Dry granulation machine for medicines
By designing a drug dry pelletizer that integrates feed, whole pellet and screening functions, the problems of uneven feeding of materials and poor mixing effects in traditional equipment are solved, and efficient pelletization and screening are integrated, which improves production efficiency and product quality, and reduces dust emissions.
Patent Information
- Application Number
- CN202421798377.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-29
- Publication Date
- 2025-05-06
- Estimated Expiration
- 2034-07-29
AI Technical Summary
The traditional drug dry pelletizer has shortcomings in the design of feed system and the performance of the stirring device, which leads to uneven feeding of the material and poor mixing effect, which affects the efficacy of the medicine. The equipment covers a large area and is prone to dust problems.
A dry-method pelletizer of pharmaceuticals was designed, integrating feeding mechanism, whole-grain mechanism and screening mechanism, and a vacuum loader and control valve were used to achieve uniform feeding and circulating granulation of materials. Combined with the design of whole-grain rollers and stirring paddles, ensuring the full mixing and granulation effect of materials.
The integration of granulation and screening is achieved, the equipment volume is reduced, the production efficiency is improved, the particle size is uniform and the quality is stable, and the dust emission is reduced, which meets the requirements of green development.
Smart Images
Figure CN222829584U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of medicine manufacturing equipment, in particular to a dry-process granulator for medicines. Background Art
[0002] In the field of modern pharmaceutical production, granules, as a common dosage form, have the advantages of being easy to take and fast to absorb, and occupy an important position in the pharmaceutical market. The dry granulator is one of the key equipment for producing pharmaceutical granules. Dry granulation is a commonly used production method that can directly press powdered raw materials into granules for tableting, capsule filling, etc. It has the advantages of low energy consumption and short production cycle.
[0003] With the rapid development of the pharmaceutical industry, the requirements for drug quality and production efficiency are increasing. Traditional dry pharmaceutical granulators have gradually exposed some shortcomings in practical applications. In previous equipment, due to the unreasonable design of the feeding system, the material feeding is uneven, and local accumulation or vacancies are prone to occur. The performance of the stirring device needs to be improved. The stirring effect is not good, the material cannot be fully mixed, and the drug components are unevenly distributed, which may affect the efficacy. In the extrusion molding process, the granulation structure design needs to be improved, the pressure roller and the mold are not accurate enough, and the pressure distribution is uneven, making it difficult for the density and strength of the particles to reach the ideal standard, affecting the yield of the first granulation, and even affecting the physical properties of the drug. Problems may also occur in the subsequent packaging process.
[0004] In addition, the dry granulator is a continuous production process. During production, powdered raw materials need to be continuously added to the feed bin, and containers are placed at the discharge port to receive semi-finished products. The semi-finished products are mixed with raw material powder and large and small particles, which need to be screened in the next step. The particles suitable for the next process have specification requirements, and the semi-finished products need to be screened to remove oversized and undersized particles and powder. The unqualified ones are returned to the dry granulator and mixed with new materials for further processing. In this process, the flow of materials and semi-finished products is usually completed by manual or other machine types. The equipment occupies a large area and is prone to dust.
[0005] In summary, in order to meet the needs of high quality and high efficiency in drug production, the development of a new type of drug dry granulator has important practical significance. Utility Model Content
[0006] In order to solve the problem of efficient granulation and realize the integration of granulation and sieving, the utility model provides a dry granulator for medicines.
[0007] The utility model provides a dry granulator for medicines, comprising a feeding mechanism, a granulating mechanism connected to an outlet of the feeding mechanism, a screening mechanism connected to the granulating mechanism and arranged at the lower end thereof, and a powder collecting tank arranged under the screening mechanism in a sealed manner. A vacuum loader is provided in the dry granulator, and the vacuum loader is connected to the powder collecting tank and the feeding mechanism through a pipeline.
[0008] Furthermore, the feeding mechanism includes a feeding bin, a feeding pipe connected to a discharge port of the feeding bin, and a feeding screw for conveying materials arranged in the feeding pipe, wherein the pitch of the feeding screw gradually decreases from one end close to the discharge port of the feeding bin to an end far from the discharge port.
[0009] Furthermore, the grain-sizing mechanism includes a grain-sizing bin in the form of a vertical cylinder, a grain-sizing screen arranged along the cylindrical side wall of the grain-sizing bin, a cavity provided between the grain-sizing screen and the grain-sizing bin, a rotating frame provided in the grain-sizing screen, and a plurality of groups of grain-sizing rollers installed on the rotating frame for rotating and applying pressure to the inner wall of the grain-sizing screen.
[0010] Furthermore, the rotary frame is provided with a plurality of groups of stirring paddles, and the stirring paddles and the plurality of groups of granulation rollers are alternately installed on the rotary frame.
[0011] Furthermore, the whole grain screen and the rotating frame are coaxially arranged in the whole grain bin through a rotating unit, and the rotating unit includes a whole grain screen bevel gear, a rotating frame bevel gear and a reverse bevel gear. The whole grain screen bevel gear and the rotating frame bevel gear are respectively meshed with the reverse bevel gear, and the rotating shaft of the rotating frame is sleeved in the rotating shaft of the whole grain screen. The reverse bevel gear is connected to the first motor, and the whole grain screen and the rotating frame rotate in opposite directions.
[0012] Furthermore, a cleaning unit is provided on the inner wall of the whole grain bin, and the cleaning unit includes a cleaning brush fitted with the whole grain screen, a connecting rod fixedly connected to the cleaning brush, an elastic unit arranged inside the whole grain bin and connected to the connecting rod, the elastic unit includes a rotating clamp, a spring arranged in the rotating clamp and providing elasticity to the connecting rod, a slot coupled to the rotating clamp, a protrusion is provided on the rotating clamp, and a notch matching with the protrusion is provided on the slot, and the coupling includes tightening after the protrusion and the notch match.
[0013] Furthermore, the screening mechanism includes a screening unit, a powder channel and a particle channel connected to the screening unit, the screening unit is fixedly installed between the powder channel and the particle channel, the screening unit includes a screen unit and a vibration unit arranged on the lower side of the screen unit, wherein the screen unit includes a screen, a lining screen arranged at the lower end of the screen, and a plurality of movable balls bouncing between the screen and the lining screen, and the vibration unit includes a paddle plate abutting against the outer side of the lining screen, a driven rod connected to the wave plate, and a cam at the lower end of the driven rod abutting against the return spring.
[0014] Furthermore, the lining net is made of flexible material, and the movable ball is made of rubber material.
[0015] Furthermore, a particle collection tank is provided at the outlet of the particle channel, and a powder collection tank is provided at the outlet of the powder channel.
[0016] Furthermore, a control valve is provided on the connecting pipeline of the vacuum feeder, and the control valve is used to control the material in the powder channel to enter the feeding mechanism.
[0017] In summary, the utility model has the following beneficial technical effects:
[0018] 1. The utility model provides a dry granulator for medicines, which reasonably integrates the traditional granulator and screening machine, realizes the integration of granulation and screening, reduces the size of the equipment, is more portable, and realizes continuous production from raw material input to finished product output, greatly improving production efficiency. The integrated process can also accurately control the process parameters of granulation and screening, making the entire production process more stable and controllable. According to different medicine requirements, the pressure, rotation speed of the granulation roller, and the aperture of the screen can be adjusted to ensure that the produced particles are uniform in size and stable in quality.
[0019] 2. The gradually decreasing pitch design of the feed screw in the feeding mechanism of the utility model can realize uniform feeding and preliminary compression of materials. The materials compressed into blocks can be quickly and effectively made into granules that meet the requirements through the centrifugal effect of the rotating cylindrical granulation screen and the granulation roller. After the powdery materials are separated by the screening mechanism, they can be returned to the feeding mechanism through the vacuum feeder for re-granulation. The cyclic granulation can also improve the quality of the granules, improve the utilization rate and yield rate of raw materials, and at the same time, for some materials with high viscosity, the rotation speed can be appropriately reduced and the pressure can be increased to ensure the granulation effect. For materials with high brittleness, the rotation speed can be increased and the pressure can be reduced to avoid material breakage.
[0020] 3. The cleaning unit installed on the outer wall of the whole particle screen can timely remove the attached particles on the outer wall of the whole particle screen, effectively prevent the blockage of the screen holes, and maintain a good granulation effect of the whole particle screen. The design of the screen unit and the vibration unit in the screening unit, especially the jumping of the movable ball between the screen and the lining mesh, can enhance the screening effect and improve the screening accuracy and efficiency.
[0021] 4. The control valve on the connecting pipeline of the vacuum feeder can control the flow rate of powdered materials returning to the feeding mechanism to ensure the quality of the granulated products. The optimized design of the entire equipment reduces dust emissions during operation, which meets the requirements of green development of modern industry. The various parts of the equipment work together, the operation is simple and easy to understand, and it is easy to replace parts. It can adapt to granulation of pharmaceutical raw materials of different types and properties, and has good adjustment and adaptability. BRIEF DESCRIPTION OF THE DRAWINGS
[0022] Figure 1 It is a three-dimensional structural schematic diagram of a dry granulator for medicines according to an embodiment of the utility model.
[0023] Figure 2 It is a structural diagram of a feeding mechanism according to an embodiment of the utility model.
[0024] Figure 3 It is a front schematic diagram of a pelletizing mechanism according to an embodiment of the utility model.
[0025] Figure 4 It is a front schematic diagram of a screening unit according to an embodiment of the present utility model.
[0026] Figure 5 It is a three-dimensional structural schematic diagram of a granulation mechanism according to an embodiment of the utility model.
[0027] Figure 6 It is a schematic diagram of the meshing relationship of the bevel gears of the rotating unit of the embodiment of the utility model.
[0028] Figure 7 It is a structural schematic diagram of a cleaning unit according to an embodiment of the utility model.
[0029] Among them, 100, feeding mechanism; 200, granulation mechanism; 300, screening mechanism; 400, vacuum feeder; 101, feeding bin; 102, feeding pipeline; 103, feeding screw; 201, granulation bin; 202, granulation screen; 203, rotating frame; 204, multiple sets of granulation rollers; 205, stirring paddle; 210, rotating unit; 211, granulation screen bevel gear; 212, rotating frame bevel gear; 213, reverse bevel gear; 220, cleaning Cleaning unit; 221, cleaning brush; 222, connecting rod; 230, elastic unit; 231, spring; 232, slot; 233, rotating clamp; 310, screen unit; 320, vibration unit; 311, screen; 312, lining net; 330, movable ball; 321, cam; 322, driven rod; 323, toggle plate; 324, second motor; 325, reset spring; 500, particle collection tank; 600, powder collection tank. DETAILED DESCRIPTION
[0030] The utility model is further described in detail below in conjunction with the accompanying drawings.
[0031] Example 1
[0032] Reference Figure 1 A dry granulator for medicines in this embodiment includes a feeding mechanism 100, a granulating mechanism 200 connected to the outlet of the feeding mechanism 100, a screening mechanism 300 connected to the granulating mechanism and arranged at the lower end thereof, and a powder collecting tank 600 arranged in a sealed manner below the screening mechanism 300. A vacuum loader 400 is provided in the dry granulator, and the vacuum loader 400 is connected to the powder collecting tank 600 and the feeding mechanism 100 through a pipeline.
[0033] Reference Figure 2 The feeding mechanism 100 includes a feeding bin 101, a feeding pipe 102 connected to a feeding port of the feeding bin 101, and a feeding screw 103 for material transportation arranged in the feeding pipe, wherein the pitch of the feeding screw 103 gradually decreases from an end close to the feeding port of the feeding bin 101 to an end far from the feeding port. The outlet of the feeding pipe 102 is connected to the inlet of the granulating mechanism 200 through a hose.
[0034] During operation, the material first enters the feed bin 101, and then enters the feed pipe 102 through the discharge port. The feed screw 103 rotates under the drive of the motor. As its pitch gradually decreases from the end close to the discharge port of the feed bin 101 to the end far from the discharge port, the material is subjected to a gradually increasing squeezing and pushing action in the feed pipe 102. This gradual compression method initially aggregates the loose powdery material into blocks, providing better feeding conditions for the subsequent granulation process, feeding evenly, and avoiding poor granulation effect caused by material accumulation or uneven feeding.
[0035] Reference Figure 3 and Figure 4 The granulation mechanism 200 includes a granulation bin 201 in the form of a vertical cylinder, a granulation screen 202 arranged along the cylindrical side wall of the granulation bin 201, a cavity is arranged between the granulation screen 202 and the granulation bin 201, a rotating frame 203 is arranged inside the granulation screen, and a plurality of granulation rollers 204 for rotating and applying pressure to the inner wall of the granulation screen 202 are installed on the rotating frame 203.
[0036] Reference Figure 3 The rotating frame 203 is also provided with a plurality of stirring paddles 205 , and the stirring paddles 205 and the plurality of granulation rollers 204 are alternately installed on the rotating frame 203 .
[0037] Reference Figure 5The whole grain screen 202 and the rotating frame 203 are coaxially arranged in the whole grain bin 201 through a rotating unit 210. The rotating unit 210 includes a whole grain screen bevel gear 211, a rotating frame bevel gear 212 and a reverse bevel gear 213. The whole grain screen bevel gear 211 and the rotating frame bevel gear 212 are respectively meshed with the reverse bevel gear 213. The rotating shaft of the rotating frame 203 is sleeved in the rotating shaft of the whole grain screen 202. The reverse bevel gear 213 is connected to the first motor. The whole grain screen 202 and the rotating frame 203 rotate in opposite directions.
[0038] During operation, the material processed by the feeding mechanism 100 enters the granulation bin 201. The granulation screen 202 and the rotary frame 203 rotate coaxially under the drive of the rotating unit 210, and the rotation directions are opposite. The granulation screen 202 exerts a centrifugal effect on the material. The granulation roller rotates along the inner wall of the granulation screen 202 and applies pressure to the inner wall under the drive of the rotary frame 203. At the same time, the stirring paddle 205 on the rotary frame 203 stirs the material and appropriately divides the compressed block material to a certain extent. The reverse rotation of the granulation screen 202 and the rotary frame 203, as well as the pressure of the granulation roller, make the material subject to multi-directional forces during the granulation process, so that it is more fully squeezed and rubbed to form uniform particles. The stirring action of the stirring paddle 205 can prevent the material from being locally accumulated during the granulation process, and further improve the consistency of the granulation effect.
[0039] Reference Figure 6 A cleaning unit 220 is provided on the inner wall of the whole grain bin 201, and the cleaning unit 220 includes a cleaning brush 221 fitted with the whole grain screen 202, a connecting rod 222 fixedly connected to the cleaning brush, and an elastic unit 230 arranged inside the whole grain bin and connected to the connecting rod 222. The elastic unit 230 includes a rotating clamp 233, a spring 231 arranged in the rotating clamp and providing elasticity to the connecting rod, and a slot 232 coupled to the rotating clamp 233. A protrusion is provided on the rotating clamp 233, and a notch matching the protrusion is provided on the slot 232. The coupling includes tightening the protrusion and the notch after they match.
[0040] During operation, during the rotation of the whole-grain screen 202, the cleaning brush 221 always keeps in contact with the outer wall of the whole-grain screen 202 through the elastic action of the spring 231. The cooperation between the rotating clamp 233 and the clamping slot 232, as well as the expansion and contraction of the spring 231, adapts to the rotation and vibration of the whole-grain screen 202. The cleaning unit 220 can timely remove the attachments on the outer wall of the whole-grain screen 202, prevent the sieve holes from being blocked, ensure the efficiency of the whole-grain screen 202, and extend the service life of the whole-grain screen 202. As the use time increases, the cleaning brush 221 may gradually wear and become thinner, and the expansion and contraction of the spring 231 can compensate for this wear to a certain extent, so that the cleaning brush 221 can still effectively contact the outer wall of the whole-grain screen 202 for cleaning.
[0041] After the work is finished, the cleaning brush 221 and the screen 311 can be disassembled by rotating the rotating clamp 233, and the cleaning brush 221 and the screen 311 can be repaired or replaced to meet the requirements of different granulation sizes.
[0042] Reference Figure 3 and Figure 4 The screening mechanism 300 includes a screening unit, a powder channel and a particle channel connected to the screening unit, the screening unit is fixedly installed between the powder channel and the particle channel, the screening unit includes a screen unit 310 and a vibration unit 320 arranged at the lower side of the screen unit, wherein the screen unit 310 includes a screen 311, a lining screen 312 arranged at the lower end of the screen 311, and a plurality of movable balls 330 bouncing between the screen 311 and the lining screen 312, the vibration unit 320 includes a paddle plate 323 abutting against the outer side of the lining screen 312, a driven rod 322 connected to the wave plate 323, and a cam at the lower end of the driven rod 322 abutting against the return spring 325.
[0043] The lining net 312 is made of flexible material, and the movable ball 330 is made of rubber material.
[0044] During operation, the granulated material enters the screening mechanism 300, and the second motor 324 in the vibration unit 320 drives the cam 321 to rotate, thereby pushing the driven rod 322 and the toggle plate 323, so that the lining net 312 vibrates. The movable ball 330 between the sieve net 311 and the lining net 312 jumps under the action of the toggle plate 323. The vibration and the jumping of the movable ball 330 enhance the screening effect, and can more quickly separate qualified particles and powdery materials. At the same time, the vibration of the flexible lining net 312 reduces the wear and noise of the equipment. The driven rod is restored to always contact and connect with the cam under the action of the reset spring. The lining net has a large mesh, and the movable ball 330 cannot fall out of the large mesh, which plays an auxiliary role in the elasticity of the movable ball.
[0045] The outlet of the particle channel is provided with a particle collection tank 500, the outlet of the powder channel is provided with a powder collection tank 600, and the connecting pipeline of the vacuum feeder 400 is provided with a control valve, and the control valve is used to control the material in the powder channel to enter the feeding mechanism 100. Both the powder collection tank 600 and the particle collection tank 500 are airtight, which can provide good protection for the prepared raw materials. The airtightness of the powder collection tank 600 can form a better vacuum environment, which is convenient for the vacuum feeder 400 to absorb the unsuccessfully granulated materials therefrom.
[0046] During operation, the powdered material in the powdered collection tank passes through the vacuum feeder 400 and the pipeline, and under the regulation of the control valve, is returned to the feeding mechanism 100 for re-granulation as needed, thereby realizing automatic recycling of the powdered material. The control valve can accurately control the amount of returned material to ensure the consistency of the granulation quality in the production process.
[0047] The above are all preferred embodiments of the present utility model, and are not intended to limit the protection scope of the present utility model. Therefore, any equivalent changes made based on the structure, shape, and principle of the present utility model should be included in the protection scope of the present utility model.
Claims
1. A dry granulator for medicines, characterized in that: The dry granulator comprises a feeding mechanism (100), a granulating mechanism (200) connected to an outlet of the feeding mechanism (100), a screening mechanism (300) connected to the granulating mechanism and arranged at the lower end thereof, and a powder collecting tank (600) arranged in a sealed manner below the screening mechanism (300). A vacuum loader (400) is provided in the dry granulator, and the vacuum loader (400) is connected to the powder collecting tank (600) and the feeding mechanism (100) via a pipeline.
2. A dry granulator for medicines according to claim 1, characterized in that: The feeding mechanism (100) comprises a feeding bin (101), a feeding pipe (102) connected to a feeding port of the feeding bin (101), and a feeding screw (103) arranged in the feeding pipe for conveying materials, wherein the pitch of the feeding screw (103) gradually decreases from an end close to the feeding port of the feeding bin (101) to an end far from the feeding port.
3. A dry granulator for medicines according to claim 1, characterized in that: The granulation mechanism (200) comprises a granulation bin (201) in the form of a vertical cylinder, a granulation screen (202) arranged along the cylindrical side wall of the granulation bin (201), a cavity being arranged between the granulation screen (202) and the granulation bin (201), a rotating frame (203) being arranged inside the granulation screen, and a plurality of groups of granulation rollers (204) being mounted on the rotating frame (203) for rotating and applying pressure to the inner wall of the granulation screen (202).
4. A dry granulator for medicines according to claim 3, characterized in that: The rotating frame (203) is also provided with a plurality of groups of stirring paddles (205), and the stirring paddles (205) and the plurality of groups of granulation rollers (204) are alternately installed on the rotating frame (203).
5. A dry granulator for medicines according to claim 3, characterized in that: The granulation screen (202) and the rotating frame (203) are coaxially arranged in the granulation bin (201) via a rotating unit (210); the rotating unit (210) comprises a granulation screen bevel gear (211), a rotating frame bevel gear (212) and a reverse bevel gear (213); the granulation screen bevel gear (211) and the rotating frame bevel gear (212) are respectively meshed with the reverse bevel gear (213); the rotating shaft of the rotating frame (203) is sleeved in the rotating shaft of the granulation screen (202); the reverse bevel gear (213) is connected to a first motor; and the granulation screen (202) and the rotating frame (203) rotate in opposite directions.
6. A dry granulator for medicines according to claim 3, characterized in that: The inner wall of the whole grain bin (201) is provided with a cleaning unit (220), the cleaning unit (220) comprising a cleaning brush (221) fitted with the whole grain screen (202), a connecting rod (222) fixedly connected to the cleaning brush, and an elastic unit (230) arranged inside the whole grain bin and connected to the connecting rod (222), the elastic unit (230) comprising a rotating clamp (233), a spring (231) arranged in the rotating clamp and providing elasticity to the connecting rod, and a clamping groove (232) coupled to the rotating clamp (233), the rotating clamp (233) being provided with a protrusion, the clamping groove (232) being provided with a notch matched with the protrusion, and the coupling comprising the protrusion and the notch being matched and then tightened.
7. A dry granulator for medicines according to claim 1, characterized in that: The screening mechanism (300) comprises a screening unit, a powder channel and a particle channel connected to the screening unit, the screening unit being fixedly installed between the powder channel and the particle channel, the screening unit comprising a screen unit (310) and a vibration unit (320) arranged at the lower side of the screen unit, wherein the screen unit (310) comprises a screen (311), a lining screen (312) arranged at the lower end of the screen (311), and a plurality of movable balls (330) bouncing between the screen (311) and the lining screen (312), and the vibration unit (320) comprises a toggle plate (323) abutting against the outer side of the lining screen (312), a driven rod (322) connected to the toggle plate (323), and a cam at the lower end of the driven rod (322) abutting against the cam via a return spring (325).
8. A dry granulator for medicines according to claim 7, characterized in that: The lining net (312) is made of a flexible material, and the movable ball (330) is made of a rubber material.
9. A dry granulator for medicines according to claim 7, characterized in that: The outlet of the particle channel is provided with a particle collection tank (500), and the outlet of the powder channel is provided with a powder collection tank (600).
10. The dry granulator for medicines according to claim 7, characterized in that: A control valve is provided on the connecting pipeline of the vacuum feeder (400), and the control valve is used to control the material in the powder channel to enter the feeding mechanism (100).