Volatile organic molecule collecting device
By designing an organic compound collection device including a blowing assembly, a sample bottle, a buffer bottle and a sampler, the problem of bubble interference in urine samples is solved, and the stable collection and accurate detection of organic compounds are achieved.
Patent Information
- Application Number
- CN202421776175.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-24
- Publication Date
- 2025-06-06
- Estimated Expiration
- 2034-07-24
AI Technical Summary
During the organic compound collection process, bubbles generated by urine samples will interfere with the release and detection of organic compounds, resulting in unstable data collection.
A volatile organic molecule collection device is designed, including a blowing assembly, a sample bottle, a buffer bottle and a sampler. Blow air into the sample bottle through the blowing assembly to promote the volatilization of organic compounds, and temporarily store and eliminate air bubbles through the buffer bottle to prevent air bubbles from clogging the air inlet of the sampler.
It effectively solves the problem of bubble interference during organic compound collection, ensures stable transportation and accurate detection of organic compounds, and improves the acquisition efficiency and data reliability.
Smart Images
Figure CN222952051U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of organic compound collection, and in particular to a volatile organic molecule collection device. Background Art
[0002] Urine excreted by the human body will volatilize a variety of organic compounds (VOCs), which can be used as diagnostic and detection samples for a variety of major diseases. In the process of collecting organic compounds, urine samples will produce bubbles, which not only affect the release of organic compounds, but also may block the air inlet of the detection equipment, resulting in unstable data collection. Utility Model Content
[0003] In view of this, the purpose of the present application is to provide a volatile organic molecule collection device for solving the problem that the process of collecting organic compounds is easily disturbed by bubbles.
[0004] In order to achieve the above technical purpose, the present application provides a volatile organic molecule collection device, including: a blowing component, a sample bottle, a buffer bottle and a sampler;
[0005] The sample bottle is connected to the air blowing assembly and the buffer bottle;
[0006] The sampler is connected to the buffer bottle;
[0007] The sample bottle is used to store samples;
[0008] The blowing component is used for blowing air toward the sample.
[0009] Furthermore, the gas outlet of the sample bottle is provided with a first short pipe;
[0010] The air inlet of the buffer bottle is provided with a second long connecting pipe;
[0011] One end of the first short pipe is connected to the bottle top inside the sample bottle;
[0012] The other end of the first short pipe is connected to one end of the second long pipe;
[0013] The other end of the second long connecting pipe extends into the bottom of the buffer bottle.
[0014] Furthermore, the air inlet of the sample bottle is provided with a first long connecting pipe;
[0015] The air blowing assembly is connected to one end of the first long pipe;
[0016] The other end of the first long connecting pipe extends into the bottom of the sample bottle.
[0017] Furthermore, the gas outlet of the buffer bottle is provided with a second short pipe;
[0018] One end of the second short pipe is connected to the top of the buffer bottle;
[0019] The sampler is connected to the other end of the second short pipe.
[0020] Further, it also includes: a heater;
[0021] The sample bottle is arranged on the heater, or the sample bottle and the buffer bottle are arranged on the heater.
[0022] Furthermore, the heater is a water bath heater.
[0023] Furthermore, the heater is a heater with a rated temperature of 60°C to 70°C.
[0024] Furthermore, the air blowing component is a nitrogen blowing component.
[0025] Furthermore, the sample bottle is provided with a 5 ml scale line and / or a 10 ml scale line.
[0026] Furthermore, the sample bottle and / or the buffer bottle is a glass bottle.
[0027] It can be seen from the above technical scheme that the present application provides a volatile organic molecule collection device, including: a blowing component, a sample bottle, a buffer bottle and a sampler; the sample bottle is connected to the blowing component and the buffer bottle; the sampler is connected to the buffer bottle; the sample bottle is used to store the sample; the blowing component is used to blow air into the sample.
[0028] During the test, the sample continues to volatilize organic compounds in the sample bottle, and then the organic compounds enter the buffer bottle. The buffer bottle serves to temporarily store and eliminate bubbles, preventing bubbles from blocking the air inlet of the sampler and reducing the interference of bubbles on the sampler's test results, thereby effectively solving the problem that the process of collecting organic compounds is easily interfered by bubbles. BRIEF DESCRIPTION OF THE DRAWINGS
[0029] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.
[0030] Figure 1 A schematic diagram of the overall structure wireframe of a volatile organic molecule collection device provided in an embodiment of the present application;
[0031] In the figure: 10, blowing assembly; 20, sample bottle; 30, buffer bottle; 40, collector; 50, heater; 60, hose; 21, first long pipe; 22, first short pipe; 31, second long pipe; 32, second short pipe. DETAILED DESCRIPTION
[0032] The technical solutions of the embodiments of the present application will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the specification of the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection requested by the present application.
[0033] In the description of the embodiments of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, which are only for the convenience of describing the embodiments of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the embodiments of the present application. In addition, the terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.
[0034] In the description of the embodiments of the present application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a replaceable connection, or an integral connection, it can be a mechanical connection, it can be an electrical connection, it can be a direct connection, it can be indirectly connected through an intermediate medium, and it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the embodiments of the present application can be understood according to specific circumstances.
[0035] A volatile organic molecule collection device provided in an embodiment of the present application can transfer organic compounds from a urine sample to a sampler 4 for detection after the organic compounds are volatilized, and can eliminate bubbles during the transfer of the organic compounds, thereby reducing the interference of bubbles on the detection results of the organic compounds.
[0036] Specifically, see Figure 1 , Figure 1 The wireframe diagram of the volatile organic molecule collection device provided in this embodiment includes: an air blowing component 10, a sample bottle 20, a buffer bottle 30 and a sampler 40. The sample bottle 20 is used to store samples, that is, to store urine samples, so that the urine samples can volatilize organic compounds in the sample bottle 20.
[0037] The sample bottle 20 is connected to the blowing assembly 10 and the buffer bottle 30; the sampler 40 is connected to the buffer bottle 30. The blowing assembly 10 is used to blow air into the sample, disturb the sample by airflow, and increase the rate of volatile organic compounds in the sample. The organic compounds generated in the sample bottle 20 enter the buffer bottle 30, and then are discharged from the buffer bottle 30 to the sampler 40. In application, the blowing assembly 10 can be a nitrogen blowing assembly, which is used to pass high-purity nitrogen into the sample bottle 20.
[0038] During the temporary storage of the organic compound in the buffer bottle 30, the bubbles will gradually disappear, thereby ensuring that the organic compound can be stably transported to the sampler 40, reducing the interference of bubbles on the detection data of the sampler 40, and avoiding the situation where the sample bottle 20 is directly connected to the sampler 40 and bubbles block the air inlet of the sampler 40.
[0039] As an embodiment, the blowing assembly 10 may be connected to the sample bottle 20 via a hose 60 ; the sample bottle 20 may be connected to the buffer bottle 30 via a hose 60 ; and the buffer bottle 30 may be connected to the sampler 40 via a hose 60 .
[0040] In application, the hose 60 connected to the blowing assembly 10 can directly extend into the bottom of the sample bottle 20 to enhance the disturbance effect on the sample bottle 20 .
[0041] In one embodiment, at least two air holes are disposed on the sample bottle 20 , and one of the air holes is used as an air inlet of the sample bottle 20 , and the other air hole is used as an air outlet of the sample bottle 20 .
[0042] A first long pipe 21 is provided on the air inlet of the sample bottle 20. The blowing assembly 10 is connected to one end of the first long pipe 21; the other end of the first long pipe 21 extends to the bottom of the sample bottle 20, so that the gas blown by the blowing assembly 10 can reach the bottom of the sample bottle 20 to ensure the disturbance effect on the sample. Specifically, the other end of the first long pipe 21 can extend to a position 2-5 mm away from the bottom of the sample bottle 20.
[0043] At the same time, through the first long connecting pipe 21, the blowing assembly 10 can be connected to the sample bottle 20 by connecting to the first long connecting pipe 21, without the need to extend the hose 60 into the sample bottle 20 during the connection process or to adjust the insertion depth of the hose 60 during the connection process.
[0044] Therefore, in this embodiment, by providing the first long connecting pipe 21 , the assembly efficiency of the device during actual application and the assembly efficiency when replacing the sample bottle 20 can be effectively improved, while ensuring the disturbance effect of the blowing component 10 on the sample bottle 20 .
[0045] In one embodiment, the air outlet of the sample bottle 20 is provided with a first short pipe 22; the air inlet of the buffer bottle 30 is provided with a second long pipe 31; one end of the first short pipe 22 is connected to the bottle top inside the sample bottle 20; the other end of the first short pipe 22 is connected to one end of the second long pipe 31; the other end of the second long pipe 31 extends to the bottle bottom inside the buffer bottle 30. Specifically, the other end of the second long pipe 31 can extend to a position 2-5 mm away from the bottle bottom inside the buffer bottle 30. One end of the first short pipe 22 can extend to 2-5 mm below the bottle cap of the sample bottle 20.
[0046] The volatile organic compounds in the sample bottle 20 enter the second long pipe 31 through the first short pipe 22 and flow to the bottom of the buffer bottle 30, where they settle and eliminate bubbles. As the amount of organic compounds in the buffer bottle 30 increases, they are discharged from the top of the buffer bottle 30 into the sampler 40.
[0047] The second long pipe 31 can ensure that the organic compound in the sample bottle 20 can enter the bottom of the buffer bottle 30, ensuring the effect of eliminating bubbles of the organic compound by the buffer bottle 30. Similarly, the first short pipe 22 and the second long pipe 31 can improve the assembly efficiency during the application process.
[0048] Optionally, the gas outlet of the buffer bottle 30 is provided with a second short pipe 32; one end of the second short pipe 32 is connected to the bottle top inside the buffer bottle 30; and the sampler 40 is connected to the other end of the second short pipe 32. One end of the second short pipe 32 can extend to 2-5 mm below the bottle cap of the buffer bottle 30.
[0049] Optionally, the buffer bottle 30 and the sample bottle 20 can be configured to have the same structure, so that during use, the staff does not need to distinguish the difference in the bottle body structure between the buffer bottle 30 and the sample bottle 20 .
[0050] In one embodiment, the device further comprises: a heater 50 ; the sample bottle 20 is disposed on the heater 50 , or the sample bottle 20 and the buffer bottle 30 are disposed on the heater 50 .
[0051] The heater 50 can be, for example, a water bath heater, which can evenly heat the periphery of the sample bottle 20 and / or the buffer bottle 30. By heating the sample bottle 20 with the heater 50, the rate at which the sample in the sample bottle 20 produces organic compounds can be increased, providing a stable volatilization environment for the urine sample.
[0052] As an embodiment, the heater 50 is a heater with a rated temperature of 60° C. to 70° C. The inventors have found that when the temperature of the urine sample is 60° C. to 70° C., it can ensure effective release of organic compounds while avoiding sample decomposition or destruction of organic compounds due to overheating.
[0053] As an embodiment, the blowing assembly 10 can be configured such that the outlet flow rate of the blowing assembly 10 is 50 to 100 ml / min at rated power. The inventors have found that at this rate, the air above the urine sample can be effectively replaced, thereby improving the collection efficiency of organic compounds. At the same time, an appropriate flow rate can also reduce the disturbance of the urine sample, avoiding the loss of organic compounds and the generation of bubbles due to excessively fast airflow.
[0054] As an embodiment, the sample bottle 20 is provided with a 5ml scale line and / or a 10ml scale line. The inventors have found that the volume of the urine sample will also directly affect the concentration and collection efficiency of the organic compound, and when the sample volume is 5 to 10ml, it can not only ensure the full volatilization of the organic compound, but also improve the sensitivity and accuracy of the collection. For this reason, the sample bottle 20 is provided with a 5ml scale line and / or a 10ml scale line to assist the staff in controlling the sample volume in the sample bottle 20 to be 5 to 10ml.
[0055] As an embodiment, the sample bottle 20 and / or the buffer bottle 30 are glass bottles. The sample bottle 20 made of glass has low adsorption to organic compounds and high chemical stability, which can reduce the interference of the bottle body on the organic compound collection structure.
[0056] As an embodiment, a reminder and a timer are provided on the heater 50; the timer can be set to send a reminder signal to the staff through the reminder after the heater 50 has been heated for a preset time. The inventors have found that the volatilization behavior of organic compounds in urine samples changes over time, so the collection time will also affect the collection efficiency; after the sample is heated for 15 to 20 minutes, the sample reaches the optimal volatilization state of the organic compounds. For this reason, the timer can be set to remind the staff to start the collector 40 through the reminder 15 to 20 minutes after the heater 50 is started.
[0057] The actual application process of the volatile organic molecule collection device provided in this embodiment may include the following steps:
[0058] 1. Sample preparation: First, collect fresh human urine samples and take 10 mL of urine samples under sterile conditions using a pipette with an accuracy of 0.01 mL, and slowly inject it into a pre-cleaned and dried sample bottle 20. During the entire transfer process, the operation should be gentle to avoid bubbles.
[0059] 2. Water bath heating: Place the sample bottle 20 containing the urine sample in a water bath set at 70° C. and maintain a constant temperature for 15 minutes to promote the effective volatilization of VOCs in the urine and prevent decomposition.
[0060] 3. Gas replacement: Use a sterile needle to pre-pierce two small holes on the bottle caps of the sample bottle 20 and the buffer bottle 30. One is used as an air inlet for nitrogen purge, and the other is used as an air outlet to connect to the sampling system. Long and short pipes are provided for the air inlet and outlet, respectively. Specifically, the blowing assembly 30 is connected to the bottom of the sample bottle 20 through the first long pipe 21, and high-purity nitrogen is blown into the sample bottle 20 at a preset flow rate (such as 50 mL per minute) to help release organic compounds from the urine sample and remove bubbles. Figure 1 As shown, nitrogen enters from the first long connecting pipe 21 and then flows out from the first short connecting pipe 22 to the buffer bottle 30 .
[0061] 4. Bubble buffer: The organic compound enters the second long pipe 31 from the first short pipe 22 and enters the bottom of the buffer bottle 30, and the buffer bottle 30 plays the role of temporarily storing the volatile organic compound and eliminating bubbles. Through this design, the smooth transmission of organic compounds can be ensured, and bubbles can be prevented from entering the air inlet of the detection instrument.
[0062] 5. Sampling and analysis: Under the action of nitrogen purge, the organic compound is transferred from the sample bottle 20 to the buffer bottle 30, and finally flows into the collector 40 from the second short pipe 32, and is collected by the sampler 40. During the collection process, the organic compound monitors and records the release of the organic compound, as well as any parameter changes that may affect the collection effect.
[0063] 6. Data recording and analysis: During the entire collection process, use data recording software to monitor the concentration changes and collection parameters of organic compounds in real time. After the collection is completed, use appropriate analytical techniques (such as GC-MS, GC-IMS) to perform qualitative and quantitative analysis on the collected organic compounds.
[0064] 7. Cleaning and preparation: After the collection is completed, the sample bottle 20, the buffer bottle 30 and the related devices are thoroughly cleaned and dried for next use. During the cleaning process, a cleaning solvent without organic pollutants is used, and a high-temperature bake is performed after cleaning to ensure that all residues are removed.
[0065] During the application of the collection device provided in this scheme, in order to further improve the collection efficiency and accuracy, this scheme also includes the optimization of various parameters in the collection process. This includes water bath temperature, nitrogen purge flow rate, collection time, headspace bottle material, etc. The optimal value of each parameter is determined through experiments, and adjustment and control are allowed to adapt to the characteristics of different urine samples and the volatility characteristics of VOCs. At the same time, the device design of this scheme takes into account integration and portability, making it suitable for different clinical environments and research sites. The integrated sampling system simplifies the operating process and improves the repeatability and reliability of collection. Integrated devices such as Figure 1Compared with the existing urine organic compound collection technology, this scheme shows higher collection efficiency and accuracy, providing a new technical means for clinical medical research and disease diagnosis.
[0066] The above are only preferred embodiments of the present application and are not intended to limit the present utility model. Although the present application has been described in detail with reference to the examples, those skilled in the art can still modify the technical solutions recorded in the aforementioned examples or make equivalent substitutions for some of the technical features therein. However, any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.
Claims
1. A volatile organic molecule collection device, characterized in that: include: An air blowing assembly (10), a sample bottle (20), a buffer bottle (30) and a sampler (40); The sample bottle (20) is connected to the air blowing assembly (10) and the buffer bottle (30); The sampler (40) is connected to the buffer bottle (30); The sample bottle (20) is used to store samples; The blowing component (10) is used for blowing air toward the sample.
2. The volatile organic molecule collection device according to claim 1, characterized in that: The gas outlet of the sample bottle (20) is provided with a first short pipe (22); The air inlet of the buffer bottle (30) is provided with a second long connecting pipe (31); One end of the first short pipe (22) is connected to the bottle top inside the sample bottle (20); The other end of the first short pipe (22) is connected to one end of the second long pipe (31); The other end of the second long connecting pipe (31) extends into the bottom of the buffer bottle (30).
3. The volatile organic molecule collection device according to claim 2, characterized in that: The air inlet of the sample bottle (20) is provided with a first long pipe (21); The blowing assembly (10) is connected to one end of the first long pipe (21); The other end of the first long connecting pipe (21) extends into the bottom of the sample bottle (20).
4. The volatile organic molecule collection device according to claim 2 or 3, characterized in that: The gas outlet of the buffer bottle (30) is provided with a second short pipe (32); One end of the second short pipe (32) is connected to the bottle top inside the buffer bottle (30); The sampler (40) is connected to the other end of the second short pipe (32).
5. The volatile organic molecule collection device according to claim 1, characterized in that: Also includes: Heater (50); The sample bottle (20) is arranged on the heater (50), or the sample bottle (20) and the buffer bottle (30) are arranged on the heater (50).
6. The volatile organic molecule collection device according to claim 5, characterized in that: The heater (50) is a water bath heater.
7. The volatile organic molecule collection device according to claim 5, characterized in that: The heater (50) is a heater with a rated temperature of 60°C to 70°C.
8. The volatile organic molecule collection device according to claim 1, characterized in that: The air blowing component (10) is a nitrogen blowing component.
9. The volatile organic molecule collection device according to claim 1, characterized in that: The sample bottle (20) is provided with a 5 ml scale mark and / or a 10 ml scale mark.
10. The volatile organic molecule collection device according to claim 1, characterized in that: The sample bottle (20) and / or the buffer bottle (30) are glass bottles.