Rat intermittent hypoxia experiment device

Abstract

The utility model relates to an intermittent hypoxia experimental device for rats, belongs to the technical field of animal experimental devices, and aims to solve the problems that the intermittent hypoxia experimental device in the prior art is difficult to fit to the mouth and nose of a rat to keep closed, the experimental operation is complicated, and the rat is severely wounded. The device comprises an air guide pipe, a fixing end, a mask unit, a one-way valve, a fastener and a fixing ring, one end of the air guide pipe is connected with an air pump, the other end of the air guide pipe is connected with the fixing end, the mask unit is connected with the fixing end, and the mask unit can wrap the mouth and nose of a rat and expose the brain of the rat. The one-way valve is arranged on the mask unit, the fastener is arranged on the mask unit and can fasten gas in the mask unit, and the fixing ring is connected with the mask unit and used for fixing the position of the fastener. The rat mouth and nose sealing device can be attached to the mouth and nose of a rat to keep sealing, operation is easy, and trauma to the rat is small.

Description

Technical Field

[0001] The utility model relates to the technical field of animal experiment devices, in particular to a rat intermittent hypoxia experiment device. Background Art

[0002] Obstructive sleep apnea (OSA) is a highly prevalent respiratory disease that affects 5% to 14% of middle-aged people. It is characterized by recurrent partial or complete obstruction of the upper airway, leading to intermittent hypoxia, hypercapnia, increased respiratory effort, sympathetic activation, and disruption of sleep architecture.

[0003] Obstructive sleep apnea is associated with a decline in quality of life and an increase in morbidity and mortality caused by metabolic, neurological, and cardiovascular alterations. Chronic intermittent hypoxia is one of the most important pathogenic factors. Studies have shown that chronic intermittent hypoxia can affect organs throughout the body, especially causing irreversible damage to the brain.

[0004] Currently, research on intermittent hypoxia is mainly carried out through animal experiments. The main methods include modeling methods of simply changing oxygen concentration intermittently, modeling methods of airway obstruction, and intermittent airway obstruction methods, etc. Due to the special shape of the rat's mouth and nose, it is difficult for existing experimental devices to fit well with the rat's mouth and nose to keep the experimental device airtight, the operation is complex, the trauma to animals is large, and it is easy to cause animal death and other problems. Summary of the Utility Model

[0005] In view of the above analysis, the utility model aims to provide a rat intermittent hypoxia experiment device to solve the problems in the prior art that the intermittent hypoxia experiment device is difficult to fit the rat's mouth and nose to keep airtight, the experimental operation is complex, and the trauma to rats is relatively large.

[0006] The purpose of the utility model is mainly achieved through the following technical solutions:

[0007] A rat intermittent hypoxia experiment device, characterized in that it includes an air duct, a fixed end, a mask unit, a one-way valve, a fastener, and a fixing ring. One end of the air duct is connected to an air pump, and the other end is connected to the fixed end. The mask unit is connected to the fixed end. The mask unit can wrap the rat's mouth and nose and expose the rat's brain. The one-way valve and the fastener are both arranged on the mask unit. The fastener can fasten the gas inside the mask unit. The fixing ring is connected to the mask unit, and the fixing ring is used to fix the position of the fastener;

[0008] The mask unit includes a support part and a liquid bladder assembly. The support part is connected to the fixed end. The liquid bladder assembly wraps the support part. One end of the liquid bladder assembly is connected to the fixed end, and the other end extends along the support part to be able to completely cover the mouth and nose of the rat and is connected to the fixing ring.

[0009] Further, the support part is a cavity structure that penetrates in two directions. Ventilation holes are provided on the support part, and the ventilation holes are connected to the one-way valve.

[0010] Further, the liquid bladder assembly includes a liquid bladder, a liquid injection hole, and a through hole. One end of the liquid bladder is connected to the fixed end, and the other end is connected to the fixing ring. The liquid injection hole and the through hole are provided on the liquid bladder.

[0011] Further, the liquid injection hole is used to inject liquid into the liquid bladder. The position and shape of the through hole match the position and shape of the one-way valve, so that the one-way valve can pass through the through hole.

[0012] Further, the fastener includes an elastic ring, an elastic cord, and a buckle. One end of the elastic ring is connected to the liquid bladder through a plurality of the elastic cords, and the other end is provided with the buckle. The buckle is used to connect the elastic ring to the fixing ring.

[0013] Further, the fixing ring includes a fixing part, a connecting end, a spring, and a locking hook. The locking hook is connected to the front end of the fixing part through the spring. The number and shape of the locking hooks match the buckle.

[0014] Further, the rear end of the fixing part is connected to the connecting end, and the connecting end is inscribed in the fixing part.

[0015] Further, the inner ring of the connecting end is connected to the liquid bladder.

[0016] Further, when air enters the mask unit, the one-way valve is in an open state; when the air pump sucks air from the mask unit through the air duct, the one-way valve is in a closed state.

[0017] Further, an air inlet is provided on the fixed end, so that air enters the mask unit through the air duct from the air inlet.

[0018] Compared with the prior art, the present utility model can at least achieve one of the following beneficial effects:

[0019] (1) The intermittent hypoxia experimental device for rats provided by the present utility model can seal the mask unit through fasteners, and can control the air inlet and outlet of the mask unit through an air duct. Without performing surgical operations such as tracheotomy on the rats, it can provide the conditions required for intermittent hypoxia experiments, without causing external injuries to the rats, and avoiding excessive trauma resulting in the death of the rats or affecting the experimental results.

[0020] (2) The present utility model provides a support part to create a gap between the mouth and nose of the rat and the experimental device, ensuring the normal breathing conditions of the rat and preventing the experimental device from blocking the mouth and nose of the rat and causing asphyxiation.

[0021] (3) Through the liquid bladder assembly, the mask unit can fit the shape of the mouth and nose of the rat, having good adaptability for rats of different body sizes and different breeds, and preventing the mask shape from not fitting the mouth and nose of the rat and affecting the experiment.

[0022] (4) The experimental device for the mouth and nose of the rat is sealed by squeezing the liquid bladder through fasteners. The structure is stable, not affected by the irregular shape of the mouth and nose of the rat, and can achieve a good sealing effect, preventing gas from entering or escaping through the gap between the mask unit and the mouth and nose of the rat.

[0023] (5) By setting a lock and a lock hook, the fastener can be connected to the fixing ring. The lock hook is connected to the fixing part through a spring, enabling the lock hook to fix the lock at different positions, so that the elastic ring always squeezes the liquid bladder, keeping the inside of the mask unit in a sealed state. Description of the Drawings

[0024] The drawings are only for the purpose of showing specific embodiments and are not considered as a limitation of the present utility model. Throughout the drawings, the same reference signs denote the same components.

[0025] Figure 1 It is a schematic diagram of the overall structure of the intermittent hypoxia experimental device of the present utility model;

[0026] Figure 2 It is a schematic diagram of the structure of the mask unit and the one-way valve of the present utility model;

[0027] Figure 3 It is a schematic diagram of the structure of the support part and the one-way valve of the present utility model;

[0028] Figure 4 It is a schematic diagram of the structure of the liquid bladder assembly of the present utility model;

[0029] Figure 5 It is a schematic diagram of the structure of the fastener of the present utility model;

[0030] Figure 6 Of the present utility model Figure 1 Schematic diagram of the structure of part A in

[0031] Reference numerals:

[0032] 1 - Air duct; 2 - Fixed end; 21 - Air inlet; 3 - Mask unit; 31 - Support part; 311 - Ventilation hole; 32 - Liquid sac assembly; 321 - Liquid sac; 322 - Liquid injection hole; 323 - Through hole; 4 - Check valve; 5 - Fastener; 51 - Elastic ring; 52 - Elastic cord; 53 - Lock; 6 - Fixed ring; 61 - Fixing part; 62 - Connection end; 63 - Spring; 64 - Lock hook; Detailed implementation manners

[0033] The following will specifically describe the preferred embodiments of the present invention with reference to the accompanying drawings. The accompanying drawings form a part of this application and are used together with the embodiments of the present invention to explain the principle of the present invention, rather than to limit the scope of the present invention.

[0034] A specific embodiment of the present invention discloses a rat intermittent hypoxia experimental device, as Figure 1 shown, which includes an air duct 1, a fixed end 2, a mask unit 3, a check valve 4, a fastener 5 and a fixed ring 6. One end of the air duct 1 is connected to an air pump, and the other end is connected to the fixed end 2. The air pump controls the air to enter and exit the mask unit 3 through the air duct 1. The mask unit 3 is connected to the fixed end 2. The mask unit 3 can wrap the mouth and nose of the rat and expose the brain of the rat. The check valve 4 is arranged on the mask unit 3, and the check valve 4 is used to control the emission of carbon dioxide generated by the rat's breathing. The fastener 5 is arranged on the mask unit 3, and the fastener 5 can fasten the gas inside the mask unit 3. The fixed ring 6 is connected to the mask unit 3, and the fixed ring 6 is used to fix the position of the fastener 5.

[0035] As Figures 1 to 2 shown, an air inlet 21 is arranged on the fixed end 2, so that air enters the mask unit 3 through the air duct 1 from the air inlet 21. The mask unit 3 includes a support part 31 and a liquid sac assembly 32. The support part 31 is connected to the fixed end 2. The support part 31 is used to support the liquid sac assembly 32 and make a gap exist between the mouth and nose part of the rat and the mask unit 3, preventing the mask unit 3 from blocking the mouth and nose of the rat and causing asphyxia to the rat, which affects the experimental results. The liquid sac assembly 32 wraps the support part 31. One end of the liquid sac assembly 32 is connected to the fixed end 2, and the other end extends along the support part 31 to be able to completely cover the mouth and nose of the rat and is connected to the fixed ring 6.

[0036] As Figure 3 shown, the support part 31 is a cavity structure that penetrates in two directions. Ventilation holes 311 are arranged on the support part 31, and the ventilation holes 311 are connected to the check valve 4, so that the carbon dioxide exhaled by the rat enters the check valve 4 through the ventilation holes 311.

[0037] AsFigure 4 As shown, the liquid bladder assembly 32 includes a liquid bladder 321, a liquid injection hole 322, and a through hole 323. One end of the liquid bladder 321 is connected to the fixed end 2, and the other end is connected to the fixing ring 6. The liquid injection hole 322 and the through hole 323 are provided on the liquid bladder 321. The liquid injection hole 322 is used to inject liquid into the liquid bladder 321. The position and shape of the through hole 323 are matched with the position and shape of the one-way valve 4, so that the one-way valve 4 can pass through the through hole 323.

[0038] Preferably, the temperature of the liquid in the liquid bladder 321 is 12°C to 18°C to prevent the liquid from causing harm to the rats due to too high or too low temperature.

[0039] The one-way valve 4 can allow gas to pass through unidirectionally. Taking the air pump pumping air into the mask unit 3 through the air duct 1 as the gas passing direction of the one-way valve 4, when air enters the mask unit 3, the one-way valve 4 is in an open state, and the carbon dioxide generated by the rats' breathing is discharged from the mask unit 3 through the one-way valve 4. When the air pump sucks air from the mask unit 3 through the air duct 1, the one-way valve 4 is in a closed state, resulting in poor air circulation inside the mask unit 3 and causing local carbon dioxide retention.

[0040] As Figure 5 shown, the fastener 5 includes an elastic ring 51, an elastic cord 52, and a buckle 53. One end of the elastic ring 51 is connected to the liquid bladder 321 through a plurality of elastic cords 52, and the other end is provided with a buckle 53. The number of buckles 53 is multiple, and the buckles 53 are used to connect the elastic ring 51 with the fixing ring 6. As Figure 6 shown, the fixing ring 6 includes a fixing portion 61, a connecting end 62, a spring 63, and a locking hook 64. A spring 63 and a locking hook 64 are provided on the front end of the fixing portion 61. The locking hook 64 is connected to the fixing portion 61 through the spring 63. The number and shape of the locking hooks 64 are matched with the buckles 53. The spring 63 is used to make the position of the locking hook 64 match with the buckle 53, so as to connect the fastener 5 with the fixing ring 6 and keep the inside of the mask unit 3 in a sealed state; the rear end of the fixing portion 61 is connected to the connecting end 62, the connecting end 62 is inscribed in the fixing portion 61, and the inner ring of the connecting end 62 is connected to the liquid bladder 321.

[0041] When it is necessary to wear the experimental device on the nose and mouth of a rat, connect the air duct 1 to an air pump, put the experimental device on the nose and mouth of the rat, so that the support part 31 covers the nose position of the rat, inject liquid into the liquid sac 321 through the liquid injection hole 322, and after the liquid sac 321 is inflated with the injected liquid and completely covers the nose and mouth of the rat, move the elastic ring 51 towards the fixing ring 6, so that the elastic ring 51 squeezes the liquid sac 321, making the liquid sac 321 in close contact with the nose and mouth of the rat. Connect the fastener 5 to the fixing ring 6 through the cooperation of the lock catch 53 and the lock hook 64, so that the elastic ring 51 always squeezes the liquid sac 321, thereby keeping the inside of the mask unit 3 in a sealed state and preventing gas from entering or escaping through the gap between the mask unit 3 and the nose and mouth of the rat.

[0042] After the experiment is completed, move the lock hook 64 out of the lock catch 53. Under the action of the elastic cord 52, the elastic ring 51 moves towards the fixed end 2, relieving the extrusion of the liquid sac 321, so that the experimental device can be removed from the nose and mouth of the rat.

[0043] Compared with the prior art, the intermittent hypoxia experimental device for rats provided by the present utility model can seal the mask unit 3 through the fastener 5, and can control the air inlet and outlet of the mask unit 3 through the air duct 1. It can provide the conditions required for intermittent hypoxia experiments without performing surgical operations such as tracheotomy on the rats, causing no trauma to the rats, and avoiding excessive trauma leading to the death of the rats or affecting the experimental results; by setting the support part 31, there is a gap between the nose and mouth of the rat and the mask unit 3, ensuring the normal breathing conditions of the rat and preventing the mask unit 3 from blocking the nose and mouth of the rat and causing asphyxia; through the liquid sac assembly 32, the mask unit 3 can fit the shape of the nose and mouth of the rat, having good adaptability to rats of different body sizes and different breeds, and preventing the mask shape from not fitting the nose and mouth of the rat and affecting the experiment; the mask unit 3 is sealed by squeezing the liquid sac 321 through the fastener 5, with a stable structure, not affected by the irregular shape of the nose and mouth of the rat, and being able to achieve a good sealing effect, preventing gas from entering or escaping through the gap between the mask unit 3 and the nose and mouth of the rat; by setting the lock catch 53 and the lock hook 64, the fastener 5 can be connected to the fixing ring 6. The lock hook 64 is connected to the fixing part 61 through a spring 63, enabling the lock hook 64 to fix the lock catch 53 at different positions, so that the elastic ring 51 always squeezes the liquid sac 321, keeping the inside of the mask unit 3 in a sealed state.

[0044] The above is only a preferred specific embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present utility model should be covered within the protection scope of the present utility model.

Claims

1. A rat intermittent hypoxia experimental device, characterized in that: The invention comprises an airway tube (1), a fixed end (2), a mask unit (3), a one-way valve (4), a fastener (5) and a fixing ring (6); one end of the airway tube (1) is connected to an air pump, and the other end is connected to the fixed end (2); the mask unit (3) is connected to the fixed end (2); the mask unit (3) is capable of covering the mouth and nose of a rat and exposing the brain of the rat; the one-way valve (4) and the fastener (5) are both arranged on the mask unit (3); the fastener (5) is capable of fixing the gas in the mask unit (3); the fixing ring (6) is connected to the mask unit (3); and the fixing ring (6) is used to fix the position of the fastener (5); The mask unit (3) comprises a supporting portion (31) and a liquid bag component (32), wherein the supporting portion (31) is connected to the fixed end (2), and the liquid bag component (32) wraps the supporting portion (31), one end of the liquid bag component (32) is connected to the fixed end (2), and the other end extends along the supporting portion (31) to completely cover the mouth and nose of the rat and is connected to the fixing ring (6).

2. The rat intermittent hypoxia experimental device according to claim 1, characterized in that: The support portion (31) is a bidirectionally penetrating cavity structure, and a vent hole (311) is provided on the support portion (31), and the vent hole (311) is connected to the one-way valve (4).

3. The rat intermittent hypoxia experimental device according to claim 2, characterized in that: The liquid sac assembly (32) comprises a liquid sac (321), a liquid injection hole (322) and a through hole (323); one end of the liquid sac (321) is connected to the fixed end (2), and the other end is connected to the fixed ring (6); the liquid injection hole (322) and the through hole (323) are arranged on the liquid sac (321).

4. The rat intermittent hypoxia experimental device according to claim 3, characterized in that: The injection hole (322) is used to inject liquid into the liquid bag (321), and the position and shape of the through hole (323) match the position and shape of the one-way valve (4), so that the one-way valve (4) can pass through the through hole (323).

5. The rat intermittent hypoxia experimental device according to claim 1, characterized in that: The fastener (5) comprises an elastic ring (51), an elastic rope (52) and a lock buckle (53); one end of the elastic ring (51) is connected to the liquid bag (321) via a plurality of the elastic ropes (52); the other end is provided with the lock buckle (53); the lock buckle (53) is used to connect the elastic ring (51) to the fixing ring (6).

6. The rat intermittent hypoxia experimental device according to claim 5, characterized in that: The fixing ring (6) comprises a fixing portion (61), a connecting end (62), a spring (63) and a locking hook (64); the locking hook (64) is connected to the front end of the fixing portion (61) via the spring (63); the number and shape of the locking hook (64) match the locking buckle (53).

7. The rat intermittent hypoxia experimental device according to claim 6, characterized in that: The rear end of the fixing portion (61) is connected to the connecting end (62), and the connecting end (62) is inscribed in the fixing portion (61).

8. The rat intermittent hypoxia experimental device according to claim 7, characterized in that: The inner ring of the connecting end (62) is connected to the liquid bag (321).

9. The rat intermittent hypoxia experimental device according to claim 1, characterized in that: When air enters the mask unit (3), the one-way valve (4) is in an open state; when the air pump draws air from the mask unit (3) through the air guide tube (1), the one-way valve (4) is in a closed state.

10. The rat intermittent hypoxia experimental device according to any one of claims 1 to 9, characterized in that: An air inlet (21) is provided on the fixed end (2), so that air passes through the air guide tube (1) and enters the mask unit (3) from the air inlet (21).

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