Separation and purification device for chenodeoxycholic acid in pig bile

Abstract

The utility model relates to the technical field of chenodeoxycholic acid production and processing, and discloses a separation and purification device for chenodeoxycholic acid in pig bile, which comprises a separation device, a purification device is arranged on the side wall of the separation device, a plurality of connecting columns are fixedly connected to the side wall of the purification device, the top of each connecting column is fixedly connected with a hydraulic rod, and the hydraulic rod is fixedly connected with the purification device. The output end of the hydraulic rod is fixedly connected with a push column, the push column is slidably connected to the interior of the connecting column, the interior of the connecting column is slidably connected with a sliding column, the interior of the connecting column is provided with a plurality of rotating grooves, the side wall of the connecting column is rotatably connected with a plurality of clamping plates, and the clamping plates are rotatably connected to the interiors of the rotating grooves. According to the utility model, through the matching of the structures such as the push column, the clamping plate and the collecting tank, the separated and purified extracting solution can be collected without tedious operation, and the quick and convenient operation mode also ensures that the extracting solution is not polluted, so that the purity and the quality of the extracting solution are ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of chenodeoxycholic acid production and processing, in particular to a separation and purification device for chenodeoxycholic acid in pig bile. Background Art

[0002] Chenodeoxycholic acid is an important bile acid and a type of bile acid. It is formed by the carboxylation of part of the hydroxyl groups of chenodeoxycholic acid and bile acid. Chenodeoxycholic acid is a major bile component and participates in the production and excretion of bile together with bile salts. It plays an important role in the digestion and absorption of fat. Chenodeoxycholic acid and its derivatives are widely used in the fields of medicine, chemical industry and biopharmaceuticals. They are used as drug ingredients, bile acid derivatives, cosmetic raw materials, etc., and play an important role in drug research and development, biocatalysis and chemical synthesis. In the extraction of chenodeoxycholic acid, a separation and purification device may be used to extract and separate chenodeoxycholic acid from pig bile.

[0003] In the traditional chenodeoxycholic acid separation and purification device in pig bile, the extracted bile will be sent to a preliminary separation device. This may be a centrifuge or a filter device, which is used to separate the solid particles and macromolecular substances in the bile to obtain a relatively pure liquid. Extraction is a common separation technology that can be used to extract the target substance from the mixture. In this process, the bile may be added to an extractor and mixed with a specific solvent or extractant. These solvents selectively dissolve the target compound (such as chenodeoxycholic acid) to achieve separation from other components. If a higher purity of chenodeoxycholic acid is required, it can be further purified by crystallization technology. This may involve crystallizing the target substance in an appropriate solvent and removing impurities by washing to obtain a purer product.

[0004] However, traditional devices for separating and purifying chenodeoxycholic acid in pig bile often lack a collection system or have a relatively simple collection system, and the collection of the extract may be controlled by the opening and closing of a valve. This collection method is not conducive to the collection and preservation of chenodeoxycholic acid in pig bile after separation and purification, which not only increases the difficulty of collection, but also poses a risk of contamination. Utility Model Content

[0005] In order to make up for the above shortcomings, the utility model provides a separation and purification device for chenodeoxycholic acid in pig bile, aiming to improve the traditional separation and purification device for chenodeoxycholic acid in pig bile, which often lacks a collection system or has a relatively single collection system, which is not conducive to the collection and preservation of chenodeoxycholic acid in pig bile after separation and purification, and not only increases the difficulty of collection, but also poses a risk of contamination.

[0006] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a separation and purification device of chenodeoxycholic acid in pig bile, comprising a separation device, a purification device is arranged on the side wall of the separation device, a plurality of connecting columns are fixedly connected to the side wall of the purification device, a hydraulic rod is fixedly connected to the top of each connecting column, a push column is fixedly connected to the output end of the hydraulic rod, the push column is slidably connected to the inside of the connecting column, a sliding column is slidably connected to the inside of the connecting column, a plurality of rotating grooves are opened inside the connecting column, a plurality of card plates are rotatably connected to the side wall of the connecting column, the card plates are rotatably connected to the inside of the rotating groove, a spring is fixedly connected to one end of the inside of the connecting column, and a collecting component is arranged on the side wall of the connecting column.

[0007] Furthermore, the collecting assembly comprises a collecting tank, and a plurality of the collecting tanks are arranged on the side wall of the connecting column.

[0008] Furthermore, a base is fixedly connected inside the separation device, and a plurality of slide rails are fixedly connected to the top of the base.

[0009] Furthermore, a motor is fixedly connected inside the base, and a rotating plate is fixedly connected to an output end of the motor.

[0010] Furthermore, two ends of the rotating plate are rotatably connected to a plurality of connecting rods, and one end of the connecting rod is rotatably connected to a slide.

[0011] Furthermore, the slide is slidably connected to the top of the slide rail, and an extractor is arranged on the top of the base.

[0012] Furthermore, a connecting frame is fixedly connected to the top of the slide, and a plurality of clamping platforms are fixedly connected to the side walls of the connecting frame.

[0013] Furthermore, each card table is rotatably connected to a pulley inside, and the pulley is slidably connected to the side wall of the extractor.

[0014] The utility model has the following beneficial effects:

[0015] 1. In the utility model, pig bile is first separated and purified by a separation device and a purification device. When the collecting tank needs to be replaced, the hydraulic rod pushes the push column so that the rotating trough is pushed by the sliding column to rotate the card plate, thereby releasing the engagement of the collecting tank, thereby realizing rapid disassembly and assembly of the collecting tank, and improving the separation and purification efficiency of chenodeoxycholic acid in pig bile.

[0016] 2. In the utility model, the rotation of the rotating plate is controlled by a motor so that the slide table slides on the top of the slide rail. At this time, the card table can engage the extractor. At the same time, the setting of the pulley ensures that the position of the extractor will not be locked. This structure facilitates the disassembly and assembly of the extractor and improves the maintenance efficiency of the extractor. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A three-dimensional diagram of a device for separating and purifying chenodeoxycholic acid in pig bile proposed in the utility model;

[0018] Figure 2 This is a schematic diagram of the structure of a purification device for separating and purifying chenodeoxycholic acid in pig bile proposed in the utility model;

[0019] Figure 3 This is a schematic diagram of the connecting column structure of the device for separating and purifying chenodeoxycholic acid in pig bile proposed by the utility model;

[0020] Figure 4 This is a schematic diagram of the structure of a separation device for separating and purifying chenodeoxycholic acid in pig bile proposed in the utility model;

[0021] Figure 5 The present invention is a schematic diagram of the base structure of the device for separating and purifying chenodeoxycholic acid in pig bile proposed by the present invention.

[0022] Legend:

[0023] 1. Separation device; 2. Purification device; 3. Connecting column; 4. Hydraulic rod; 5. Push column; 6. Sliding column; 7. Rotating trough; 8. Card plate; 9. Spring; 10. Collecting tank; 11. Base; 12. Motor; 13. Slide rail; 14. Slide table; 15. Rotating plate; 16. Connecting rod; 17. Connecting frame; 18. Card table; 19. Pulley; 20. Extractor. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] Reference Figure 1 , Figure 2 and Figure 3 The utility model provides an embodiment: a separation and purification device for chenodeoxycholic acid in pig bile, comprising a separation device 1, a purification device 2 is arranged on the side wall of the separation device 1, a plurality of connecting columns 3 are fixedly connected to the side wall of the purification device 2, a hydraulic rod 4 is fixedly connected to the top of each connecting column 3, a push column 5 is fixedly connected to the output end of the hydraulic rod 4, the push column 5 is slidably connected to the inside of the connecting column 3, a sliding column 6 is slidably connected to the inside of the connecting column 3, a plurality of rotating grooves 7 are opened inside the connecting column 3, a plurality of card plates 8 are rotatably connected to the side wall of the connecting column 3, the card plates 8 are rotatably connected to the inside of the rotating groove 7, a spring 9 is fixedly connected to one end of the inside of the connecting column 3, and a collecting component is arranged on the side wall of the connecting column 3.

[0026] Specifically, the separation device 1 and the purification device 2 separate and purify chenodeoxycholic acid in pig bile. The hydraulic rod 4 drives the push column 5 to slide inside the connecting column 3 by outputting a push-pull force. This action causes the push column 5 to push the sliding column 6, which in turn causes the sliding column 6 to slide inside the connecting column 3. In this process, one end of the sliding column 6 contacts the card plate 8, triggering the rotation of multiple card plates 8 inside the rotating groove 7 and changing their own inclination angles. Through the rotation of the card plate 8, the engagement state of the edge card groove of the collecting tank 10 can be changed. In addition, through the setting of the spring 9, the card plate 8 can be reset to ensure that it is restored to its original state. Such a design structure realizes the rapid disassembly and assembly of the collecting tank 10, and the separated and purified extract can be collected without cumbersome operations. This fast and convenient operation method also ensures that the extract will not be contaminated, thereby ensuring the purity and quality of the extract. The efficient execution of this process makes the experiment or production process smoother and improves work efficiency and product quality.

[0027] Reference Figure 1 , Figure 4 and Figure 5 The collecting assembly includes a collecting tank 10, and a plurality of collecting tanks 10 are arranged on the side wall of the connecting column 3. A base 11 is fixedly connected inside the separating device 1, and a plurality of slide rails 13 are fixedly connected to the top of the base 11. A motor 12 is fixedly connected inside the base 11, and a rotating plate 15 is fixedly connected to the output end of the motor 12. A plurality of connecting rods 16 are rotatably connected at both ends of the rotating plate 15, and a slide 14 is rotatably connected at one end of the connecting rod 16. The slide 14 is slidably connected to the top of the slide rail 13. An extractor 20 is arranged on the top of the base 11, and a connecting frame 17 is fixedly connected to the top of the slide 14. A plurality of card tables 18 are fixedly connected to the side wall of the connecting frame 17, and a pulley 19 is rotatably connected inside each card table 18, and the pulley 19 is slidably connected to the side wall of the extractor 20.

[0028] Specifically, the motor 12 drives the rotating plate 15 to rotate on the top of the base 11 and change its own inclination angle through the rotational force output by it. This action causes the connecting rods 16 at both ends of the rotating plate 15 to be pushed and pulled, so that the side walls of the rotating plate 15 rotate and change the inclination angle. At the same time, the slide 14 is subjected to force to slide on the surface of the slide rail 13. Through the following of the connecting frame 17, the sliding of the slide 14 drives the multiple clamping tables 18 on its side wall to engage the extractor 20. In this process, the setting of multiple pulleys 19 ensures that the extractor 20 will not be locked, but maintains a stable position and can rotate freely. This design structure makes the disassembly and assembly of the extractor 20 convenient and efficient. There is no need to adjust the position or release the fixation laboriously. The operator can easily complete the maintenance and cleaning work, thereby improving the maintenance efficiency. Such a mechanism not only saves time, but also reduces the inconvenience and difficulty of operation during the maintenance process, making the maintenance and management of the equipment more convenient and efficient.

[0029] Working principle: When it is necessary to separate and purify chenodeoxycholic acid in pig bile, it is extracted and separated by the separation device 1 and the purification device 2. When the above process is completed and the extract is collected, the hydraulic rod 4 is first started. The hydraulic rod 4 outputs a push-pull force to the push column 5 to drive the push column 5 to slide inside the connecting column 3. At this time, the push column 5 pushes the sliding column 6 so that the sliding column 6 also slides inside the connecting column 3. At this time, one end of the sliding column 6 touches the card plate 8, so that multiple card plates 8 rotate inside the rotating groove 7 and change their own inclination angle. The card plate 8 can be rotated to change the card state of the edge card groove of the collection tank 10, and the card plate 8 can be reset by the setting of the spring 9. This structure realizes the rapid disassembly and assembly of the collection tank 10, and the separated and purified extract can be purified without complicated operations. The collection is carried out quickly and conveniently, and the extraction liquid is not contaminated. When the extractor 20 inside the separation device 1 needs to be maintained and cleaned, the motor 12 is started, and the motor 12 outputs a rotating force to the rotating plate 15 to drive the rotating plate 15 to rotate on the top of the base 11 and change its own inclination angle. At this time, the connecting rods 16 at both ends of the rotating plate 15 are pushed and pulled, and the side wall of the rotating plate 15 rotates and changes its inclination angle. At this time, the slide 14 is forced to slide on the surface of the slide rail 13, and the connecting frame 17 follows the sliding of the slide 14 to drive the multiple clamping tables 18 on its side wall to clamp the extractor 20. At the same time, the setting of multiple pulleys 19 ensures that the extractor 20 will not be locked, and the position is stable and can be rotated. Therefore, the structure facilitates the disassembly and assembly of the extractor 20, and improves the maintenance efficiency of the extractor 20.

[0030] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A separation and purification device for chenodeoxycholic acid in pig bile, comprising a separation device (1), characterized in that: The side wall of the separation device (1) is provided with a purification device (2), and the side wall of the purification device (2) is fixedly connected with a plurality of connection columns (3), and the top of each connection column (3) is fixedly connected with a hydraulic rod (4), and the output end of the hydraulic rod (4) is fixedly connected with a push column (5), and the push column (5) is slidably connected to the inside of the connection column (3), and the inside of the connection column (3) is slidably connected with a sliding column (6), and a plurality of rotation grooves (7) are opened inside the connection column (3), and the side wall of the connection column (3) is rotatably connected with a plurality of clamping plates (8), and the clamping plates (8) are rotatably connected to the inside of the rotation groove (7), and a spring (9) is fixedly connected to one end of the connection column (3), and a collecting component is provided on the side wall of the connection column (3).

2. The separation and purification device for chenodeoxycholic acid in pig bile according to claim 1, characterized in that: The collecting assembly comprises a collecting tank (10), and a plurality of the collecting tanks (10) are arranged on the side wall of the connecting column (3).

3. The separation and purification device for chenodeoxycholic acid in pig bile according to claim 2, characterized in that: The separation device (1) is fixedly connected to a base (11) inside, and a plurality of slide rails (13) are fixedly connected to the top of the base (11).

4. The separation and purification device for chenodeoxycholic acid in pig bile according to claim 3, characterized in that: A motor (12) is fixedly connected inside the base (11), and a rotating plate (15) is fixedly connected to the output end of the motor (12).

5. The separation and purification device for chenodeoxycholic acid in pig bile according to claim 4, characterized in that: The two ends of the rotating plate (15) are rotatably connected to a plurality of connecting rods (16), and one end of the connecting rod (16) is rotatably connected to a slide table (14).

6. The separation and purification device for chenodeoxycholic acid in pig bile according to claim 5, characterized in that: The slide table (14) is slidably connected to the top of the slide rail (13), and an extractor (20) is arranged on the top of the base (11).

7. The separation and purification device for chenodeoxycholic acid in pig bile according to claim 6, characterized in that: The top of the slide (14) is fixedly connected to a connecting frame (17), and the side wall of the connecting frame (17) is fixedly connected to a plurality of clamping tables (18).

8. The device for separating and purifying chenodeoxycholic acid in pig bile according to claim 7, characterized in that: Each card table (18) is rotatably connected to a pulley (19) inside, and the pulley (19) is slidably connected to the side wall of the extractor (20).

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