Perfusion device for pig heart

Abstract

The utility model discloses a perfusion device for a pig heart, which belongs to the technical field of heart perfusion and comprises a base, an operating table arranged on the base, an adjusting component arranged on one side of the operating table and connected with the base, a plurality of volumetric flasks connected to the output end of the adjusting component, and catheters connected to the bottoms of the volumetric flasks. A collecting pipe is arranged at one ends of the guide pipes, one ends of the guide pipes are all communicated with the collecting pipe, a needle tube is installed on the collecting pipe, a support is installed on the base, a plurality of bayonets are evenly formed in the support and correspond to the guide pipes, the guide pipes are located in the bayonets, and pressing devices are arranged on the bayonets. The pressing device comprises a mounting frame, a first spring, a pressing block and a pull rope, the mounting frame is mounted on the support, the pressing block is located above the corresponding bayonet, the pressing block penetrates through the mounting frame and is in sliding fit with the mounting frame, the first spring is used for enabling the pressing block to move downwards, one end of the pull rope is fixedly connected with the pressing block, and convenient operation can be achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of cardiac perfusion, and more specifically, to a perfusion device for porcine hearts. Background Art

[0002] Cardiac perfusion often adopts the single-infusion burette titration method, which is as follows: a semi-open container is connected to an infusion set with a drip rate adjustment device, and the other end of the infusion set is connected to a blunt perfusion needle. First, fill the perfusion device container with normal saline and flush the tube. After the mouse is anesthetized, place it on ice to expose the heart. Hold the apex of the mouse heart with a tissue forceps in the left hand, and insert the blunt perfusion needle into the left ventricle and enter the aorta from the apex with the right hand. Randomly cut a small hole in the right auricle with an ophthalmic scissors, open the speed adjustment device of the infusion set to the fastest drip rate, and it can be seen that blood is continuously washed out at the right auricle. After the normal saline perfusion, add PFA fixative and continue perfusion until the body becomes rigid and then stop perfusion.

[0003] When the above solution is implemented, since multiple liquids need to be perfused, sequential perfusion is required. When the existing equipment is operated, it requires two-handed operation and will cause the line of sight to leave the operating area, which is likely to cause the heart to shift during replacement, resulting in the subsequent perfusion needle falling off. The existing technology is rather troublesome and not easy to control when switching the liquid to be perfused each time. To address the above problems, a solution is proposed below. Summary of the Utility Model

[0004] Aiming at the problems existing in the prior art, the purpose of the utility model is to provide a perfusion device for porcine hearts, which can achieve convenient operation.

[0005] To solve the above problems, the utility model adopts the following technical solutions.

[0006] A perfusion device for porcine hearts includes a base, an operating table is arranged on the base, an adjusting component connected to the base is arranged on one side of the operating table, the output end of the adjusting component is connected with a plurality of volumetric flasks, the bottom of the volumetric flask is connected with a catheter, one ends of the plurality of catheters are provided with a confluence tube, one ends of the plurality of catheters are all communicated with the confluence tube, a syringe needle is installed on the confluence tube, a bracket is installed on the base, a plurality of bayonets are evenly opened on the bracket, the plurality of bayonets correspond to the catheters, and the catheters are located inside the bayonets. A pressing device is arranged on the bayonet, and the pressing device includes a mounting frame, a first spring, a pressing block and a pulling rope. The mounting frame is installed on the bracket, the pressing block is located above the corresponding bayonet, the pressing block passes through the mounting frame and is in sliding fit, the first spring is used for pressing the pressing block to move downward, and one end of the pulling rope is fixedly connected with the pressing block.

[0007] Preferably, the adjusting assembly includes support rods, sleeves, bolts, connecting rods and hooks. There are two support rods which are symmetrically arranged on the base. There are two sleeves which are respectively sleeved on the two support rods, and the sleeves are in sliding fit with the support rods. The bolts pass through the sides of the sleeves and contact the support rods, and the bolts are in threaded fit with the sleeves. The connecting rod is located between the two sleeves and its two ends are respectively connected to the two sleeves. There are several hooks which are sequentially sleeved and slidably arranged on the connecting rod, and the volumetric flask is hung on the hooks.

[0008] Preferably, one end of each of the several pull ropes is provided with a pressing plate, and the several pressing plates are respectively hinged to the base.

[0009] Preferably, a Murphy's dropper is installed between the conduit and the volumetric flask.

[0010] Preferably, a top rod is arranged on the bracket, and the pull rope passes through the top rod and is in sliding fit.

[0011] Preferably, a second spring for resetting the pressing plate is arranged between the pressing plate and the base.

[0012] Preferably, a notch is arranged at the bottom of the operating table, and the operating table is arranged inside the notch.

[0013] Compared with the prior art, the advantages of the present utility model are as follows:

[0014] First, this solution uses an operating table to place the pig heart. Different required solutions are respectively contained in multiple volumetric flasks to meet the requirements during the entire perfusion process. And the pressing block will press the corresponding conduit under the pressure of the first spring, so that the conduit is closed. When it is necessary for the solution in the corresponding volumetric flask to flow out, pull the corresponding pull rope, and the pull rope will drive the corresponding pressing block to move, so as to separate from the conduit, so that the corresponding conduit is opened, and the solution in the corresponding volumetric flask will flow into the conduit, and then enter the pig heart through the confluence pipe and the syringe. When it is necessary to replace the solution, just release the pull rope, and under the action of the spring, the pressing block resets, so as to close the conduit again. It can be operated with one hand, is simple to use, and does not require the human eye to leave, which can avoid deviation and ensure correctness. The height of the volumetric flask can be adjusted through the adjusting assembly, so as to control the pressure of the outflowing water flow and adapt to different requirements.

[0015] Second, the two support rods will ensure the stability of the forces at both ends of the connecting rod. When the bolt is loosened, the restriction on the sleeve and the support rod can be removed, so that the sleeve can be slid, and the movement of the sleeve on the support rod will drive the connecting rod to move, so as to adjust the height of the connecting rod, that is, adjust the height of the hook. The hook can adjust the height of the corresponding volumetric flask. The design of using hooks can facilitate the removal of the volumetric flask for convenient cleaning and adding of the solution.

[0016] III. The pressing plate facilitates pulling the rope and can fix the position of the pulling rope, making the operation convenient. The addition of the pressing plate enables the use of positions such as the elbow for operation, further ensuring the stability of the actual perfusion.

[0017] IV. The Murphy's dropper can ensure a stable flow rate of the solution flowing out of the volumetric flask, thereby controlling the progress of perfusion. The Murphy's dropper can accurately control the amount of liquid dropped, reducing the waste of liquid in the experiment.

[0018] V. The addition of the ejector rod can convert the vertical force on the pulling rope into a horizontal force, facilitating the operation. The ejector rod provides a fixed point for the pulling rope, helping to maintain the stability of the pulling rope during use and reducing instability caused by the sliding of the pulling rope.

[0019] VI. The second spring is used for the reset of the pressing plate, avoiding the trouble of manual reset. Due to the existence of the second spring, the operator can focus more on other experimental steps without worrying about the reset problem of the pressing plate, simplifying the operation process.

[0020] VII. The notch has a detachable effect on the operating table, ensuring that the operating table is detachable for easy cleaning. At the same time, it can play a limiting effect and is more stable during use. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a front view structural schematic diagram of the present utility model;

[0022] Figure 2 is a side view structural schematic diagram of the present utility model;

[0023] Figure 3 is a top view structural schematic diagram of the present utility model;

[0024] Figure 4 is a cross-sectional structural schematic diagram of the pressing device of the present utility model;

[0025] Figure 5 is a cross-sectional structural schematic diagram of the adjusting component of the present utility model;

[0026] Figure 6 is a cross-sectional structural schematic diagram of the base, operating table and notch of the present utility model.

[0027] Explanation of the reference numerals in the drawings:

[0028] 1. Base; 2. Operating table; 3. Adjusting component; 4. Volumetric flask; 5. Conduit; 6. Manifold pipe; 7. Syringe; 8. Bracket; 9. Bayonet; 10. Pressing device; 11. Mounting frame; 12. First spring; 13. Pressing block; 14. Pulling rope; 15. Support rod; 16. Sleeve; 17. Bolt; 18. Connecting rod; 19. Hook; 20. Pressing plate; 21. Murphy drip; 22. Thrust rod; 23. Second spring; 24. Notch. Detailed implementation mode

[0029] Example 1:

[0030] Please refer to Figures 1-6 , a perfusion device for a pig heart, including a base 1, an operating table 2 is arranged on the base 1, a notch 24 is arranged at the bottom of the operating table 2, the operating table 2 is arranged inside the notch 24, the operating table 2 is used to place the pig heart, and the notch 24 has a detachable effect on the operating table 2, ensuring that the operating table 2 is detachable, facilitating cleaning, and at the same time can play a limiting effect, and is more stable during use.

[0031] One side of the operating table 2 is provided with an adjusting component 3 connected to the base 1. The adjusting component 3 includes a support rod 15, a sleeve 16, a bolt 17, a connecting rod 18 and a hook 19. There are two support rods 15 which are symmetrically arranged on the base 1. There are two sleeves 16 which are respectively sleeved on the two support rods 15, and the sleeve 16 and the support rod 15 are in sliding fit. The bolt 17 passes through the side of the sleeve 16 and contacts the support rod 15, and the bolt 17 and the sleeve 16 are in threaded fit. The connecting rod 18 is located between the two sleeves 16 and the two ends are respectively connected to the two sleeves 16. There are several hooks 19, and several hooks 19 are sequentially sleeved and slidably arranged on the connecting rod 18. A volumetric flask 4 is detachably installed on the hook 19. Different required solutions are respectively contained in multiple volumetric flasks 4 to meet the requirements during the entire perfusion process. The design of the hook 19 can facilitate the removal of the volumetric flask 4, facilitating cleaning and adding solution.

[0032] The two support rods 15 will ensure the stability of the forces at both ends of the connecting rod 18. When the bolt 17 is loosened, the restriction on the sleeve 16 and the support rod 15 can be removed, so that the sleeve 16 can be slid. Thus, the movement of the sleeve 16 on the support rod 15 will drive the connecting rod 18 to move, thereby adjusting the height of the connecting rod 18, that is, adjusting the height of the hook 19. The hook 19 can adjust the height of the corresponding volumetric flask 4. The height of the volumetric flask 4 can be adjusted through the adjusting component 3, thereby controlling the pressure of the flowing water to adapt to different requirements.

[0033] A catheter 5 is connected to the bottom of the volumetric flask 4. A Murphy's dropper 21 is installed between the catheter 5 and the volumetric flask 4. The Murphy's dropper 21 can ensure a stable flow rate of the solution flowing out of the volumetric flask 4, thereby controlling the perfusion process. A bracket 8 is installed on the base 1. A number of clamping openings 9 are evenly formed on the bracket 8. The number of clamping openings 9 corresponds to the catheter 5, and the catheter 5 is located inside the clamping opening 9. A pressing device 10 is arranged on the clamping opening 9. The pressing device 10 includes a mounting frame 11, a first spring 12, a pressing block 13 and a pulling rope 14. The mounting frame 11 is installed on the bracket 8. The pressing block 13 is located above the corresponding clamping opening 9. The pressing block 13 presses the corresponding catheter 5 under the pressure of the first spring 12, so that the catheter 5 is closed. The pressing block 13 passes through the mounting frame 11 and is in sliding fit. The first spring 12 is used for the downward movement of the pressing block 13. One end of the pulling rope 14 is fixedly connected to the pressing block 13. A push rod 22 is arranged on the bracket 8. The pulling rope 14 passes through the push rod 22 and is in sliding fit. The addition of the push rod 22 can convert the vertical force on the pulling rope 14 into a horizontal force, which is convenient for operation. One ends of a number of pulling ropes 14 are respectively provided with pressing plates 20. The number of pressing plates 20 are respectively hinged to the base 1. A second spring 23 for resetting the pressing plate 20 is arranged between the pressing plate 20 and the base 1. The pressing plate 20 is convenient for pulling the pulling rope 14 and can fix the position of the pulling rope 14, which is convenient for operation. The addition of the pressing plate 20 can facilitate the operation with the elbow or other positions, further ensuring the stability of the actual perfusion. The second spring 23 is used for the resetting of the pressing plate 20, avoiding the trouble of manual resetting.

[0034] When it is necessary for the corresponding solution inside the flow bottle to flow out, press the pressing plate 20. The pressing plate 20 pulls the corresponding pulling rope 14. The pulling rope 14 will drive the corresponding pressing block 13 to move, so as to separate from the catheter 5, enabling the corresponding catheter 5 to open. One ends of a number of catheters 5 are provided with a confluence tube 6. One ends of the number of catheters 5 are all connected to the confluence tube 6. A syringe needle 7 is installed on the confluence tube 6. The solution inside the corresponding flow bottle will flow into the catheter 5, and then enter the pig heart through the confluence tube 6 and the syringe needle 7. When it is necessary to replace the solution, just release the pulling rope 14. Under the action of the spring, the pressing block 13 resets, thus closing the catheter 5 again. It is a single-handed operation, simple to use, without the need to take the eyes away, which can avoid deviation and ensure correctness.

[0035] Working principle:

[0036] In use, first place the pig's heart on the operating table 2, insert the syringe 7 into the corresponding position of the pig's heart. According to the perfusion steps, press the pressing plate 20 corresponding to the volumetric flask 4 containing the first solution. The pressing plate 20 will pull the pulling rope 14, and the pulling rope 14 will pull the corresponding pressing block 13 to move upward, so that the pressing block 13 removes the pressure on the conduit 5. The conduit 5 is connected, and the solution inside the corresponding volumetric flask 4 enters the pig's heart through the conduit 5, the confluence pipe 6 and the syringe 7. When the next solution is needed to perfuse the pig's heart, release the pressing plate 20. The pressing plate 20 resets under the action of the second spring 23. Due to the existence of the second spring 23, the operator can focus more on other experimental steps without worrying about the reset problem of the pressing plate 20, which simplifies the operation process. Thus, the pulling force on the pulling rope 14 is removed, and the pressing block 13 resets under the elastic force of the first spring 12, that is, the pressing block 13 will again block the flow of the solution inside the pipeline. Then, open the next section of the conduit 5 through the corresponding pressing block 13 and proceed in sequence until the entire perfusion step is completed. The addition of the pressing plate 20 facilitates the operation using positions such as the elbow, is simple to use, does not require the human eye to leave, can avoid deviation, and further ensures the stability of the actual perfusion.

[0037] At the same time, when the bolt 17 is loosened, the restrictions on the sleeve 16 and the support rod 15 can be removed, so that the sleeve 16 can slide. Thus, the movement of the sleeve 16 on the support rod 15 will drive the connecting rod 18 to move, thereby adjusting the height of the connecting rod 18, that is, adjusting the height of the hook 19. The hook 19 can adjust the height of the corresponding volumetric flask 4, thereby controlling the pressure of the outflowing water to meet different requirements.

Claims

1. A perfusion device for a pig heart, characterized in that: The invention comprises a base (1), an operating table (2) is arranged on the base (1), an adjusting component (3) connected to the base (1) is arranged on one side of the operating table (2), the output end of the adjusting component (3) is connected to a plurality of volumetric flasks (4), the bottom of the volumetric flask (4) is connected to a conduit (5), one end of the plurality of conduits (5) is provided with a manifold (6), one end of the plurality of conduits (5) is connected to the manifold (6), a needle tube (7) is installed on the manifold (6), a bracket (8) is installed on the base (1), a plurality of bayonet holes (9) are evenly opened on the bracket (8), and a plurality of The bayonet (9) corresponds to the conduit (5), and the conduit (5) is located inside the bayonet (9). A pressing device (10) is provided on the bayonet (9), and the pressing device (10) comprises a mounting frame (11), a first spring (12), a pressing block (13) and a pull rope (14). The mounting frame (11) is mounted on the bracket (8), and the pressing block (13) is located above the corresponding bayonet (9). The pressing block (13) passes through the mounting frame (11) and is slidably fitted. The first spring (12) is used to move the pressing block (13) downward, and one end of the pull rope (14) is fixedly connected to the pressing block (13).

2. A pig heart perfusion device according to claim 1, characterized in that: The adjustment assembly (3) comprises a support rod (15), a sleeve (16), a bolt (17), a connecting rod (18) and a hook (19); two support rods (15) are provided and are symmetrically arranged on the base (1); two sleeves (16) are provided and are respectively sleeved on the two support rods (15); the sleeves (16) and the support rod (15) are slidably matched; the bolt (17) passes through the side of the sleeve (16) and contacts the support rod (15); the bolt (17) and the sleeve (16) are threadedly matched; the connecting rod (18) is located between the two sleeves (16) and its two ends are respectively connected to the two sleeves (16); a plurality of hooks (19) are provided, and the plurality of hooks (19) are sequentially sleeved and slidably arranged on the connecting rod (18); the volumetric flask (4) is hung on the hooks (19).

3. A pig heart perfusion device according to claim 1, characterized in that: A pressure plate (20) is respectively provided at one end of a plurality of the pull ropes (14), and a plurality of the pressure plates (20) are respectively hinged to the base (1).

4. A pig heart perfusion device according to claim 1, characterized in that: A Murphy's dropper (21) is arranged between the conduit (5) and the volumetric flask (4).

5. A pig heart perfusion device according to claim 1, characterized in that: The bracket (8) is provided with a push rod (22), and the pull rope (14) passes through the push rod (22) and is slidably fitted thereon.

6. A pig heart perfusion device according to claim 3, characterized in that: A second spring (23) is provided between the pressing plate (20) and the base (1) for returning the pressing plate (20).

7. A pig heart perfusion device according to claim 1, characterized in that: The bottom of the operating table (2) is provided with a recess (24), and the operating table (2) is arranged inside the recess (24).

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