Penicillin bottle for cryopreservation of stem cells

Abstract

The penicillin bottle comprises a bottle body, a bottle opening is formed in the top end of the bottle body, a rubber plug is inserted into the bottle opening, an aluminum cover is installed on the bottle opening, a positioning seat is fixedly connected to the top of the aluminum cover, a puncture opening is formed in the center of the positioning seat, a protective cover is installed on the aluminum cover, and the protective cover is fixedly connected with the bottle opening. The bottle body is sleeved with an anti-skid sleeve, a plurality of second anti-skid grooves are formed in the side wall of the top end of the anti-skid sleeve, a plurality of clamping blocks are fixedly connected to the side wall of the bottom end of the anti-skid sleeve, clamping grooves are formed between the clamping blocks and the anti-skid sleeve, and a protective sleeve is inserted into the clamping grooves. The rubber plug and the aluminum cover can be protected, the problem that the sealing performance is reduced due to abrasion is solved, the anti-skid performance is good, the phenomenon that under the freezing condition, the bottle body becomes satiny and slides in the taking and using process can be avoided, and the bottle body can be buffered and protected in the transporting and dumping process so that the bottle body can be prevented from being damaged and broken.

Description

Technical Field

[0001] The utility model belongs to the technical field of vials, in particular to a vial for cryopreservation of stem cells. Background Art

[0002] Stem cells are a type of cell with the potential for self-renewal and multidirectional differentiation. They can develop into various types of cells and therefore have important applications in regenerative medicine and tissue engineering. Stem cell cryopreservation technology provides a reliable guarantee for the preservation and application of stem cells and has important medical, scientific research and commercial value. Through this technology, long-term preservation and effective utilization of stem cell resources can be achieved, promoting the development of regenerative medicine and personalized medicine, and benefiting more patients.

[0003] Vials play an important role in stem cell cryopreservation. Their sealing and material properties make them ideal for storing and transporting stem cell preparations. At present, there are some vial products on the market, such as a vial with a publication number of CN208492695U disclosed on the China Patent Network. This vial has the advantages of easy preparation, low cost, easy operation, and convenient storage and dissolution of powders and solvents. However, there are some defects and deficiencies that need to be improved: (1) Some existing vials are mainly sealed by rubber stoppers and aluminum caps, but there is a lack of effective protection for the rubber stoppers and aluminum caps. After the rubber stoppers and aluminum caps are exposed to the outside for a long time, they are prone to the problem of reduced sealing performance due to wear during transportation and storage, thereby causing the stem cell sample in the vial to volatilize or be contaminated; (2) Due to the structural design of some existing vials, the bottle body tends to become slippery under freezing conditions, which makes it easy to slip during handling and use; (3) When some existing vials are transported, the bottle bodies are prone to collision, resulting in wear or even breakage of the bottle body, and when the vials placed flat on a contact surface such as a desktop fall over due to collision or other external forces, the bottle body is also easily damaged. Therefore, in view of the above problems, the utility model provides a vial for cryopreservation of stem cells, which is of great significance. Utility Model Content

[0004] The utility model provides a vial for cryopreservation of stem cells, wherein the bottle mouth can be sealed by a rubber stopper and an aluminum cap, and the rubber stopper and the aluminum cap can be protected by a protective cover, thereby effectively preventing the rubber stopper and the aluminum cap from being easily exposed to the outside for a long time and the sealing performance being reduced due to wear during transportation and storage; the friction between the fingers and the anti-slip cover can be increased by the second anti-slip grooves on the top of the anti-slip cover to play an anti-slip role, thereby effectively preventing the bottle body from becoming slippery under freezing conditions and causing slipping during taking and use; the protective cover can play a buffering and protective role when the vial is transported, thereby preventing the bottle body from being worn or even broken due to collision caused by direct contact; a plurality of groups of buffer blocks are arranged on the outer wall surface of the protective cover, and when the vial placed flat on a contact surface such as a desktop tops down due to collision or other external forces, the buffer blocks can play a buffering and protective role, thereby effectively preventing the bottle body from being damaged, thereby solving the problems in the background technology in summary.

[0005] In order to solve the above technical problems, the utility model is realized by the following technical solutions:

[0006] The utility model discloses a syringe bottle for cryopreservation of stem cells, comprising a bottle body, a bottle mouth is formed on the top of the bottle body, a rubber stopper is inserted into the bottle mouth, and an aluminum cover is installed on the bottle mouth, the inner wall of the aluminum cover and the outer wall of the bottle mouth are respectively engraved with internal threads and external threads that match each other, and a positioning seat is fixedly connected to the top of the aluminum cover, the cross section of the positioning seat is circular, a puncture hole is formed at the center, the bottom of the puncture hole passes through the aluminum cover, a protective cover is installed on the aluminum cover, an anti-slip sleeve is sleeved on the bottle body, the cross section of the anti-slip sleeve is annular, and the inner diameter thereof is correspondingly equal to the diameter of the bottle body, and a plurality of second anti-slip grooves are formed on the top side wall of the anti-slip sleeve, a plurality of clamping blocks are fixedly connected to the bottom side wall of the anti-slip sleeve, a clamping groove is formed between the clamping block and the anti-slip sleeve, and the protective sleeve is inserted into the clamping groove.

[0007] Furthermore, the bottom diameter and the top diameter of the rubber stopper are respectively equal to the inner diameter of the bottle mouth and the inner diameter of the aluminum cover, and the inner diameter of the aluminum cover is respectively equal to the outer diameter of the bottle mouth.

[0008] Furthermore, a plurality of first anti-skid grooves are engraved on the outer wall of the aluminum cover, wherein the first anti-skid grooves are rectangular groove structures, and the first anti-skid grooves are distributed in an equidistant annular pattern along the circumferential direction of the aluminum cover.

[0009] Furthermore, the inner diameter of the protective cover is equal to the outer diameter of the aluminum cover, and a positioning block is fixedly connected to the top inner wall of the protective cover. The positioning block is annular and its inner diameter is equal to the diameter of the positioning seat.

[0010] Furthermore, the second anti-skid grooves are arc-shaped groove structures and are distributed in an equidistant annular pattern along the circumferential direction of the anti-skid sleeve, and the groove wall surface of each of the second anti-skid grooves is engraved with herringbone anti-skid patterns.

[0011] Furthermore, the cross section of the protective cover is annular, the inner diameter of the protective cover is correspondingly equal to the outer diameter of the anti-slip cover, and the thickness of the protective cover is correspondingly equal to the slot width of the card slot.

[0012] Furthermore, a plurality of groups of buffer blocks are arranged on the outer wall surface of the protective sleeve, each group of the buffer blocks is respectively located at the top and bottom ends of the protective sleeve, and each group of the buffer blocks is distributed in an equidistant annular pattern along the circumferential direction of the protective sleeve.

[0013] Compared with the prior art, the utility model has the following beneficial effects:

[0014] (1) When the vial for cryopreservation of stem cells in the utility model is used, the bottle mouth can be sealed by the rubber stopper and the aluminum cap, and the rubber stopper and the aluminum cap can be protected by the protective cover, thereby effectively avoiding the problem of the rubber stopper and the aluminum cap being exposed to the outside for a long time and being easily worn during transportation and storage, resulting in the problem of reduced sealing performance;

[0015] (2) When a stem cell cryopreservation vial of the utility model is used, the friction between the fingers and the anti-slip sleeve can be increased by the second anti-slip grooves on the top of the anti-slip sleeve to prevent slipping, thereby effectively preventing the bottle body from becoming slippery under freezing conditions and causing slipping during handling and use;

[0016] (3) When a vial for cryopreservation of stem cells in the utility model is in use, the protective cover can play a role of buffering and protecting the vial during transportation, thereby avoiding wear and even breakage caused by collision between the vials due to direct contact. The outer wall surface of the protective cover is provided with a plurality of groups of buffer blocks. When the vial placed flat on a contact surface such as a desktop topples over due to collision or other external force, each buffer block can play a role of buffering and protecting, thereby effectively avoiding damage to the vial.

[0017] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0019] Figure 1This is a schematic diagram of the structure of a vial for cryopreservation of stem cells according to the utility model;

[0020] Figure 2 This is a schematic diagram of the structure of the bottle body in the utility model;

[0021] Figure 3 This is a schematic diagram of the structure of the rubber plug in the utility model;

[0022] Figure 4 This is a schematic diagram of the structure of the aluminum cover in the utility model;

[0023] Figure 5 It is a bottom view of the protective cover in the utility model;

[0024] Figure 6 This is a front cross-sectional view of the rubber plug, aluminum cover and protective cover in the utility model;

[0025] Figure 7 It is a structural schematic diagram of the anti-slip sleeve in the utility model;

[0026] Figure 8 It is a structural schematic diagram of the protective cover in the utility model.

[0027] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0028] 1. Bottle body; 2. Bottle mouth; 3. Rubber stopper; 4. Aluminum cover; 5. Positioning seat; 6. Puncture port; 7. Protective cover; 8. Anti-skid sleeve; 9. Second anti-skid groove; 10. Card block; 11. Card slot; 12. Protective cover; 13. First anti-skid groove; 14. Positioning block; 15. Buffer block. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0030] In the description of the present invention, it should be understood that terms such as "relative", "one end", "inside", "lateral", "end", "two ends", "both sides", "front", "one end face", "the other end face" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0031] See also Figure 1-8As shown, a stem cell cryopreservation vial of the utility model comprises a bottle body 1, a bottle mouth 2 is formed at the top of the bottle body 1, a rubber stopper 3 is inserted into the bottle mouth 2, and an aluminum cover 4 is installed on the bottle mouth 2, and the inner wall of the aluminum cover 4 and the outer wall of the bottle mouth 2 are respectively engraved with internal threads and external threads that match each other. When the rubber stopper 3 is inserted into the bottle mouth 2, the aluminum cover 4 can be fixed on the bottle mouth 2 by threaded connection, so as to fix the rubber stopper 3. At this time, the bottle mouth 2 can be sealed by the rubber stopper 3 and the aluminum cover 4. A positioning seat 5 is fixedly connected to the top of the aluminum cover 4. The cross section of the positioning seat 5 is circular, and a puncture hole 6 is formed at the center thereof. The bottom of the puncture hole 6 penetrates the aluminum cover 4, and a syringe or a needle can pass through the puncture hole 6 to puncture the rubber stopper 3. Puncture is performed to take out the stem cell sample in the bottle body 1. A protective cover 7 is installed on the aluminum cover 4, and the protective cover 7 can cover the aluminum cover 4 and the rubber plug 3. The rubber plug 3 and the aluminum cover 4 can be protected by the protective cover 7, thereby effectively avoiding the problem that the rubber plug 3 and the aluminum cover 4 are easily exposed to the outside for a long time, and the sealing performance is easily reduced due to wear during transportation and storage. An anti-slip sleeve 8 is sleeved on the bottle body 1. The cross-section of the anti-slip sleeve 8 is annular, and its inner diameter is equal to the diameter of the bottle body 1. The top side wall of the anti-slip sleeve 8 is provided with a plurality of second anti-slip grooves 9, and the bottom side wall of the anti-slip sleeve 8 is fixedly connected with a plurality of clamping blocks 10, and a clamping groove 11 is formed between the clamping block 10 and the anti-slip sleeve 8, and a protective sleeve 12 is inserted into the clamping groove 11.

[0032] Among them, the bottom diameter and the top diameter of the rubber stopper 3 are respectively equal to the inner diameter of the bottle mouth 2 and the inner diameter of the aluminum cover 4, and the inner diameter of the aluminum cover 4 is respectively equal to the outer diameter of the bottle mouth 2. After the rubber stopper 3 is inserted into the bottle mouth 2, it can fit tightly on the inner wall of the bottle mouth 2. When the aluminum cover 4 is threadedly connected to the bottle mouth 2, it can fit on the top outer wall of the rubber stopper 3, thereby effectively avoiding the generation of gaps.

[0033] Among them, the outer wall of the aluminum cover 4 is engraved with a plurality of first anti-slip grooves 13, the first anti-slip grooves 13 are rectangular groove structures, and the first anti-slip grooves 13 are equidistantly distributed in annular shapes along the circumferential direction of the aluminum cover 4. When the aluminum cover 4 needs to be unscrewed, the fingers can be attached to the outer wall of the aluminum cover 4. At this time, the friction between the fingers and the aluminum cover 4 can be effectively increased by using each first anti-slip groove 13 to play an anti-slip role, thereby avoiding slipping and slipping when twisting the aluminum cover 4.

[0034] Among them, the inner diameter of the protective cover 7 is equal to the outer diameter of the aluminum cover 4, and the top inner wall of the protective cover 7 is fixedly connected with a positioning block 14, the positioning block 14 is annular, and its inner diameter is equal to the diameter of the positioning seat 5. When the protective cover 7 is covered on the aluminum cover 4, the positioning block 14 can be attached to the outer wall of the positioning seat 5. At this time, the protective cover 7 can be fixed on the aluminum cover 4 through the mutual cooperation between the positioning block 14 and the positioning seat 5 to prevent it from loosening. When the protective cover 7 needs to be removed, the positioning block 14 can be pulled out from the side wall of the positioning seat 5.

[0035] Among them, the second anti-skid groove 9 is an arc-shaped groove structure, and is equidistantly distributed in an annular shape along the circumferential direction of the anti-skid sleeve 8, and the groove wall surface of each second anti-skid groove 9 is engraved with a herringbone anti-skid pattern. When you need to take and use the syringe bottle, you can fit your fingers into the second anti-skid groove 9. At this time, the anti-skid pattern in the second anti-skid groove 9 can increase the friction between the fingers and the anti-skid sleeve 8 to play an anti-skid role, thereby effectively avoiding the bottle body 1 becoming slippery under freezing conditions and causing slipping during taking and use.

[0036] Among them, the cross-section of the protective cover 12 is annular, and its inner diameter is equal to the outer diameter of the anti-slip cover 8, and the thickness of the protective cover 12 is equal to the groove width of the card slot 11. When the protective cover 12 is inserted into the card slot 11 on the card block 10, it can cover the outside of the entire bottle body 1. The protective cover 12 is made of elastic materials such as silicone, and can play a buffering and protective role when the vial is transported, thereby avoiding wear and even breakage caused by collisions caused by direct contact between the bottle bodies 1.

[0037] Among them, a plurality of groups of buffer blocks 15 are arranged on the outer wall surface of the protective cover 12, each group of buffer blocks 15 is respectively located at the top and the bottom of the protective cover 12, and each group of buffer blocks 15 is equidistantly distributed in annular shapes along the circumferential direction of the protective cover 12. The buffer blocks 15 are made of the same silicone material as the protective cover 12. When the vial placed flat on a contact surface such as a desktop topples over due to a collision or other external force, each buffer block 15 will first contact the contact surface to play a role of buffering protection, thereby effectively preventing the bottle body 1 from being damaged.

[0038] The circuits, electronic components and chip modules involved in the utility model are all existing technologies and can be fully implemented by those skilled in the art. Needless to say, the content protected by the utility model does not involve improvements to software and methods.

[0039] The standard parts used in the application documents can all be purchased from the market. All the components in this application document can be customized according to the description in the specification and drawings. The specific connection methods of each part adopt mature conventional means such as bolts, rivets, welding, etc. in the prior art. Machinery, parts and equipment all adopt conventional models in the prior art. The electrical components appearing in this article are all electrically connected to the external main controller and 220V AC power, and the main controller can be a conventional known device that controls the LED lamp body, etc.

[0040] The working principle of the utility model is:

[0041] When the utility model is in use, the stem cell sample to be frozen can be introduced into the bottle body 1 through the bottle mouth 2, and then the rubber plug 3 is inserted into the bottle mouth 2, and the aluminum cover 4 is threadedly connected to the bottle mouth 2, so that the bottle mouth 2 is sealed by the rubber plug 3 and the aluminum cover 4, and then the vial is placed in a freezing environment to freeze the stem cell sample in the bottle body 1. A protective cover 7 is installed on the top of the aluminum cover 4, and the protective cover 7 can cover the aluminum cover 4 and the rubber plug 3. The rubber plug 3 and the aluminum cover 4 can be protected by the protective cover 7, thereby effectively avoiding the problem of reduced sealing performance due to wear and tear during transportation and storage after the rubber plug 3 and the aluminum cover 4 are exposed to the outside for a long time. The bottle body 1 is provided with an anti-skid cover 8. When the vial needs to be taken and used, the finger can be attached to the second anti-skid groove 9 at the top of the anti-skid cover 8. At this time, the anti-skid pattern in the second anti-skid groove 9 can be used to increase the friction between the fingers and the anti-skid sleeve 8 to play an anti-skid role, thereby effectively preventing the bottle body 1 from becoming slippery under freezing conditions and causing slipping during picking up and use. A protective sleeve 12 is inserted into the card groove 11 of the card block 10 at the bottom end of the anti-skid sleeve 8. The protective sleeve 12 can cover the outside of the entire bottle body 1 and play a buffering and protective role when the vial is transported, thereby avoiding wear and even breakage caused by collisions caused by direct contact between the bottle bodies 1. A plurality of groups of buffer blocks 15 are arranged on the outer wall surface of the protective sleeve 12. When the vial placed flat on a contact surface such as a desktop topples over due to collision or other external forces, each buffer block 15 will first contact the contact surface to play a buffering and protective role, thereby effectively preventing the bottle body 1 from being damaged.

[0042] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the utility model to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that technicians in the relevant technical field can well understand and use the utility model. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A vial for cryopreservation of stem cells, characterized in that: The invention comprises a bottle body, the top of the bottle body is provided with a bottle mouth, a rubber stopper is inserted into the bottle mouth, and an aluminum cover is installed on the bottle mouth, the inner wall of the aluminum cover and the outer wall of the bottle mouth are respectively engraved with internal threads and external threads that match each other, and the top of the aluminum cover is fixedly connected with a positioning seat, the cross section of the positioning seat is circular, a puncture hole is provided at the center, the bottom of the puncture hole passes through the aluminum cover, a protective cover is installed on the aluminum cover, an anti-slip sleeve is sleeved on the bottle body, the cross section of the anti-slip sleeve is annular, and the inner diameter thereof is equal to the diameter of the bottle body, and a plurality of second anti-slip grooves are provided on the top side wall of the anti-slip sleeve, a plurality of clamping blocks are fixedly connected to the bottom side wall of the anti-slip sleeve, a clamping groove is formed between the clamping block and the anti-slip sleeve, and a protective sleeve is inserted into the clamping groove.

2. A vial for cryopreservation of stem cells according to claim 1, characterized in that: The bottom diameter and top diameter of the rubber stopper are respectively equal to the inner diameter of the bottle mouth and the inner diameter of the aluminum cover, and the inner diameter of the aluminum cover is respectively equal to the outer diameter of the bottle mouth.

3. A vial for cryopreservation of stem cells according to claim 1, characterized in that: The outer wall of the aluminum cover is engraved with a plurality of first anti-skid grooves, the first anti-skid grooves are rectangular groove structures, and the first anti-skid grooves are distributed in an equidistant annular pattern along the circumference of the aluminum cover.

4. A vial for cryopreservation of stem cells according to claim 1, characterized in that: The inner diameter of the protective cover is equal to the outer diameter of the aluminum cover, and a positioning block is fixedly connected to the inner wall of the top of the protective cover. The positioning block is annular, and its inner diameter is correspondingly equal to the diameter of the positioning seat.

5. A vial for cryopreservation of stem cells according to claim 1, characterized in that: The second anti-skid grooves are arc-shaped groove structures and are distributed in an equidistant annular pattern along the circumferential direction of the anti-skid sleeve, and the groove wall surface of each of the second anti-skid grooves is engraved with herringbone anti-skid patterns.

6. A vial for cryopreservation of stem cells according to claim 1, characterized in that: The cross section of the protective cover is annular, the inner diameter of the protective cover is equal to the outer diameter of the anti-slip cover, and the thickness of the protective cover is equal to the width of the slot.

7. A vial for cryopreservation of stem cells according to claim 1, characterized in that: A plurality of groups of buffer blocks are arranged on the outer wall surface of the protective sleeve, each group of the buffer blocks is respectively located at the top end and the bottom end of the protective sleeve, and each group of the buffer blocks is distributed in an equidistant annular pattern along the circumferential direction of the protective sleeve.

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