Biopharmaceutical homogenate tank

Abstract

The utility model provides a homogenate tank for biopharmacy, belongs to the technical field of biopharmacy equipment, and is used for solving the technical problem that the service life of a stirring blade is shortened due to the fact that the stirring blade of the existing homogenate tank for biopharmacy is easy to deform. Comprising a tank body, a rotating rod is rotationally arranged in the tank body, a spiral blade is arranged at the lower end of the rotating rod, two sealing bearings are arranged on the rotating rod, a rotating ring is arranged on the outer sides of the two sealing bearings, two stirring blades are fixed to the outer side of the rotating ring, and a plurality of first magnetic shoes which are circumferentially and evenly distributed are fixed to the outer side of the rotating rod; second magnetic tiles with the same number as the first magnetic tiles are fixed to the inner side of the rotating ring. According to the homogenate tank for biopharmacy, the filler can be driven to rotate by using the relatively narrow spiral blade when stirring is started, and the filler is stirred by using the relatively wide stirring blade after rotating, so that the stirring blade can be prevented from deforming, and the service life of the stirring blade is prolonged.

Description

Technical Field

[0001] The utility model belongs to the technical field of biopharmaceutical equipment and relates to a homogenizing tank for biopharmaceutical use. Background Technique

[0002] In the field of biopharmaceuticals, a filler is often used for the separation and purification of liquid medicines. This filler will stratify after standing still. Before use, it needs to be pre-homogenized, and the preservation solvent in the filler is replaced with a use solvent. The filler is a micron-level solid sphere with a diameter generally of 90 microns and is insoluble in both the preservation solvent and the use solvent.

[0003] The filler stored in the homogenizing tank will cover the stirring blades after precipitation. When homogenizing, at the beginning when the stirring motor drives the stirring blades to rotate, the stirring blades are subject to the frictional resistance of the filler. The frictional resistance has a large torque on the stirring blades, which is likely to cause deformation of the stirring blades and shorten the service life of the stirring blades.

[0004] Based on this, we have designed a homogenizing tank for biopharmaceutical use. Content of the Utility Model

[0005] The purpose of the utility model is to address the above problems existing in the prior art and propose a homogenizing tank for biopharmaceutical use. The technical problem to be solved by this device is: how to reduce the frictional resistance of the filler on the stirring blades and improve the service life of the stirring blades of the biopharmaceutical homogenizing tank.

[0006] The purpose of the utility model can be achieved by the following technical solutions:

[0007] A homogenizing tank for biopharmaceutical use includes a tank body. A rotating rod is rotatably arranged in the tank body, and a driving motor for driving the rotating rod to rotate is arranged above the tank body. A spiral blade is arranged at the lower end of the rotating rod. Two sealing bearings are arranged on the rotating rod, and a rotating ring is arranged outside the two sealing bearings. Two stirring blades are fixed outside the rotating ring. A number of first magnetic tiles are fixedly arranged on the outside of the rotating rod in a circumferentially uniform distribution, and the N-poles and S-poles of the first magnetic tiles are alternately distributed on the outside. The same number of second magnetic tiles as the first magnetic tiles are fixed on the inside of the rotating ring, and the N-poles and S-poles of the second magnetic tiles are alternately distributed on the inside.

[0008] A sleeve is arranged on the outside of the rotating rod, and a number of stirring sheets are arranged on the outside of the sleeve in a circumferentially uniform distribution, and the stirring sheets are located above the stirring blades.

[0009] With the above structure, during use, the stirring sheets are located above the filler and in the use solvent layer. During stirring, the rotating rod drives the stirring sheets to rotate, thereby driving the use solvent to rotate in the tank body. In cooperation with the spiral blade, the filler and the use solvent in the tank body can be stirred as soon as possible, thereby driving the stirring blades to rotate faster, thus improving the stirring speed.

[0010] A limiting groove is formed in the rotating rod, a limiting strip is arranged inside the sleeve, and the limiting strip is slidably arranged in the limiting groove. A floating ring is arranged above the stirring blade, and a connecting rod is connected between the floating ring and the stirring blade.

[0011] With the above structure, when stirring fillers with different capacities, the height of the solvent used is different, and the floating ring floats above the solvent used, so as to ensure that the stirring blade is located in the solvent layer used, which is more convenient to use.

[0012] The connecting rod is a screw rod. A number of round holes are formed in the floating ring, and the connecting rod passes through the round holes at corresponding positions. Two nuts are threadedly connected to the connecting rod, and the nuts are respectively abutted against the upper and lower sides of the floating ring.

[0013] With the above structure, the operator can change the distance between the floating ring and the stirring blade through the nuts, so that the stirring blade is at different depth layers of the solvent used, improving the adaptability of the device to different amounts of the solvent used and expanding the application range of the device.

[0014] An elastic sheet is fixed at one end of the stirring blade away from the rotating rod.

[0015] With the above structure, during stirring, the elastic sheet can increase the length of the stirring blade, improve the stirring effect, and the elastic sheet can undergo elastic deformation, thereby reducing the resistance of the solvent used to the elastic sheet and preventing deformation.

[0016] The distance between the first magnetic tile and the second magnetic tile is 0.5 - 0.8 millimeters.

[0017] With the above structure, during use, the distance between the first magnetic tile and the second magnetic tile is relatively small, which can improve the magnetic force between the two, and then drive the stirring blade to rotate.

[0018] Compared with the prior art, the homogenizing tank for biopharmaceuticals has the following advantages:

[0019] 1. Through the stirring blade, spiral blade, first magnetic tile and second magnetic tile, when starting to stir, the spiral blade with a narrower blade can be used to drive the filler to rotate, and after the filler starts to rotate, the wider stirring blade can be used for stirring, which can prevent the stirring blade from deforming and extend the service life of the stirring blade.

[0020] 2. Through the stirring blade, floating ring and connecting rod, the solvent used above the filler can be agitated, and in cooperation with the spiral blade, the filler and the solvent used in the tank body can be agitated as soon as possible, so as to drive the stirring blade to rotate faster, thereby improving the stirring speed.

[0021] 3. Through the elastic sheet, the stirring efficiency of the solvent used can be improved, and the elastic sheet can undergo elastic deformation, with strong anti-deformation ability and more stable structure. Brief Description of the Drawings

[0022] Figure 1 is a schematic three-dimensional structure diagram of the present utility model;

[0023] Figure 2 is a schematic internal structure diagram of the tank body in the present utility model;

[0024] Figure 3 is a schematic disassembled structure diagram of the rotating ring in the present utility model;

[0025] Figure 4 is a schematic bottom structure diagram of the sleeve in the present utility model;

[0026] Figure 5 is the present utility model Figure 4 an enlarged schematic structure diagram at position A.

[0027] In the figure: 1, tank body; 2, rotating rod; 3, driving motor; 4, spiral blade; 5, sealing bearing; 6, rotating ring; 7, stirring blade; 8, first magnetic tile; 9, second magnetic tile; 10, sleeve; 11, stirring piece; 12, limiting groove; 13, limiting strip; 14, floating ring; 15, connecting rod; 16, elastic piece; 17, nut. Detailed Description of the Preferred Embodiment

[0028] The technical solutions of this patent will be further described in detail below in conjunction with the specific embodiments.

[0029] The embodiments of this patent are described in detail below. The examples of the embodiments are shown in the drawings, where the same or similar reference numerals represent the same or similar elements or elements with the same or similar functions from beginning to end. The embodiments described below with reference to the drawings are exemplary and are only used to explain this patent and should not be construed as a limitation of this patent.

[0030] In the description of this patent, it should be understood that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing this patent and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this patent.

[0031] In the description of this patent, it should be noted that unless otherwise clearly specified and defined, the terms "installation", "connection", "linkage", and "setting" should be understood in a broad sense. For example, it can be fixedly connected and set, or detachably connected and set, or integrally connected and set. For those of ordinary skill in the art, the specific meanings of the above terms in this patent can be understood according to specific circumstances.

[0032] Please refer to Figures 1-5 , this embodiment provides a homogenizing tank for biopharmaceuticals, including a tank body 1. A rotating rod 2 is rotatably arranged inside the tank body 1, and a driving motor 3 for driving the rotation of the rotating rod 2 is arranged above the tank body 1. A spiral blade 4 is arranged at the lower end of the rotating rod 2. Two sealing bearings 5 are arranged on the rotating rod 2, and a rotating ring 6 is arranged outside the two sealing bearings 5. Two stirring blades 7 are fixed on the outside of the rotating ring 6. A number of first magnetic tiles 8 evenly distributed in a circle are fixed on the outside of the rotating rod 2, and the N-poles and S-poles are alternately distributed on the outside of the first magnetic tiles 8. The same number of second magnetic tiles 9 as the first magnetic tiles 8 are fixed on the inside of the rotating ring 6, and the N-poles and S-poles are alternately distributed on the inside of the second magnetic tiles 9.

[0033] A sleeve 10 is arranged on the outside of the rotating rod 2, and a number of stirring vanes 11 evenly distributed in a circle are arranged on the outside of the sleeve 10, and the stirring vanes 11 are located above the stirring blades 7; during use, the stirring vanes 11 are located above the filler and in the solvent layer in use. During stirring, the rotating rod 2 drives the stirring vanes 11 to rotate, thereby driving the solvent in use to rotate in the tank body 1. Cooperating with the spiral blade 4, the filler and the solvent in use in the tank body 1 can be stirred as soon as possible, thereby driving the stirring blades 7 to rotate faster, thus improving the stirring speed.

[0034] A limiting groove 12 is formed on the rotating rod 2, a limiting strip 13 is arranged inside the sleeve 10, and the limiting strip 13 is slidably arranged in the limiting groove 12. A floating ring 14 is arranged above the stirring vane 11, and a connecting rod 15 is connected between the floating ring 14 and the stirring vane 11; when stirring fillers with different capacities, the height of the solvent in use is different. The floating ring 14 floats above the solvent in use, thereby ensuring that the stirring vane 11 is located in the solvent layer in use, making it more convenient to use.

[0035] The connecting rod 15 is a spiral rod. A number of round holes are formed in the floating ring 14, and the connecting rod 15 passes through the round holes at corresponding positions. Two nuts 17 are threadedly connected to the connecting rod 15, and the nuts 17 are respectively abutted against the upper and lower sides of the floating ring 14; the operator can change the distance between the floating ring 14 and the stirring vane 11 through the nuts 17, so that the stirring vane 11 is located at different depth layers of the solvent in use, improving the adaptability of the device to different amounts of the solvent in use and expanding the applicable range of the device.

[0036] One end of the stirring blade 11 away from the rotating rod 2 is fixed with an elastic piece 16; during stirring, the elastic piece 16 can increase the length of the stirring blade 11, improve the stirring effect, and the elastic piece 16 can undergo elastic deformation, thereby reducing the resistance of the solvent to the elastic piece 16 and preventing deformation.

[0037] The distance between the first magnetic tile 8 and the second magnetic tile 9 is 0.5 - 0.8 mm; during use, the distance between the first magnetic tile 8 and the second magnetic tile 9 is relatively small, which can improve the magnetic force between them, and then drive the stirring blade 7 to rotate.

[0038] In this embodiment, the above fixing methods are the most commonly used fixed connection methods in the art, such as welding, bolt connection, etc.; the above electrical components, such as the drive motor 3, are all products of the prior art and can be directly purchased and used in the market, and the specific principles will not be elaborated.

[0039] The working principle of the present utility model:

[0040] During use, the drive motor 3 drives the rotating rod 2 to rotate. When starting to rotate, the resistance of the stirring blade 7 to the filler is relatively large. At this time, the rotating rod 2 continues to rotate, and the resistance of the stirring blade 7 to the filler is greater than the torsion between the first magnetic tile 8 and the second magnetic tile 9, so the stirring blade 7 does not rotate. At this time, the spiral blade 4 rotates with the rotating rod 2, the floating ring 14 floats above the solvent, the stirring blade 11 is located above the filler and in the solvent layer. During stirring, the rotating rod 2 drives the stirring blade 11 to rotate, and then drives the solvent to rotate in the tank body 1. Cooperating with the spiral blade 4, it can quickly stir the filler and the solvent in the tank body 1, thereby driving the materials inside the tank body 1 to rotate. At this time, the resistance of the filler to the stirring blade 7 decreases. When the resistance of the stirring blade 7 to the filler is less than the torsion between the first magnetic tile 8 and the second magnetic tile 9, the stirring blade 7 can rotate synchronously with the rotating rod 2, further accelerating the stirring speed, and can prevent the stirring blade 7 from being deformed due to excessive resistance, and prolong the service life of the stirring blade 7.

[0041] The above has described the preferred embodiments of this patent in detail, but this patent is not limited to the above embodiments. Within the scope of knowledge possessed by ordinary technicians in the art, various changes can be made without departing from the purpose of this patent.

Claims

1. A homogenization tank for biopharmaceuticals, comprising a tank body (1), characterized in that: A rotating rod (2) is rotatably arranged inside the tank body (1), and a driving motor (3) for driving the rotating rod (2) to rotate is arranged above the tank body (1), a spiral blade (4) is arranged at the lower end of the rotating rod (2), two sealed bearings (5) are arranged on the rotating rod (2), and a rotating ring (6) is arranged outside the two sealed bearings (5), and two stirring blades (7) are fixed outside the rotating ring (6), a plurality of first magnetic tiles (8) uniformly distributed around the circumference are fixed outside the rotating rod (2), and the outer sides of the first magnetic tiles (8) are alternately distributed in N-level and S-level, and the inner sides of the second magnetic tiles (9) are alternately distributed in N-level and S-level. The same number of second magnetic tiles (9) as the first magnetic tiles (8) are fixed inside the rotating ring (6), and the inner sides of the second magnetic tiles (9) are alternately distributed in N-level and S-level.

2. A biopharmaceutical homogenization tank according to claim 1, characterized in that: A sleeve (10) is arranged on the outside of the rotating rod (2), and a plurality of stirring blades (11) evenly distributed around the circumference are arranged on the outside of the sleeve (10), and the stirring blades (11) are located above the stirring blades (7).

3. A biopharmaceutical homogenization tank according to claim 2, characterized in that: A limit groove (12) is provided on the rotating rod (2), and a limit strip (13) is provided inside the sleeve (10), and the limit strip (13) is slidably arranged in the limit groove (12), a floating ring (14) is provided above the stirring blade (11), and a connecting rod (15) is connected between the floating ring (14) and the stirring blade (11).

4. A biopharmaceutical homogenization tank according to claim 3, characterized in that: The connecting rod (15) is a spiral rod. The floating ring (14) is provided with a plurality of circular holes, and the connecting rod (15) passes through the circular holes at corresponding positions. Two nuts (17) are threadedly connected to the connecting rod (15), and the nuts (17) are respectively pressed against the upper and lower sides of the floating ring (14).

5. A biopharmaceutical homogenization tank according to claim 2, characterized in that: An elastic sheet (16) is fixed to one end of the stirring sheet (11) away from the rotating rod (2).

6. A biopharmaceutical homogenization tank according to claim 1 or 2, characterized in that: The distance between the first magnetic tile (8) and the second magnetic tile (9) is 0.5-0.8 mm.

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