Liquid chromatogram or liquid chromatogram tandem mass spectrometer sample introduction plate

Abstract

The utility model discloses a liquid chromatogram or liquid chromatogram tandem mass spectrometer sample introduction plate, comprising a main body assembly which comprises a sample introduction plate; the placing assembly comprises a sample injection pipe, a sealing cover, a fixing ring and a clamping groove; a sample injection pipe penetrates through the sample injection plate, a sealing cover is fixed to the upper end of the sample injection pipe, a fixing ring is installed on the periphery of the lower end of the sample injection pipe, and a clamping groove is formed in the side wall of the outer surface of the fixing ring. The utility model solves the problems that the conventional sample feeding plate is divided into a small notch, liquid to be detected is put in the notch, the whole sample feeding plate needs to be cleaned after the detection is completed and the liquid to be detected is put in the notch, each hole is very small and is troublesome to clean, other pollutants need to be specially noticed not to be introduced, and if the cleaning is not thorough, the sample feeding plate is inconvenient to clean. And residual reagents or samples may cause cross contamination, so that the accuracy of the experiment is influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of sample injection plates, in particular to a sample injection plate for a liquid chromatography or a liquid chromatography tandem mass spectrometer. Background Art

[0002] In the field of chemical testing, chromatographic testing plays an important role. Its characteristic is that the injected drugs cannot be contaminated. Therefore, in the process of testing samples by liquid chromatography tandem mass spectrometer, the injection plate is often used. At present, liquid chromatography tandem mass spectrometer is widely used in the field of life sciences, from basic research to drug discovery and development, functional medicine, food safety and environmental analysis of pesticide residues, as well as forensic toxicology, trace analysis of clinical research, etc. In the process of using liquid chromatography tandem mass spectrometer, the injection plate is usually used to hold the liquid to be tested.

[0003] However, it still has the following disadvantages in actual use:

[0004] The existing sample injection plate is divided into small slots, and the liquid to be tested is placed in the slots. When the test is completed, the entire sample injection plate needs to be cleaned after the liquid to be tested is placed. Since each hole is very small, it is troublesome to clean. Special attention should be paid to avoid introducing other contaminants. If the cleaning is not thorough, the residual reagents or samples may cause cross contamination and affect the accuracy of the experiment.

[0005] Therefore, a new liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate is proposed to solve the above problems. Utility Model Content

[0006] The utility model aims to provide a liquid chromatography or liquid chromatography tandem mass spectrometer injection plate to solve the problem proposed in the above background technology that the existing injection plate is divided into small slots, and the liquid to be detected is placed in the slots. When the detection is completed, the entire injection plate needs to be cleaned after the liquid to be detected is placed. Since each hole is very small, it is troublesome to clean it, and special attention needs to be paid to avoid introducing other contaminants. If the cleaning is not thorough, the residual reagents or samples may cause cross contamination, affecting the accuracy of the experiment.

[0007] In order to solve the above technical problems, the utility model is realized by the following technical solutions:

[0008] The utility model is a liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate, comprising:

[0009] A main body component, the main body component includes a sample injection plate;

[0010] A placement component, the placement component comprising a sample injection tube, a sealing cover, a fixing ring, and a card slot;

[0011] The sample injection plate is penetrated by a sample injection tube, the upper end of the sample injection tube is fixed with a sealing cover, the lower end of the sample injection tube is peripherally installed with a fixing ring, and the outer surface side wall of the fixing ring is provided with a card slot.

[0012] Furthermore, the main body assembly also includes a placement slot, a connection block, and a bottom plate;

[0013] A placement groove is provided on the upper surface of the sample injection plate, a connecting block is fixed to the middle of the side wall of the outer surface of the sample injection plate, and a bottom plate is fixed to the lower end of the outer surface of the connecting block.

[0014] Furthermore, the sample injection tube passes through the interior of the placement groove, and the fixing ring is fixed on the upper surface of the bottom plate and corresponds to the lower end of the sample injection tube in a positive direction.

[0015] Furthermore, the placement assembly also includes a connecting column, a clamping block, a spring, and a fixing plate;

[0016] A connecting column is passed through the slot, a clamping block is fixed on one side of the outer surface of the connecting column, a spring is passed through one side of the outer surface of the connecting column, and a fixing plate is fixed on the other side of the connecting column.

[0017] Furthermore, the spring runs through the middle of the fixing ring and the fixing plate, and two connecting columns are provided, respectively running through both sides of the fixing ring.

[0018] Further, it also includes a fixing component;

[0019] The fixing assembly includes a side plate, a fixing tube, a rubber ring, and a vent hole;

[0020] A side plate is fixed on one side of the outer surface of the connection block, a fixing pipe is fixedly passed through the outer surface of the side plate, a rubber ring is connected to the lower surface of the fixing pipe, and a vent hole is opened inside the rubber ring.

[0021] Furthermore, the fixing assembly also includes a rubber block, an upper connecting rod, a top plate, and an electric push rod;

[0022] A rubber block is slidably mounted inside the fixed tube, an upper connecting rod is connected to the center of the upper surface of the rubber block, a top plate is fixed to the upper surface of the upper connecting rod, and an electric push rod is fixed to one side of the lower surface of the top plate.

[0023] Furthermore, the electric push rod is fixed on both sides of the upper surface of the side plate, and the top end of the electric push rod is fixed on the lower surface of the top plate.

[0024] Compared with the prior art, the advantages of the present invention are:

[0025] 1. The utility model, through the set sample injection tube, sealing cover, fixing ring, card slot, connecting column, card block, spring, fixing plate, the liquid to be detected is put into the sample injection tube, the sealing cover is plugged into the upper end of the sample injection tube, and then the sample injection tube is put into the placement groove. When the lower end of the sample injection tube contacts the fixing plate, the spring contracts, driving the connecting column to move outward, and driving the fixing plate to move outward at the same time. Under the elastic force of the spring, the spring drives the fixing plate to fix the sample injection tube. In this way, the liquid to be detected can be put into the sample injection tube. If several liquids need to be detected, several sample injection tubes can be cleaned. The sample injection tubes can be quickly replaced and cleaned, thereby ensuring the independence between different samples and the accuracy of detection.

[0026] 2. Based on beneficial effect 1, by setting the side panels, fixed tubes, rubber rings, air holes, rubber blocks, upper connecting rods, top plates and electric push rods, when placing the sample tube, in order to prevent the sample plate from moving, it is only necessary to start the electric push rod through the external control module, and the electric push rod drives the top plate to move upward, and the top plate drives the upper connecting rod to move upward, and moves the rubber block upward, extracting the air inside the fixed tube, so that the rubber ring is adsorbed on the operating table, keeping the position of the sample plate fixed, preventing it from moving during the experiment, and ensuring the stability of the experiment.

[0027] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0029] Figure 1 This is a schematic diagram of the main components of the utility model;

[0030] Figure 2 This is a schematic diagram of the placement of components of the utility model;

[0031] Figure 3 It is a schematic diagram of the interior of the utility model where components are placed;

[0032] Figure 4 This is a structural diagram of the fixing assembly of the utility model;

[0033] Figure 5 It is a cross-sectional view of the fixing assembly of the utility model.

[0034] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0035] 11. Sample feeding plate; 12. Placement slot; 13. Connection block; 14. Bottom plate;

[0036] 21. Injection tube; 22. Sealing cover; 23. Fixing ring; 24. Card slot; 25. Connecting column; 26. Card block; 27. Spring; 28. Fixing plate;

[0037] 31. Side panel; 32. Fixed tube; 33. Rubber ring; 34. Air vent; 35. Rubber block; 36. Upper connecting rod; 37. Top plate; 38. Electric push rod. DETAILED DESCRIPTION

[0038] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below with reference to the accompanying drawings.

[0039] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific implementation methods disclosed below.

[0040] Secondly, the present invention is described in detail with reference to the schematic diagram. When describing the implementation of the present invention, for the sake of convenience, the cross-sectional diagram showing the device structure will not be partially enlarged according to the general scale, and the schematic diagram is only an example, which should not limit the scope of protection of the present invention. In addition, in actual production, the three-dimensional dimensions of length, width and depth should be included.

[0041] In order to make the purpose, technical solution and advantages of the present invention more clear, the implementation mode of the present invention will be further described in detail below with reference to the accompanying drawings.

[0042] See also Figure 1-Figure 3 As shown, this embodiment is a liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate, comprising:

[0043] The main body component includes a sample injection plate 11;

[0044] The main body assembly also includes a placement slot 12, a connection block 13, and a bottom plate 14;

[0045] A placement groove 12 is provided on the upper surface of the sample injection plate 11, a connection block 13 is fixed to the middle of the side wall of the outer surface of the sample injection plate 11, and a bottom plate 14 is fixed to the lower end of the outer surface of the connection block 13;

[0046] The sample introduction plate 11 is a platform for experimental operation, and is provided with placement slots 12 for placing the liquid sample to be tested, and each slot can independently accommodate a liquid container;

[0047] A placement component, which includes a sample injection tube 21, a sealing cover 22, a fixing ring 23, and a card slot 24;

[0048] The sample injection plate 11 is provided with a sample injection tube 21, a sealing cover 22 is fixed to the upper end of the sample injection tube 21, a fixing ring 23 is installed on the outer periphery of the lower end of the sample injection tube 21, and a slot 24 is provided on the outer side wall of the fixing ring 23;

[0049] The injection tube 21 is the part that directly contacts the liquid to be tested, and a sealing cover 22 is fixed on its upper end to prevent liquid leakage and external contamination. A fixing ring 23 is installed on the outer periphery of the lower end of the injection tube 21 to provide additional support and fixing effect;

[0050] The placement assembly also includes a connecting column 25, a clamping block 26, a spring 27, and a fixing plate 28;

[0051] A connecting column 25 is passed through the slot 24, a block 26 is fixed to one side of the outer surface of the connecting column 25, a spring 27 is passed through one side of the outer surface of the connecting column 25, and a fixing plate 28 is fixed to the other side of the connecting column 25;

[0052] The connecting column 25 passes through the card slot 24, and a card block 26 is fixed on one side of its outer surface for connecting with a spring 27. The spring 27 is sleeved on the connecting column 25 and can provide elastic force for pushing a fixing plate 28 connected thereto. The fixing plate 28 is fixed on the other side of the connecting column 25 for further fixing the sample injection tube 21.

[0053] Working principle:

[0054] Put the liquid to be tested into the injection tube 21;

[0055] First, the sealing cover 22 is plugged into the upper end of the sample injection tube 21, and then the sample injection tube 21 is placed in the placement groove 12. When the lower end of the sample injection tube 21 contacts the fixing plate 28,

[0056] At this time, the spring 27 contracts, driving the connecting column 25 to move outward, and driving the fixing plate 28 to move outward at the same time. Under the elastic force of the spring 27, the spring 27 drives the fixing plate 28 to fix the injection tube 21.

[0057] In this way, the liquid to be tested can be placed in the sample injection tube 21. If several liquids need to be tested, several sample injection tubes 21 can be cleaned. The sample injection tubes 21 can be quickly replaced and cleaned.

[0058] This step ensures the independence between different samples and the accuracy of detection.

[0059] See also Figure 4-Figure 5 As shown, this embodiment is based on the above embodiment 1 and also includes:

[0060] Fixing components;

[0061] The fixing assembly includes a side plate 31, a fixing tube 32, a rubber ring 33, and a vent hole 34;

[0062] A side plate 31 is fixed to one side of the outer surface of the connecting block 13, a fixing pipe 32 is fixedly passed through the outer surface of the side plate 31, a rubber ring 33 is connected to the lower surface of the fixing pipe 32, and a vent hole 34 is opened inside the rubber ring 33;

[0063] The side plate 31 is fixed to one side of the outer surface of the connecting block 13 to provide support for the fixing tube 32. The fixing tube 32 is fixed to the side plate 31, and a rubber ring 33 is connected to the lower surface thereof to adsorb and fix the sample injection plate 11. The rubber ring 33 is connected to the fixing tube 32, and a vent hole 34 is provided inside to adjust the adsorption force or achieve a vacuum adsorption effect.

[0064] The fixing assembly also includes a rubber block 35, an upper connecting rod 36, a top plate 37, and an electric push rod 38;

[0065] A rubber block 35 is slidably mounted inside the fixed tube 32, an upper connecting rod 36 is connected to the center of the upper surface of the rubber block 35, a top plate 37 is fixed to the upper surface of the upper connecting rod 36, and an electric push rod 38 is fixed to one side of the lower surface of the top plate 37;

[0066] The rubber block 35 is slidably mounted inside the fixed tube 32, and an upper connecting rod 36 is connected to the center of the upper surface thereof for transmitting force to adjust the position or adsorption force of the fixed tube 32. The upper connecting rod 36 connects the rubber block 35 and the top plate 37 for adjusting the position of the rubber block 35;

[0067] Working principle:

[0068] When the sample injection tube 21 is placed;

[0069] First, to prevent the sample injection plate 11 from moving, it is only necessary to start the electric push rod 38 through the external control module.

[0070] Then, the electric push rod 38 drives the top plate 37 to move upward, and the top plate 37 drives the upper connecting rod 36 to move upward.

[0071] The rubber block 35 is moved upward to extract the air inside the fixed tube 32, so that the rubber ring 33 is adsorbed on the operating table to keep the position of the sample injection plate 11 fixed.

[0072] This step prevents it from moving during the experiment and ensures the stability of the experiment.

[0073] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0074] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate, characterized in that: include: A main body component, the main body component comprising a sample injection plate (11); A placement component, the placement component comprising a sample injection tube (21), a sealing cover (22), a fixing ring (23), and a card slot (24); A sample injection tube (21) passes through the sample injection plate (11), a sealing cover (22) is fixed to the upper end of the sample injection tube (21), a fixing ring (23) is installed on the outer periphery of the lower end of the sample injection tube (21), and a clamping groove (24) is provided on the side wall of the outer surface of the fixing ring (23).

2. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate according to claim 1, characterized in that: The main body assembly further comprises a placement slot (12), a connection block (13), and a bottom plate (14); The upper surface of the sample injection plate (11) is provided with a placement groove (12), a connecting block (13) is fixed to the middle of the side wall of the outer surface of the sample injection plate (11), and a bottom plate (14) is fixed to the lower end of the outer surface of the connecting block (13).

3. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate according to claim 1, characterized in that: The sample injection tube (21) passes through the interior of the placement groove (12), and the fixing ring (23) is fixed on the upper surface of the bottom plate (14) and corresponds to the lower end of the sample injection tube (21).

4. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate according to claim 1, characterized in that: The placement assembly further comprises a connecting column (25), a clamping block (26), a spring (27), and a fixing plate (28); A connecting column (25) passes through the interior of the clamping slot (24), a clamping block (26) is fixed to one side of the outer surface of the connecting column (25), a spring (27) passes through one side of the outer surface of the connecting column (25), and a fixing plate (28) is fixed to the other side of the connecting column (25).

5. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate according to claim 4, characterized in that: The spring (27) passes through the middle of the fixing ring (23) and the fixing plate (28), and two connecting columns (25) are provided, respectively passing through two sides of the fixing ring (23).

6. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate according to claim 2, characterized in that: Also included are fixing components; The fixing assembly comprises a side plate (31), a fixing tube (32), a rubber ring (33), and a vent hole (34); A side plate (31) is fixed to one side of the outer surface of the connection block (13), a fixing pipe (32) is fixedly passed through the outer surface of the side plate (31), a rubber ring (33) is connected to the lower surface of the fixing pipe (32), and a vent hole (34) is provided inside the rubber ring (33).

7. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate according to claim 6, characterized in that: The fixing assembly further comprises a rubber block (35), an upper connecting rod (36), a top plate (37), and an electric push rod (38); A rubber block (35) is slidably mounted inside the fixed tube (32); an upper connecting rod (36) is connected to the center of the upper surface of the rubber block (35); a top plate (37) is fixed to the upper surface of the upper connecting rod (36); and an electric push rod (38) is fixed to one side of the lower surface of the top plate (37).

8. A liquid chromatography or liquid chromatography tandem mass spectrometer sample injection plate according to claim 7, characterized in that: The electric push rod (38) is fixed to both sides of the upper surface of the side plate (31), and the top end of the electric push rod (38) is fixed to the lower surface of the top plate (37).

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