Endoscope imaging system integrating fluorescence detection and photodynamic diagnosis

Abstract

The utility model provides a medical endoscope imaging system integrating fluorescence detection and photodynamic diagnosis, and mainly solves the technical problems that an existing imaging device based on NBI is complex in structure, an imaging device based on BLI is poor in adaptability and the like. The system comprises a light source module, an optical reflector, a coupling light guide and an endoscope system, the light source module comprises a first light source, a second light source and a third light source; wherein the first light source and the second light source are laser light sources with the wavelength of 405 nm respectively, and a light splitting coupling piece is arranged at the intersection of the optical axes of the two paths of emergent light and used for coupling the two paths of emergent light into one path of laser beam; the third light source is an illumination light source and is used for providing illumination light for the endoscope system; the optical reflector is used for coupling the laser beam and the illumination light into one path of diagnosis light, the diagnosis light is transmitted to the endoscope system through the coupling light guide, and fluorescence detection and photodynamic diagnosis are carried out on a target focus through the endoscope system.

Description

Technical Field

[0001] The utility model belongs to the technical field of endoscope imaging, and in particular relates to an endoscope imaging system integrating fluorescence detection and photodynamic diagnosis. Background Art

[0002] The most traditional clinical method of determining the characteristics of lesions is to use ordinary white light endoscopy (WLE), which uses white light for illumination. In order to achieve precise inspection of lesions, the commonly used precise inspection methods for existing medical endoscope imaging are mainly through narrow band imaging (NBI) and blue laser imaging (BLI).

[0003] NBI is based on the absorption characteristics of hemoglobin absorption spectrum for blue and green light, and achieves the effect of enhancing local details through narrow-band filters or directly using LEDs of corresponding bands for illumination. NBI requires the use of red, green, blue (RGB)-light emitting diodes (LED) light sources, or xenon lamps and krypton lamps with blue and green narrow-band filters, and mechanical rotating mirrors and other devices. The purpose is to use blue and green light to illuminate the target tissue when detailed examination is required, and to synthesize RGB into white light or directly use xenon lamps and krypton lamps for white light illumination when ordinary lighting is required. This method either uses a three-color LED or needs to be used with a filter, making the device more complicated. At the same time, a high-quality coated reflector, transmission mirror or mechanical rotating mirror device is required in the optical path, which has high requirements for the overall structure of the device.

[0004] BLI is also based on the absorption spectrum of hemoglobin, but the difference is that this technology only uses light sources in the blue band for detail enhancement, specifically using 410nm LD light sources and 450nm LED or LD light sources, and generally uses a dedicated endoscope (the tip of the dedicated endoscope is equipped with a special fluorescent substance, which can emit a spectrum similar to that of a xenon light source under the excitation of the 450nm spectrum) for illumination. 450nm is also a necessary laser light source for precise imaging under this technology (similar to the blue light of NBI technology). However, this method requires special fluorescent substances for illumination, which involves materials science and is relatively complicated; in addition, devices using the BLI mode often have multiple modes, the essence of which is to adjust the light energy ratio of the two light sources of 410nm and 450nm. Devices relying on this technology often require dedicated endoscopes, and the application scenarios are dedicated to the machine, with poor adaptability and difficult to extend. Utility Model Content

[0005] The purpose of the utility model is to provide a medical endoscope imaging system integrating fluorescence detection and photodynamic diagnosis, mainly to solve the technical problems such as the complex structure of existing NBI-based imaging devices and the poor adaptability of BLI-based imaging devices.

[0006] In order to achieve the above purpose, the technical solution of the utility model is:

[0007] An endoscopic imaging system that integrates fluorescence detection and photodynamic diagnosis. Its special features are:

[0008] It includes a light source module, an optical reflector, a coupling light guide and an endoscope system;

[0009] The light source module includes a first light source, a second light source and a third light source; wherein the first light source and the second light source are laser light sources with a wavelength of 405nm, respectively, and are used to emit one path of outgoing light, and the optical axes of the two paths of outgoing light intersect vertically and are located in the same plane; a splitter coupling element is provided at the intersection of the optical axes of the two paths of outgoing light, for coupling the two paths of outgoing light into one laser beam; the third light source is an illumination light source, for providing illumination light for the endoscope system;

[0010] The optical reflector is used to couple the laser beam and the illumination light into one diagnostic light;

[0011] The light input end of the coupling lightguide is close to the diagnostic light output end of the optical reflector, and the light output end is connected to the optical interface of the endoscope system; the diagnostic light is transmitted to the endoscope system via the coupling lightguide, and fluorescence detection and / or photodynamic diagnosis of the target lesion is performed through the endoscope system.

[0012] Furthermore, collimating mirrors are provided between the third light source and the optical reflector, and between the beam splitting coupling mirror and the optical reflector, respectively, for collimating the light path.

[0013] Furthermore, the first light source includes a heat dissipation fixture and a laser mounted on the heat dissipation fixture; and the second light source has the same structure as the first light source.

[0014] Further, the laser is a LD or LED light source with a wavelength of 405nm;

[0015] The third light source is a white light LED lighting source.

[0016] Furthermore, a bandpass film system is coated on the lens of the optical reflector.

[0017] Furthermore, the lens of the optical reflector is coated with a bandpass film system of 520-580nm.

[0018] Furthermore, the light splitting coupling element is a polarization beam splitter.

[0019] Compared with the prior art, the beneficial effects of the utility model are as follows:

[0020] 1. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis provided by the utility model includes a light source module, an optical reflector, a coupling light guide and an endoscope system, and the overall structure is simple and easy to implement. At the same time, the first light source and the second light source in the light source module are laser light sources with a wavelength of 405nm, which can enhance the display of tissue at the target lesion, thereby enhancing the recognition, which is more conducive to the observation and detection of the target lesion.

[0021] 2. The endoscopic imaging system provided by the utility model integrates fluorescence detection and photodynamic diagnosis, does not require the coordination of optical lenses of various film systems and other devices, and is applicable to more diverse scenarios.

[0022] 3. In the endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis provided by the utility model, the first light source and the second light source also include a heat dissipation fixing device, which can promptly dissipate the heat generated during the operation of the laser. Therefore, it can not only ensure the stability of the laser operation, but also improve the service life of the laser.

[0023] 4. The utility model provides an endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis, and collimating mirrors are respectively provided between the third light source and the optical reflector, and between the spectroscopic coupling mirror and the optical reflector, so that each light beam can be collimated and transmitted to the endoscopic system, thereby improving the utilization rate of the light beam and the imaging quality of the endoscopic system.

[0024] 5. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis provided by the utility model is not limited by hardware limitations, can be adapted to more devices, can perform precise imaging, and can also be applied to PDD. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a structural schematic diagram of an embodiment of the utility model.

[0026] Figure 2 It is a schematic diagram of the structure of the first light source in the embodiment of the utility model.

[0027] Figure 3 The figures are comparison diagrams of the imaging effects of standard white light endoscope imaging and the imaging effects of the embodiment of the utility model, wherein: (a) is a standard white light endoscope imaging diagram; (b) is an endoscope imaging diagram of the embodiment of the utility model at the same target position.

[0028] The reference numerals are as follows:

[0029] 1-first light source, 11-heat dissipation fixture, 12-laser, 2-second light source, 3-third light source, 4-optical reflector, 5-coupling light guide, 6-endoscopic system, 7-spectrometric coupling element. DETAILED DESCRIPTION

[0030] The present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0031] like Figure 1 As shown, this embodiment provides an endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis, including a light source module, an optical reflector 4, a coupling light guide 5 and an endoscope system 6.

[0032] The light source module includes a first light source 1, a second light source 2 and a third light source 3; wherein the first light source 1 and the second light source 2 have the same structure and are respectively used to emit one path of outgoing light, and the optical axes of the two paths of outgoing light intersect vertically and are located in the same plane.

[0033] like Figure 2 As shown, the first light source 1 includes a heat dissipation fixture 11 and a laser 12 mounted on the heat dissipation fixture 11. The laser 12 is a 405nm wavelength LD or LED light source. In this embodiment, a 405nm wavelength LD light source is selected, and the energy density and coupling efficiency of the LD light source are relatively higher.

[0034] This embodiment uses a 405nm LD light source as the main light source for precision imaging, and only uses one light source to achieve a detail enhancement effect that is no less than that of NBI and BLI. The main mechanism is based on the fact that the absorption spectrum of hemoglobin reaches a peak near 405nm, that is, the absorption efficiency of hemoglobin for light energy in this band reaches a peak. At this time, blue light penetrates the mucosal surface and reflects on the mucosal surface, highlighting the superficial vascular system. Since mucosal hemoglobin selectively absorbs blue light, the mucosa around the blood vessels reflects blue light, thereby increasing the contrast of the image and allowing a fine estimation of the mucosal microvascular structure.

[0035] The heat dissipation fixture 11 is used to provide support for the laser 12 and timely dissipate the heat generated by the laser 12 during operation, thereby ensuring the stability of the operation of the laser 12 .

[0036] A beam splitter coupling element 7 is provided at the intersection of the optical axes of the outgoing light of the first light source 1 and the second light source 2, for coupling the two outgoing lights into one laser beam. The beam splitter coupling element 7 can be a polarization beam splitter, or other optical coupling devices with the same function.

[0037] The third light source 3 is an illumination light source, used to provide illumination light for the endoscope system 6. In this embodiment, the third light source 3 is a white light LED illumination light source, which has better electro-optical efficiency than xenon lamps and krypton lamps, and the thermal effect is better managed.

[0038] The optical reflector 4 is used to couple the laser beam and the illumination light into a diagnostic light. The lens of the optical reflector 4 is coated with a bandpass film system of 520-580nm. The component lenses and film system of the optical reflector 4 can be changed according to actual detection needs.

[0039] The light input end of the coupling light guide 5 is close to the diagnostic light output end of the optical reflector 4, and the light output end is connected to the optical interface of the endoscope system 6. The diagnostic light is transmitted to the endoscope system 6 through the coupling light guide 5, and enters the human body through the human body cavity through the endoscope system 6 to achieve the purpose of transmitting light energy, thereby realizing fluorescence detection and / or photodynamic diagnosis of the target lesion. Photodynamic diagnosis (PDD) is to inject or orally introduce a fluorescent agent into the patient's body and selectively attach it to the diseased tissue. When irradiated with light of a specific wavelength, the fluorescent agent is excited to produce fluorescence, thereby helping doctors distinguish between healthy and diseased tissues.

[0040] In order to improve imaging quality, in this embodiment, collimating mirrors are respectively provided between the third light source 3 and the optical reflector 4 and between the light splitting coupling element 7 and the optical reflector 4 for collimating the corresponding light paths.

[0041] The application scenarios of this embodiment are no longer limited to the cooperation of other hardware. It not only has the effect of precision inspection (i.e., precise inspection) imaging, but can also be applied to photodynamic diagnosis based on 5-Aminolevulinic Acid (5-ALA) drugs.

[0042] Figure 3 The following is a comparison of the imaging effects of the existing standard white light endoscope and the imaging effect of the embodiment of the utility model, wherein (a) is the image of the target lesion formed by the existing standard ordinary white light endoscope (white light endoscopy, WLE), and (b) is the image formed by the endoscope imaging system based on the embodiment at the same target lesion. It can be seen from the figure that the endoscope system based on the embodiment can see the distribution of superficial blood vessels more clearly, and its recognition is higher. From the perspective of practical application, the blood vessel distribution of cancer cells and other normal tissues is also more obvious. Therefore, it can be seen that the difference in the ability to identify blood vessels is large when there is or is not the irradiation of the light source of the embodiment.

[0043] Based on this embodiment, light sources of other wavelengths can also be added and adapted, including the green light that has been tested. Compared with the NBI technology, the blue light wavelength of this embodiment selects a 405nm laser light source, which has better quality than the blue LED wide spectrum beam of NBI, and the laser display is better than the blue LED.

[0044] Based on the above embodiments, ordinary technicians are sufficient to implement the content of the utility model. Within the framework of the claims, any improvement based on the idea of ​​the utility model is deemed to fall within the protection scope of the utility model.

Claims

1. An endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis, characterized in that: It comprises a light source module, an optical reflector (4), a coupling light guide (5) and an endoscope system (6); The light source module comprises a first light source (1), a second light source (2) and a third light source (3); wherein the first light source (1) and the second light source (2) are respectively laser light sources with a wavelength of 405 nm, and are respectively used to emit one path of outgoing light, and the optical axes of the two paths of outgoing light intersect vertically and are located in the same plane; a beam splitter coupling element (7) is provided at the intersection of the optical axes of the two paths of outgoing light, and is used to couple the two paths of outgoing light into one laser beam; the third light source (3) is an illumination light source, and is used to provide illumination light for the endoscope system (6); The optical reflector (4) is used to couple the laser beam and the illumination light into one path of diagnostic light; The light input end of the coupling light guide (5) is close to the diagnostic light output end of the optical reflector (4), and the light output end is connected to the optical interface of the endoscope system (6); the diagnostic light is transmitted to the endoscope system (6) via the coupling light guide (5), and the endoscope system (6) performs fluorescence detection and / or photodynamic diagnosis on the target lesion.

2. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis according to claim 1, characterized in that: Collimating mirrors are provided between the third light source (3) and the optical reflector (4), and between the light splitting coupling element (7) and the optical reflector (4), respectively, for collimating the light path.

3. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis according to claim 2, characterized in that: The first light source (1) comprises a heat dissipation fixture (11) and a laser (12) mounted on the heat dissipation fixture (11); The second light source (2) has the same structure as the first light source (1).

4. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis according to claim 3, characterized in that: The laser (12) is a LD or LED light source with a wavelength of 405 nm; The third light source (3) is a white light LED lighting source.

5. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis according to any one of claims 1 to 4, characterized in that: The lens of the optical reflector (4) is plated with a bandpass film system.

6. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis according to claim 5, characterized in that: The lens of the optical reflector (4) is coated with a bandpass film system of 520 to 580 nm.

7. The endoscopic imaging system integrating fluorescence detection and photodynamic diagnosis according to claim 6, characterized in that: The light splitting coupling element (7) is a polarization light splitter.

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