Preparation device of concentrated solution for levetiracetam injection

Abstract

The utility model discloses a preparation device of a concentrated solution for injection of levetiracetam. The device comprises a mixing tank, a feeding port is formed in the upper side of the mixing tank and connected with a liquid pump through a liquid pipe, a first valve and a second valve, the second valve is connected with an electrolytic bath, the liquid pump is connected with a heat exchange coil and a fourth valve arranged in a heat exchange box through the liquid pipe and a third valve, and a heating element and water are arranged in the heat exchange box. A fifth valve and a sixth valve are sequentially arranged on the water inlet pipe and the water outlet pipe, the heat exchange coil pipe is connected with one end of a seventh valve and one end of an eighth valve through liquid pipes, the other end of the seventh valve is connected with the mixing tank through a liquid pipe, and the other end of the eighth valve is arranged on the upper side of the electrolytic cell through a liquid pipe; the fourth valve is connected with the filtering tank through a liquid pipe. According to the utility model, the concentrated solution can be quickly and uniformly mixed, and overhigh local temperature caused by direct contact between the concentrated solution and the heating element is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of the preparation of levetiracetam concentrated solution for injection, and particularly relates to a device for preparing levetiracetam concentrated solution for injection. Background Art

[0002] Levetiracetam is an anti-epileptic drug, which can be administered orally or by injection. Oral administration is divided into tablets and oral liquids, while injection administration uses a concentrated solution diluent. When preparing levetiracetam concentrated solution for injection, electrochemical treatment is carried out after liquid preparation. When carrying out electrochemical treatment, the prepared solution needs to be heated to a temperature of 50 - 60 °C. After the electrochemical treatment is completed, the prepared solution needs to be cooled to about 25 °C and then ultrafiltered. Currently, natural cooling is generally used for cooling, and since the natural cooling time of the solution is relatively long, the preparation efficiency of levetiracetam concentrated solution for injection is low. Reducing the solution cooling time is a technical problem that needs to be solved by those skilled in the art currently. Content of the Utility Model

[0003] The purpose of the utility model is to provide a device for preparing levetiracetam concentrated solution for injection aiming at the deficiencies existing in the prior art.

[0004] To achieve the above purpose, the utility model provides a device for preparing levetiracetam concentrated solution for injection, including a mixing tank. A feeding port is arranged on the upper side of the mixing tank, and it is connected to one end of a first valve through a liquid pipe. The other end of the first valve is connected to one end of a second valve and the inlet of a liquid pump through a liquid pipe. The other end of the second valve is connected to an electrolytic cell through a liquid pipe. The outlet of the liquid pump is connected to one end of a third valve through a liquid pipe. The other end of the third valve is respectively connected to a heat exchange coil arranged in a heat exchange box and one end of a fourth valve through a liquid pipe. A heating element, a temperature sensor and water are arranged in the heat exchange box, and it is connected with a water inlet pipe and a water outlet pipe. A fifth valve and a sixth valve are sequentially arranged on the water inlet pipe and the water outlet pipe. The heat exchange coil is connected to one end of a seventh valve and an eighth valve respectively through a liquid pipe. The other end of the seventh valve is connected to the mixing tank through a liquid pipe. The other end of the eighth valve is arranged above the electrolytic cell through a liquid pipe. The fourth valve is connected to a filtration tank through a liquid pipe. A plurality of filter membranes are arranged in the filtration tank, and a liquid outlet pipe is arranged on one side of it.

[0005] Further, a first liquid distributor is arranged in the mixing tank. The other end of the seventh valve is connected to the first liquid distributor, and a plurality of liquid outlet ports are arranged below the first liquid distributor.

[0006] Further, an avoidance port is arranged in the middle of the first liquid distributor, and the liquid outlet ports are arranged on the outer periphery around the avoidance port.

[0007] Further, a second liquid distributor is provided inside the filtration tank. The second liquid distributor is arranged on the upper side of the filtration membrane, and a plurality of nozzles are provided on its lower side.

[0008] Further, the second liquid distributor is in a grid shape, and the plurality of nozzles are arranged in a matrix.

[0009] Further, an upper cover is provided on the upper side of the feeding port.

[0010] Further, the heating element is a heating resistor.

[0011] Beneficial effects: By providing a liquid pump and a heat exchange tank in the present utility model, the concentrated solution in the mixing tank can be pumped into the heat exchange tank by the liquid pump for heating. The heated concentrated solution is sprayed into the mixing tank through the first liquid distributor, which can quickly make the concentrated solution mix evenly. The heat exchange tank heats the water inside through the heating element, and then uses the water to heat the concentrated solution in the heat exchange coil, which can avoid the direct contact between the concentrated solution and the heating element resulting in too high local temperature. By switching the valves on both the input and output sides of the liquid pump, one liquid pump can be used to complete the extraction of concentrated solution at different positions and transport it to different positions to meet the preparation requirements. Description of the Drawings

[0012] Figure 1 It is a schematic structural diagram of a preparation device for concentrated solution of levetiracetam for injection according to an embodiment of the present utility model. Detailed Embodiment

[0013] The following further clarifies the present utility model in conjunction with the drawings and specific embodiments. These embodiments are implemented on the premise of the technical solution of the present utility model, and it should be understood that these embodiments are only used to illustrate the present utility model and not to limit the scope of the present utility model.

[0014] Such as Figure 1As shown, the embodiment of the utility model provides a device for preparing a concentrated solution of levetiracetam for injection, including a mixing tank 1, which is preferably made of stainless steel, and is provided with a delivery port 2 on the upper side of the mixing tank 1, and preferably an upper cover 11 is provided on the upper side of the delivery port 2, and the upper cover 11 can be opened and closed on the upper side of the delivery port 2. After opening the upper cover 11, ingredients such as levetiracetam, water for injection, sodium chloride and sodium acetate can be put into the mixing tank 1 from the delivery port 2. The mixing tank 1 is connected to one end of the first valve 3 through a liquid pipe, and the other end of the first valve 3 is connected to one end of the second valve 4 and the inlet of the liquid pump 5 through a liquid pipe, and the other end of the second valve 4 is connected to the electrolytic cell 6 through a liquid pipe. The outlet of the liquid pump 5 is connected to one end of the third valve 7 through a liquid pipe, and the other end of the third valve 7 is connected to a heat exchange coil 12 and one end of the fourth valve 9 respectively arranged in the heat exchange box 8 through a liquid pipe. The heat exchange box 8 is provided with a heating element 10, a temperature sensor and water, and the heating element 10 is preferably a heating resistor. The temperature sensor and the heating resistor are connected to the temperature controller to heat the water in the heat exchange box 8 to a preset temperature. The heat exchange box 8 is connected to an inlet pipe and an outlet pipe, and the fifth valve 13 and the sixth valve 14 are arranged on the inlet pipe and the outlet pipe respectively. The inlet pipe can be connected to tap water or a water source in a water tank. After opening the fifth valve 13 and the sixth valve 14, the water in the heat exchange box 8 can be replaced. The other end of the heat exchange coil 12 is connected to one end of the seventh valve 15 and the eighth valve 16 respectively through a liquid pipe, the other end of the seventh valve 15 is connected to the mixing tank 1 through a liquid pipe, and the other end of the eighth valve 16 is arranged on the upper side of the electrolytic cell 6 through a liquid pipe. The fourth valve 9 is connected to the filter tank 17 through a liquid pipe, and a plurality of filter membranes 18 are arranged in the filter tank 17. The filter membrane 18 is preferably arranged in two layers, the upper layer is a 0.4μm PVDF microporous filter membrane, and the lower layer is a 0.22μm PVDF microporous filter membrane. A liquid outlet pipe 19 is arranged on one side of the filter tank.

[0015] In order to improve the mixing effect, a first liquid distributor 20 is provided in the mixing tank 1, the other end of the seventh valve 15 is connected to the first liquid distributor 20, and a plurality of liquid outlets 21 are provided at the lower side of the first liquid distributor 20. In order not to affect the feeding, it is also preferred to provide an avoidance port 22 in the middle of the first liquid distributor 20, that is, the first liquid distributor 20 is provided in a ring shape, and the above-mentioned liquid outlets 21 are provided around the outer side of the avoidance port 22.

[0016] In order to improve the filtering effect, a second liquid distributor 23 is preferably provided in the filter tank 17, the second liquid distributor 23 is arranged on the upper side of the filter membrane 18, and a plurality of nozzles 24 are provided on the lower side of the second liquid distributor 23. The second liquid distributor 23 is preferably arranged in a grid shape, and the plurality of nozzles 24 are arranged in a matrix, so that the concentrated solution is sprayed on the upper side of the filter membrane 18 more evenly.

[0017] In use, after the ingredients are sequentially added to the mixing tank 1, open the first valve 3, the third valve 7, and the seventh valve 15, and start the liquid pump 5 to run. At the same time, turn on the heating element 10 to heat the water in the heat exchange tank 8 to a preset temperature (50 - 60 °C), so that the concentrated solution in the mixing tank 1 is fully mixed and dissolved and heated to initially obtain the heated concentrated solution. Then open the eighth valve 16 and close the seventh valve 15, and then pump the heated concentrated solution into the electrolytic cell 6. When the concentrated solution in the mixing tank 1 is completely pumped out, control the first valve 3 to close and the liquid pump 5 to stop running, and then perform electrochemical treatment. During this period, if the temperature of the concentrated solution in the electrolytic cell 6 drops to the preset temperature, control the second valve 4 to open and the liquid pump 5 to run, and use the hot water in the heat exchange tank 8 to heat the concentrated solution. After heating, control the second valve 4 to close and the liquid pump 5 to stop running. Repeat this cycle to keep the temperature of the concentrated solution in the electrolytic cell 6 within the preset temperature range. After the electroprocessing is completed, first stop the heat exchange coil 12 from working, open the fifth valve 13 and the sixth valve 14 to quickly reduce the water temperature in the heat exchange tank 8; then control the second valve 4 and the eighth valve 16 to open and start the liquid pump 5 to work to reduce the temperature of the concentrated solution. When the temperature drops to the preset temperature (25 °C), control the fourth valve 9 to open and the eighth valve 16 to close, so as to pump the electroprocessed concentrated solution in the electrolytic cell 6 into the filter tank 17 for filtration. The filtered concentrated solution is discharged from the liquid outlet pipe 19, and then potting and sterilization treatments can be carried out.

[0018] The above is only the preferred embodiment of the present invention. It should be noted that for those of ordinary skill in the art of this technology, the other parts not specifically described belong to the prior art or common general knowledge. Without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A device for preparing a concentrated solution of levetiracetam for injection, characterized in that: It includes a mixing tank, wherein a loading port is provided on the upper side of the mixing tank, and the loading port is connected to one end of a first valve through a liquid pipe, the other end of the first valve is connected to one end of a second valve and an inlet of a liquid pump through a liquid pipe, the other end of the second valve is connected to an electrolytic cell through a liquid pipe, the outlet of the liquid pump is connected to one end of a third valve through a liquid pipe, the other end of the third valve is respectively connected to a heat exchange coil and one end of a fourth valve arranged in a heat exchange box through a liquid pipe, a heating element, a temperature sensor and water are arranged in the heat exchange box, and a water inlet pipe and a water outlet pipe are connected to the heat exchange box, a fifth valve and a sixth valve are arranged on the water inlet pipe and the water outlet pipe in sequence, the heat exchange coil is respectively connected to one end of a seventh valve and an eighth valve through a liquid pipe, the other end of the seventh valve is connected to the mixing tank through a liquid pipe, the other end of the eighth valve is arranged on the upper side of the electrolytic cell through a liquid pipe, the fourth valve is connected to a filter tank through a liquid pipe, a plurality of filter membranes are arranged in the filter tank, and a liquid outlet pipe is arranged on one side of the filter tank.

2. A device for preparing a concentrated solution of levetiracetam for injection according to claim 1, characterized in that: A first liquid distributor is provided in the mixing tank, the other end of the seventh valve is connected to the first liquid distributor, and a plurality of liquid outlets are provided at the lower side of the first liquid distributor.

3. A device for preparing a concentrated solution of levetiracetam for injection according to claim 2, characterized in that: A avoidance opening is provided in the middle of the first liquid distributor, and the liquid outlet is arranged around the outer side of the avoidance opening.

4. A device for preparing a concentrated solution of levetiracetam for injection according to claim 1, characterized in that: A second liquid distributor is provided in the filter tank. The second liquid distributor is arranged on the upper side of the filter membrane, and a plurality of nozzles are provided on the lower side thereof.

5. A device for preparing a concentrated solution of levetiracetam for injection according to claim 4, characterized in that: The second liquid distributor is in a grid shape, and the plurality of nozzles are arranged in a matrix.

6. A device for preparing a concentrated solution of levetiracetam for injection according to claim 1, characterized in that: An upper cover is arranged on the upper side of the delivery port.

7. A device for preparing a concentrated solution of levetiracetam for injection according to claim 1, characterized in that: The heating element is a heating resistor.

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