An exhaust mechanism for a pharmacokinetic experiment liquid-mass spectrometer

Abstract

The utility model discloses an exhaust mechanism of a pharmacokinetic experiment liquid-mass spectrometer, including an exhaust gas tank; two circular holes are provided at the right end of the exhaust gas tank, the two circular holes are symmetrically distributed up and down, an exhaust pipe and an air inlet pipe are fixedly connected to the circular holes respectively, a conversion tube is provided at the right end of the exhaust pipe and the air inlet pipe, four evenly distributed arc-shaped card slots are provided on the outer arc surfaces of the exhaust pipe and the air inlet pipe, four arc-shaped card blocks corresponding to the arc-shaped card slots are provided on the inner side of the conversion tube, a cylindrical compression spring is provided between each arc-shaped card block and the inner side of the conversion tube, and one end of the cylindrical compression spring is fixedly connected to the inner wall of the conversion tube. The utility model can effectively prevent a small amount of liquid brought out by the mobile phase from accumulating and blocking the exhaust hole; when the exhaust is not smooth, the fault can be discovered and discharged in time; the gas flow rate can be controlled, the fixing and sealing effects are good, and the stability is high.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmacokinetic experiments, in particular to an exhaust mechanism of a pharmacokinetic experiment liquid-mass spectrometer. Background Art

[0002] Liquid Chromatograph Mass Spectrometer (LC-MS) is an instrument that combines liquid chromatography with mass spectrometry. It combines the ability of liquid chromatography to effectively separate thermally unstable and high-boiling point compounds with the strong component identification ability of mass spectrometer. It is an effective means of separating and analyzing complex organic mixtures.

[0003] During pharmacokinetic experiments, since the concentrations of many drugs in plasma are relatively low, a liquid chromatography-mass spectrometer with higher sensitivity and lower detection limit is often required. The exhaust device of the liquid chromatography-mass spectrometer currently used has the following defects:

[0004] 1. Since the waste gas tank of the liquid chromatography-mass spectrometer cannot be mixed with other non-inert gases, the liquid chromatography-mass spectrometer uses an input exhaust method. High-purity nitrogen is filled into the exhaust inlet to form air pressure and the waste gas is discharged, resulting in a huge waste of high-purity nitrogen and increasing the use of the instrument.

[0005] 2. Since the exhaust gas often contains a small amount of mobile phase liquid during the generation process, the liquid accumulates in the exhaust tank, which will cause poor exhaust at the exhaust port and seriously affect the use of the instrument.

[0006] 3. Since the liquid chromatography-mass spectrometer adopts an input-type exhaust method, the pressure display and control are at the gas input. Therefore, when the exhaust is not smooth, it is impossible to detect and eliminate the fault in time, resulting in the instrument not being able to be used normally.

[0007] 4. The sealing and fixing effects of the exhaust connection are poor, which can easily cause gas leakage, thereby causing environmental pollution and being detrimental to the stability of the exhaust process. For this reason, we propose an exhaust mechanism for a pharmacokinetic experimental LC-MS instrument. Utility Model Content

[0008] The technical problem to be solved by the utility model is to overcome the existing defects and provide an exhaust mechanism for a pharmacokinetic experimental liquid-mass spectrometer, which can effectively prevent the accumulation of a small amount of liquid brought out by the mobile phase and block the exhaust hole; when the exhaust is not smooth, the fault can be discovered and discharged in time; the gas flow rate can be controlled; the fixing and sealing effects are better, the stability and practicality are higher, and the problems in the background technology can be effectively solved.

[0009] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: an exhaust mechanism of a pharmacokinetic experiment liquid-mass spectrometer comprises an exhaust gas tank;

[0010] Two circular holes are provided at the right end of the exhaust gas tank, and the two circular holes are symmetrically distributed up and down. The circular holes are respectively fixedly connected with an exhaust pipe and an intake pipe. A conversion pipe is provided at the right end of each of the exhaust pipe and the intake pipe. Four evenly distributed arc-shaped grooves are provided on the outer arc surfaces of the exhaust pipe and the intake pipe. Four arc-shaped blocks corresponding to the arc-shaped grooves are provided on the inner side of the conversion pipe. A cylindrical compression spring is provided between each of the arc-shaped blocks and the inner side of the conversion pipe. One end of the cylindrical compression spring is fixedly connected to the inner wall of the conversion pipe, and the other end of the cylindrical compression spring is fixedly connected to the outer side of the arc-shaped block. The arc-shaped groove and the arc-shaped block are used in conjunction with each other. A connecting pipe 2 is fixedly connected to the right end of the upper conversion pipe, and a connecting pipe 1 is fixedly connected to the right end of the lower conversion pipe.

[0011] It also includes a controller, which is fixedly arranged on the top of the exhaust gas tank.

[0012] First, move the two conversion tubes toward the exhaust pipe and the intake pipe respectively. The edge of the arc-shaped block is subjected to extrusion force and then transmitted to the cylindrical compression spring. The cylindrical compression spring is compressed until the arc-shaped block is engaged with the arc-shaped groove. The cylindrical compression spring is reset, so that the conversion tubes can be fixed to the exhaust pipe and the intake pipe respectively, which can improve the stability during the exhaust process. The exhaust gas tank is used to receive the gas and transfer it. The top of the connecting pipe can be connected to the external pipeline, so that the gas enters the exhaust gas tank through the intake pipe and is discharged through the exhaust pipe.

[0013] Furthermore, a pressure alarm is fixedly provided in the middle of the connecting pipe, a pressure regulator is fixedly installed on the upper side of the pressure alarm, and the output end of the controller is electrically connected to the input end of the pressure alarm and the pressure regulator.

[0014] The pressure alarm consists of a pressure gauge, a GSM alarm host, a power adapter and a siren. Before exhausting, the pressure alarm and pressure regulator are activated by the controller. When the pressure during the exhaust process exceeds the set pressure range, the siren will sound an alarm. The GSM alarm host can send text messages or make phone calls to relevant staff to inform them of emergency situations in a timely manner.

[0015] Furthermore, a vacuum pump is provided on the right side of the pressure alarm, the air outlet of the connecting pipe 1 is connected to the air inlet of the vacuum pump, the air outlet of the vacuum pump is connected to the air inlet at the left end of the control valve, an adjusting component is provided inside the control valve, and the output end of the controller is electrically connected to the input end of the vacuum pump.

[0016] The vacuum pump is started through the controller. The vacuum pump generates suction and can extract the gas in the waste gas tank through the connecting pipe 1. This can effectively prevent the accumulation of a small amount of liquid brought out by the mobile phase and block the exhaust hole. When the exhaust is not smooth, the fault can be discovered and eliminated in time.

[0017] Furthermore, the adjustment component includes an arc-shaped sliding door, a fixed block, a connecting block and a hydraulic push rod. A circular hole is opened on the left end of the inner side of the control valve, and an arc-shaped semicircular groove is opened on the inner wall of the circular hole. The arc-shaped semicircular groove is slidably connected to the arc-shaped sliding door. Two symmetrically distributed fixed blocks are fixedly connected to the inner wall of the control valve near the arc-shaped sliding door. The rear sides of the two arc-shaped sliding doors are fixedly connected with connecting blocks. The fixed block and the connecting block are fixedly connected via a hydraulic push rod, and the output end of the controller is electrically connected to the hydraulic pump input end of the hydraulic push rod.

[0018] The controller can be used to control the hydraulic push rod to extend or shorten, thereby driving the arc sliding door to slide horizontally in the arc semicircular groove. While the arc sliding door slides, the distance between the two arc sliding doors can be changed, thereby controlling the flow rate of the gas, which is beneficial to exhaust stability.

[0019] Furthermore, a collecting bottle is provided at the right end of the control valve, and two holes are opened on the upper side of the collecting bottle. The hole on the left side is connected with the end of the guide tube one, and the air inlet at the left end of the guide tube one is connected with the air outlet at the right end of the control valve, and the hole on the right side is connected with the air inlet of the guide tube two, and the end air outlet of the guide tube two is connected to the external collector. A chemical filter is fixedly arranged on the outside of the guide tube two, and the output end of the controller is electrically connected to the input end of the chemical filter.

[0020] Before exhausting, the chemical filter is started by the controller, the gas enters the collection bottle through the guide tube 1, the liquid flows into the collection bottle, the gas passes through the chemical filter, which can filter out part of the residual liquid in the gas, and then flows into the external collector through the guide tube 2.

[0021] Furthermore, an air pressure regulator is fixedly arranged in the middle of the upper side of the exhaust gas tank, and the output end of the controller is electrically connected to the input end of the air pressure regulator.

[0022] The setting of the air pressure regulator can increase the air pressure in the exhaust gas tank while the vacuum pump is extracting gas, thereby maintaining the stability inside the exhaust gas tank and helping to increase the service life of the exhaust mechanism.

[0023] Compared with the prior art, the beneficial effects of the utility model are:

[0024] 1. First, move the two conversion tubes toward the exhaust pipe and the intake pipe respectively. The edge of the arc-shaped block is subjected to the extrusion force and then transmitted to the cylindrical compression spring. The cylindrical compression spring is compressed until the arc-shaped block is engaged with the arc-shaped slot. The cylindrical compression spring is reset, so that the conversion tubes can be fixed to the exhaust pipe and the intake pipe respectively, which can improve the stability during the exhaust process. The exhaust gas tank is used to receive the gas and transfer it. The top of the connecting pipe can be connected to the external pipeline so that the gas enters the exhaust gas tank through the intake pipe and is discharged through the exhaust pipe.

[0025] 2. Start the vacuum pump through the controller. The vacuum pump generates suction and can extract the gas in the waste gas tank through the connecting pipe. This can effectively prevent the accumulation of a small amount of liquid brought out by the mobile phase and block the exhaust hole. When the exhaust is not smooth, the fault can be discovered and eliminated in time.

[0026] 3. The controller can be used to control the extension or shortening of the hydraulic push rod, thereby driving the arc sliding door to slide horizontally in the arc semicircular groove. While the arc sliding door slides, the distance between the two arc sliding doors can be changed, thereby controlling the flow rate of the gas, which is beneficial to the stability of exhaust. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a schematic diagram of the structure of the utility model.

[0028] Figure 2 This is a schematic diagram of the interior of the structural conversion tube of the utility model.

[0029] Figure 3 This is a schematic diagram of the structural control valve of the utility model.

[0030] Figure 4 It is a schematic diagram of the structural adjustment component of the utility model.

[0031] In the figure: 1 exhaust gas tank, 2 exhaust pipe, 21 arc-shaped card slot, 3 intake pipe, 4 conversion pipe, 41 cylindrical compression spring, 42 arc-shaped card block, 5 connecting pipe 1, 6 connecting pipe 2, 7 pressure alarm, 8 pressure regulator, 9 vacuum pump, 10 control valve, 100 adjustment component, 101 arc-shaped sliding door, 102 fixing block, 103 connecting block, 104 hydraulic push rod, 11 collecting bottle, 12 guide pipe 1, 13 guide pipe 2, 14 chemical filter, 15 air pressure regulator, 16 controller. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0033] See also Figure 1-4 This embodiment provides a technical solution: an exhaust mechanism of a pharmacokinetic experiment liquid-mass spectrometer includes an exhaust gas tank 1; and also includes a controller 16, which is fixedly arranged on the top of the exhaust gas tank 1.

[0034] Among them, two circular holes are opened at the right end of the exhaust gas tank 1, and the two circular holes are symmetrically distributed up and down. The exhaust pipe 2 and the intake pipe 3 are fixedly connected at the circular holes respectively. The right ends of the exhaust pipe 2 and the intake pipe 3 are provided with a conversion pipe 4. The outer arc surfaces of the exhaust pipe 2 and the intake pipe 3 are opened with four evenly distributed arc grooves 21. The inner side of the conversion pipe 4 is provided with four arc blocks 42 corresponding to the arc grooves 21. A cylindrical compression spring 41 is provided between each arc block 42 and the inner side of the conversion pipe 4. One end of the cylindrical compression spring 41 is fixedly connected to the inner wall of the conversion pipe 4, and the other end of the cylindrical compression spring 41 is fixedly connected to the outer side of the arc block 42. The arc groove 21 and the arc block 42 are used together. The right end of the upper conversion pipe 4 is fixedly connected to the connecting pipe 2 6, and the right end of the lower conversion pipe 4 is fixedly connected to the connecting pipe 1 5.

[0035] First, move the two conversion tubes 4 toward the exhaust pipe 2 and the intake pipe 3 respectively. The edge of the arc-shaped block 42 is subjected to extrusion force and the force is transmitted to the cylindrical compression spring 41. The cylindrical compression spring 41 is compressed until the arc-shaped block 42 is engaged with the arc-shaped groove 21. The cylindrical compression spring 41 is reset, so that the conversion tube 4 can be fixed to the exhaust pipe 2 and the intake pipe 3 respectively, which can improve the stability of the exhaust process. The exhaust gas tank 1 is used to receive the gas and transfer it. The top of the connecting pipe 2 6 can be connected to the external pipeline, so that the gas enters the exhaust gas tank 1 through the intake pipe 3 and is discharged through the exhaust pipe 2.

[0036] Among them, a pressure alarm 7 is fixedly provided in the middle of the connecting pipe 15, a pressure regulator 8 is fixedly installed on the upper side of the pressure alarm 7, and the output end of the controller 16 is electrically connected to the input end of the pressure alarm 7 and the pressure regulator 8. The pressure alarm 7 is composed of a pressure gauge, a GSM alarm host, a power adapter and a siren. Before exhausting, the pressure alarm 7 and the pressure regulator 8 are started by the controller 16. When the pressure during the exhaust process exceeds the set pressure range, the siren will sound an alarm, and the GSM alarm host can send text messages or make calls to relevant staff to inform them of the emergency in time.

[0037] A vacuum pump 9 is provided on the right side of the pressure alarm 7, the air outlet of the connecting pipe 5 is connected to the air inlet of the vacuum pump 9, the air outlet of the vacuum pump 9 is connected to the air inlet at the left end of the control valve 10, an adjustment component 100 is provided inside the control valve 10, and the output end of the controller 16 is electrically connected to the input end of the vacuum pump 9. The vacuum pump 9 is started by the controller 16, and the vacuum pump 9 generates suction, which can extract the gas in the waste gas tank 1 through the connecting pipe 5, which can effectively prevent the accumulation of a small amount of liquid brought out by the mobile phase and block the exhaust hole. When the exhaust is not smooth, the fault can be discovered and eliminated in time.

[0038] The regulating assembly 100 includes an arc-shaped sliding door 101, a fixed block 102, a connecting block 103 and a hydraulic push rod 104. A circular hole is provided at the left end of the inner side of the control valve 10. An arc-shaped semicircular groove is provided on the inner wall of the circular hole. The arc-shaped semicircular groove is slidably connected to the arc-shaped sliding door 101. Two symmetrically distributed fixed blocks 102 are fixedly connected to the inner wall of the control valve 10 near the arc-shaped sliding door 101. The rear sides of the two arc-shaped sliding doors 101 are fixedly connected with connecting blocks 103. The fixed blocks 102 and the connecting blocks 103 are fixedly connected through the hydraulic push rod 104. The output end of the controller 16 is electrically connected to the hydraulic pump input end of the hydraulic push rod 104. The controller 16 can control the hydraulic push rod 104 to extend or shorten, thereby driving the arc-shaped sliding door 101 to slide horizontally in the arc-shaped semicircular groove. When the arc-shaped sliding door 101 slides, the distance between the two arc-shaped sliding doors 101 can be changed, thereby controlling the flow rate of the gas, which is conducive to stable exhaust.

[0039] A collecting bottle 11 is provided at the right end of the control valve 10. Two holes are provided on the upper side of the collecting bottle 11. The left hole is connected to the end of the guide tube 12. The air inlet at the left end of the guide tube 12 is connected to the air outlet at the right end of the control valve 10. The right side hole is connected to the air inlet of the guide tube 2 13. The air outlet at the end of the guide tube 2 13 is connected to an external collector. A chemical filter 14 is fixedly provided on the outside of the guide tube 2 13. The output end of the controller 16 is electrically connected to the input end of the chemical filter 14. Before exhausting, the chemical filter 14 is started by the controller 16, and the gas enters the collecting bottle 11 through the guide tube 12, and the liquid flows into the collecting bottle 11. The gas passes through the chemical filter 14, which can filter out a part of the residual liquid in the gas, and then flows into the external collector through the guide tube 2 13.

[0040] A gas pressure regulator 15 is fixedly arranged in the middle of the upper side of the exhaust gas tank 1, and the output end of the controller 16 is electrically connected to the input end of the gas pressure regulator 15. The arrangement of the gas pressure regulator 15 can increase the gas pressure of the exhaust gas tank 1 while the vacuum pump 9 extracts gas, maintain the stability of the inside of the exhaust gas tank 1, and is conducive to improving the service life of the exhaust mechanism.

[0041] The working principle of the utility model is as follows:

[0042] First, the two conversion tubes 4 are moved toward the exhaust pipe 2 and the intake pipe 3 respectively. The edge of the arc-shaped clamping block 42 is subjected to the extrusion force and then transmitted to the cylindrical compression spring 41. The cylindrical compression spring 41 is compressed until the arc-shaped clamping block 42 is clamped with the arc-shaped clamping groove 21. The cylindrical compression spring 41 is reset, so that the conversion tube 4 can be fixed to the exhaust pipe 2 and the intake pipe 3 respectively, which can improve the stability during the exhaust process. The exhaust tank 1 is used to receive and transfer the gas. The top of the connecting pipe 2 6 can be connected to the external pipeline, so that the gas enters the exhaust tank 1 through the intake pipe 3 and is then discharged through the exhaust pipe 2;

[0043] The pressure alarm 7, the pressure regulator 8 and the chemical filter 14 are started by the controller 16. The pressure alarm 7 is composed of a pressure gauge, a GSM alarm host, a power adapter and a siren. Before exhaust, when the pressure in the exhaust process exceeds the set pressure range, the siren will sound an alarm. The GSM alarm host can send a text message or make a phone call to the relevant staff to inform them of the emergency in time. The vacuum pump 9 is started by the controller 16. The vacuum pump 9 generates suction and can extract the gas in the waste gas tank 1 through the connecting pipe 5, which can effectively prevent the accumulation of a small amount of liquid brought by the mobile phase from clogging the exhaust hole. When the exhaust is not smooth, the fault can be discovered and eliminated in time;

[0044] The controller 16 can control the hydraulic push rod 104 to extend or shorten, thereby driving the arc-shaped sliding door 101 to slide horizontally in the arc-shaped semicircular groove. When the arc-shaped sliding door 101 slides, the distance between the two arc-shaped sliding doors 101 can be changed, thereby controlling the flow rate of the gas, which is conducive to stable exhaust.

[0045] The gas enters the collecting bottle 11 through the guide tube 12, and the liquid flows into the collecting bottle 11. The gas passes through the chemical filter 14 to filter out a part of the residual liquid in the gas, and then flows into the external collector through the guide tube 2 13. The setting of the air pressure regulator 15 can increase the air pressure of the waste gas tank 1 while the vacuum pump 9 extracts the gas, thereby maintaining the stability of the inside of the waste gas tank 1 and helping to increase the service life of the exhaust mechanism.

[0046] The above are only embodiments of the present invention, and are not intended to limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. An exhaust mechanism for a pharmacokinetic experiment liquid-mass spectrometer, characterized in that: including an exhaust gas tank (1); The exhaust gas tank (1) has two circular holes at its right end, the two circular holes are symmetrically distributed up and down, the exhaust pipe (2) and the intake pipe (3) are fixedly connected to the circular holes respectively, the exhaust pipe (2) and the intake pipe (3) are both provided with a conversion pipe (4) at their right ends, the outer arc surfaces of the exhaust pipe (2) and the intake pipe (3) are both provided with four evenly distributed arc-shaped grooves (21), the inner side of the conversion pipe (4) is provided with four arc-shaped blocks (42) corresponding to the arc-shaped grooves (21), each of the arc-shaped grooves (21) is provided with a plurality of arc-shaped blocks (42) corresponding to the arc-shaped grooves (21), and the arc-shaped grooves (21) are each provided with a plurality of arc-shaped blocks (42) corresponding to the arc-shaped grooves (21). A cylindrical compression spring (41) is provided between the arc-shaped clamping block (42) and the inner side of the conversion tube (4); one end of the cylindrical compression spring (41) is fixedly connected to the inner wall of the conversion tube (4); the other end of the cylindrical compression spring (41) is fixedly connected to the outer side of the arc-shaped clamping block (42); the arc-shaped clamping groove (21) and the arc-shaped clamping block (42) are used in conjunction with each other; the right end of the upper conversion tube (4) is fixedly connected to a second connecting tube (6); and the right end of the lower conversion tube (4) is fixedly connected to a first connecting tube (5); It also includes a controller (16), which is fixedly arranged on the top of the exhaust gas tank (1).

2. The exhaust mechanism of a pharmacokinetic experiment liquid spectrometer according to claim 1, characterized in that: A pressure alarm (7) is fixedly provided in the middle of the connecting pipe (5), a pressure regulator (8) is fixedly installed on the upper side of the pressure alarm (7), and the output end of the controller (16) is electrically connected to the input ends of the pressure alarm (7) and the pressure regulator (8).

3. The exhaust mechanism of a pharmacokinetic experiment liquid spectrometer according to claim 2, characterized in that: A vacuum pump (9) is provided on the right side of the pressure alarm (7); the air outlet of the connecting pipe (5) is connected to the air inlet of the vacuum pump (9); the air outlet of the vacuum pump (9) is connected to the air inlet at the left end of the control valve (10); an adjusting component (100) is provided inside the control valve (10); and the output end of the controller (16) is electrically connected to the input end of the vacuum pump (9).

4. The exhaust mechanism of a pharmacokinetic experiment liquid spectrometer according to claim 3, characterized in that: The regulating assembly (100) comprises an arc-shaped sliding door (101), a fixed block (102), a connecting block (103) and a hydraulic push rod (104); a circular hole is opened on the inner side of the control valve (10) at the left end; an arc-shaped semicircular groove is opened on the inner wall of the circular hole; the arc-shaped semicircular groove is slidably connected to the arc-shaped sliding door (101); two symmetrically distributed fixed blocks (102) are fixedly connected to the inner wall of the control valve (10) near the arc-shaped sliding door (101); the rear sides of the two arc-shaped sliding doors (101) are fixedly connected with connecting blocks (103); the fixed blocks (102) and the connecting blocks (103) are fixedly connected via the hydraulic push rod (104); and the output end of the controller (16) is electrically connected to the hydraulic pump input end of the hydraulic push rod (104).

5. The exhaust mechanism of a pharmacokinetic experiment liquid spectrometer according to claim 3, characterized in that: A collecting bottle (11) is provided at the right end of the control valve (10), and two holes are provided on the upper side of the collecting bottle (11), the left hole being connected to the end of the guide tube 1 (12), the air inlet at the left end of the guide tube 1 (12) being connected to the air outlet at the right end of the control valve (10), and the right hole being connected to the air inlet of the guide tube 2 (13), the end air outlet of the guide tube 2 (13) being connected to an external collector, a chemical filter (14) being fixedly provided on the outside of the guide tube 2 (13), and the output end of the controller (16) being electrically connected to the input end of the chemical filter (14).

6. The exhaust mechanism of a pharmacokinetic experiment liquid spectrometer according to claim 1, characterized in that: An air pressure regulator (15) is fixedly arranged in the middle of the upper side of the exhaust gas tank (1), and the output end of the controller (16) is electrically connected to the input end of the air pressure regulator (15).

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