Adjustable biological medicine reaction kettle

Abstract

The utility model discloses an adjustable biological medicine reaction kettle and relates to the technical field of reaction kettles. The reaction kettle comprises a supporting plate, supporting frames are fixedly connected to the two sides, close to the middle, of the upper surface of the supporting plate, the upper ends of the two supporting frames are fixedly connected with a reaction kettle body through bolts, and the reaction kettle body is used for medicine synthesis; the stirring assembly comprises a stirring shaft rotationally mounted in the reaction kettle body. According to the reaction kettle disclosed by the utility model, the reaction kettle body is transversely arranged, so that the stirring efficiency can be improved, and the scrapers and the stirring blades on the stirring shaft are fixedly connected through bolts, so that the positions of the scrapers and the stirring blades can be adjusted according to the condition of reactants, the mixing efficiency of the reactants can be improved, and non-uniform local concentration is avoided; and the heating assembly and the temperature sensor are matched for use, so that the temperature in the reaction kettle is more convenient and accurate to adjust.

Description

Technical Field

[0001] The utility model belongs to the technical field of reaction kettles, in particular to an adjustable biomedical reaction kettle. Background Art

[0002] Biopharmaceutical reactors are key equipment used in biotechnology and pharmaceutical industries for chemical reactions, biological fermentation, cell culture, drug synthesis and other processes. Biopharmaceutical reactors are generally used for various biochemical reactions to ensure product quality and production efficiency, but there are the following deficiencies when using them:

[0003] 1. The stirring effect of some existing biopharmaceutical reactors is poor, and the reactants are not mixed sufficiently, resulting in uneven local concentrations, which may lead to a decrease in overall production efficiency.

[0004] 2. At the same time, some biomedical reactors are not convenient for adjusting the temperature of the reactor, which may lead to unstable reaction conditions and affect the reaction process.

[0005] For this purpose, we propose an adjustable biopharmaceutical reactor. Utility Model Content

[0006] The purpose of the utility model is to solve the problems in the prior art that some biopharmaceutical reactors have poor stirring effect and insufficient mixing of reactants, resulting in uneven local concentrations, which may lead to reduced overall production efficiency. At the same time, some biopharmaceutical reactors are not convenient for adjusting the temperature of the reactors, which may lead to unstable reaction conditions and affect the reaction process. An adjustable biopharmaceutical reactor is proposed.

[0007] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0008] An adjustable biopharmaceutical reactor, comprising:

[0009] A support plate, wherein both sides of the upper surface of the support plate near the middle are fixedly connected with support frames, and the upper ends of the two support frames are fixedly connected with the reactor body by bolts, and are used for the synthesis of drugs;

[0010] A stirring assembly, the stirring assembly comprises a stirring shaft rotatably mounted inside the reactor body, the outer wall of the stirring shaft is fixedly connected to two scrapers by bolts, and the outer wall of the stirring shaft is fixedly connected to two stirring blades by bolts;

[0011] A heating assembly, the heating assembly comprising a heating wire fixedly mounted on the inner wall of the reactor body, a temperature sensor fixedly connected to the lower portion of the inner wall at the rear end of the reactor body, for heating the reaction medium;

[0012] The front end of the upper surface of the support plate is fixedly connected with a protective cover by bolts, and the upper surface of the protective cover is fixedly connected with a PLC controller.

[0013] In a possible design, both sides of the upper surface of the support plate are fixedly connected to limit plates by bolts, and the limit plates are rotatably connected to the stirring shaft. The front end of the upper surface of the support plate is fixedly connected to a servo motor, and the output end of the servo motor is fixedly connected to a small pulley. The front end of the stirring shaft passes through the limit plate and is fixedly connected to a large pulley. The outer walls of the small pulley and the large pulley are provided with belts for driving the stirring shaft to rotate.

[0014] In a possible design, an end cover is hingedly connected to the upper end of the reactor body, and the reactor body and the end cover are fixedly connected by bolts.

[0015] In a possible design, an observation window is provided on one side of the upper end of the end cover, feeding ports are provided at both ends of the upper surface of the end cover, and a sampling port is fixedly connected to the middle of the upper surface of the end cover.

[0016] In a possible design, a second handle is fixedly connected to one side of the upper surface of the end cover.

[0017] In a possible design, self-locking universal wheels are fixedly connected to the four corners of the lower surface of the support plate, and a first handle is fixedly connected to the upper portion of the front end outer wall of the protective cover.

[0018] In the present application, when in use, first start the servo motor, and drive the stirring shaft connected to the large pulley to rotate through the belt. The two scrapers and two stirring blades installed on the stirring shaft can be used to stir the reaction medium. By setting a heating wire, it can be used to heat the reaction medium. By setting a temperature sensor, it can be used to monitor the temperature. The PLC controller, the heating wire, the temperature sensor and the servo motor can adjust the temperature inside the reactor body, and at the same time, the stirring speed of the stirring shaft can be adjusted according to different reactants. By setting an observation window, a feeding port and a sampling port on the end cover, it can facilitate observation, feeding and sampling. By setting a self-locking universal wheel, the mobility and convenience of operation of the reactor can be improved.

[0019] In the utility model, the adjustable biopharmaceutical reactor can improve the stirring efficiency by placing the reactor body horizontally, and the scraper and the stirring blade on the stirring shaft are fixedly connected by bolts, so that the positions of the scraper and the stirring blade can be adjusted according to the situation of the reactants, which can improve the mixing efficiency of the reactants and avoid local uneven concentration, thereby improving the overall production efficiency. The coordinated use of the heating component and the temperature sensor makes the temperature adjustment in the reactor more convenient and accurate. The use of the PLC controller realizes the automatic control of the stirring and heating process, reduces manual intervention, and improves the convenience of operation and the repeatability of the reaction.

[0020] In the utility model, the adjustable biopharmaceutical reactor is designed to facilitate observation, feeding and sampling during the reaction process by arranging an observation window, a feeding port and a sampling port. The mobility of the equipment and the safety during operation are improved by arranging a self-locking universal wheel and two handles. The inner wall of the reactor can be cleaned and maintained by arranging a scraper on the stirring shaft, which helps to maintain the long-term stable operation of the equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0022] Figure 1 This is a schematic diagram of a three-dimensional structure of an embodiment of the utility model;

[0023] Figure 2 A rear three-dimensional structural schematic diagram of an embodiment of the utility model;

[0024] Figure 3 This is a schematic diagram of the three-dimensional structure inside the reactor body of an embodiment of the utility model;

[0025] Figure 4 This is a schematic diagram of a three-dimensional cross-sectional structure of a reactor body according to an embodiment of the utility model;

[0026] Figure 5 This is a schematic diagram of the three-dimensional structure of a stirring shaft according to an embodiment of the utility model.

[0027] In the figure: 1. support plate; 2. support frame; 3. reactor body; 4. end cover; 5. servo motor; 6. small pulley; 7. large pulley; 8. belt; 9. stirring shaft; 10. scraper; 11. stirring blade; 12. heating wire; 13. temperature sensor; 14. protective cover; 15. PLC controller; 16. observation window; 17. feeding port; 18. sampling port; 19. first handle; 20. second handle; 21. self-locking universal wheel; 22. limit plate. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0029] In the description of the present invention, it should be understood that the terms "opening", "upper", "middle", "length", "inside" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0030] In order to keep the following description of the embodiments of the present invention clear and concise, the present invention omits detailed descriptions of known functions and known components.

[0031] Example 1

[0032] Reference Figure 1-Figure 5 , a reaction kettle, comprising:

[0033] A support plate 1, both sides of the upper surface of the support plate 1 near the middle are fixedly connected with support frames 2, and the upper ends of the two support frames 2 are fixedly connected with a reactor body 3 by bolts, which is used for the synthesis of drugs;

[0034] A stirring assembly, the stirring assembly comprises a stirring shaft 9 rotatably mounted inside the reactor body 3, the outer wall of the stirring shaft 9 is fixedly connected to two scrapers 10 by bolts, and the outer wall of the stirring shaft 9 is fixedly connected to two stirring blades 11 by bolts;

[0035] A heating assembly, the heating assembly includes a heating wire 12 fixedly mounted on the inner wall of the reactor body 3, and a temperature sensor 13 is fixedly connected to the lower part of the inner wall at the rear end of the reactor body 3, for heating the reaction medium;

[0036] A protective cover 14 is fixedly connected to the front end of the upper surface of the support plate 1 through bolts, and a PLC controller 15 is fixedly connected to the upper surface of the protective cover 14 .

[0037] In the above technical solution, two scrapers 10 and two stirring blades 11 installed on the stirring shaft 9 can be used to stir the reaction medium, and a heating wire 12 is provided to heat the reaction medium. A temperature sensor 13 is provided to monitor the temperature. The PLC controller 15, the heating wire 12, the temperature sensor 13 and the servo motor 5 can adjust the temperature in the reactor body 3, and adjust the stirring speed of the stirring shaft 9 according to different reactants.

[0038] In one aspect of this embodiment, Figure 3 As shown, both sides of the upper surface of the support plate 1 are fixedly connected with a limit plate 22 by bolts, the limit plate 22 is rotatably connected to the stirring shaft 9, the front end of the upper surface of the support plate 1 is fixedly connected with a servo motor 5, the output end of the servo motor 5 is fixedly connected with a small pulley 6, the front end of the stirring shaft 9 passes through the limit plate 22 and is fixedly connected with a large pulley 7, and the outer walls of the small pulley 6 and the large pulley 7 are provided with a belt 8.

[0039] In the above technical solution, a servo motor 5 is provided to drive the stirring shaft 9 to rotate.

[0040] In one aspect of this embodiment, Figure 1 As shown, the upper end of the reactor body 3 is hingedly connected with an end cover 4, and the reactor body 3 and the end cover 4 are fixedly connected by bolts.

[0041] In the above technical solution, the end cover 4 is provided to seal the reactor body 3 .

[0042] In one aspect of this embodiment, Figure 1 As shown, an observation window 16 is provided on one side of the upper end of the end cover 4 , feeding ports 17 are provided at both ends of the upper surface of the end cover 4 , and a sampling port 18 is fixedly connected to the middle of the upper surface of the end cover 4 .

[0043] In the above technical solution, observation, feeding and sampling can be conveniently performed during the reaction process through the observation window 16, the feeding port 17 and the sampling port 18.

[0044] In one aspect of this embodiment, Figure 1 As shown, a second handle 20 is fixedly connected to one side of the upper surface of the end cover 4 .

[0045] In the above technical solution, the second handle 20 is provided to facilitate opening of the end cover 4 .

[0046] This application can be used in the field of pharmaceutical preparation reactors, and can also be used in other fields applicable to this application

[0047] Example 2

[0048] Improved on the basis of Example 1: An adjustable biopharmaceutical reactor, which is used in the field of pharmaceutical preparation reactors,

[0049] In another aspect of this embodiment, Figure 1 As shown, self-locking universal wheels 21 are fixedly connected to the four corners of the lower surface of the support plate 1, and a first handle 19 is fixedly connected to the upper part of the front end outer wall of the protective cover 14.

[0050] In the above technical solution, the convenience of the reactor is improved by providing the self-locking universal wheels 21.

[0051] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0052] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the utility model to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that technicians in the relevant technical field can well understand and use the utility model. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. An adjustable biopharmaceutical reactor, characterized in that: include: A support plate (1), wherein both sides of the upper surface of the support plate (1) near the middle are fixedly connected to support frames (2), and the upper ends of the two support frames (2) are fixedly connected to a reactor body (3) by bolts, and are used for the synthesis of drugs; A stirring assembly, the stirring assembly comprising a stirring shaft (9) rotatably mounted inside the reactor body (3), the outer wall of the stirring shaft (9) being fixedly connected to two scrapers (10) by bolts, and the outer wall of the stirring shaft (9) being fixedly connected to two stirring blades (11) by bolts; A heating assembly, the heating assembly comprising a heating wire (12) fixedly mounted on the inner wall of the reactor body (3), a temperature sensor (13) fixedly connected to the lower portion of the inner wall at the rear end of the reactor body (3) for heating the reaction medium; The front end of the upper surface of the support plate (1) is fixedly connected to a protective cover (14) via bolts, and the upper surface of the protective cover (14) is fixedly connected to a PLC controller (15).

2. The adjustable biopharmaceutical reactor according to claim 1, characterized in that: The two sides of the upper surface of the support plate (1) are fixedly connected to the limit plates (22) by bolts, and the limit plates (22) are rotatably connected to the stirring shaft (9). The front end of the upper surface of the support plate (1) is fixedly connected to a servo motor (5), and the output end of the servo motor (5) is fixedly connected to a small pulley (6). The front end of the stirring shaft (9) passes through the limit plates (22) and is fixedly connected to a large pulley (7). The outer walls of the small pulley (6) and the large pulley (7) are provided with belts (8) for driving the stirring shaft (9) to rotate.

3. The adjustable biopharmaceutical reactor according to claim 1, characterized in that: The upper end of the reactor body (3) is hingedly connected to an end cover (4), and the reactor body (3) and the end cover (4) are fixedly connected by bolts.

4. The adjustable biopharmaceutical reactor according to claim 3, characterized in that: An observation window (16) is provided on one side of the upper end of the end cover (4), feeding ports (17) are provided at both ends of the upper surface of the end cover (4), and a sampling port (18) is fixedly connected to the middle of the upper surface of the end cover (4).

5. The adjustable biopharmaceutical reactor according to claim 3, characterized in that: A second handle (20) is fixedly connected to one side of the upper surface of the end cover (4).

6. The adjustable biopharmaceutical reactor according to claim 1, characterized in that: Self-locking universal wheels (21) are fixedly connected at the four corners of the lower surface of the support plate (1), and a first handle (19) is fixedly connected to the upper portion of the front end outer wall of the protective cover (14).

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