Suction filtration device for fosfomycin calcium salt synthesis

Abstract

The utility model provides a suction filtration device for fosfomycin calcium salt synthesis, and particularly relates to the technical field of pharmaceutical production, the suction filtration device comprises a filter funnel and a suction filtration bottle, the bottle body of the suction filtration bottle is provided with a suction filtration opening, the filter funnel comprises a filter tank and a filter pipe arranged at the lower end of the filter tank, and the lower end of the filter pipe is provided with a first flange surface; a second flange face is arranged at the upper end of the suction filtration bottle, and the first flange face and the second flange face are attached in a sealed mode; a hoop is arranged on the filter pipe and can rotate on the filter pipe, connecting beams are symmetrically arranged at the two ends of the hoop, and C-shaped buckles are arranged at the ends of the connecting beams; notches are symmetrically formed in the end faces of the two sides of the second flange face, the lower ends of the buckles penetrate through the notches, and the buckles rotate to clamp the first flange face and the second flange face. According to the utility model, the convenience of placing and taking the filter funnel can be improved, so that the suction filtration efficiency is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of pharmaceutical production, and in particular relates to a suction filtration device for synthesizing fosfomycin calcium salt. Background Art

[0002] Fosfomycin calcium salt is a white or nearly white crystalline powder, and a suction filtration operation is required in the small-scale preparation. The existing suction filtration device generally includes a suction filter bottle and a filter bucket. The lower end of the filter bucket is connected to the suction filter bottle through a stopper by interference fit. The suction filter bottle is provided with a suction filtration port, and the material in the filter bucket is suction filtered through the suction filtration port.

[0003] However, in the existing device, the plug, filter bucket and suction filter bottle are connected by interference fit. In order to improve the airtightness, the connection is very tight, which also leads to the difficulty in removing the filter bucket after the filtration operation. In addition, excessive force is often used, causing the filter bucket to slip and the material to fall over, or even the filter bucket cannot be removed, which greatly affects the work efficiency.

[0004] In view of the above shortcomings, a suction filtration device for the synthesis of fosfomycin calcium salt is now needed, which can improve the convenience of putting and taking out the filter bucket, thereby improving the efficiency of suction filtration. Utility Model Content

[0005] The utility model aims to provide a suction filtration device for synthesis of fosfomycin calcium salt, which can improve the convenience of putting in and taking out the filter bucket, thereby improving the efficiency of suction filtration.

[0006] The utility model provides the following technical solutions:

[0007] A suction filtration device for synthesizing fosfomycin calcium salt comprises a filter bucket and a suction filter bottle, wherein the suction filter bottle is provided with a suction filtration port.

[0008] The filter bucket includes a filter tank and a filter tube arranged at the lower end of the filter tank, and the lower end of the filter tube is provided with a first flange surface; the upper end of the suction filter bottle is provided with a second flange surface, and the first flange surface and the second flange surface are tightly fitted;

[0009] A clamp is provided on the filter tube, and the clamp can rotate on the filter tube. Connecting beams are symmetrically provided at both ends of the clamp, and a C-shaped buckle is provided at the end of the connecting beam.

[0010] The end surfaces on both sides of the second flange surface are symmetrically provided with notches, the lower end of the buckle passes through the notches, and the buckle engages the first flange surface with the second flange surface by rotating.

[0011] Preferably, a limit block is provided on the upper side surface of the first flange surface, located on the side of the connecting beam.

[0012] Preferably, two limit blocks are provided on the sides of the two connecting beams, and the limit blocks are centrally symmetrically arranged.

[0013] Preferably, a sealing gasket is provided between the first flange surface and the second flange surface.

[0014] Preferably, both the first flange surface and the second flange surface are provided with an annular sealing groove, and an annular sealing gasket is provided in the sealing groove.

[0015] Preferably, the clamp comprises two semicircular first clamps and a second clamp, and the ends of the first clamp and the second clamp are symmetrically provided with connecting ears, and the connecting ears are connected by bolts.

[0016] Preferably, the bolts are long-shank bolts, and the screw rods of the bolts at both ends of the clamp are respectively located on both sides of the filter tube.

[0017] Preferably, a shaft sleeve is provided on the connecting ear, and a bolt passes through the shaft sleeve to connect the connecting ears in series.

[0018] Preferably, the wall thickness of the lower end of the buckle gradually decreases from one side to the other side.

[0019] Beneficial effects of the utility model:

[0020] 1. The device is connected by a sealed fit between flange surfaces, and the flange surfaces can be separated and joined by rotating the buckle, so the filter bucket and the suction filter bottle can be separated conveniently.

[0021] 2. The device uses the bolt as a rotating handle, which can improve the convenience of rotating and engaging. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0023] Figure 1 This is the overall structure diagram;

[0024] Figure 2 It is an overall exploded diagram;

[0025] Figure 3 It is a partial exploded view;

[0026] Figure 4 is a cross-sectional view;

[0027] The markings in the figure are: 1, filter tank; 2, filter tube; 3, suction bottle; 4, filter port; 5, first flange surface; 6, second flange surface; 7, clamp; 7a, first clamp; 7b, second clamp; 7c, connecting ear; 8, connecting beam; 9, buckle; 10, notch; 11, sealing gasket; 12, limit block; 13, bushing; 14, bolt. DETAILED DESCRIPTION

[0028] Embodiment 1:

[0029] like Figures 1 to 4 A suction filtration device for synthesizing calcium salt of fosfomycin comprises a filter bucket and a suction filter bottle 3. A suction filter port 4 is arranged on the body of the suction filter bottle 3. Negative pressure is extracted from the suction filter bottle 3 through the suction filter port 4 to realize the suction filtration operation. The filter bucket comprises a filter tank 1 and a filter tube 2 arranged at the lower end of the filter tank 1. The filter tank 1 and the filter tube 2 are an integrated structure. The internal structure of the filter tank 1 adopts a traditional Buchner funnel structure; a first flange surface 5 is arranged at the lower end of the filter tube 2, and an integrated structure can also be adopted between the first flange surface 5 and the filter tube 2; a second flange surface 6 is arranged at the upper end of the suction filter bottle 3, and the first flange surface 5 and the second flange surface 6 are tightly fitted;

[0030] In order to ensure the reliability of the connection between the first flange surface 5 and the second flange surface 6, a clamp 7 is provided on the filter tube 2. The clamp 7 can be made of stainless steel. The clamp 7 can rotate on the filter tube 2. In order to ensure the smooth rotation of the clamp 7, the diameter of the clamp 7 can be slightly larger than the filter tube 2 by about 2 mm. Too large or too small will lead to unsmooth rotation; connecting beams 8 are symmetrically provided at both ends of the clamp 7, and the connecting beams 8 can be welded or integrally formed; a C-shaped buckle 9 is provided at the end of the connecting beam 8, and the buckle 9 and the connecting beam 8 are an integrally formed structure;

[0031] The end surfaces on both sides of the second flange surface 6 are symmetrically provided with notches 10, and the lower end of the buckle 9 passes through the notch 10. In order to ensure that the buckle 9 passes through the notch 10 smoothly, the width of the notch 10 should be about 1 cm larger than the width of the buckle 9; the connecting beam 8 is driven to rotate by rotating the clamp 7, and the connecting beam 8 drives the buckle 9 to rotate to engage the first flange surface 5 with the second flange surface 6. In order to ensure the stability of the engagement, the buckle 9 is composed of a flat metal sheet to increase the engagement contact area;

[0032] like Figure 3 and 4 In order to ensure smooth engagement, the wall thickness of the lower end of the buckle 9 gradually decreases from one side to the other side, so that the clamping force of the buckle 9 on the first flange surface 5 and the second flange surface 6 can be gradually increased. In order to ensure smoother rotation of the buckle 9, the surface of the buckle 9 in contact with the edges of the first flange surface 5 and the second flange surface 6 adopts an arc structure, that is, the concave part of the buckle 9 is an arc structure, and it matches the arc of the edges of the first flange surface 5 and the second flange surface 6.

[0033] Example 2

[0034] On the basis of Example 1, in order to facilitate the limiting of the connection beam 8 and facilitate the buckle 9 to quickly pass through the notch 10, a limiting block 12 is provided on the upper side of the first flange surface 5, and the limiting block 12 and the first flange surface 5 are an integrally formed structure; two limiting blocks 12 are provided on the sides of the two connection beams 8, so that the connection beams 8 can be limited. It should be noted that the limiting blocks 12 are centrally symmetrically arranged to ensure the rotation of the connection beam 8, and the reliability of the limiting can be further ensured. In order to ensure airtightness, a sealing gasket 11 is provided between the first flange surface 5 and the second flange surface 6. In order to further improve the airtightness, the first flange surface 5 and the second flange surface 6 are both provided with annular sealing grooves, and an annular sealing gasket 11 is provided in the sealing groove. The sealing gasket 11 can be limited by the sealing groove, and the sealing performance can be further improved;

[0035] Example 3

[0036] On the basis of implementation 2, in order to facilitate the disassembly and maintenance of the clamp 7, the clamp 7 includes two semicircular first clamps 7a and second clamps 7b, and the ends of the first clamps 7a and the second clamps 7b are symmetrically provided with connecting ears 7c, and the connecting ears 7c are connected by bolts 14. The first clamp 7a and the second clamp 7b are separated and assembled by disassembling the bolts, and the clamp 7 is disassembled and assembled;

[0037] In order to facilitate the rotation of the clamp 7, the bolt 14 is a long-handled bolt. When rotating, the rotation can be achieved by holding the long-handled part of the bolt 14. The length of the bolt 14 is determined according to actual needs. It should be noted that the screw rods of the bolts 14 at both ends of the clamp 7 are respectively located on both sides of the filter tube 2, which is more convenient for operation. If the long-handled parts of the bolts 14 are located on the same side, they will block each other, which is not conducive to the rotation operation. In order to ensure the reliability of the connection of the bolt 14, a shaft sleeve 13 is provided on the connecting ear 7c, and the bolt 14 passes through the shaft sleeve 13 to connect the connecting ear 7c in series, thereby ensuring a secure connection.

[0038] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions described in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A suction filtration device for synthesizing fosfomycin calcium salt, comprising a filter bucket and a suction filter bottle, wherein the suction filter bottle is provided with a suction filtration port, characterized in that: The filter bucket includes a filter tank and a filter tube arranged at the lower end of the filter tank, and the lower end of the filter tube is provided with a first flange surface; the upper end of the suction filter bottle is provided with a second flange surface, and the first flange surface and the second flange surface are tightly fitted; A clamp is provided on the filter tube, and the clamp can rotate on the filter tube. Connecting beams are symmetrically provided at both ends of the clamp, and a C-shaped buckle is provided at the end of the connecting beam. The end surfaces on both sides of the second flange surface are symmetrically provided with notches, the lower end of the buckle passes through the notches, and the buckle engages the first flange surface with the second flange surface by rotating.

2. A suction filtration device for synthesizing fosfomycin calcium salt according to claim 1, characterized in that: A limit block is provided on the upper side surface of the first flange surface and located on the side of the connecting beam.

3. A suction filtration device for synthesizing fosfomycin calcium salt according to claim 2, characterized in that: Limit blocks are arranged on the sides of the two connecting beams, and the limit blocks are arranged symmetrically with respect to the center.

4. A suction filtration device for synthesizing fosfomycin calcium salt according to claim 1, characterized in that: A sealing gasket is provided between the first flange surface and the second flange surface.

5. A suction filtration device for synthesizing fosfomycin calcium salt according to claim 4, characterized in that: The first flange surface and the second flange surface are both provided with an annular sealing groove, and an annular sealing gasket is arranged in the sealing groove.

6. A suction filtration device for synthesis of fosfomycin calcium salt according to claim 1, characterized in that: The clamp comprises a first clamp and a second clamp of two semicircles. The ends of the first clamp and the second clamp are symmetrically provided with connecting ears, and the connecting ears are connected by bolts.

7. A suction filtration device for synthesis of fosfomycin calcium salt according to claim 6, characterized in that: The bolts are long-shank bolts, and the screw rods of the bolts at both ends of the clamp are respectively located on both sides of the filter tube.

8. A suction filtration device for synthesis of fosfomycin calcium salt according to claim 7, characterized in that: A shaft sleeve is arranged on the connecting ear, and a bolt passes through the shaft sleeve to connect the connecting ears in series.

9. A suction filtration device for synthesis of fosfomycin calcium salt according to claim 1, characterized in that: The wall thickness of the lower end of the buckle gradually decreases from one side to the other side.

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