Magnetic particle reagent bottle placing box for chemiluminescence
By designing a reagent bottle placement box for chemiluminescence, a built-in mixing box and a motor, the continuous mixing of magnetic particles in the reagent bottle is achieved, and the problem of magnetic particles aggregation and precipitation is solved, and the accuracy of the detection results is improved.
Patent Information
- Application Number
- CN202421368577.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-17
- Publication Date
- 2025-05-13
- Estimated Expiration
- 2034-06-17
AI Technical Summary
In chemiluminescence immunoassay, magnetic particles tend to accumulate and precipitate during the detection process, resulting in inaccurate detection results.
Design a reagent bottle placement box for chemiluminescence, with a built-in mixing box and a motor. The rotating disc drives the rotating disk to continuously mix the magnetic particles in the reagent bottle to prevent aggregation and precipitation.
Effectively prevent the aggregation and precipitation of magnetic particles while waiting for detection, ensure uniform liquid extraction every time, and improve the accuracy and effectiveness of the detection results.
Smart Images
Figure CN222866337U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of mixing tubes, in particular to a magnetic particle reagent bottle placement box for chemiluminescence. Background Art
[0002] Chemiluminescent immunoassay is a highly sensitive micro-determination technology. The rapid automation of magnetic separation technology, the high sensitivity of chemiluminescence technology and the specificity of immunoassay make it play an irreplaceable role in the field of bioanalysis and is also an inevitable trend in the development of medical diagnosis. Magnetic particles, namely magnetic nanoparticles, are indispensable reagent components in chemiluminescent reagents. According to different applications, the sizes of magnetic particles vary to meet and improve their binding efficiency and stability. No matter how large the particle size is, the magnetic particles will aggregate and precipitate as long as they stop rotating.
[0003] During the detection process, the magnetic particles need to be constantly rotated and fully mixed to ensure that the liquid is taken the same each time to ensure the accuracy and effectiveness of the test results; during the test, multiple magnetic particles will be queued for testing, which will cause the magnetic particles in some reagent bottles to aggregate and precipitate.
[0004] Therefore, a chemiluminescent magnetic particle reagent bottle placement box is provided to prevent the magnetic particles from aggregating and precipitating when waiting for detection. Utility Model Content
[0005] Therefore, the purpose of the utility model is to provide a chemiluminescent magnetic particle reagent bottle placement box to solve the problems raised in the above background technology.
[0006] In order to solve the above technical problems, the utility model provides the following technical solutions: a chemiluminescence magnetic particle reagent bottle placement box, which includes a box body, a bottom plate is arranged at the bottom of the box body, a wiring socket is arranged on one side of the bottom plate, and a power cord is arranged on the outside of the wiring socket; a connector is arranged at the bottom of the inner side wall of the box body, and a connecting groove is arranged at the bottom on the opposite side of the connector; a mixing box is arranged inside the bottom plate.
[0007] As a preferred solution of the chemiluminescence magnetic microparticle reagent bottle placement box described in the utility model, a mixing seat is arranged at the bottom of the mixing box, an expansion head is arranged on one side of the mixing seat, and an expansion slot is arranged on the opposite side of the expansion head.
[0008] As a preferred solution of the chemiluminescence magnetic particle reagent bottle placement box described in the utility model, the interior of the mixing box is hollow, and a limiting ring is provided on the inner top of the mixing box.
[0009] As a preferred solution of the magnetic particle reagent bottle placement box for chemiluminescence described in the utility model, a motor is arranged on the top of the mixing seat, the motor is located at the center of the mixing seat, and a switch is arranged on one side of the motor on the mixing seat.
[0010] As a preferred solution of the magnetic particle reagent bottle placement box for chemiluminescence described in the utility model, a rotating shaft is arranged at the top center of the motor, and a second gear is arranged at the top end of the rotating shaft.
[0011] As a preferred solution of the chemiluminescent magnetic particle reagent bottle placement box described in the utility model, a plurality of notches are arranged on the top surface of the mixing seat, and the notches are evenly distributed around the motor.
[0012] As a preferred solution of a chemiluminescence magnetic particle reagent bottle placement box described in the utility model, a placement plate is arranged on the top of the mixing seat, a notch is arranged on the bottom surface of the placement plate, a compression spring is arranged inside the notch, and the position and number of the notch correspond to the notch on the mixing seat.
[0013] As a preferred solution of the chemiluminescent magnetic particle reagent bottle placement box described in the utility model, a rotating disk is arranged inside the placement disk, and the rotating disk is located on the inner side of the notch.
[0014] As a preferred solution of a chemiluminescence magnetic particle reagent bottle placement box described in the utility model, the top surface of the rotating disk is flush with the top surface of the placement disk, a plurality of first fixing rods are arranged on the bottom surface of the rotating disk, a first gear is arranged at one end of the first fixing rod, and the first fixing rods are evenly distributed around the center of the rotating disk.
[0015] As a preferred solution of a chemiluminescence magnetic particle reagent bottle placement box described in the utility model, a second fixing rod is arranged at the bottom of the placement plate, a contact head is arranged at one end of the second fixing rod, the length of the second fixing rod is greater than the length of the first fixing rod, the second fixing rod is located between the rotating plate and the slot, and the second fixing rod corresponds to the position of the switch.
[0016] Beneficial effects of the utility model:
[0017] 1. The utility model provides a box for placing magnetic particle reagent bottles for chemiluminescence. By arranging a mixing box, multiple mixing boxes can be placed in the box body at the same time, thereby improving the utilization rate of the space in the box body.
[0018] 2. The utility model provides a chemiluminescent magnetic particle reagent bottle placement box, which makes the installation of the mixing box more flexible and the operation more convenient by arranging a connecting head, a connecting slot, an extension head and an extension slot.
[0019] 3. The utility model provides a box for placing magnetic particle reagent bottles for chemiluminescence. By setting a mixing box, the reagent bottles placed in the mixing box are continuously mixed, preventing the magnetic particles from aggregating and precipitating while waiting for detection. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the following briefly introduces the drawings required for the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative labor. Among them:
[0021] Figure 1 This is a schematic diagram of the overall structure of a chemiluminescent magnetic particle reagent bottle placement box of the utility model;
[0022] Figure 2 This is a structural schematic diagram of a box body for placing a magnetic particle reagent bottle for chemiluminescence according to the utility model;
[0023] Figure 3 This is a structural schematic diagram of a box body for placing a magnetic particle reagent bottle for chemiluminescence according to the utility model;
[0024] Figure 4 This is a structural schematic diagram of a chemiluminescent magnetic particle reagent bottle placement box and a mixing box of the utility model;
[0025] Figure 5 This is a structural schematic diagram of a chemiluminescent magnetic particle reagent bottle placement box and a mixing box of the utility model;
[0026] Figure 6 This is a schematic diagram of the internal structure of a chemiluminescent magnetic particle reagent bottle placement box and a mixing box of the utility model;
[0027] Figure 7 This is a schematic diagram of the structure of a mixing seat for placing a magnetic particle reagent bottle for chemiluminescence according to the utility model;
[0028] Figure 8 The utility model is a structural schematic diagram of a chemiluminescence magnetic particle reagent bottle placement box and a placement plate.
[0029] Description of reference numerals:
[0030] 1. Box body; 11. Bottom plate; 12. Terminal block; 13. Power cord; 14. Connector; 15. Connecting slot; 2. Mixing box; 21. Mixing seat; 22. Limiting ring; 23. Extension head; 24. Extension slot; 25. Placement plate; 26. Rotating plate; 3. Notch; 31. Compression spring; 4. First fixing rod; 41. First gear; 5. Second fixing rod; 51. Contact head; 6. Motor; 61. Switch; 62. Rotating shaft; 63. Second gear. DETAILED DESCRIPTION
[0031] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings.
[0032] Reference Figure 1-8 , a chemiluminescent magnetic particle reagent bottle placement box provided by the utility model, this chemiluminescent magnetic particle reagent bottle placement box includes a box body 1, a bottom plate 11 is arranged at the bottom of the box body 1, a wiring seat 12 is arranged on one side of the bottom plate 11, and a power cord 13 is arranged on the outside of the wiring seat 12; a connector 14 is arranged at the bottom of the inner side wall of the box body 1, and a connecting groove 15 is arranged at the bottom on the opposite side of the connector 14; a mixing box 2 is arranged inside the bottom plate 11.
[0033] Specifically, a bottom plate 11 is provided at the bottom of the box body 1, a wiring socket 12 is provided on one side of the bottom plate 11, a power cord 13 is provided on the outer side of the wiring socket 12, and the device is powered on by the wiring socket 12 and the power cord 13; a power cord 13 is provided on the outer side of the wiring socket 12; a connector 14 is provided at the bottom of the inner side wall of the box body 1, and a connecting groove 15 is provided at the bottom on the opposite side of the connector 14; a mixing box 2 is provided inside the bottom plate 11, which is connected to the mixing box 2 through the connector 14 or the connecting groove 15, so that the mixing box 2 is fixed inside the box body 1, and the wiring socket 12 is powered on.
[0034] A mixing seat 21 is disposed at the bottom of the mixing box 2 , an expansion head 23 is disposed on one side of the mixing seat 21 , and an expansion slot 24 is disposed on the opposite side of the expansion head 23 .
[0035] Specifically, a mixing seat 21 is provided at the bottom of the mixing box 2, an expansion head 23 is provided on one side of the mixing seat 21, and an expansion slot 24 is provided on the opposite side of the expansion head 23. The size of the expansion head 23 is the same as that of the connecting head 14, and the size of the expansion slot 24 is the same as that of the connecting slot 15. A single mixing box 2 can be connected to the box body 1 by connecting the expansion head 23 to the connecting slot 15 or by connecting the expansion slot 24 to the connecting head 14; multiple mixing boxes 2 can be connected in series through the connection between the connecting head 14 and the connecting slot 15.
[0036] The interior of the mixing box 2 is hollow, and a limiting ring 22 is provided on the inner top of the mixing box 2 .
[0037] Specifically, a limiting ring 22 is provided at the inner top of the mixing box 2 , and one end of the reagent bottle placed in the mixing box 2 is limited by the limiting ring 22 . The inner wall of the limiting ring 22 is smooth, so that the reagent bottle can rotate in the limiting ring 22 .
[0038] A motor 6 is disposed on the top of the mixing seat 21 . The motor 6 is located at the center of the mixing seat 21 . A switch 61 is disposed on one side of the motor 6 on the mixing seat 21 .
[0039] Specifically, the motor 6 is connected to an external power source through the expansion head 23 or the expansion slot 24 ; and the operation of the motor 6 is controlled by the switch 61 .
[0040] A rotating shaft 62 is disposed at the top center of the motor 6 , and a second gear 63 is disposed at the top end of the rotating shaft 62 .
[0041] Specifically, the motor 6 outputs power to the outside through the rotating shaft 62 .
[0042] A plurality of notches 3 are arranged on the top surface of the mixing seat 21 , and the notches 3 are evenly distributed around the motor 6 .
[0043] Specifically, the downward force is dispersed through a plurality of notches 3 .
[0044] A placement plate 25 is arranged on the top of the mixing seat 21 , a notch 3 is arranged on the bottom surface of the placement plate 25 , a compression spring 31 is arranged inside the notch 3 , and the position and number of the notch 3 correspond to the notch 3 on the mixing seat 21 .
[0045] Specifically, a placement plate 25 is provided on the top of the mixing seat 21, and the top surface of the placement plate 25 is slotted; a notch 3 is provided on the bottom surface of the placement plate 25, and a compression spring 31 is provided inside the notch 3, and one end of the compression spring 31 is fixed in the notch 3; the position and number of the notches 3 correspond to the notches 3 on the mixing seat 21, so that the other end of the compression spring 31 is placed in the notch 3 on the mixing seat 21. When the placement plate 25 is pressed down, the downward pressure is dispersed to reduce the wear on the mixing seat 21, and at the same time, the notch 3 on the mixing seat 21 is prevented from limiting the bottom of the compression spring 31.
[0046] A rotating disk 26 is disposed inside the placement disk 25 , and the rotating disk 26 is located at the inner side of the slot 3 .
[0047] Specifically, the reagent bottle placed in the placement plate 25 is rotated by the rotating plate 26 , and the rotating plate 26 is located at the inner side of the notch 3 , so that the rotation of the rotating plate 26 does not affect the movement of the compression spring 31 .
[0048] The top surface of the rotating disk 26 is flush with the top surface of the placement disk 25 . A plurality of first fixing rods 4 are arranged on the bottom surface of the rotating disk 26 . A first gear 41 is arranged at one end of the first fixing rods 4 . The first fixing rods 4 are evenly distributed around the center of the rotating disk 26 .
[0049] Specifically, the top surface of the rotating disk 26 is flush with the top surface of the placement disk 25, so that the top surface of the placement disk 25 is a plane; a plurality of first fixing rods 4 are arranged on the bottom surface of the rotating disk 26, and a first gear 41 is arranged at one end of the first fixing rod 4. The first fixing rods 4 are evenly distributed around the center of the rotating disk 26, and the first gear 41 is engaged with the second gear 63, so that the rotating disk 26 is driven to rotate when the motor 6 is working.
[0050] A second fixing rod 5 is provided at the bottom of the placement plate 25, and a contact head 51 is provided at one end of the second fixing rod 5. The length of the second fixing rod 5 is greater than that of the first fixing rod 4. The second fixing rod 5 is located between the rotating plate 26 and the slot 3, and the second fixing rod 5 corresponds to the position of the switch 61.
[0051] Specifically, the contact head 51 applies downward pressure to the switch 61 by lowering the placement plate 25 , without affecting the meshing of the first gear 41 and the second gear 63 , or the rotation of the rotating plate 26 .
[0052] During use, the power cord 13 is used to connect to the external power supply to provide power to the box body 1. Multiple mixing boxes 2 can be placed inside the box body 1 at the same time and power is provided to them. One end of the reagent bottle is placed on the placement tray 25 in the mixing box 2. The reagent bottle generates downward pressure on the placement tray 25, compressing the compression spring 31, driving the contact head 51 to apply downward pressure on the compression spring 31, and at the same time making the first gear 41 mesh with the second gear 63. The continuous downward pressure of the contact head 51 keeps the motor 6 working, driving the rotating disk 26 to rotate continuously, and the other end of the reagent bottle rotates in the limit ring 22. When the reagent bottle is taken out, the compression spring 31 rebounds, the contact head 51 and the switch 61 are disengaged, the first gear 41 and the second gear 63 are disengaged, and the motor 6 stops working.
[0053] It should be noted that the above embodiments are only used to illustrate the technical solution of the utility model rather than to limit it. Although the utility model has been described in detail with reference to the preferred embodiments, ordinary technicians in the field should understand that the technical solution of the utility model can be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the utility model, which should be included in the scope of the claims of the utility model.
Claims
1. A chemiluminescent magnetic particle reagent bottle placement box, characterized in that: The invention comprises a box body (1), wherein a bottom plate (11) is arranged at the bottom of the box body (1), a wiring seat (12) is arranged on one side of the bottom plate (11), and a power line (13) is arranged outside the wiring seat (12); a connector (14) is arranged at the bottom of the inner side wall of the box body (1), and a connecting groove (15) is arranged at the bottom of the side opposite to the connector (14); and a mixing box (2) is arranged inside the bottom plate (11).
2. A chemiluminescent magnetic particle reagent bottle placement box according to claim 1, characterized in that: The mixing box (2) is provided with a mixing seat (21) at the bottom, an expansion head (23) is provided on one side of the mixing seat (21), and an expansion slot (24) is provided on the opposite side of the expansion head (23).
3. A chemiluminescent magnetic particle reagent bottle placement box according to claim 2, characterized in that: The interior of the mixing box (2) is hollow, and a limiting ring (22) is provided on the inner top of the mixing box (2).
4. A chemiluminescent magnetic particle reagent bottle placement box according to claim 3, characterized in that: A motor (6) is arranged on the top of the mixing seat (21), the motor (6) is located at the center of the mixing seat (21), and a switch (61) is arranged on one side of the motor (6) on the mixing seat (21).
5. The chemiluminescent magnetic particle reagent bottle placement box according to claim 4, characterized in that: A rotating shaft (62) is arranged at the top center of the motor (6), and a second gear (63) is arranged at the top end of the rotating shaft (62).
6. The chemiluminescent magnetic particle reagent bottle placement box according to claim 5, characterized in that: A plurality of notches (3) are provided on the top surface of the mixing seat (21), and the notches (3) are evenly distributed around the motor (6).
7. The chemiluminescent magnetic particle reagent bottle placement box according to claim 6, characterized in that: A placement plate (25) is provided on the top of the mixing seat (21), a notch (3) is provided on the bottom surface of the placement plate (25), a compression spring (31) is provided inside the notch (3), and the position and number of the notch (3) correspond to the notches (3) on the mixing seat (21).
8. The chemiluminescent magnetic particle reagent bottle placement box according to claim 7, characterized in that: A rotating disk (26) is disposed inside the placement disk (25), and the rotating disk (26) is located on the inner side of the notch (3).
9. A chemiluminescent magnetic particle reagent bottle placement box according to claim 8, characterized in that: The top surface of the rotating disk (26) is flush with the top surface of the placement disk (25); a plurality of first fixing rods (4) are arranged on the bottom surface of the rotating disk (26); a first gear (41) is arranged at one end of the first fixing rod (4); and the first fixing rods (4) are evenly distributed around the center of the rotating disk (26).
10. The chemiluminescent magnetic particle reagent bottle placement box according to claim 9, characterized in that: A second fixing rod (5) is provided at the bottom of the placement plate (25), a contact head (51) is provided at one end of the second fixing rod (5), the length of the second fixing rod (5) is greater than the length of the first fixing rod (4), the second fixing rod (5) is located between the rotating plate (26) and the notch (3), and the second fixing rod (5) corresponds to the position of the switch (61).