SPECT multi-parallel-hole collimator, collimator device and detection device

By designing a SPECT multi-parallel hole collimator device containing transverse continuous collimator positions, the transverse guide rail and transmission mechanism are used to achieve rapid replacement and adjustment of collimator, the problem of cumbersome collimator replacement in SPECT detection in small animals is solved, and flexible detection and multiple image acquisition are achieved.

CN222942354UActive Publication Date: 2025-06-06SHANDONG MADIC TECH CO LTD
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Patent Information

Application Number
CN202421198951.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-05-29
Publication Date
2025-06-06
Estimated Expiration
2034-05-29

AI Technical Summary

Technical Problem

SPECT detection in small animals requires frequent replacement and adjustment of parallel hole collimator, which leads to cumbersome operation and high cost, making it difficult to meet flexible detection needs.

Method used

A SPECT multi-parallel hole collimator device is designed, including three collimator positions arranged in a transverse continuous manner. The translation and position adjustment of the collimator are achieved through the transverse guide rail and transmission mechanism, avoiding disassembly and reinstallation when replacing the collimator.

Benefits of technology

It enables quick replacement and adjustment of collimator without shutting down the device, simplifies operational processes, reduces costs, and supports image acquisition with multiple definitions, meeting flexible detection needs.

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Abstract

The utility model discloses an SPECT multi-parallel-hole collimator, a collimator device and a detection device. The SPECT multi-parallel-hole collimator comprises three collimator positions, a calibration position, a first collimator position and a second collimator position which are transversely and continuously arranged, or the first collimator position, the second collimator position, or the zero collimator position, the first collimator position, and the second collimator position. The utility model relates to an SPECT (Single Photon Emission Computed Tomography) multi-parallel-hole collimator device, which comprises two SPECT multi-parallel-hole collimators which are oppositely arranged in parallel. The two PECT multi-parallel-hole collimators which are oppositely arranged in parallel further comprise a set of transverse guide rails, collimator transmission pieces and transmission mechanisms. A single photon emission computed tomography (SPECT) detection device comprises a multi-parallel-hole collimator device and two opposite detectors, each detector is fixed in a detector frame, and a transverse guide rail is fixed on the inner side of the detector frame. The utility model relates to an SPECT imaging method, which utilizes an SPECT detection device to implement detection and comprises a debugging step and a testing step.
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Description

Technical Field

[0001] The utility model relates to the technical field of SPECT multi-parallel hole collimators, in particular to a SPECT multi-parallel hole collimator, a collimator device and a detection device. Background Art

[0002] SPECT (Single-Photon Emission Computed Tomography) is one of the two ECT (Emission Computed Tomography) technologies in nuclear medicine imaging. It uses radioactive drugs that only emit a single photon per decay for tomographic imaging. By showing the distribution of drugs in the body, it reflects the function, metabolism and physiological status of the body. Compared with PET, SPECT has both advantages and disadvantages. Overall, it is one of the more important nuclear medicine impact detection methods and is widely used in clinical testing.

[0003] In addition to clinical use, SPECT is currently widely used in small animal drug research. Due to the increase in safety margins, small animal research can withstand more radiation / irradiation than human medicine, and spect is less restricted in small animal drug research. Therefore, small animal SPECT is widely used in the clinical research of new drugs and is often used for the detection and research of experimental animals. Since the photons emitted by drugs in the body are isotropic, a collimator is required to limit the direction of the photons incident on the detector. The performance of the collimator directly determines the quality of the final image obtained. In the prior art, the collimator of the small animal SPECT device, taking the parallel hole collimator as an example, is composed of thousands of precisely aligned holes (channels), which can limit the incident direction of photons to ensure that the collected image is clear. A parallel hole collimator, for example, has dozens by dozens, hundreds by hundreds of parallel holes in a matrix.

[0004] However, compared with human body detection, the detector and collimator of human body detection are generally relatively fixed after debugging, and the detector collects data in a relatively fixed way for medical analysis. For example, each time, data is collected from one of the patient's chest, abdomen, or head. The collection method is relatively fixed, and the collimator generally does not need to be replaced or moved (the position is fixed relative to the detector). For small animals used in experiments, the demand for collecting spect data is more flexible. For example, the test animal collected this time is small (mice), and the test animal collected next time is much larger (rabbits, etc.). Or although the animal liver is tested, for the purpose of research, for the same test object, it is also desired to see the image of a certain position of the animal or the whole body image, or more generally, for the imaging of the liver area, it is desired to have image results of different resolutions, for example, it is desired to obtain three levels of images of the same liver area with resolutions of 1 / 2 / 3, so as to select the most suitable one for subsequent analysis and processing. Later, when different conditions are met, the image of the appropriate resolution can be selected according to the needs for research or analysis. Due to the flexibility of small animal drug research, it is often necessary to cooperate with different collimators for detection and data acquisition, but the collimator must be replaced every time. If the collimator must be replaced by shutting down, it is very troublesome and laborious, and the replacement of the collimator also requires the adjustment of the distance (FOV). Small animal spect detection often requires the detection of different collimators. It is best to be able to replace without shutting down the machine, so that multiple detections with changed collimators can be performed at one time. This demand and the cumbersome operation of replacing the collimator detection are obviously contradictory. There are few technical solutions to solve such problems in the prior art. If it is solved by using multiple different devices, although it is simple, the equipment cost is significantly increased, and the technical solution is very uneconomical. Utility Model Content

[0005] The purpose of the utility model is to provide a device, which mainly solves the problem that small animal spect detection often needs to cooperate with different parallel hole collimators for detection, and the cumbersome operation of replacing the collimator for detection is an obvious contradiction. This method is original to this application and has no prior art inspiration. Under the careful design of the device, the operation method of this application is simple and convenient, and the cost is low. Moreover, the matching detection of different parallel hole collimators can be realized through programming operation, and the cost of accessories is not high. At most, three to four different parallel hole collimators can be replaced for a small animal / small animal area of ​​interest. Image detection imaging, three or four different image data with different clarity can be collected in one detection, providing simple but comprehensive data support for subsequent analysis and research.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a SPECT multi-parallel hole collimator, characterized in that it includes three collimator positions arranged in a transverse sequence, namely a calibration position, a first collimator position, and a second collimator position.

[0007] The calibration position, the first collimator position and the second collimator position are integrally manufactured on a substrate, or are embedded and fixed in parallel on a frame substrate.

[0008] The calibration position is a whole blank space on the substrate or frame substrate or a blank space surrounded by a square frame; the first collimator and the second collimator positions are respectively installed with the first collimator and the second collimator.

[0009] Furthermore, the second collimator is composed of two or more collimators of the same specification as the first collimator, which are aligned in the Z-axis direction and stacked in sequence.

[0010] A SPECT multi-parallel hole collimator, characterized in that it includes three collimator positions arranged in a transverse sequence, namely a zeroth collimator position, a first collimator position, and a second collimator position.

[0011] The zeroth collimator position, the first collimator position and the second collimator position are integrally manufactured on a substrate, or are embedded and fixed in parallel on a frame substrate.

[0012] The zeroth collimator, the first collimator and the second collimator positions are respectively installed with the zeroth collimator, the first collimator and the second collimator.

[0013] Furthermore, the first collimator is composed of two or more collimators with the same specifications as the zeroth collimator aligned in the Z-axis direction and stacked in sequence; the second collimator is composed of three or more collimators with the same specifications as the zeroth collimator aligned in the Z-axis direction and stacked in sequence.

[0014] A SPECT multi-parallel hole collimator device is characterized by comprising two parallel and opposite SPECT multi-parallel hole collimators as above.

[0015] Further, the two parallel and opposite SPECT multi-parallel hole collimators each include a set of transverse guide rails and a collimator transmission member and a transmission mechanism, the collimator transmission member is fixed together with the SPECT multi-parallel hole collimator on the same side and moves left and right under the drive of the transmission mechanism, and the transmission mechanism is one of a ball screw, a gear rack, a synchronous belt, a chain drive, and a threaded screw;

[0016] Two SPECT multi-parallel hole collimators are respectively installed on the transverse guide rails.

[0017] Each transverse guide rail is mounted on the combination of the second threaded screw and the nut, and is moved closer to or farther from the detection position under the rotation control of the second threaded screw.

[0018] A SPECT detection device, characterized in that it comprises the multi-parallel hole collimator device as above, and is also provided with two opposing detectors, each detector is fixed in a detector frame, and two transverse guide rails are respectively fixed on the inner sides of the two detector frames.

[0019] Each detector, together with the SPECT multi-parallel hole collimator on the same side, is moved closer to or farther from the detection position under the rotation control of the second threaded lead screw.

[0020] Furthermore, the second threaded screw is a left-right bidirectional screw, and the rotation of the second threaded screw drives the opposite detector pair and collimator pair to move synchronously in opposite directions.

[0021] Furthermore, each collimator position or calibration position is provided with an inwardly disposed proximity sensor.

[0022] Compared with the prior art, the present application has many non-obvious advantages: First, it avoids the situation that the collimator part / detector part / overall device needs to be disassembled or replaced every time the collimator is changed. Only lateral translation and position adjustment are needed to achieve the replacement of the collimator and imaging; Second, it is very easy to adjust from the structural setting. First, the collimator is an integrated lateral plate combination, or is arranged horizontally and embedded in the frame to form a plate combination, and then the plate combination is fixed on the detector frame with a lateral guide rail. In this way, as long as the detector frame is driven by the lead screw to move in the Z-axis direction, the detector can move with the collimator, which is an effective measure to ensure detection. Then, using different collimators means that the FOV is different (generally different in radial and circumferential directions). At this time, the appropriate detection distance can be adjusted by the rotation of the lead screw. This adjustment can be driven by a preset program to accurately move and execute. Third, the use and switching of different collimators is easy to operate. You only need to move the lateral guide rail, and then fine-tune the lead screw according to the preset FOV corresponding distance to make it meet the preset detection distance of the current collimator, and then you can perform detection. Moreover, the fourth advantage is that this operation is perfectly adapted to programmed automatic control. For example, according to the control distance of the lead screw and the transverse guide rail measured in advance, it is programmed to automatically shoot according to the zero-hole collimator - the first multi-pinhole collimator - the second multi-pinhole collimator, and all are completed automatically. Fourth, it is also convenient to adjust the FOV. Under the premise that the cross-section of the square cone hole is a rectangle, the axial FOV direction is the longer side, which can increase the axial FOV. Conversely, the radial direction is the longer side, which can increase the radial FOV. Fifth, the assembly is simple. The zero-hole collimator is, for example, a 68*68 parallel hole collimator, and the first collimator is two stacked, and the second collimator is three stacked, so the preparation of the entire device is also very simple. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1Schematic diagram of the SPECT detection device.

[0024] Figure 2 Schematic diagram of the detector composition.

[0025] Figure 3 This is a diagram of the first configuration style of a multi-parallel hole collimator.

[0026] Figure 4 Schematic diagram of three different collection positions to cope with changes in the detection device's morphology.

[0027] Reference numerals: 1, multi-parallel hole collimator device; 22, crystal; 23, light guide; 24, FEE plate / SiPM array plate; 31, transverse guide rail; 32, rigid coupling; 33, servo motor bracket; 34, lead screw support assembly; 35, second lead screw; 36, second rigid coupling; 37, second servo motor; 38, micro switch; 39, vertical guide rail; 40, left and right threaded lead screws. 5, multi-parallel hole collimator, 51, calibrator, 52, first collimator position, 53, second collimator position. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0029] Example 1

[0030] A SPECT multi-parallel hole collimator, characterized in that it comprises three collimator positions arranged in a transverse sequence, namely a calibration position, a first collimator position, and a second collimator position.

[0031] The calibration position, the first collimator position and the second collimator position are integrally manufactured on a substrate, or are embedded and fixed in parallel on a frame substrate.

[0032] The calibration position is a whole blank space on the substrate or frame substrate or a blank space surrounded by a square frame; the first collimator and the second collimator positions are respectively installed with the first collimator and the second collimator.

[0033] Furthermore, the second collimator is composed of two or more collimators of the same specification as the first collimator, which are aligned in the Z-axis direction and stacked in sequence.

[0034] A SPECT multi-parallel hole collimator, characterized in that it includes three collimator positions arranged in a transverse sequence, namely a zeroth collimator position, a first collimator position, and a second collimator position.

[0035] The zeroth collimator position, the first collimator position and the second collimator position are integrally manufactured on a substrate, or are embedded and fixed in parallel on a frame substrate.

[0036] The zeroth collimator, the first collimator and the second collimator positions are respectively installed with the zeroth collimator, the first collimator and the second collimator.

[0037] Furthermore, the first collimator is composed of two or more collimators with the same specifications as the zeroth collimator aligned in the Z-axis direction and stacked in sequence; the second collimator is composed of three or more collimators with the same specifications as the zeroth collimator aligned in the Z-axis direction and stacked in sequence.

[0038] Simply put, two types of multi-parallel hole collimators with similar functions are mentioned in this embodiment. One is arranged in sequence: the calibration position (i.e., an empty position, without an actual collimator), the first collimator position, and the second collimator position. The second is to arrange three collimator positions in succession. The configuration of multiple parallel hole collimators is very necessary. Many times, especially in the experimental stage, it is not easy for mice to determine whether they are only concerned about a certain organ, a certain area of ​​a certain organ, or the organ area adjacent to it. Therefore, it is very necessary to continuously take samples with different collimators. Continuous sampling can also better ensure that the situation at the time of sampling is basically the same. If the collimator is replaced and then tested, it is not only troublesome, but also time-consuming, and the state of the experimental animals cannot be guaranteed.

[0039] The collimator can be a collimator with different arrangements, such as a 68*68 collimator and a 90*90 collimator, but a convenient operation is that the collimator has a reference piece, wherein the actual collimator is, for example, a single reference piece, or is formed by stacking two or more collimators. The reference pieces are, for example, all of the same configuration, such as 30*30 / 50*50 / 60*60 / 80*80 parallel hole collimators.

[0040] Typical reference components include, for example, parallel hole collimator 1: aperture 1.36 mm, wall thickness 0.1 mm, height 14.6 mm, number of holes 68×68.

[0041] It should be noted that the concept of the present application does not limit the specifications of the collimator. The above example configuration is only a configuration value that can be used, and it does not mean that the collimator must be installed in the above configuration. Collimators with other configurations with not too great a difference in values ​​can also complete the sampling of mice of different specifications.

[0042] Several collimators or collimator positions are made in one piece on a substrate, or embedded and fixed on a frame substrate side by side. Both methods can be used, each with its own advantages and disadvantages. The former is more stable in use and more assured in lateral movement, but the disadvantage is that it cannot be adjusted and replaced. The latter can easily adjust and replace one or more collimators, but its fixing is not as stable as the former method, and more consideration needs to be given to the fixing means.

[0043] The collimators on the multi-parallel hole collimator have different magnification and FOV. Basically, in order to obtain different images, it is not necessary to set the same collimator. Of course, in special cases, two of them can be the same, so that only one of them can be used to collect data.

[0044] The FOVs are different in pairs, which means at least one of the theoretical axial FOV and the theoretical radial FOV is different. A more preferred mode is that the radial and axial FOVs of the multiple pinholes are different in pairs, but it is also possible that some remain unchanged, for example, the theoretical axial FOV remains basically unchanged or changes slightly.

[0045] Example 2

[0046] A SPECT multi-parallel hole collimator device is characterized by comprising two parallel and opposite SPECT multi-parallel hole collimators as above.

[0047] Further, the two parallel and opposite SPECT multi-parallel hole collimators each include a set of transverse guide rails and a collimator transmission member and a transmission mechanism, the collimator transmission member is fixed together with the SPECT multi-parallel hole collimator on the same side and moves left and right under the drive of the transmission mechanism, and the transmission mechanism is one of a ball screw, a gear rack, a synchronous belt, a chain drive, and a threaded screw;

[0048] Two SPECT multi-parallel hole collimators are respectively installed on the transverse guide rails.

[0049] Each transverse guide rail is mounted on the combination of the second threaded screw and the nut, and is moved closer to or farther from the detection position under the rotation control of the second threaded screw.

[0050] In the present application, two opposed multi-parallel hole collimators are used, and the two collimators are mirror-symmetrical, so that the detectors on both sides can perform detection at the same time just by mirror operation.

[0051] The two SPECT multi-parallel hole collimators are respectively mounted on transverse guide rails that enable them to move laterally, and are driven by a transmission mechanism to move laterally; the transverse guide rails are, for example, divided into front and rear double guide rails, and the front and rear are clamped to ensure the stability of movement and fixation.

[0052] Each transverse guide rail is mounted on the combination of the second threaded screw and the guide rail, and the SPECT multi-pinhole collimator is moved closer to or farther away from the detection position under the rotation control of the second threaded screw. The threaded screw is, for example, two screws with mirror images of the upper and lower spirals (or more simply, a left and right threaded screw with reverse threads from the middle to the two ends), which can achieve opposite movement, or a screw whose threads are opposite at the top and bottom, and the midpoint / midline corresponds to the center position of the detection animal / detection shooting hole (circular or square). In this way, the rotation of the screw can achieve the two collimators to move closer to or farther away from each other.

[0053] Example 3

[0054] A SPECT detection device, characterized in that it includes a multi-parallel hole collimator device as described above, and also has two opposing detectors, each detector is fixed in a detector frame, and two transverse guide rails are respectively fixed on the inner side of the two detector frames. The inner side here refers to the side close to the detection animal / detection position / shooting hole. This arrangement ensures a fixed spacing between the collimator and the detector, and the detector and the collimator can also adjust the radial distance (distance from the detection center) together to adapt to different detection conditions.

[0055] Each detector, together with the SPECT multi-parallel hole collimator on the same side, moves closer to or farther from the detection position under the rotation control of the second threaded screw. The two detectors are similarly (mirrored) mounted on the combination of the second threaded screw and the guide rail.

[0056] Further, the second threaded screw is a left-right bidirectional screw, and the rotation of the second threaded screw drives the opposite detector pair and collimator pair to move synchronously in opposite directions. The threaded screw is a left-right bidirectional screw (the threads are opposite from the midpoint upward and downward), and the rotation of the threaded screw drives the opposite detector pair and collimator pair to move synchronously in opposite directions. In this way, when the screw turns left or right, the upper and lower detector pairs and collimator pairs will move closer or farther away from each other, rather than moving in the same direction.

[0057] Furthermore, each collimator position or calibration position is equipped with an inwardly arranged proximity sensor. Since the collimator combination may be very long in the horizontal direction, there may be two or more proximity sensors, which are used to prevent the collimator from getting too close to the middle, for example, colliding with animals or other components.

[0058] Implementation method: In conjunction with a SPECT imaging method, it uses a SPECT detection device as described above to implement detection, which is characterized by: (1) Debugging step: by controlling the rotation of the second threaded screw, each detector on the upper and lower sides is controlled to move closer to or farther away from the detection position together with the SPECT multi-pinhole collimator on the same side under the control of the rotation of the threaded screw, and testing is performed, and the two SPECT multi-pinhole collimators are controlled to move left and right on the transverse guide rail so that each collimator on them is located at the detection position at least once; debugging is completed.

[0059] (2) Test steps: After debugging, place the test object or calibration object at the test position and perform the following test: move the calibration position or collimator position on the leftmost side of the current SPECT multi-parallel hole collimator horizontally to align with the detector, adjust it according to its preset FOV, control the rotation of the second threaded screw, adjust the distance between the current collimator and the test position to the preset distance, and perform the test.

[0060] Repeat the above steps for the other two collimator positions in the order of left and right adjacency to complete the detection.

[0061] Implementation method: A SPECT imaging method is used to implement detection using the SPECT detection device as described above, which is characterized by: (1) Debugging step: By controlling the rotation of the second threaded screw, each detector on the upper and lower sides is controlled to move closer to or farther away from the detection position together with the SPECT multi-pinhole collimator on the same side under the control of the rotation of the threaded screw, and testing is performed, and the two SPECT multi-pinhole collimators are controlled to move left and right on the transverse guide rail so that each collimator on them is located at the detection position at least once; debugging is completed.

[0062] (2) Test steps: After debugging, place the test object or calibration object at the test position and perform the following test: randomly select the calibration position or one of the collimator positions of the current SPECT multi-parallel hole collimator, move it laterally to align with the detector, adjust it according to its preset FOV, control the rotation of the second threaded screw, adjust the distance between the current collimator and the test position to the preset distance, and perform the test.

[0063] Repeat the above steps for all other calibration positions and / or collimator positions of the current SPECT multi-parallel hole collimator in random order to complete the detection.

[0064] For example Figure 1 As shown in the multi-parallel hole collimator, it can be seen that the detector 2 has one on the top and one on the bottom, and the detector is housed in a rectangular frame (the present application Figure 1The detector is not actually shown in the figure, but the detector is square in size and easy to install. Those skilled in the art can understand how it moves with the collimator). A transverse guide rail is fixed on the inner side of the detector frame. The multi-parallel hole collimator is fixed on the transverse guide rail. The multi-parallel hole collimator moves left and right, and can be adapted to different collimators (holes) and detectors. The left and right movement of the multi-parallel hole collimator is, for example, driven by the second servo motor to drive the first threaded screw. When different collimators are used, the adaptation distance is often different, and the distance between the collimator and the detection position needs to be adjusted. At this time, the main servo motor drives the second threaded screw to complete the simultaneous approach / distance of the detectors and collimators on both sides.

[0065] like Figure 2 As shown, the detector has a three-layer structure, typically composed of a crystal, a photoconductive layer, and a PMT layer, for example, a crystal layer, a photoconductive layer, and a FEE (array SiPM layer). The crystal may be a common SPECT crystal.

[0066] like Figure 3 As shown, the calibration position, the first collimator position, and the second collimator position are arranged in sequence. The calibration position is empty, and the first collimator position is a reference collimator: parallel hole collimator 1: aperture 1.36mm, wall thickness 0.1mm, height 14.6mm, number of holes 68×68. The second collimator position is two reference collimators stacked.

[0067] like Figure 4 What is shown is a specific diagram of the calibration position, the first collimator position, and the second collimator position being in the detection state. The distance between the collimators on both sides is also different, and the FOV of different collimators is different. The parameters are, for example, the same as those described in the previous paragraph. The FOV here is a specific one that can be implemented, and the numerical value should not be considered as a limitation to the application.

[0068] The above is only an embodiment of the utility model, and the common sense such as the known specific structure and characteristics in the scheme is not described too much here. For those skilled in the art, it is obvious that the utility model is not limited to the details of the above exemplary embodiments, and the utility model can be implemented in other specific forms without departing from the spirit or basic features of the utility model. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the utility model is limited by the attached claims rather than the above description, and it is intended to include all changes within the meaning and scope of the equivalent elements of the claims in the utility model. Any figure mark in the claims should not be regarded as limiting the claims involved.

Claims

1. A SPECT multi-parallel hole collimator, characterized in that : It includes three collimator positions which are arranged in a transverse sequence, namely a calibration position, a first collimator position, and a second collimator position; The calibration position, the first collimator position, and the second collimator position are integrally manufactured on a substrate, or are embedded and fixed in parallel on a frame substrate; The calibration position is a whole blank space on the substrate or frame substrate or a blank space surrounded by a square frame; the first collimator and the second collimator positions are respectively installed with the first collimator and the second collimator.

2. A SPECT multi-parallel hole collimator as claimed in claim 1, characterized in that: The second collimator is composed of two or more collimators of the same specification as the first collimator, which are aligned in the Z-axis direction and stacked in sequence.

3. A SPECT multi-parallel hole collimator, characterized in that : It includes three collimator positions which are arranged in a transverse sequence, namely, a zeroth collimator position, a first collimator position, and a second collimator position; The zeroth collimator position, the first collimator position, and the second collimator position are integrally manufactured on a substrate, or are embedded and fixed in parallel on a frame substrate; The zeroth collimator, the first collimator and the second collimator positions are respectively installed with the zeroth collimator, the first collimator and the second collimator.

4. A SPECT multi-parallel hole collimator as claimed in claim 3, characterized in that: The first collimator is composed of two or more collimators with the same specifications as the zeroth collimator aligned in the Z-axis direction and stacked in sequence; the second collimator is composed of three or more collimators with the same specifications as the zeroth collimator aligned in the Z-axis direction and stacked in sequence.

5. A SPECT multi-parallel hole collimator device, characterized in that: The method comprises two parallel and opposing SPECT multi-parallel hole collimators according to any one of claims 1 to 4.

6. A SPECT multi-parallel hole collimator device as claimed in claim 5, characterized in that: The two parallel and opposite SPECT multi-parallel hole collimators each include a set of transverse guide rails and a collimator transmission member and a transmission mechanism. The collimator transmission member is fixed together with the SPECT multi-parallel hole collimator on the same side and moves left and right under the drive of the transmission mechanism. The transmission mechanism is one of a ball screw, a gear rack, a synchronous belt, a chain drive, and a threaded screw. Two SPECT multi-parallel hole collimators are respectively mounted on the transverse guide rails; Each transverse guide rail is mounted on the combination of the second threaded screw and the nut, and is moved closer to or farther from the detection position under the rotation control of the second threaded screw.

7. A SPECT detection device, characterized in that: It comprises a multi-parallel-hole collimator device as claimed in claim 5, and is further provided with two opposing detectors, each detector being fixed in a detector frame, and two transverse guide rails being fixed on the inner sides of the two detector frames respectively; Each detector, together with the SPECT multi-parallel hole collimator on the same side, is moved closer to or farther from the detection position under the rotation control of the second threaded lead screw.

8. A SPECT detection device as claimed in claim 7, characterized in that: The second threaded screw is a left-right bidirectional screw, and the rotation of the second threaded screw drives the opposite detector pair and collimator pair to move synchronously in opposite directions.

9. A SPECT detection device according to claim 7 or 8, characterized in that: Each collimator position or calibration position is provided with an inwardly disposed proximity sensor.