Four-selection-channel dog vision evaluation device

Abstract

The utility model discloses a four-choice channel dog vision assessment device, including main box, exit tunnel, lighting system and monitoring device, the side plate of main box is with one exit tunnel detachable connection, the lighting system is installed on the main box, the exit tunnel is communicated with the inside of main box, and the monitoring device is installed on the exit tunnel. The exit tunnel is a lightproof tunnel, at least one side face of the main box body is a hinged door which is divided into two parts along the vertical central axis, and the monitoring device is installed in the main box body. One side face of the main box body is arranged to be in a side-by-side mode, so that animals and experimenters can conveniently enter and exit, and the main box body can be conveniently cleaned and disinfected after an experiment; the lighting system provides more comprehensive data for adjustable intensity and evaluation, and the exit tunnel is detachably connected with the main box body, so that replacement and deep cleaning of the exit tunnel are facilitated.

Description

Technical Field

[0001] The utility model belongs to the technical field of animal experiment equipment, and particularly relates to a four-choice channel canine vision assessment device. Background Art

[0002] Recent research has shown that canine models of human retinal dystrophy are becoming increasingly important for the development of vision restoration therapies. At the launch of Luxturna (an AAV-based gene therapy for the treatment of inherited retinal dystrophy caused by biallelic mutations in RPE65), Spark Therapeutics announced a video of a Briard (RPE65- / -) dog showing improved visual function in an obstacle test, which laid the foundation for the US Food and Drug Administration to approve Luxturna.

[0003] However, although the traditional obstacle test method has been widely used, it may be subjective in nature and the results are difficult to be used for quantitative statistics. At present, some laboratories have designed and applied a relatively more objective four-choice channel. The four-choice channel experimental device proposed in "ANovel Method for Objective Vision Testing in Canine Models of InheritedRetinalDisease" is a whole. During the experiment, animals need to enter and exit from the exit tunnel or the top of the main box body, which is not convenient for animals to enter and exit. If the device is small, experimenters cannot enter. After the experiment, the device cannot be disassembled, and the main box body cannot be opened or it is inconvenient to open, resulting in difficulties in carrying out the cleaning work inside it and there are dead corners in disinfection and sterilization, and there is a risk of infection for animals and experimenters; on the other hand, since the whole device is opaque, it is not convenient to observe the behavior of animals during the experiment. Content of the Utility Model

[0004] Purpose of the utility model: In order to overcome the above deficiencies, the purpose of the utility model is to provide a four-choice channel canine vision assessment device, which has a simple structure and reasonable design. The device adopts a split connection, which is convenient for entry, exit, disinfection and sterilization.

[0005] Technical solution: In order to achieve the above purpose, the utility model provides a four-choice channel canine vision assessment device, which includes a main box body, an exit tunnel, a lighting system and a monitoring device. The side plates of the main box body are detachably connected to an exit tunnel. The lighting system is installed on the main box body. The exit tunnel is communicated with the main box body. At least one side of the main box body is a pair of doors that are divided into two along the vertical central axis. The monitoring device is installed inside the main box body.

[0006] Furthermore, the lighting system includes a white intensity adjustable lamp, a red light illuminating lamp, and a lighting controller. The white intensity adjustable lamp and the red light illuminating lamp are fixedly installed on the top plate of the main box body, and the lighting controller is installed outside the main box body. First, in our previous exploration, we found that the visual functions of animals are different under different light intensities. Therefore, we equipped the box body with a lighting system whose light intensity can be adjusted to achieve the visual functions of animals under different light intensities in the experiment.

[0007] Furthermore, the double-leaf doors are installed on the main box body through hinges, and the two double-leaf doors are locked by a bolt lock. Opening the bolt lock can open the double-leaf doors, which is convenient and fast.

[0008] Furthermore, the exit tunnel is an opaque cylindrical shape. The exit tunnel includes a wire frame and a black opaque canvas wrapped outside the wire frame. The wire frame prevents the exit tunnel from collapsing and deforming during use.

[0009] Furthermore, a detachable end plate is provided at the port of the exit tunnel. Experimenters can choose to open any exit tunnel by removing the end plate.

[0010] Furthermore, the exit tunnel is connected to the main box body through quick-release buckles. When installing the exit tunnel, it only needs to be inserted into the main box body.

[0011] Furthermore, the monitoring device is a rotatable and trackable monitoring probe installed on the top plate of the main box body. The experiment recorder observes the behavior of the animals in the box body through the video system and records whether the experimental dog chooses the open tunnel when first attempting to exit the device and the time required to completely exit the device.

[0012] From the above technical solutions, it can be seen that the present utility model has the following beneficial effects:

[0013] 1. A four-choice channel canine vision evaluation device provided by the present utility model is provided with side plates in the form of double-leaf doors on the main box body, which can facilitate the entry and exit of animals and experimenters, and is also more convenient for cleaning and disinfection of the main box body at the end of the later experiment; the exit tunnel and the main box body are connected by buckles, which is convenient for installation, disassembly and replacement, and can also remove the exit tunnel for thorough cleaning.

[0014] 2. In the present utility model, a lighting system with adjustable intensity and a monitoring device are installed in the main box body. The lighting system with adjustable intensity meets the experiment of the visual behavior of animals under different light intensities, and the monitoring device is convenient for experimenters to observe the behavior of animals in the box body and record whether the experimental dog chooses the open tunnel when first attempting to exit the device and the time required to completely exit the device. Description of the Drawings

[0015] Figure 1Structural diagram of a four - selection channel canine vision assessment device according to the present utility model;

[0016] Figure 2 Cross - sectional view of an automatic insertion mold cavity tooling for a soft sealing strip according to the present utility model.

[0017] In the figure: 1 - main box body, 11 - double - leaf door, 12 - bolt lock, 2 - exit tunnel, 21 - end plate, 3 - lighting system, 31 - white intensity adjustable lamp, 32 - red light illuminating lamp, 33 - lighting controller, 4 - monitoring device. Specific implementation manners

[0018] It should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model.

[0019] As Figure 1 - Figure 2 shown: A four - selection channel canine vision assessment device includes a main box body 1, an exit tunnel 2, a lighting system 3 and a monitoring device 4. The side plates of the main box body 1 are detachably connected to an exit tunnel 2 respectively. The lighting system 3 is installed on the main box body 1. The exit tunnel 2 is communicated with the main box body 1. At least one side of the main box body 1 is a double - leaf door 11 which is divided into two along the vertical central axis. The monitoring device 4 is installed inside the main box body 1.

[0020] Please refer to again Figure 2 , the lighting system includes a white intensity adjustable lamp 31, a red light illuminating lamp 32 and a lighting controller 33. The white intensity adjustable lamp 31 and the red light illuminating lamp 32 are fixedly installed on the top plate of the main box body 1. The lighting controller 33 is installed outside the main box body 1. In addition, the lighting system can be set as a color - changeable light to test the visual behavior of animals under different - colored lights. Additionally, an ultraviolet lamp can be installed on the top plate of the main box body 1 to perform preliminary disinfection of the device after the experiment.

[0021] The double - leaf door 11 is installed on the main box body 1 through hinges and is locked between the two double - leaf doors 11 by a bolt lock 12. At least one side plate of the main box body 1 can also be set as a liftable shutter.

[0022] In a further optimized solution, the exit tunnel 2 is an opaque cylinder. The exit tunnel 2 includes a steel wire frame and a black opaque canvas wrapped outside the steel wire frame.

[0023] In a further optimized solution, a detachable end plate 21 is provided at the port of the exit tunnel 2.

[0024] In a further optimized solution, the outlet tunnel 2 is connected to the main box 1 by a quick release buckle. It should be noted that the outlet tunnel and the main box are not limited to being connected in the form of a quick release buckle, and other quick release structures can also be used.

[0025] In a further optimized solution, the monitoring device 4 is a rotatable and trackable monitoring probe installed on the top plate of the main box body 1.

[0026] When using the four-selection channel canine vision assessment device provided by the utility model: open the double-door 11, and adjust the required light intensity through the light controller 33 outside the main box 1; the experimenter brings the experimental dog into the main box 1, closes the double-door 11, and installs the exit tunnel 2 on the double-door 11, and the animal adapts in the main box 1 for at least 10 minutes; then uncovers the end plate 21 of any one of the exit tunnels 2, and the other three exit tunnels 2 remain closed; the experimenter opens the monitoring device 4 and releases the experimental dog, and the experimental recorder observes the animal's behavior in the box through the monitoring device 4, records whether the experimental dog chooses to open the tunnel when trying to exit the main box 1 for the first time and the time required to completely exit the main box 1, adjusts the lights of different intensities, and repeats the above steps; after the experiment, open the double-door to clean, disinfect and sterilize the main box 1, and remove the exit tunnel 2 to clean, disinfect and sterilize it.

[0027] The above is only a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements without departing from the principle of the present invention, and these improvements should also be regarded as within the protection scope of the present invention.

Claims

1. A four-selection channel canine vision assessment device, characterized in that: The invention comprises a main box (1), an exit tunnel (2), a lighting system (3) and a monitoring device (4), wherein the side panels of the main box (1) are detachably connected to an exit tunnel (2), the lighting system (3) is mounted on the main box (1), the exit tunnel (2) is connected to the main box (1), at least one side of the main box (1) is a double-leaf door (11) divided into two along a vertical central axis, and the monitoring device (4) is mounted inside the main box (1).

2. A four-selection channel canine vision assessment device according to claim 1, characterized in that: The lighting system comprises a white intensity adjustable lamp (31), a red light illuminating lamp (32) and a lighting controller (33); the white intensity adjustable lamp (31) and the red light illuminating lamp (32) are fixedly mounted on a top plate of a main box (1); and the lighting controller (33) is mounted on the outside of the main box (1).

3. A four-selection channel canine vision assessment device according to claim 1, characterized in that: The two doors (11) are mounted on the main housing (1) via hinges, and the two doors (11) are locked via a latch lock (12).

4. A four-selection channel canine vision assessment device according to claim 1, characterized in that: The exit tunnel (2) is in the shape of a light-proof cylinder, and comprises a steel wire frame and a black opaque canvas covering the steel wire frame.

5. A four-selection channel canine vision assessment device according to claim 1, characterized in that: A detachable end plate (21) is provided at the port of the outlet tunnel (2).

6. A four-selection channel canine vision assessment device according to claim 1, characterized in that: The outlet tunnel (2) is connected to the main box (1) via a quick-release buckle.

7. A four-selection channel canine vision assessment device according to claim 1, characterized in that: The monitoring device (4) is a rotatable and trackable monitoring probe mounted on the top plate of the main box (1).

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