Detection device capable of simultaneously detecting various types of body fluid samples of human body

Abstract

The utility model provides a detection device capable of simultaneously detecting various types of body fluid specimens of a human body, which relates to the technical field of medical detection and comprises a box body, a shell is arranged at the central position of the box body, a mass spectrometer is mounted on one side of the shell, a movable cavity is formed in the shell, a sample plate is arranged in the movable cavity and movably connected with the shell, and the mass spectrometer is mounted on one side of the shell. A turnover cover is hinged to the top surface of the shell, reagent boxes are arranged on the other side of the shell, hoses are connected to interfaces of the reagent boxes and the mass spectrometer, an electric push rod is arranged in the movable cavity, a rotating plate is connected to the bottom of the electric push rod, and a corresponding liquid sample on the sample disc can be rotated to a specified position in a mode that the sample disc ascends, descends and is matched with rotation. Specific reagents are added to different liquid samples according to detected items, finally, the sample disc continuously rotates, the samples and the reagents can be repeatedly mixed and wait for being extracted and detected, manual pretreatment of the samples is not needed, manual operation is facilitated, and automatic extraction and detection are achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical detection, in particular to a detection device capable of simultaneously detecting various types of body fluid specimens of the human body. Background Art

[0002] Human pterin compounds are alkaline substances, including neopterin, biopterin, xanthopterin, etc., which are mainly present in various body fluids of the human body. Among them, neopterin and biopterin are metabolites of guanosine triphosphate in the body and are used for auxiliary diagnosis of various diseases. They are also related to the metabolism of phenylalanine, tryptophan and tyrosine in the body. BP deficiency can cause phenylalanine metabolism disorders and changes in neurotransmitters. Especially in the identification of the typing of neonatal genetic metabolic disease hyperphenylalaninemia, the pterin content in urine plays a key role. In addition, the pterin spectrum results in the amniotic fluid of pregnant women are also of great value for the prenatal diagnosis of certain genetic metabolic diseases.

[0003] According to the patent publication number CN218819522U, a portable mass spectrometer relates to the technical field of portable mass spectrometers. In order to solve the problem that the control panels of existing portable mass spectrometers all rely on U-shaped brackets to tilt one end of the control panel, and the tilt angle is limited, when the height difference between the portable mass spectrometer and the personnel is large, the personnel need to squat to operate the control panel, which causes inconvenience for the personnel to use. A control panel is arranged at the front end of the mass spectrometer body, a display screen assembly is arranged on the front surface of the control panel, and a button assembly is arranged on one side of the display screen assembly; it also includes: a rotating shaft connecting seat, which is arranged at the front end surface of the mass spectrometer body, and the rotating shaft connecting seat and the mass spectrometer body are an integrated structure, and a screen rolling shaft is arranged inside the rotating shaft connecting seat; a rotating shaft end seat, which is arranged at both ends of the control panel, and the rotating shaft end seat and the control panel are an integrated structure, and a rotating groove is arranged between the two rotating shaft end seats.

[0004] The above introduces pterin, creatinine and mass spectrometry detection. The existing pterin and creatinine detection methods generally use mass spectrometry to detect pterin spectrum and then use biochemical methods to detect creatinine. The operation is relatively complicated and different tests cannot be performed on different liquid specimens in the same detection device, resulting in low detection efficiency. Utility Model Content

[0005] The purpose of the utility model is to solve the technical problem that different liquid specimens cannot be tested in the same testing device in the prior art, and the testing efficiency is low, and to propose a testing device that can simultaneously test multiple types of body fluid specimens of the human body.

[0006] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a detection device that can simultaneously detect various types of body fluid specimens of the human body, comprising a box body, a shell is provided at the center of the box body, a mass spectrometer is installed on one side of the shell, an active cavity is opened inside the shell, a sample tray is provided in the active cavity, and the sample tray is movably connected to the shell, a flip cover is hinged on the top surface of the shell, a reagent box is provided on the other side of the shell, a hose is connected to the interface of the reagent box and the mass spectrometer, an electric push rod is provided in the active cavity, and a rotating plate is connected to the bottom of the electric push rod.

[0007] Preferably, the internal screws of the box body are fixed with a limit seat, and the mass spectrometer and the reagent box are both engaged with the mounting grooves of the limit seat, and the shell is located on the top surface of the limit seat on both sides of the bottom, and the shell is bolted to the top surface of the limit seat.

[0008] Preferably, a magnetic ring is connected to the surface of one end of the hose, and the magnetic ring is magnetically attracted to the top surface of the flip cover.

[0009] Preferably, the top of the flip cover is penetrated by an extraction hole and a reagent hole, respectively, and the hoses are connected to the corresponding extraction hole and reagent hole, respectively.

[0010] Preferably, the surface of the sample tray and the inner wall of the shell are provided with scale lines in a circumferential array, and the top surface of the sample tray is provided with placement grooves in a circumferential array.

[0011] Preferably, the telescopic end of the electric push rod is connected to the bottom surface of the sample tray, and the rotating plate is fixed to the electric push rod, and the rotating ends of the rotating plate are both rotatably connected to the connection between the shell and the box body.

[0012] Preferably, a driving member is connected to the bottom of the shell, and gears are fixed to the rotating ends of the driving member and the rotating plate respectively, and the two gears are meshed with each other.

[0013] Beneficial Effects

[0014] In the utility model, the sample plate is lifted and rotated in coordination so that the corresponding liquid specimen on the sample plate can be rotated to a specified position, and specific reagents can be added to different liquid samples according to the items to be tested. Finally, the sample plate is continuously rotated so that the sample and the reagent can be repeatedly mixed, waiting to be extracted and tested. There is no need for personnel to manually pre-treat the sample, which is convenient for personnel to operate and realizes automated extraction and testing. At the same time, multiple test samples are placed in the same box, and the mass spectrometry method can be used to simultaneously detect the values ​​of pterin and creatinine in multiple body fluid samples, which is convenient and fast, and improves the efficiency of detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is an axonometric drawing of the utility model;

[0016] Figure 2It is a three-dimensional diagram of the utility model;

[0017] Figure 3 It is a cross-sectional view of the utility model;

[0018] Figure 4 It is a front view of the utility model.

[0019] Legend:

[0020] 1. Box body; 2. Mass spectrometer; 3. Shell; 4. Sample tray; 5. Flip cover; 6. Reagent box; 7. Reagent hole; 8. Extraction hole; 9. Hose; 10. Electric push rod; 11. Turn plate; 12. Gear; 13. Driving part; 14. Limit seat; 15. Movable cavity; 16. Scale line; 17. Magnetic ring. DETAILED DESCRIPTION

[0021] In order to make the technical means, creative features, objectives and effects of the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments and drawings, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without creative work are all within the protection scope of the present invention.

[0022] The specific embodiments of the present utility model are described below in conjunction with the accompanying drawings. Specific embodiment:

[0024] Embodiment 1:

[0025] Reference Figure 1-4, a detection device capable of simultaneously detecting various types of body fluid specimens of the human body, comprising a box body 1, a shell 3 is provided at the center of the box body 1, a mass spectrometer 2 is installed on one side of the shell 3, the box body 1 is the outer shell of the entire detection device, it is necessary to explain that the detection device is used for detecting pterin and creatinine, and is mainly used for genetic metabolic diseases related to mass spectrometry detection, and the project is pterin substances in the human body, and can also be used for other types of detection projects, wherein the mass spectrometer 2 inside the box body 1 is an instrument for detecting liquid samples, and pterin or creatinine in the liquid sample is detected by mass spectrometry to obtain the result, and the mass spectrometer 2 is a prior art that has been published in patent number CN21 The document 3752623U describes its principles and other parts. A sample tray 4 is provided inside the shell 3. The shell 3 is the outer shell of the sample tray 4 and is located in the box body 1. The mass spectrometer 2 is also located in the box body 1. Under normal circumstances, it is directly connected to the shell 3, so that multiple components are integrated on the box body 1, thereby forming a detection device that can detect liquid specimens. During the detection, liquid specimens of the human body need to be collected in advance, where the specimens include but are not limited to urine specimens and amniotic fluid specimens of pregnant women. The liquid specimens are loaded into designated sample tubes and placed into the through holes on the sample tray 4, and wait for the designated reagents to be added for sufficient mixing, and the liquid samples are extracted into the mass spectrometer 2 for detection in turn.

[0026] The surface of the sample tray 4 and the inner wall of the shell 3 are both provided with scale lines 16 in a circumferential array, and the top surface of the sample tray 4 is provided with placement grooves in a circumferential array. It is further explained that after the sample tube is placed in the sample tray 4, the position of the sample tray 4 is adjusted so that the scale lines 16 on the sample tray 4 are aligned with the scale lines 16 on the inner wall of the shell 3, ensuring that the subsequent designated reagents and sample extraction can proceed normally.

[0027] An active cavity 15 is provided inside the shell 3, and a sample tray 4 is provided inside the active cavity 15, and the sample tray 4 is movably connected to the shell 3. The sample tray 4 is located in the active cavity 15 inside the shell 3, and the sample tray 4 can be lifted and rotated in the active cavity 15. The flip cover 5 can be opened or closed. After closing, the extraction tube on the mass spectrometer 2 and the addition tube on the reagent box 6 are respectively connected to the extraction hole 8 and the reagent hole 7 on the flip cover 5. The sample tray 4 rotates and cooperates with the lifting method to rotate different liquid specimen tubes to the specified position for adding or extracting specific reagents. The top surface of the shell 3 is hinged with a flip cover 5, and the other side of the shell 3 is respectively provided with a reagent box 6. It is further explained that the reagent box 6 stores specific reagents for pterin and creatinine. The reagent box 6 has two groups of different reagents, and a pump can be added to the reagent box 6 to extract the reagent into the reagent tube and add it to the corresponding liquid sample tube.

[0028] Embodiment 2:

[0029] Reference Figure 1-4, the interfaces of the reagent box 6 and the mass spectrometer 2 are both connected with a hose 9, and a magnetic ring 17 is connected to the surface of one end of the hose 9, and the magnetic ring 17 is magnetically attracted to the top surface of the flip cover 5, and the top of the flip cover 5 is respectively penetrated with an extraction hole 8 and a reagent hole 7, and the hose 9 is respectively connected to the corresponding extraction hole 8 and reagent hole 7. Further explanation, the extraction tube and the reagent tube are both hoses 9, wherein one end of the hose 9 is a magnetic ring 17. During detection, the hose 9 is inserted into the corresponding through hole until the magnetic ring 17 and the top surface of the flip cover 5 are magnetically limited. The placement slots on each sample disk 4 are numbered. For example, the samples at numbers 1, 3, 5, and 7 need to be tested for pterin, and the samples at numbers 2, 4, 6, and 8 need to be tested for creatinine values. At this time, the samples for pterin detection and creatinine detection need to be rotated to the corresponding reagent hole 7 positions in turn, and the sample disk 4 is rotated after adding a specific reagent to repeatedly mix the reagent and the sample. After the mixing is completed, the sample disk 4 is rotated and then lifted to move the samples at 1-8 The sample tray 4 is rotated to the position of the extraction tube in turn, and samples at different heights in the sample tube can be extracted for detection by controlling the lifting of the sample tray 4, thereby realizing the detection of pterin and creatinine. The samples can be selected to be the same or different according to needs. For example, every two groups of samples are the same sample, such as 1-2 are the same sample. Different reagents are added to the 1-2 samples and mixed, and then the pterin spectrum and creatinine value in the sample can be detected by mass spectrometry. The pterin value is compared with the creatinine value and the ratio is calculated. This ratio is then used as the final report result. This approach can help reduce the impact of factors such as the diet of the subject to be tested on the test results, and improve the accuracy and reliability of the test. Under normal circumstances, the ratio of pterin to creatinine will be more stable in urine or amniotic fluid, so it can better reflect the physiological state of the subject to be tested. Similarly, the samples can also be different samples. According to the needs of the test, specific reagents are added to detect the pterin or creatinine values ​​in turn, and the flexibility of the equipment is higher.

[0030] Embodiment three:

[0031] Reference Figure 1-4 The internal screws of the box body 1 are fixed with a limit seat 14, and the mass spectrometer 2 and the reagent box 6 are both engaged with the mounting grooves of the limit seat 14, and the shell 3 is located on the top surfaces of the limit seats 14 on both sides of the bottom, and the shell 3 is bolted to the top surfaces of the limit seats 14, and the limit seat 14 is U-shaped, wherein the position of the U-shaped groove is used to limit the engagement of the box body 1 and the reagent box 6, and to support and connect the shell 3.

[0032] Embodiment 4:

[0033] Reference Figure 1-4, an electric push rod 10 is arranged in the movable cavity 15, the telescopic end of the electric push rod 10 is connected to the bottom surface of the sample tray 4, and the rotating plate 11 is fixed to the electric push rod 10, and the rotating end of the rotating plate 11 is rotatably connected to the connection between the shell 3 and the box body 1, the bottom of the electric push rod 10 is connected to the rotating plate 11, the sample tray 4 is lifted and lowered by the electric push rod 10, and the electric push rod 10 is electrically driven to lift and lower the moving end to complete the lifting and lowering of the sample tray 4, the electric push rod 10 is rotatably connected to the connection between the shell 3 and the box body 1 by the rotating plate 11, the bottom of the shell 3 is connected to a driving member 13, and the driving member 13 and the rotating end of the rotating plate 11 are respectively fixed. A gear 12 is fixed, and the two gears 12 are meshed with each other. A driving member 13 is added. The driving member 13 is a driving motor. Gears 12 are provided on the rotating ends of the driving member 13 and the rotating plate 11. The two gears 12 are meshed with each other. The driving member 13 can rotate the rotating plate 11 together with the electric push rod 10 and the sample disk 4 to complete the mixing of the reagents. Since the extraction end of the extraction tube is to be inserted into the sample tube, the sample disk 4 is located in the lower part of the active cavity 15 before the extraction test. After waiting for the mixing to be completed, the required sample is rotated to the position of the extraction tube, and the sample disk 4 is made to be inserted into the sample tube at a suitable height to wait for the extraction test.

[0034] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0035] The above shows and describes the basic principle, main features and advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the utility model and are not used to limit the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection of the utility model is defined by the attached claims and their equivalents.

Claims

1. A detection device capable of simultaneously detecting multiple types of body fluid samples of a human body, comprising a box body (1), characterized in that: A shell (3) is provided at the center of the box body (1), a mass spectrometer (2) is installed on one side of the shell (3), an active cavity (15) is provided inside the shell (3), a sample tray (4) is provided inside the active cavity (15), and the sample tray (4) is movably connected to the shell (3), a flip cover (5) is hingedly connected to the top surface of the shell (3), a reagent box (6) is provided on the other side of the shell (3), the interfaces of the reagent box (6) and the mass spectrometer (2) are both connected to a hose (9), an electric push rod (10) is provided inside the active cavity (15), and a rotating plate (11) is connected to the bottom of the electric push rod (10).

2. A detection device capable of simultaneously detecting multiple types of body fluid specimens of the human body according to claim 1, characterized in that: The box body (1) is internally screwed to fix the limit seat (14), and the mass spectrometer (2) and the reagent box (6) are both engaged with the mounting grooves of the limit seat (14), and the shell (3) is located on the top surfaces of the limit seat (14) on both sides of the bottom, and the shell (3) is bolted to the top surfaces of the limit seat (14).

3. The detection device capable of simultaneously detecting multiple types of body fluid specimens of the human body according to claim 1, characterized in that: A magnetic attraction ring (17) is connected to one end surface of the hose (9), and the magnetic attraction ring (17) is magnetically attracted to the top surface of the flip cover (5).

4. The detection device capable of simultaneously detecting multiple types of body fluid specimens of the human body according to claim 1, characterized in that: The top of the flip cover (5) is respectively penetrated by an extraction hole (8) and a reagent hole (7), and the hose (9) is respectively connected to the corresponding extraction hole (8) and reagent hole (7).

5. The detection device capable of simultaneously detecting multiple types of body fluid specimens of the human body according to claim 1, characterized in that: The surface of the sample plate (4) and the inner wall of the shell (3) are both provided with scale lines (16) in a circumferential array, and the top surface of the sample plate (4) is provided with placement grooves in a circumferential array.

6. The detection device capable of simultaneously detecting multiple types of body fluid specimens of the human body according to claim 1, characterized in that: The telescopic end of the electric push rod (10) is connected to the bottom surface of the sample tray (4), and the rotating plate (11) is fixed to the electric push rod (10), and the rotating end of the rotating plate (11) is rotatably connected to the connection between the shell (3) and the box body (1).

7. A detection device capable of simultaneously detecting multiple types of body fluid specimens of the human body according to claim 6, characterized in that: The bottom of the housing (3) is connected to a driving member (13), and gears (12) are fixed to the rotating ends of the driving member (13) and the rotating plate (11), respectively, and the two gears (12) are meshed with each other.

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