Biological sample detection device

Abstract

The utility model provides a biological sample detection device which comprises a pressing device, a limiting device, a reagent bottle, an upper cover, a sample injector and a shell, the upper cover and the shell are matched to form an upper containing cavity and a lower reaction cavity, the reagent bottle and the sample injector are both installed in the containing cavity, and the sample injector is communicated with the reaction cavity; the downward pressing device is arranged above the reagent bottle, when the downward pressing device is separated from the limiting device, the downward pressing device is in a downward pressing state, the downward pressing device can crush the reagent bottle, and a reagent in the reagent bottle flows into the reaction cavity. The internal space of the detection device is planned, so that the space is saved, the operation is simplified, reagents and samples are prevented from overflowing, and the biochemical harm to an operator and the surrounding environment is greatly reduced.

Description

Technical Field

[0001] The utility model relates to the field of in vitro medical detection, and specifically, to a biological sample detection device. Background Art

[0002] In vitro medical detection is an important means for disease diagnosis, health monitoring, and biomedical research, and is widely used in fields such as clinical diagnosis, public health, food safety, and environmental monitoring. In vitro medical detection refers to the detection of samples such as human blood, body fluids, and tissues outside the human body to assist in disease diagnosis, treatment monitoring, and health assessment, etc.

[0003] There is a Chinese patent with the publication number CN109839510A, which discloses a biological sample detection device, including a housing. A turntable is arranged inside the housing, and a plurality of telescopic rods are arranged on the turntable. A detection plate is arranged at the top of the telescopic rod. A notch is arranged on the side wall of the housing, and the notch and the detection plate are selectively matched. A buckle is fixed above the notch, and a sampler is movably buckled on the buckle.

[0004] However, traditional in vitro detection methods usually rely on detection reagents containing harmful chemicals, such as heavy metals, organic solvents, or radioactive substances. The open use of these reagents not only poses a potential threat to the health of operators but also causes environmental pollution. For example, the p-hydroxyphenylalanine (tyrosine) detection reagent (chemical method) is used for the qualitative detection of p-hydroxyphenylalanine in urine and the clinical auxiliary diagnosis of human amino acid metabolism disorder diseases, as well as inflammations such as gastric ulcer, gastritis, breast system inflammation, and acute appendicitis. This reagent mainly consists of nitric acid, sulfuric acid, mercurous nitrate, mercury sulfate, and nickel nitrate. The components of this reagent are all highly harmful to the environment and are likely to cause harm to the human body. Therefore, for non-professional people who need to use a biological sample detection device for self-testing, it is very important to avoid direct contact with the reagent and prevent the reagent from leaking after use. Further, when facing volatile reagents, it is even more necessary for the operator to have no contact with the reagent throughout the process to ensure operation safety.

[0005] However, there is a lack of a detection device in the prior art that arranges detection reagents, samplers, etc. inside, and the reagent and the sample react completely in a sealed environment, which can avoid the overflow of the reagent and the sample, and is also simple to operate, greatly reducing the biochemical hazards to the operator and the surrounding environment. Summary of the Utility Model

[0006] Aiming at the deficiencies in the prior art, the purpose of the utility model is to provide a biological sample detection device.

[0007] A biological sample detection device provided by the present utility model includes: a pressing device, a limiting device, a reagent bottle, an upper cover, a sampler, and a housing. The upper cover and the housing cooperate to form an upper accommodation cavity and a lower reaction cavity. The reagent bottle and the sampler are both installed in the accommodation cavity, and the sampler communicates with the reaction cavity.

[0008] The pressing device is arranged above the reagent bottle, and the pressing device includes an initial state and a pressing state.

[0009] When the pressing device is firmly connected to the limiting device, the pressing device is in the initial state and does not contact the reagent bottle.

[0010] When the pressing device is separated from the limiting device, the pressing device is in the pressing state, and the pressing device can crush the reagent bottle, and the reagent inside the reagent bottle flows into the reaction cavity.

[0011] Preferably, a partition is formed in the middle of the housing. The partition divides the accommodation cavity into two non - communicating first accommodation cavities and second accommodation cavities. The first accommodation cavity and the second accommodation cavity communicate with the reaction cavity respectively. The reagent bottle is installed in the first accommodation cavity, and the sampler is installed in the second accommodation cavity.

[0012] Preferably, the reagent bottle does not contact the housing and the partition, and a protective member is filled around the reagent bottle.

[0013] Preferably, a supporting surface is arranged below the reagent bottle. The periphery of the supporting surface is firmly connected to the housing and the partition respectively. One or more through - holes for communicating the first accommodation cavity and the reaction cavity are arranged on the supporting surface. The reagent bottle does not contact the supporting surface, and a protective member is filled between them.

[0014] Preferably, a sharp protrusion is arranged on the lower surface of the pressing device and / or the upper surface of the supporting surface.

[0015] Preferably, the sampler includes a syringe, and the bottom of the second accommodation cavity contracts inward to form an annular limiting structure matching the syringe.

[0016] Preferably, a protective member is filled between the reagent bottle and the pressing device.

[0017] Preferably, the pressing device includes a pressing block, and the limiting device includes a limiting pin. The limiting pin is inserted and fixed with the pressing block.

[0018] Preferably, the limiting pin passes through the housing horizontally and is inserted into the pressing block. The limiting pin is hermetically connected to the housing. A through - hole matching the limiting pin is arranged on the housing. When the limiting pin is separated from the pressing block, the limiting pin is not separated from the housing.

[0019] Preferably, the upper cover and the outer shell are hermetically connected through a snap structure.

[0020] Compared with the prior art, the utility model has the following beneficial effects:

[0021] By dividing the space inside the outer shell into a connected accommodation cavity and a reaction cavity, and installing the reagent bottle and the sampler in the accommodation cavity respectively, the utility model makes a detailed plan for the space inside the detection device, saves space and simplifies the operation steps; the pressing device is limited by the limiting device, and when in use, the limiting device is removed, and then the reagent bottle can be crushed by pressing down the pressing device, which is simple and safe to operate; by properly placing the reagent bottle and placing protective materials around it, it helps to ensure the safety of the reagent, avoids the overflow of the reagent and the sample, and greatly reduces the biochemical hazards to the operator and the surrounding environment. Description of the Drawings

[0022] By reading the following detailed description of the non-limiting embodiments with reference to the accompanying drawings, other features, objects and advantages of the utility model will become more apparent:

[0023] Figure 1 It is a cross-sectional view mainly showing the biological sample detection device of the utility model;

[0024] Figure 2 It is a structural schematic diagram mainly showing the biological sample detection device of the utility model;

[0025] Figure 3 It is a structural schematic diagram mainly showing the upper cover of the utility model;

[0026] Figure 4 It is a structural schematic diagram mainly showing the outer shell of the utility model;

[0027] Figure 5 It is an exploded view mainly showing the biological sample detection device of the utility model.

[0028] Reference numerals: pressing device 1; limiting device 2; reagent bottle 3; upper cover 4; sampler 5; reaction cavity 6; outer shell 7; support surface 8. Detailed Embodiments

[0029] The following specifically describes the utility model with reference to specific embodiments. The following embodiments will help those skilled in the art to further understand the utility model, but do not limit the utility model in any form. It should be noted that for those of ordinary skill in the art, without departing from the concept of the utility model, several changes and improvements can still be made. These all belong to the protection scope of the utility model.

[0030] Such as Figures 1-5As shown in the figure, a biological sample detection device provided by the present utility model includes: a pressing device 1, a limiting device 2, a reagent bottle 3, an upper cover 4, a sampler 5, and a housing 7. The housing 7 includes a transparent shell, and the reagent reaction result can be directly observed. The upper cover 4 and the housing 7 cooperate to form an upper accommodation cavity and a lower reaction cavity 6. The reagent bottle 3 and the sampler 5 are both installed in the accommodation cavity, and the sampler 5 is communicated with the reaction cavity 6; the pressing device 1 is arranged above the reagent bottle 3, and the pressing device 1 includes an initial state and a pressing state; when the pressing device 1 is fixedly connected to the limiting device 2, the pressing device 1 is in the initial state, and the pressing device 1 does not contact the reagent bottle 3; when the pressing device 1 is separated from the limiting device 2, the pressing device 1 is in the pressing state, and the pressing device 1 can crush the reagent bottle 3, and the reagent inside the reagent bottle 3 flows into the reaction cavity 6.

[0031] In this application, a pressing device 1 is arranged above the reagent bottle 3. After removing the limiting device 2, the reagent bottle 3 can be crushed, and the reagent in the reagent bottle 3 will flow into the reaction cavity 6 and react with the sample added by the sampler 5.

[0032] In a specific embodiment, the pressing device 1 includes a pressing block, and the limiting device 2 includes a limiting pin, and the limiting pin is inserted and fixed with the pressing block. In other specific embodiments, other limiting methods can be adopted.

[0033] The pressing block itself has a certain weight. When the limiting pin is pulled out, the pressing block can crush the reagent bottle 3 by its own gravity. In other specific embodiments, other methods can be adopted. For example, there is a pressing margin at the connection between the upper cover 4 and the housing 7. After the upper cover 4 is covered, the upper cover 4 can be directly pressed downwards, and the pressing block moves downwards by the downward pressing of the upper cover 4, so as to crush the reagent bottle 3. The pressing process of the pressing block in this application is all carried out inside the sealed shell, and there is no need to manually contact the pressing block for pressing, so as to ensure that the user does not need to contact the reagent throughout the process, which is particularly important for users who need to perform self-tests at home.

[0034] A partition is formed in the middle of the housing 7. The partition divides the accommodation cavity into two non-communicating first accommodation cavities and second accommodation cavities. The first accommodation cavity and the second accommodation cavity are respectively communicated with the reaction cavity 6. The reagent bottle 3 is installed in the first accommodation cavity, and the sampler 5 is installed in the second accommodation cavity.

[0035] The reagent bottle 3 does not contact the housing 7 and the partition, and a protective member is filled around the reagent bottle 3. Soft materials for protecting the periphery of the reagent bottle 3 are filled to prevent it from being knocked and broken.

[0036] A support surface 8 is arranged below the reagent bottle 3. The periphery of the support surface 8 is fixedly connected to the housing 7 and the partition respectively. One or more through holes for communicating the first accommodation cavity and the reaction cavity 6 are arranged on the support surface 8. The reagent bottle 3 does not contact the support surface 8, and a protective member is filled between the two.

[0037] The lower surface of the pressing device 1 and / or the upper surface of the supporting surface 8 are provided with sharp protrusions, so that it is easy to break the reagent bottle 3 during contact, and the reagent bottle 3 can be broken completely. Further, the material of the reagent bottle 3 is set as the material of an ampoule bottle, which is fragile after a certain pressure is applied manually and is not easily broken by general small collisions.

[0038] The sampler 5 includes a syringe, and the bottom of the second accommodating cavity is inwardly contracted to form an annular limiting structure matching the syringe.

[0039] A protective member is filled between the reagent bottle 3 and the pressing device 1.

[0040] The limiting pin is inserted into the pressing block through the housing 7 in the horizontal direction, the limiting pin is hermetically connected to the housing 7, and the housing 7 is provided with a through hole matching the limiting pin. When the limiting pin is separated from the pressing block, the limiting pin is not separated from the housing 7, so as to ensure that after use, the solution inside the housing will not flow out from the through hole of the limiting pin.

[0041] The upper cover 4 and the housing 7 are hermetically connected through a snap structure, ensuring the sealing and stability of the overall structure.

[0042] In this application, the detection reagent is placed in the reagent bottle 3. During use, the limiting pin is removed, and the pressing block presses down to crush the reagent bottle 3, solving the problem of ensuring the safety of the reagent. The syringe is placed inside, taken out after opening the upper cover 4, and still placed in place after sampling to inject the sample into the reaction chamber 6, saving space and simplifying the operation steps.

[0043] This application is further described through the following specific embodiments.

[0044] p-Hydroxyphenylalanine (tyrosine) detection reagent (chemical method), which mainly consists of nitric acid, sulfuric acid, mercurous nitrate, mercury sulfate, and nickel nitrate. Expected use: for qualitative detection of p-hydroxyphenylalanine in urine, clinical auxiliary diagnosis of human amino acid metabolism disorder diseases, and inflammation such as gastric ulcer, gastritis, breast system inflammation, acute appendicitis, etc. In addition, detecting p-hydroxyphenylalanine in urine can be used for cancer screening. When there are cancer cells active in the body of the examinee, abnormal proliferation of tumor cells triggers a stress response in the body, abnormal increase in specific amino acid metabolism in the body, resulting in an increase in tyrosine level in urine. Checking this indicator is beneficial for early detection, early diagnosis, and early treatment of cancer. Therefore, this reagent can be used for non-professional personnel to conduct regular self-tests in the future, screen for early lesions, and improve the cure rate of major diseases.

[0045] The components of this reagent are all highly harmful to the environment and are easy to cause harm to the human body. And self-testing requires improving the safety of reagent use. Applying this device to this reagent can prevent the user from directly contacting the reagent, and at the same time, the reagent does not leak after use, greatly improving the safety performance.

[0046] The usage method includes the following steps: The reagent bottle 3 contains the detection reagent. First, open the upper cover 4, take a urine sample with the sampler 5, and add it into the reaction chamber 6; then close the upper cover 4 so that the upper cover 4 and the outer shell 7 are sealed and connected, remove the limit pin, press down the pressing block, and the pressing block crushes the reagent bottle 3, causing the reagent bottle 3 to flow through the support surface 8 into the reaction chamber 6. The reagent and the sample react in the reaction chamber 6. The reaction chamber is a transparent housing. When there is a large amount of tyrosine in the urine, a brick-red precipitate will be produced, and the result is positive at this time, indicating that the patient's body is abnormal.

[0047] In this application, the space inside the outer shell 7 is divided into a connected accommodation chamber and a reaction chamber 6, and the reagent bottle 3 and the sampler 5 are respectively installed in the accommodation chamber, which carefully plans the space inside the detection device, saves space and simplifies the operation steps. Moreover, the user can directly observe the reaction result through the transparent housing; the pressing device 1 is limited by the limiting device 2. When in use, remove the limiting device 2, and then the reagent bottle 3 can be crushed by pressing down the pressing device 1. The operation is simple and safe. Whether before use, during use or after use, the user will not come into contact with the reagent, especially the volatile reagent. The crushing of the reagent bottle 3 and the reaction process of the reagent and the sample are all completed inside the sealed housing, which can fully ensure the safety of use; by properly placing the reagent bottle 3 and placing protective materials around it, it helps to ensure the safety of the reagent, avoid the overflow of the reagent and the sample, and greatly reduce the biochemical hazards to the operator and the surrounding environment.

[0048] In the description of this application, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing this application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to this application.

[0049] The specific embodiments of the present utility model have been described above. It should be understood that the present utility model is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essence of the present utility model. Without conflict, the embodiments of this application and the features in the embodiments can be combined with each other arbitrarily.

Claims

1. A biological sample detection device, characterized in that: include: A pressing device (1), a limiting device (2), a reagent bottle (3), an upper cover (4), an injector (5) and a housing (7), wherein the housing (7) comprises a transparent shell, the upper cover (4) and the housing (7) cooperate to form an upper accommodating chamber and a lower reaction chamber (6), the reagent bottle (3) and the injector (5) are both installed in the accommodating chamber, and the injector (5) is connected to the reaction chamber (6); A support surface (8) is provided below the reagent bottle (3); the pressing device (1) is provided above the reagent bottle (3); the pressing device (1) comprises a pressing block; the limiting device (2) comprises a limiting pin, and the limiting pin passes through the housing (7) in a horizontal direction and is inserted into the pressing block; The pressing device (1) comprises an initial state and a pressing state; When the pressing device (1) and the limiting device (2) are connected by plugging and fastening, the pressing device (1) is in an initial state, and the pressing device (1) is not in contact with the reagent bottle (3); When the limiting device (2) is separated from the pressing device (1) by being pulled outward, the pressing device (1) is in a pressing state, the pressing device (1) is able to crush the reagent bottle (3), and the reagent inside the reagent bottle (3) flows through the supporting surface (8) into the reaction chamber (6).

2. The biological sample detection device according to claim 1, characterized in that: A partition is formed in the middle of the housing (7), the partition dividing the accommodating chamber into two non-connected first accommodating chamber and second accommodating chamber, the first accommodating chamber and the second accommodating chamber are respectively connected to the reaction chamber (6), the reagent bottle (3) is installed in the first accommodating chamber, and the sample injector (5) is installed in the second accommodating chamber.

3. The biological sample detection device according to claim 2, characterized in that: The reagent bottle (3) is not in contact with the outer shell (7) or the partition, and the surrounding side of the reagent bottle (3) is filled with a protective piece.

4. The biological sample detection device according to claim 3, characterized in that: The peripheral sides of the support surface (8) are respectively fastened to the outer shell (7) and the partition plate. The support surface (8) is provided with one or more through holes for connecting the first accommodating chamber and the reaction chamber (6). The reagent bottle (3) does not contact the support surface (8), and a protective member is filled between the two.

5. The biological sample detection device according to claim 4, characterized in that: The lower surface of the pressing device (1) and / or the upper surface of the supporting surface (8) are provided with pointed protrusions.

6. The biological sample detection device according to claim 2, characterized in that: The sample injector (5) comprises a syringe, and the bottom of the second accommodating chamber is contracted inwardly to form an annular limiting structure matching the syringe.

7. The biological sample detection device according to claim 1, characterized in that: A protective piece is filled between the reagent bottle (3) and the pressing device (1).

8. The biological sample detection device according to claim 1, characterized in that: The limit pin is sealedly connected to the outer shell (7); a through hole matching the limit pin is provided on the outer shell (7); when the limit pin is separated from the pressing block, the limit pin and the outer shell (7) are not separated.

9. The biological sample detection device according to claim 1, characterized in that: The upper cover (4) and the outer shell (7) are sealed and connected via a snap-fit ​​structure.

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