Single-channel pipetting work station capable of automatically replacing waste liquid bottles
By designing a single-channel automatic replacement waste liquid bottle pipetting workstation, combining a three-axis motion system and sensor, the accuracy and automated processing of solution preparation are achieved, and the temperature control function is integrated, which solves the problems of large size, inaccurate preparation and lack of temperature control in the existing equipment, and improves experimental efficiency and data reliability.
Patent Information
- Application Number
- CN202421693690.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-17
- Publication Date
- 2025-05-23
- Estimated Expiration
- 2034-07-17
AI Technical Summary
The multi-channel pipetting equipment used in existing chemical laboratories is large in size and takes up a lot of space. When there are problems with the quality of the liquid suction gun head, mechanical assembly and electrical control procedures, it is easy to lead to inaccurate solution preparation and lack the target solution temperature control function, which cannot meet customers' requirements for solution temperature.
A single-channel automatic waste liquid bottle pipetting workstation is designed, using a three-axis motion system and sensor combination to ensure accurate operation of the liquid suction gun head, and automatic waste liquid treatment is achieved by clamping the electric claws and clamping the plastic claws. At the same time, the target solution temperature control device of integrated semiconductor refrigeration sheet can adjust the solution temperature between 0-100 degrees.
It realizes efficient automatic liquid dispensing with single channels and small volumes, ensuring the accuracy and accuracy of solution preparation, reducing the possibility of manual intervention, meeting the control needs for solution temperature, and improving experimental efficiency and data reliability.
Smart Images
Figure CN222889834U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of chemical experiment tools, in particular to a single-channel automatic waste liquid bottle replacement liquid transfer workstation. Background Art
[0002] The use of pipettes in chemical laboratories is complex, and when there are multiple tubes of solution, the workload is large and the labor cost is high. In addition, during manual preparation, a certain solute or solvent may be missed or over-added. After missing or over-adding a small amount of solute or solvent, it is not easy to detect from visual inspection, which will cause deviations in subsequent experimental data results, seriously affecting scientific research efficiency. At present, the automated pipetting equipment on the market is basically multi-channel pipetting, which is very efficient, but generally large in size and occupies a large space in the laboratory. During use, due to quality problems of the pipette tip, mechanical errors, electronic control program bugs and other reasons, the dosage of a certain tube of target solution may be inaccurate after preparation. After the interface prompts, the operator needs to manually remove the target solution with an inaccurate dosage. In addition, most equipment on the market does not have the function of temperature control of the target solution. When customers have requirements for the temperature of the target solution, it cannot meet customer needs.
[0003] Based on the above problems, we propose a new type of single-channel automatic waste liquid bottle replacement pipetting workstation. Utility Model Content
[0004] The purpose of this section is to summarize some aspects of the embodiments of the utility model and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract of the specification and the name of the utility model of this application to avoid blurring the purpose of this section, the abstract of the specification and the name of the utility model, and such simplifications or omissions cannot be used to limit the scope of the utility model.
[0005] In view of the problems existing in the prior art, the present utility model is proposed.
[0006] Therefore, the purpose of the utility model is to provide a single-channel automatic waste liquid bottle replacement pipetting workstation, to provide a single-channel, small-volume pipetting workstation, which can accurately absorb and spit out solutes and solvents through the pipette tip to prepare the target solution required by the customer, providing customers with a high-efficiency automatic liquid preparation equipment that replaces manual labor.
[0007] In order to solve the above technical problems, according to one aspect of the present invention, the present invention provides the following technical solutions:
[0008] A single-channel automatic waste liquid bottle replacement pipetting workstation comprises a frame:
[0009] The frame is provided with a pipetting mechanism X-axis, a pipetting mechanism Y-axis, and a pipetting mechanism Z-axis, and is provided with an air pump, an industrial camera, and a pipetting gun head that move with the pipetting mechanism X-axis, the pipetting mechanism Y-axis, and the pipetting mechanism Z-axis;
[0010] The frame is provided with a bottle moving mechanism X-axis, a bottle moving mechanism Z-axis, and a bottle moving mechanism Y-axis. The frame is also provided with a clamping electric claw and a clamping plastic claw that move with the bottle moving mechanism X-axis, the bottle moving mechanism Z-axis, and the bottle moving mechanism Y-axis.
[0011] The rack is also equipped with a target solution temperature control device, a pipette tip placement rack, a solute solution placement rack, a 50 ml solute solution bottle, a 5 ml solute solution bottle, a waste gun tip placement rack, a 250 ml solvent solution bottle, a target solution placement rack, a 5 ml target solution, a normal target solution spare rack, a spare normal 5 ml target solution, a discarded 5 ml target solution placement rack, and a discarded 5 ml target solution.
[0012] As an optimal solution of a single-channel automatic waste liquid bottle replacement pipetting workstation described in the utility model, the pipetting mechanism X-axis, pipetting mechanism Y-axis and pipetting mechanism Z-axis are respectively provided with a pipetting mechanism X-axis sensor, a pipetting mechanism Y-axis sensor and a pipetting mechanism Z-axis sensor.
[0013] As an optimal solution of a single-channel automatic waste liquid bottle replacement pipetting workstation described in the utility model, the bottle moving mechanism X-axis, bottle moving mechanism Z-axis, and bottle moving mechanism Y-axis are respectively provided with a bottle moving mechanism X-axis sensor, a bottle moving mechanism Z-axis sensor, and a bottle moving mechanism Y-axis sensor.
[0014] As a preferred solution of a single-channel automatic waste liquid bottle replacement pipetting workstation described in the utility model, wherein: the liquid pipetting gun tips include 50uL gun tips, 200uL gun tips, and 1000uL gun tips.
[0015] Compared with the prior art, the beneficial effects of the utility model are: providing a single-channel, small-volume pipetting workstation, which can accurately absorb and spit out solutes and solvents through the pipette tip to prepare the target solution required by the customer, and provide customers with a highly efficient automatic liquid preparation device that replaces manual labor. It mainly solves the problem of waste liquid caused by the probability of quality of the pipette tip, the quality of mechanical assembly, and the existence of bugs in the stage of the electronic control program in other liquid preparation equipment. This system will enable the three-axis bottle transfer mechanism to move the waste liquid pipe to the waste liquid placement area, so that the operator takes away the target solution that fully meets the dosage under the self-check of the equipment, without any manual intervention that may cause errors, and can ensure that the target deep liquid dosage provided for subsequent experiments is completely accurate. The utility model can control the temperature of the target solution through a semiconductor refrigeration sheet. The operator can set the temperature of the target solution from 0 to 100 degrees on the host computer, and the system will automatically control the temperature of the target solution. The utility model is characterized in that in the same space, there are two sets of three-axis motion systems, one for liquid transfer and one for bottle transfer, and the two will not collide. The three axes of liquid transfer must all return to the origin and all three sensors must detect before the three axes of bottle transfer can move and work. Conversely, the three axes of bottle transfer must all return to the origin and all three sensors must detect before the three axes of liquid transfer can move and work. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] In order to more clearly illustrate the technical solution of the implementation of the utility model, the utility model will be described in detail below in combination with the drawings and detailed implementation. Obviously, the drawings described below are only some implementations of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative labor. Among them:
[0017] Figure 1 It is a schematic diagram of the structure of the utility model;
[0018] Figure 2 This is a schematic diagram of the placement structure of the utility model;
[0019] Figure 3 This is a schematic diagram of the placement structure of the liquid suction gun head of the utility model;
[0020] Figure 4 This is a schematic diagram of the structure of the solute, solvent and waste gun tip delivery rack of the utility model;
[0021] Figure 5 This is a schematic diagram of the structure of the target solution placement rack of the utility model;
[0022] Figure 6 This is a schematic diagram of the waste liquid pipe clamping structure of the utility model;
[0023] Figure 7 A schematic diagram of the structure for placing five milliliters of target solution is used for the utility model;
[0024] Figure 8 This is a schematic diagram of the structure of the normal target solution standby rack of the utility model;
[0025] Fig. 9 This is a schematic diagram of the structure of the liquid transfer mechanism sensors of the utility model when all sensors are reset to zero position;
[0026] Fig.10 This is a schematic diagram of the structure of the bottle moving mechanism sensors of the utility model when all sensors are reset to zero position.
[0027] In the figure; 1 pipetting mechanism X-axis, 101 pipetting mechanism X-axis sensor, 2 pipetting mechanism Y-axis, 201 pipetting mechanism Y-axis sensor, 3 pipetting mechanism Z-axis, 301 pipetting mechanism Z-axis sensor, 4 air pump, 5 industrial camera, 6 pipetting gun tip, 60150uL gun tip, 602200uL gun tip, 6031000uL gun tip, 7 bottle transfer mechanism X-axis, 701 bottle transfer mechanism X-axis sensor, 8 clamping electric claw, 9 target solution temperature control device, 10 clamping plastic claw, 11 bottle transfer mechanism Z-axis, 110 1 bottle moving mechanism Z-axis sensor, 12 bottle moving mechanism Y-axis, 1201 bottle moving mechanism Y-axis sensor, 13 pipette tip placement rack, 14 solute solution placement rack, 15 50 ml solute solution bottle, 16 5 ml solute solution bottle, 17 waste pipette tip placement rack, 18 250 ml solvent solution bottle, 19 target solution placement rack, 20 5 ml target solution, 21 normal target solution spare rack, 22 spare normal 5 ml target solution, 23 invalid 5 ml target solution placement rack, 24 invalid 5 ml target solution. DETAILED DESCRIPTION
[0028] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below with reference to the accompanying drawings.
[0029] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific implementation methods disclosed below.
[0030] Secondly, the present invention is described in detail with reference to the schematic diagram. When describing the implementation of the present invention, for the sake of convenience, the cross-sectional diagram showing the device structure will not be partially enlarged according to the general proportion, and the schematic diagram is only an example, which should not limit the scope of protection of the present invention. In addition, in actual production, the three-dimensional dimensions of length, width and depth should be included.
[0031] In order to make the purpose, technical solution and advantages of the present invention more clear, the implementation mode of the present invention will be further described in detail below with reference to the accompanying drawings.
[0032] The utility model provides the following technical solutions: a single-channel automatic waste liquid bottle replacement pipetting workstation, providing a single-channel, small-volume pipetting workstation, which can accurately absorb and spit out solutes and solvents through the pipette tip to prepare the target solution required by the customer, providing customers with a highly efficient automatic liquid preparation device that replaces manual labor;
[0033] Figures 1 to 10 It shows a structural schematic diagram of an embodiment of a single-channel automatic waste liquid bottle replacement pipetting workstation of the utility model;
[0034] Example 1
[0035] 4 The air pump can move left and right along the X-axis of the 1 pipetting mechanism, move forward and backward along the Y-axis of the 2 pipetting mechanism, and move up and down along the Z-axis of the 3 pipetting mechanism. The liquid aspiration range covers 13 the pipette tip placement rack, 14 the solute solution placement rack, two 18 250 ml solvent solution bottles and 19 the target solution placement rack.
[0036] First, Figure 1 , Figure 2 , Figure 3 : 5 industrial cameras move left and right along the X axis of the 1 pipette mechanism, 2 the Y axis of the pipette mechanism moves forward and backward, and 3 the Z axis of the pipette mechanism moves up and down, and come to the top of the 13 pipette tip placement rack, and take pictures of the three areas A, B, and C respectively. Through the image algorithm, the number and position of the 6 pipette tips are recorded, and then the 4 air pumps are used to take the position of the 6 pipette tips. Each area A, B, and C can hold up to 96 6 pipette tips, and can hold three types of 6 pipette tips of 50uL, 200uL, and 1000uL, 60150uL tips in area A, 602200uL tips in area B, and 6031000uL tips in area C, with one tip in each area. Three micron-level precision closed-loop stepping integrated motors are used to control the movement of the X, Y, and Z axes of the pipette mechanism.
[0037] like Figure 3 , Figure 4 :The program determines the need to use one or more of the 60150uL gun tip, 602200uL gun tip, and 6031000uL gun tip according to the calculated target solution concentration required by the operator. The 4 air pump first takes the required 6 liquid aspiration gun tip, and then goes to the 15 50 ml solute solution bottle ( Figure 4 No. 7, 8, 9, 10) or 16 5 ml solute solution bottle ( Figure 4 Sequence number 1, 2, 3, 4, 5, 6) Take the solute.
[0038] like Figure 5:The program goes to the top of the 19 target solution placement racks according to the calculated target solution concentration required by the operator, selects the 20 5 ml target solution to be spit out, and spits out the solute in place. The 19 target solution placement racks are composed of 27 target solution positions according to A, B, C and 1 to 9.
[0039] like Figure 4 : After discharging the solute, use 4 air pumps to go to the top of the 17 waste pipette tip rack and discard the 6 pipette tip.
[0040] like Figure 3 , Figure 4 : After retaking the required 6 pipette tips, go to the 18 250 ml solvent solution bottle to get the solvent. There are two solvents, S1 and S2.
[0041] like Figure 5 : The program goes to the top of the target solution placement rack 19 according to the target solution concentration required by the operator calculated in advance, selects the 20 5 ml target solution that needs to be spit out, and puts the solvent into place.
[0042] like Figure 4 : After spitting out the solvent, use 4 air pumps to go to the top of the 17 waste gun tip placement rack and discard the 6 pipette tip.
[0043] Repeat the above steps for a maximum of 27 tubes of 22 normal 5 ml target solution. After the preparation is completed, the program determines whether there is an aspiration error or a spitting error. The 20 5 ml target solution with an error is judged as waste liquid.
[0044] like Figure 1 , Figure 2 , Figure 6 : 8 clamping electric claws move left and right along the X axis of the 7 bottle transfer mechanism, 11 bottle transfer mechanism moves up and down along the Z axis, 12 bottle transfer mechanism moves forward and backward along the Y axis, and arrives above the 19 target solution placement rack where the five milliliters of target solution is judged to be invalid. Two 10 clamping plastic claws clamp the 20 five milliliters of target solution and rise to grab it. The coverage range of 8 clamping electric claws is the 19 target solution placement rack, 21 normal target solution standby rack, and 23 invalid five milliliters target solution placement rack. Three micron-level precision closed-loop stepping integrated motors are used to control the X, Y, and Z axis movement of the bottle transfer mechanism.
[0045] like Figure 7 : 8 Clamp the electric claw to place 24 waste 5 ml target solution on the 23 waste 5 ml target solution placement rack with eight positions. According to A, B and 1 to 4, 8 waste solution positions are formed. When 8 are full, the system will prompt the operator to take out 8 tubes of waste solution.
[0046] If the target solution required by the operator is much larger than 27 tubes, hundreds or even thousands of tubes. Figure 1 , Figure 2 , Figure 8: 8 clamping electric claws move left and right along the X-axis of 7 bottle transfer mechanism, 11 bottle transfer mechanism moves up and down along the Z-axis, 12 bottle transfer mechanism moves forward and backward along the Y-axis, and come to the top of 19 target solution placement rack. Two 10 clamping plastic claws clamp 20 five milliliters of target solution and grab it. First take 6 tubes of normal 20 five milliliters of target solution and grab them to the 21 normal target solution standby rack with six positions as 22 normal five milliliters of target solution reserve. After that, when the 27 tube of target solution is wasted and taken away by the 8 clamping electric claws, it can be taken out from the 21 normal target solution standby rack and placed on the 19 target solution placement rack. According to A, B and 1 to 3, 6 waste solution positions are formed.
[0047] The target solution temperature control device uses a built-in semiconductor refrigeration chip with a temperature control range of 0 to 100 degrees. After briefly controlling the temperature of the 22 normal 5 ml target solutions in the 19 target solution placement racks above, the operator can take out 27 tubes of target solution each time.
[0048] like Fig. 9 , Fig.10 :There are two sets of three-axis motion systems, one for liquid transfer and one for bottle transfer. The two cannot collide. The three-axis liquid transfer system 101 liquid transfer mechanism X-axis sensor, 201 liquid transfer mechanism Y-axis sensor, and 301 liquid transfer mechanism Z-axis sensor must all return to the origin and all three sensors must be detected before the three-axis bottle transfer system can move and work. On the contrary, the three-axis bottle transfer system 701 bottle transfer mechanism X-axis sensor 1101 bottle transfer mechanism Z-axis sensor, and 1201 bottle transfer mechanism Y-axis sensor must all return to the origin and all three sensors must be detected before the three-axis liquid transfer system can move and work, otherwise the two will collide.
[0049] Although the present invention has been described above with reference to the embodiments, various modifications may be made thereto and parts thereof may be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the various features in the embodiments disclosed in the present invention may be used in combination with each other in any manner, and the fact that these combinations are not exhaustively described in this specification is only for the sake of omitting space and saving resources. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.
Claims
1. A single-channel automatic waste liquid bottle replacement pipetting workstation, characterized in that: Included rack: The frame is provided with a liquid transfer mechanism X-axis (1), a liquid transfer mechanism Y-axis (2), and a liquid transfer mechanism Z-axis (3); the frame is provided with an air pump (4) that moves following the liquid transfer mechanism X-axis (1), the liquid transfer mechanism Y-axis (2), and the liquid transfer mechanism Z-axis (3), an industrial camera (5), and a liquid pipette head (6); The frame is provided with a bottle moving mechanism X-axis (7), a bottle moving mechanism Z-axis (11), and a bottle moving mechanism Y-axis (12); the frame is also provided with a clamping electric claw (8) and a clamping plastic claw (10) that move following the bottle moving mechanism X-axis (7), the bottle moving mechanism Z-axis (11), and the bottle moving mechanism Y-axis (12); The rack is also provided with a target solution temperature control device (9), a liquid pipette tip placement rack (13), a solute solution placement rack (14), a 50 ml solute solution bottle (15), a 5 ml solute solution bottle (16), a waste pipette tip placement rack (17), a 250 ml solvent solution bottle (18), a target solution placement rack (19), a 5 ml target solution (20), a normal target solution standby rack (21), a standby normal 5 ml target solution (22), a discarded 5 ml target solution placement rack (23), and a discarded 5 ml target solution (24).
2. A single-channel automatic waste liquid bottle replacement pipetting workstation according to claim 1, characterized in that: A pipetting mechanism X-axis sensor (101), a pipetting mechanism Y-axis sensor (201), and a pipetting mechanism Z-axis sensor (301) are respectively arranged on the pipetting mechanism X-axis (1), the pipetting mechanism Y-axis (2), and the pipetting mechanism Z-axis (3).
3. A single-channel automatic waste liquid bottle replacement pipetting workstation according to claim 1, characterized in that: The bottle moving mechanism X-axis (7), the bottle moving mechanism Z-axis (11), and the bottle moving mechanism Y-axis (12) are respectively provided with a bottle moving mechanism X-axis sensor (701), a bottle moving mechanism Z-axis sensor (1101), and a bottle moving mechanism Y-axis sensor (1201).
4. A single-channel automatic waste liquid bottle replacement pipetting workstation according to claim 1, characterized in that: The pipette tips (6) include a 50uL tip (601), a 200uL tip (602), and a 1000uL tip (603).