Vacuum mixing equipment for producing hydrocortisone acetate

Abstract

The utility model belongs to the technical field of vacuum mixing, and particularly relates to vacuum mixing equipment for producing hydrocortisone acetate, which comprises a bottom plate and a locking plate ring, a back plate is vertically arranged on the rear side of the top of the bottom plate, a mixing barrel is placed on the upper surface of the bottom plate, the inside of the mixing barrel is hollow, and the top of the mixing barrel is open. An inner supporting table is arranged on the upper portion of the interior of the mixing barrel, a sliding groove is vertically formed in the upper portion of the surface of the back plate, a hydraulic cylinder is fixed to the top of the back plate, a sliding block is slidably installed in the sliding groove, and a lower boss is arranged below a top cover of the mixing barrel and can enter the mixing barrel during sealing. And meanwhile, in the downward moving process of the top cover, multiple sliding bolts can be extruded at the same time, so that the sliding bolts move upwards, then multiple movable plates are extruded at the same time, the movable plates rotate, then a pressing ring is pressed downwards, and a sealing rubber ring can be extruded through an arc face at the bottom of the pressing ring, so that the sealing rubber ring deforms outwards.

Description

Technical Field

[0001] The utility model belongs to the technical field of vacuum mixing, and in particular relates to vacuum mixing equipment used for producing fludrocortisone acetate. Background Art

[0002] Fludrocortisone acetate tablets are used to treat salt-losing congenital adrenal hypersensitivity and salt-losing chronic adrenal insufficiency (Addison's disease). They are mainly prepared from fludrocortisone acetate, lactose, disintegrants, glidants and lubricants. Fludrocortisone acetate can be made into fludrocortisone acetate tablets for oral administration and fludrocortisone acetate ointment for external application.

[0003] Since fludrocortisone acetate is sensitive to temperature, humidity, air oxidation, light and other environmental factors, vacuum constant temperature mixing equipment is often used in the preparation and mixing to prevent the agent from reacting with oxygen in the air during the mixing process. The so-called vacuum mixing equipment is to evacuate the inside of the mixing barrel to form a vacuum inside the mixing barrel. However, in order to facilitate loading and unloading, there must be an opening on the surface of the mixing barrel, which requires the opening to be sealed before vacuuming. If the seal is tight, air leakage will occur, affecting the mixing of the internal agents. Most of the existing equipment achieves sealing by relative extrusion. If the size is closely matched, scratches will occur during relative movement, and surface scratches will also affect the sealing. Utility Model Content

[0004] In view of the problems existing in the prior art, the purpose of the utility model is to provide a vacuum mixing device for the production of fludrocortisone acetate, which can effectively seal the open mouth of the mixing barrel, prevent air leakage, and improve the overall sealing of the mixing barrel.

[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0006] A vacuum mixing device for producing fludrocortisone acetate comprises a bottom plate and a locking plate ring, wherein a back plate is vertically arranged on the rear side of the top of the bottom plate, a mixing barrel is placed on the upper surface of the bottom plate, the interior of the mixing barrel is hollow and the top is open, an inner support platform is arranged above the interior of the mixing barrel, a slide groove is vertically arranged above the surface of the back plate, a hydraulic cylinder is fixed on the top of the back plate, a slider is slidably installed inside the slide groove, an output end of the hydraulic cylinder is fixed on the upper surface of the slider, a mounting plate is arranged on the front side of the slider, the mounting plate is placed outside the slide groove, a top cover is fixed on the bottom of the mounting plate, the top cover is placed above the mixing barrel, a lower boss is arranged on the lower surface of the top cover, the lower boss is matched with the opening at the top of the mixing barrel, the lower surface of the lower boss is in contact with the upper surface of the inner support platform, a mounting concave ring is arranged on the surface of the lower boss, a sealing rubber ring is arranged on the inner side of the mounting concave ring, the sealing rubber ring exceeds the outer surface of the lower boss, a pressure ring is vertically slidably installed inside the lower boss, the bottom of the pressure ring is arranged as an arc surface, and the pressure ring is placed above the inner side of the sealing rubber ring.

[0007] Furthermore, a mounting cavity is provided inside the lower boss, and the mounting cavity is placed above the pressure ring.

[0008] Furthermore, an arc-shaped convex strip is arranged on the upper surface of the pressure ring, and movable plates are evenly installed on the upper part of the installation cavity through a pin shaft, and the lower surfaces of one end of a plurality of movable plates are in contact with the arc-shaped convex strip.

[0009] Furthermore, sliding bolts are evenly and slidably installed on the lower surface of the top cover, and a plurality of the sliding bolts are placed outside the lower boss, and the tops of the sliding bolts are in contact with the lower surface of the movable plate on the side away from the arc-shaped convex strip.

[0010] Furthermore, a limit plate is provided on the surface of the sliding bolt, and the limit plate is placed below the interior of the installation cavity.

[0011] Furthermore, a fixing seat is arranged on the front side of the back plate, the back of the mixing barrel is in contact with the fixing seat, the locking plate ring is placed on the front side of the mixing barrel, and locking bolts are screwed on both ends of the locking plate ring and the fixing seat.

[0012] Furthermore, a vacuum butt joint is provided on the surface of the mixing barrel, and the vacuum butt joint is connected to a vacuum pump.

[0013] Furthermore, a motor is fixed at the top center of the mounting plate, and the output shaft of the motor passes through the mounting plate, the top cover, and the lower boss from top to bottom, and a stirring rod is connected to the bottom of the mounting recessed ring.

[0014] Compared with the prior art, the utility model has the following beneficial effects: a lower boss is provided under the top cover of the mixing barrel, and the lower boss will enter into the interior of the mixing barrel during sealing, and in the process of the top cover moving downward, multiple sliding bolts will be squeezed at the same time, so that the sliding bolts move upward, and then the multiple movable plates will be squeezed at the same time, so that the movable plates will rotate, and then the pressure ring will be pressed down, and the sealing rubber ring can be squeezed through the arc surface at the bottom of the pressure ring, so that the sealing rubber ring is deformed outward, and then the contact strength between the sealing rubber ring and the inner wall of the mixing barrel is increased, thereby increasing the sealing performance and preventing air leakage. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0016] Figure 2 It is a schematic diagram of the cross-sectional structure of the mounting plate and the top cover of the utility model;

[0017] Figure 3 For the utility model Figure 2 A schematic diagram of the enlarged structure of area A;

[0018] Figure 4 It is a schematic diagram of the three-dimensional structure of the cross section of the pressure ring of the present utility model.

[0019] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0020] 1. Bottom plate; 2. Back plate; 3. Mixing barrel; 31. Vacuum butt joint; 32. Inner support platform; 4. Fixed seat; 5. Locking plate ring; 6. Locking bolt; 7. Slide groove; 8. Slider; 9. Hydraulic cylinder; 10. Mounting plate; 11. Top cover; 111. Lower boss; 12. Mounting concave ring; 13. Motor; 14. Stirring rod; 15. Sealing rubber ring; 16. Pressure ring; 161. Arc convex strip; 17. Mounting cavity; 18. Movable plate; 19. Sliding bolt; 20. Limit plate. DETAILED DESCRIPTION

[0021] In order to make the purpose and advantages of the utility model more clear, the utility model is specifically described in combination with the following embodiments. It should be understood that the following text is only used to describe one or several specific implementations of the utility model, and does not strictly limit the protection scope of the specific request of the utility model.

[0022] Please refer to Figure 1-Figure 4 As shown, a vacuum mixing device for fludrocortisone acetate production,

[0023] It includes a bottom plate 1 and a locking plate ring 5. Rollers can be arranged under the bottom plate 1 to facilitate the movement of the entire device. A back plate 2 is vertically arranged on the rear side of the top of the bottom plate 1. A mixing barrel 3 is placed on the upper surface of the bottom plate 1. The mixing barrel 3 is hollow inside and the top is open. An inner support platform 32 is arranged above the inside of the mixing barrel 3. A slide groove 7 is vertically opened above the surface of the back plate 2. A hydraulic cylinder 9 is fixed on the top of the back plate 2. A slider 8 is slidably installed inside the slide groove 7. The output end of the hydraulic cylinder 9 is fixed on the upper surface of the slider 8. A mounting plate 10 is arranged on the front side of the slider 8. Through the hydraulic cylinder 9 The sliding block 8 is controlled to move up and down, and then the mounting plate 10 is controlled to move up and down. The mounting plate 10 is placed outside the slide groove 7. A top cover 11 is fixed to the bottom of the mounting plate 10. The top cover 11 is placed above the mixing barrel 3. The top opening of the mixing barrel 3 is sealed by the top cover 11. A lower boss 111 is provided on the lower surface of the top cover 11. The lower boss 111 is matched with the top opening of the mixing barrel 3. The lower surface of the lower boss 111 is in contact with the upper surface of the inner support platform 32. In order to facilitate docking, the size of the lower boss 111 is slightly smaller than the internal size of the mixing barrel 3.

[0024] Among them, a vacuum docking tube 31 is provided on the surface of the mixing barrel 3, and the vacuum docking tube 31 is connected to the vacuum pump to facilitate vacuuming the interior after sealing. A motor 13 is fixed to the top center of the mounting plate 10, and the output shaft of the motor 13 penetrates the mounting plate 10, the top cover 11, and the lower boss 111 from top to bottom. A stirring rod 14 is connected to the bottom of the mounting recessed ring 12, and the stirring rod 14 can be driven to rotate by the motor 13 to stir the raw materials inside the mixing barrel 3.

[0025] Please refer to Figure 2 and Figure 3 As shown, a mounting recessed ring 12 is provided on the surface of the lower boss 111, and a sealing rubber ring 15 is installed on the inner side of the mounting recessed ring 12. The sealing rubber ring 15 exceeds the outer surface of the lower boss 111. After sealing, the lower boss 111 is placed inside the mixing barrel 3. At this time, the sealing rubber ring 15 is slightly in contact with the inner wall of the mixing barrel 3. A pressing ring 16 is vertically slidably installed inside the lower boss 111. The bottom of the pressing ring 16 is set as an arc surface. The pressing ring 16 is placed above the inner side of the sealing rubber ring 15. When the pressing ring 16 moves downward, the sealing rubber ring 15 can be squeezed to deform outward, thereby increasing the contact strength between the sealing rubber ring 15 and the inner wall of the mixing barrel 3 and improving the sealing performance. At the same time, the lower boss 111 does not contact the inner wall of the mixing barrel 3 to prevent scratches.

[0026] Among them, an installation cavity 17 is opened inside the lower boss 111, and the installation cavity 17 is placed above the pressure ring 16. An arc-shaped convex strip 161 is arranged on the upper surface of the pressure ring 16. A movable plate 18 is evenly installed on the upper part of the installation cavity 17 through a pin shaft. The lower surfaces of one end of multiple movable plates 18 are in contact with the arc-shaped convex strip 161. When the end of the movable plate 18 close to the motor 13 is tilted downward, the pressure ring 16 can be squeezed to move downward.

[0027] Please refer to Figure 3 As shown, a slide bolt 19 is evenly and slidably installed on the lower surface of the top cover 11, and multiple slide bolts 19 are placed on the outside of the lower boss 111. The top of the slide bolt 19 contacts the lower surface of the movable plate 18 on the side away from the arc-shaped convex strip 161. When the top cover 11 is installed in place, multiple slide bolts 19 can be squeezed at the same time to make the movable plate 18 tilt. A limit plate 20 is provided on the surface of the slide bolt 19, and the limit plate 20 is placed at the bottom of the installation cavity 17 to prevent the slide bolt 19 from falling.

[0028] Please refer to Figure 1 and Figure 2 As shown, a fixing seat 4 is provided on the front side of the back plate 2, the back of the mixing barrel 3 is in contact with the fixing seat 4, a locking plate ring 5 is placed on the front side of the mixing barrel 3, and locking bolts 6 are screwed on both ends of the locking plate ring 5 and the fixing seat 4 to fix the mixing barrel 3 and ensure stability during the mixing process.

[0029] The working principle of the utility model is as follows: the material to be mixed is placed inside the mixing barrel 3, and the mixing barrel 3 is placed on the upper surface of the bottom plate 1. The stability of the position of the mixing barrel 3 is maintained by the cooperation of the locking plate ring 5, the fixing seat 4 and the locking bolt 6. The hydraulic cylinder 9 is used to control the sliding block 8 to move up and down along the track of the slide 7. When mixing, the stirring rod 14 enters the mixing barrel 3, and the top cover 11 is moved downward to seal the top opening of the mixing barrel 3. During the downward movement, the lower boss 111 gradually enters the mixing barrel 3, and the outer side of the sealing rubber ring 15 contacts the inner wall of the mixing barrel 3. The top cover 11 is continuously moved downward to seal the top cover 11. The bottom of the cover 11 contacts the upper surface of the mixing barrel 3 and squeezes the sliding bolt 19, so that the sliding bolt 19 moves upward, and then controls the internal multiple movable plates 18 to rotate, and then makes the inner end of the movable plate 18 deviate downward to squeeze the arc convex strip 161, so that the pressure ring 16 slides downward, and the sealing rubber ring 15 is squeezed through the arc surface at the bottom of the pressure ring 16, so that the sealing rubber ring 15 is deformed outward, increasing the squeezing force between the outer side of the sealing rubber ring 15 and the inner wall of the mixing barrel 3 to improve the sealing performance, and then the vacuum connection pipe 31 is connected to the vacuum pump to vacuum the inside of the mixing barrel 3.

[0030] The above is only a preferred embodiment of the present invention. It should be noted that, for ordinary technicians in the technical field, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention shall be implemented according to the conventional means in the field unless otherwise specified and limited.

Claims

1. A vacuum mixing device for fludrocortisone acetate production, comprising a bottom plate (1) and a locking plate ring (5), wherein a back plate (2) is vertically arranged on the top rear side of the bottom plate (1), characterized in that: A mixing barrel (3) is placed on the upper surface of the bottom plate (1), the mixing barrel (3) is hollow inside and has an open top, an inner support platform (32) is arranged above the inside of the mixing barrel (3), a slide groove (7) is vertically opened above the surface of the back plate (2), a hydraulic cylinder (9) is fixed on the top of the back plate (2), a sliding block (8) is slidably installed inside the slide groove (7), the output end of the hydraulic cylinder (9) is fixed on the upper surface of the sliding block (8), a mounting plate (10) is arranged on the front side of the sliding block (8), the mounting plate (10) is placed outside the slide groove (7), a top cover (11) is fixed on the bottom of the mounting plate (10), and the top cover (11) is placed on the mixing barrel ( 3), a lower boss (111) is arranged on the lower surface of the top cover (11), the lower boss (111) is adapted to the top opening of the mixing barrel (3), the lower surface of the lower boss (111) is in contact with the upper surface of the inner support platform (32), a mounting recessed ring (12) is provided on the surface of the lower boss (111), a sealing rubber ring (15) is installed on the inner side of the mounting recessed ring (12), the sealing rubber ring (15) protrudes from the outer side surface of the lower boss (111), a pressing ring (16) is vertically slidably installed inside the lower boss (111), the bottom of the pressing ring (16) is arranged to be an arc surface, and the pressing ring (16) is placed above the inner side of the sealing rubber ring (15).

2. A vacuum mixing device for fludrocortisone acetate production according to claim 1, characterized in that: The lower boss (111) is provided with a mounting cavity (17) inside, and the mounting cavity (17) is placed above the pressure ring (16).

3. A vacuum mixing device for fludrocortisone acetate production according to claim 2, characterized in that: The upper surface of the pressure ring (16) is provided with an arc-shaped convex strip (161), and movable plates (18) are evenly installed on the upper part of the interior of the installation cavity (17) through a pin shaft, and the lower surfaces of one end of a plurality of movable plates (18) are in contact with the arc-shaped convex strip (161).

4. A vacuum mixing device for fludrocortisone acetate production according to claim 3, characterized in that: The lower surface of the top cover (11) is evenly and slidably mounted with sliding bolts (19), and a plurality of the sliding bolts (19) are all placed outside the lower boss (111), and the top of the sliding bolt (19) contacts the lower surface of the movable plate (18) on the side away from the arc-shaped convex strip (161).

5. A vacuum mixing device for fludrocortisone acetate production according to claim 4, characterized in that: A limiting plate (20) is provided on the surface of the sliding bolt (19), and the limiting plate (20) is placed at the lower part of the installation cavity (17).

6. A vacuum mixing device for fludrocortisone acetate production according to claim 1, characterized in that: A fixing seat (4) is arranged on the front side of the back plate (2); the back of the mixing barrel (3) is in contact with the fixing seat (4); the locking plate ring (5) is arranged on the front side of the mixing barrel (3); and locking bolts (6) are screwed on both ends of the locking plate ring (5) and the fixing seat (4).

7. The vacuum mixing equipment for fludrocortisone acetate production according to claim 1, characterized in that: A vacuum butt joint (31) is provided on the surface of the mixing barrel (3), and the vacuum butt joint (31) is connected to a vacuum pump.

8. The vacuum mixing equipment for fludrocortisone acetate production according to claim 1, characterized in that: A motor (13) is fixed at the top center of the mounting plate (10), and an output shaft of the motor (13) penetrates the mounting plate (10), the top cover (11), and the lower boss (111) from top to bottom. A stirring rod (14) is connected to the bottom of the mounting recessed ring (12).

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