323 are gradually reduced in the direction toward the throat section 322; the side wall of the throat section 322 is formed with a suction port 324, and the suction port 324 is connected to the second waste discharge channel 21; the interface component 2 is used to install the ion source chamber 1 into the mass spectrometer.

[0036] The working principle of an ion source device provided in an embodiment of the present application is as follows: due to the auxiliary gas and the nebulizer gas entering the ion source chamber 1, the internal pressure of the ion source chamber 1 is slightly higher than the atmospheric pressure; the positive pressure inside the ion source chamber 1 will discharge the waste samples and solvent vapors generated by the ion source into the first waste discharge channel 11, the second waste discharge channel 21 and the waste discharge assembly 3; at the same time, a high-volume gas is input through the air inlet section 321 of the third waste discharge channel 32. Since the air inlet section 321 gradually shrinks in the direction toward the throat section 322, a negative pressure is generated at the suction port 324, thereby sucking the waste samples and solvent vapors in the ion source chamber 1 into the high-volume gas, and then entering the waste container through the exhaust section 323.

[0037] The beneficial effects of an ion source device provided by the embodiment of the present application are as follows: the ion source device utilizes the Venturi negative pressure effect generated when blowing air into the air inlet section 321 of the Venturi seat 31 to complete the suction and discharge of the waste sample and solvent vapor generated by the ion source chamber 1, thereby avoiding corrosive damage to the mass spectrometer, effectively removing the water vapor and turbulent airflow in the electrospray ion source chamber 1, and improving the stability of the mass spectrometer and the service life of the mass spectrometer. In addition, the distance from the waste sample and solvent vapor generated by the ion source chamber 1 to the exhaust section 323 is short, making the structure of the ion source device compact and simple, reducing costs on the basis of effective waste discharge, so as to facilitate industrialization and control costs.

[0038] like Figure 4 As shown, further, the first waste exhaust channel 11 includes a collecting section 111, a connecting section 112 and a discharge section 113 which are connected in sequence, the collecting section 111 is connected to the ion source chamber 1, the discharge section 113 is connected to the second waste exhaust channel 21, the aperture of the collecting section 111 gradually decreases in the direction toward the connecting section 112, and the discharge section 113 is inclined in the direction toward the second waste exhaust channel 21.

[0039] In this embodiment, the diameter of the collecting section 111 gradually decreases in the direction toward the connecting section 112, so that the collecting section 111 is inverted cone shape, which is conducive to guiding the waste samples and solvent vapors generated by the ion source chamber 1 into the connecting section 112; the discharge section 113 is inclined in the direction toward the second waste discharge channel 21, which can speed up the flow of waste samples into the second waste discharge channel 21; this embodiment improves the waste discharge efficiency of the waste samples and solvent vapors generated by the ion source chamber 1.

[0040] Furthermore, the second waste discharge channel 21 and the suction port 324 are both arranged to be inclined in a direction away from the ion source chamber 1 .

[0041] In this embodiment, since the discharge section 113 is connected with the second waste discharge channel 21 and the suction port 324 in sequence, when the discharge section 113, the second waste discharge channel 21 and the suction port 324 are all inclined in the direction away from the ion source chamber 1, the inner walls of the three form a continuous inclined surface, thereby improving the waste discharge efficiency of the waste sample and solvent vapor generated by the ion source chamber 1.

[0042] Further, the discharge section 113 includes a first inclined section 1131 and a second inclined section 1132 which are connected in sequence, the first inclined section 1131 is connected to the connecting section 112, and the second inclined section 1132 is connected to the second waste discharge channel 21; the ion source chamber 1 includes a shell 12 and a discharge seat 13 arranged on the shell 12, the discharge seat 13 is provided with an exhaust port 131 connected to the shell 12, the collecting section 111 and the first inclined section 1131 are opened on the discharge seat 13, the collecting section 111 is connected to the exhaust port 131, and the second inclined section 1132 is opened on the shell 12.

[0043] In this embodiment, since the ion source chamber 1 includes a shell 12 and an exhaust seat 13, and the Venturi seat 31 is disposed on the interface assembly 2, the exhaust section 113 is divided into a first inclined section 1131 disposed on the exhaust seat 13, and a second inclined section 1132 disposed on the shell 12, so as to effectively shorten the distance from the waste sample and solvent vapor generated by the ion source chamber 1 to the exhaust section 323.

[0044] Furthermore, the ion source chamber 1 further comprises a sample injection assembly 14 and a heating assembly 15 which are arranged on the shell 12 , and the discharge seat 13 is located below the sample injection assembly 14 .

[0045] In this embodiment, there are two heating components 15 , and the two heating components 15 are respectively disposed on both sides of the sample injection component 14 to improve work efficiency.

[0046] like Figure 4As shown, further, a first sealing member 4 is provided at a connection between the discharge seat 13 and the shell 12 , a connection between the shell 12 and the interface assembly 2 , and a connection between the interface assembly 2 and the Venturi seat 31 .

[0047] In this embodiment, a first seal 4 is provided at the connection between the discharge seat 13 and the shell 12, at the connection between the shell 12 and the interface assembly 2, and at the connection between the interface assembly 2 and the Venturi seat 31 to improve the sealing performance of the ion source device and prevent leakage of waste samples and solvent vapors generated by the ion source chamber 1.

[0048] Specifically, the first sealing member 4 is a sealing ring.

[0049] like Figures 4 to 6 As shown, further, the interface assembly 2 includes a connecting seat 22, a step seat 23 and a metal cone 24, the connecting seat 22 is connected to the shell 12, the step seat 23 is arranged on the connecting seat 22, and the metal cone 24 is sleeved on the step seat 23 and is located in the shell 12; an ion entrance hole 241 is opened at the top of the metal cone 24, the step seat 23 has a first through hole 231 passing through both sides, and the connecting seat 22 has a second through hole 221 passing through both sides, and the ion entrance hole 241, the first through hole 231 and the second through hole 221 are located on the same axis.

[0050] In this embodiment, the connecting seat 22 is used to install the ion source device into the mass spectrometer, and the ion entrance hole 241, the first through hole 231 and the second through hole 221 are located on the same axis to form a channel for ion transmission; specifically, the ions generated by the ion source chamber 1 are transmitted through the ion entrance hole 241, the first through hole 231 and the second through hole 221 in sequence.

[0051] like Figure 1 , Figure 5 , Figure 6 As shown, further, the ion source device also includes a fixed handle 5 and a fixed seat 6, the fixed seat 6 is arranged on the connecting seat 22, the fixed handle 5 includes a connecting rod 51 and a baffle 52, the connecting rod 51 passes through the shell 12 and is connected to the fixed seat 6, and the baffle 52 abuts against the shell 12.

[0052] In this embodiment, when installing the ion source chamber 1, the shell 12 is fitted with the connecting seat 22, and then the connecting rod 51 passes through the shell 12 and the connecting seat 22 in sequence, so that the connecting rod 51 is connected to the fixed seat 6, and the baffle 52 is abutted against the shell 12, so that the shell 12 and the connecting seat 22 can be fixed; when disassembling the ion source chamber 1, the baffle 52 is rotated to cancel the abutment of the baffle 52 on the shell 12 and the connection between the connecting rod 51 and the fixed seat 6, and then the connecting rod 51 is pulled out from the fixed seat 6, the connecting seat 22 and the shell 12, so that the ion source chamber 1 can be disassembled.

[0053] Furthermore, a second sealing member 7 is provided at the connection between the connecting seat 22 and the step seat 23 .

[0054] In this embodiment, a second seal 7 is provided at the connection between the connection seat 22 and the step seat 23 to improve the sealing of the ion source device so that the ions generated by the ion source chamber 1 can only be transmitted through the ion entrance hole 241, the first through hole 231 and the second through hole 221.

[0055] Furthermore, the exhaust assembly 3 further includes an air intake pipe 33 and an exhaust pipe 34 , the air intake pipe 33 is connected to the air intake section 321 , and the exhaust pipe 34 is connected to the exhaust section 323 .

[0056] In this embodiment, an air inlet pipe 33 is provided to facilitate the input of high-volume gas into the air inlet section 321; an exhaust pipe 34 is provided to facilitate the exhaust of waste samples and solvent vapor into a waste container.

[0057] Obviously, the embodiments described above are only some embodiments of the present application, rather than all embodiments. The preferred embodiments of the present application are given in the accompanying drawings, but they do not limit the patent scope of the present application. The present application can be implemented in many different forms. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive. Although the present application is described in detail with reference to the aforementioned embodiments, for those skilled in the art, it is still possible to modify the technical solutions recorded in the aforementioned specific implementation methods, or to perform equivalent replacement of some of the technical features therein. Any equivalent structure made using the contents of the specification and drawings of this application, directly or indirectly used in other related technical fields, is similarly within the scope of patent protection of this application.

Claims

1. An ion source device, characterized in that: include: An ion source chamber is provided with a first row of waste channels; an interface assembly connected to the ion source chamber and disposed in a second waste discharge channel communicating with the first waste discharge channel; A waste discharge assembly comprises a venturi seat connected to the interface assembly, a third waste discharge channel is provided in the venturi seat, the third waste discharge channel comprises an air intake section, a throat section and an exhaust section which are connected in sequence, the calibers of the air intake section and the exhaust section are gradually reduced in the direction toward the throat section; a suction port is formed on the side wall of the throat section, and the suction port is connected to the second waste discharge channel.

2. The ion source device according to claim 1, characterized in that: The first waste discharge channel includes a collecting section, a connecting section and a discharging section which are connected in sequence, the collecting section is connected to the ion source chamber, the discharging section is connected to the second waste discharge channel, the aperture of the collecting section gradually decreases in the direction toward the connecting section, and the discharging section is inclined in the direction toward the second waste discharge channel.

3. The ion source device according to claim 2, characterized in that: The second waste discharge channel and the suction port are both arranged to be inclined in a direction away from the ion source chamber.

4. The ion source device according to claim 2, characterized in that: The discharge section comprises a first oblique section and a second oblique section which are connected in sequence, wherein the first oblique section is connected to the connecting section, and the second oblique section is connected to the second waste discharge channel; The ion source chamber includes a shell and a discharge seat arranged on the shell, the discharge seat is provided with an exhaust port connected to the shell, the collecting section and the first inclined section are opened on the discharge seat, the collecting section is connected to the exhaust port, and the second inclined section is opened on the shell.

5. The ion source device according to claim 4, characterized in that: The ion source chamber also includes an injection assembly and a heating assembly arranged on the shell, and the discharge seat is located below the injection assembly.

6. The ion source device according to claim 4, characterized in that: A first sealing member is provided at a connection between the discharge seat and the shell, a connection between the shell and the interface assembly, and a connection between the interface assembly and the venturi seat.

7. The ion source device according to any one of claims 4 to 6, characterized in that: The interface component includes a connecting seat, a step seat and a metal cone, the connecting seat is connected to the shell, the step seat is arranged on the connecting seat, the metal cone is sleeved on the step seat and is located in the shell; an ion entrance hole is opened at the top of the metal cone, the step seat has a first through hole passing through both sides, the connecting seat has a second through hole passing through both sides, and the ion entrance hole, the first through hole and the second through hole are located on the same axis.

8. The ion source device according to claim 7, characterized in that: The ion source device also includes a fixed handle and a fixed seat, the fixed seat is arranged on the connecting seat, the fixed handle includes a connecting rod and a baffle, the connecting rod passes through the shell and is connected to the fixed seat, and the baffle abuts against the shell.

9. The ion source device according to claim 7, characterized in that: A second sealing member is provided at the connection between the connecting seat and the step seat.

10. The ion source device according to claim 1, characterized in that: The exhaust assembly further comprises an air intake pipe and an exhaust pipe, wherein the air intake pipe is connected to the air intake section, and the exhaust pipe is connected to the exhaust section.

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