Electrochemical biosensor
By distributing the two ends of the electrode and the connecting lines on the substrate of the CGM system and setting an insulating layer to isolate electrical interference, the problem of insufficient signal sensitivity and accuracy in the existing CGM system is solved, and higher signal strength and transmission stability are achieved.
Patent Information
- Application Number
- CN202421496081.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-27
- Publication Date
- 2025-06-17
- Estimated Expiration
- 2034-06-27
AI Technical Summary
The existing continuous glucose monitoring system (CGM) has limitations in electrode design and layout, resulting in the impact of signal sensitivity and accuracy.
By providing at least one first electrode and the second electrode on the first and second surfaces of the substrate, and arranging both ends of the electrode and the connecting wires on the same plane, electrical interference is reduced, and electrical interference is isolated by providing an insulating layer.
It realizes the distribution of more working electrodes in a limited space and area, improves the signal strength and transmission stability, and enhances the performance of the sensor and the reliability of long-term monitoring.
Smart Images
Figure CN222994383U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the technical field of medical analysis instruments, and particularly to an electrochemical biosensor. Background Art
[0002] A continuous glucose monitoring system (CGM) is an important medical device for monitoring the blood glucose level of diabetic patients, thereby enabling more precise disease management and treatment. Such a system typically consists of three main components: a sensor component, a circuit transmitting component (transmitter), and a receiver (such as a mobile phone). The sensor component is fixed on a base and operates through electrodes printed on a flexible substrate such as polyimide (PI) or polyethylene terephthalate (PET). These electrodes are connected to the transmitter through connectors formed by conductive materials, transmitting the current caused by biological signals.
[0003] Although the prior art provides powerful CGM products, they have certain limitations in electrode design and layout. Generally, all electrode wires and electrode connectors of the sensor (at least including a reference electrode, a counter electrode, and multiple working electrodes) are distributed on the same side of the flexible substrate. This design simplifies the manufacturing process but also limits the electrode area, which may affect the sensitivity and accuracy of the signal. Since the performance of an electrochemical sensor depends to a large extent on the effective area and layout of the electrodes, the current design may lead to poor signal transmission, especially in a complex biochemical environment. Summary of the Invention
[0004] The purpose of this application is to provide an electrochemical biosensor that can distribute more working electrodes in a limited space and area through electrode distribution design and limiting structure design, detect different signals, and can ensure the electrode signal intensity and signal transmission stability.
[0005] This application discloses an electrochemical biosensor, including: a substrate 1, a first electrode 2, and a second electrode 3;
[0006] The substrate 1 is L-shaped, the first end of the substrate 1 is the test end, and the second end of the substrate 1 is the emission end;
[0007] At least one of the first electrodes 2 is disposed on the first surface of the substrate 1. The first end of the first electrode 2 is disposed on the emission end, the second end of the first electrode 2 is disposed on the test end, and the first end and the second end of the first electrode 2 are connected by a first conductive connection line. The first end of the first electrode 2, the second end of the first electrode 2, and the first conductive connection line are on the same plane;
[0008] At least one of the second electrodes 3 is disposed on the second surface of the substrate 1. The first end of the second electrode 3 is disposed on the transmitting end, and the second end of the second electrode 3 is disposed on the testing end. The first end and the second end of the second electrode 3 are connected by a second conductive connection line, and the first end, the second end of the second electrode 3, and the second conductive connection line are located on the same plane.
[0009] In a preferred example, it further includes at least one third electrode 4. The third electrode 4 is disposed on the first surface or the second surface of the substrate 1. The first end of the third electrode 4 is disposed on the transmitting end, and the second end of the third electrode 4 is disposed on the testing end. The first end and the second end of the third electrode 4 are connected by a third conductive connection line, and the first end, the second end of the third electrode 4, and the third conductive connection line are located on the same plane.
[0010] In a preferred example, an insulating layer 5 is interposed between the third electrode 4, the third conductive connection line and the first electrode 2, the first conductive connection line.
[0011] In a preferred example, an insulating layer 5 is interposed between the third electrode 4, the third conductive connection line and the second electrode 3, the second conductive connection line.
[0012] In a preferred example, the first electrode 2, the second electrode 3, and the third electrode 4 are a reference electrode, a working electrode, and a counter electrode respectively.
[0013] In a preferred example, at least one positioning bayonet 6 is provided at the edge of the substrate 1, and the positioning bayonet 6 is used to connect with the inside of the transmitter base for positioning and fixing.
[0014] In a preferred example, the first end of the electrode is rectangular, circular, triangular, or polygonal.
[0015] In a preferred example, a guiding portion 7 protruding outward is provided on the transmitting end of the substrate 1, and the guiding portion 7 is configured to guide the half-wall needle.
[0016] In a preferred example, the electrode and the conductive connection line are printed at one time by screen printing.
[0017] In a preferred example, the conductive connection line is overprinted or printed in parallel.
[0018] In the embodiments of the present application, by respectively providing at least one first electrode and a second electrode on the first side and the second side of the substrate, and by arranging the two ends of the first electrode and the connection line in the same plane and arranging the two ends of the second electrode and the connection line in another plane, electrical interference in the electrode system can be reduced. Because in a traditional CGM system, the connection of the two ends of the electrode often passes through a through-hole in the substrate, which may cause interference to the signal when passing through the substrate, affecting the stability of the signal. However, the present application avoids the need for threading through the through-hole, thereby reducing electrical noise and signal attenuation and ensuring higher signal integrity.
[0019] Furthermore, by providing an insulating layer between the third electrode and its conductive connection line and other electrodes, electrical interference can be effectively isolated, enhancing the purity and reliability of the signal, reducing signal interference, and thus achieving higher sensor performance and more stable long-term monitoring capabilities.
[0020] Furthermore, by providing positioning bayonets at the edge of the substrate, precise docking and quick fixation between the sensor and the transmitter base can be ensured.
[0021] A large number of technical features are recorded in the specification of the present application, distributed in various technical solutions. If all possible combinations of technical features (i.e., technical solutions) of the present application are to be listed, the specification will be too lengthy. To avoid this problem, each technical feature disclosed in the above-mentioned invention content of the present application, each technical feature disclosed in the following embodiments and examples, and each technical feature disclosed in the drawings can be freely combined with each other to form various new technical solutions (these technical solutions are all regarded as having been recorded in this specification), unless the combination of such technical features is technically infeasible. For example, in one example, features A + B + C are disclosed, and in another example, features A + B + D + E are disclosed, and features C and D are equivalent technical means that play the same role and only one of them can be used technically and they cannot be used simultaneously. Feature E can be combined with feature C technically. Then, the solution of A + B + C + D should not be regarded as having been recorded because it is technically infeasible, while the solution of A + B + C + E should be regarded as having been recorded. Brief Description of the Drawings
[0022] Figure 1 is a schematic structural diagram of an electrochemical biosensor according to an embodiment of the present application;
[0023] Figure 2 is a schematic structural diagram of an electrochemical biosensor according to an embodiment of the present application;
[0024] Figure 3 is a schematic structural diagram of an electrochemical biosensor according to an embodiment of the present application;
[0025] Figure 4 It is a schematic structural diagram of an electrochemical biosensor according to an embodiment of the present application;
[0026] Figure 5 It is a schematic structural diagram of an electrochemical biosensor according to an embodiment of the present application.
[0027] Description of the reference numerals:
[0028] 1 - Substrate, 2 - First electrode, 3 - Second electrode, 4 - Third electrode, 5 - Insulating layer, 6 - Positioning bayonet, 7 - Guiding portion. Detailed implementation manners
[0029] In the following description, many technical details are presented for the reader to better understand the present application. However, those of ordinary skill in the art can understand that even without these technical details and various changes and modifications based on the following embodiments, the technical solutions claimed in the present application can still be implemented.
[0030] Terms
[0031] As used herein, "first side" refers to the side of the sensor substrate facing the observer, and "second side" refers to the other side of the sensor substrate. It should be understood that the descriptions and applications of "first side" and "second side" are not restrictive, and the sides indicated by these two terms can be interchanged according to specific design needs and functional requirements.
[0032] As used herein, "PAD" refers to a pad, which is used to provide a safe and reliable surface to connect the pins of a sensor, chip, or other electronic components to the substrate or circuit board by soldering or other connection methods, or can be used to transmit signals and connect components such as sensor electrodes to capture, process, and transmit data, such as monitoring and responding to physiological signals in a sensor device.
[0033] To make the objectives, technical solutions, and advantages of the present application clearer, the embodiments of the present application will be further described in detail below with reference to the accompanying drawings.
[0034] The present application relates to an electrochemical biosensor, and its structural diagram is as shown in Figures 1-3 shown, including: substrate 1, first electrode 2, and second electrode 3.
[0035] The substrate 1 is L-shaped. The first end of the substrate 1 is the test end, and the second end of the substrate 1 is the emitting end. At least one first electrode 2 is disposed on the first surface of the substrate 1. The first end of the first electrode 2 is disposed on the emitting end, and the second end of the first electrode 2 is disposed on the test end. The first end and the second end of the first electrode 2 are connected by a first conductive connection line. The first end of the first electrode 2, the second end of the first electrode 2, and the first conductive connection line are located on the same surface. At least one second electrode 3 is disposed on the second surface of the substrate 1. The first end of the second electrode 3 is disposed on the emitting end, and the second end of the second electrode 3 is disposed on the test end. The first end and the second end of the second electrode 3 are connected by a second conductive connection line. The first end of the second electrode 3, the second end of the second electrode 3, and the second conductive connection line are located on the same surface.
[0036] In an alternative embodiment, it may further include at least one third electrode 4. The third electrode 4 is disposed on the first surface or the second surface of the substrate 1. The first end of the third electrode 4 is disposed on the emitting end, and the second end of the third electrode 4 is disposed on the test end. The first end and the second end of the third electrode 4 are connected by a third conductive connection line. The first end of the third electrode 4, the second end of the third electrode 4, and the third conductive connection line are located on the same surface.
[0037] In an alternative embodiment, an insulating layer 5 may be interposed between the third electrode 4, the third conductive connection line and the first electrode 2, the first conductive connection line. The function of the insulating layer 5 is to prevent electrical interference and signal crosstalk, ensuring electrical isolation between the electrodes, thereby improving the signal stability and measurement accuracy of the sensor. The insulating layer 5 may be composed of a variety of materials, mainly depending on its electrical insulation performance, chemical stability, mechanical strength, and compatibility with other components of the sensor. The insulating materials in this application may include, but are not limited to: polyimide PI, polytetrafluoroethylene PTFE, silicone rubber, and epoxy resin, etc. These materials can be used alone or in combination to adapt to specific application requirements and environmental conditions, so as to ensure that the sensor can maintain good performance under various operating conditions. In addition, the thickness and specific layout of the insulating layer 5 can also be optimized according to the electrode design and intended use to maximize the overall performance of the sensor.
[0038] In an alternative embodiment, an insulating layer 5 may be interposed between the third electrode 4, the third conductive connection line and the second electrode 3, the second conductive connection line.
[0039] In an alternative embodiment, the lower edge of the insulating layer 5 is aligned with the lower edge of the substrate 1, the upper edge of the insulating layer 5 is located in the middle section of the substrate 1, the insulating layer 5 covers the conductive connection line, and the first ends of the first electrode 2, the second electrode 3, and the third electrode 4 are not covered by the insulating layer 5.
[0040] In an alternative embodiment, the first electrode 2, the second electrode 3, and the third electrode 4 may be a reference electrode, a working electrode, and a counter electrode, respectively. Optionally, the first electrode 2 is the reference electrode, the second electrode 3 is the working electrode, and the third electrode 4 is the counter electrode. Optionally, the first electrode 2 is the reference electrode, the second electrode 3 is the counter electrode, and the third electrode 4 is the working electrode. Optionally, the first electrode 2 is the working electrode, the second electrode 3 is the reference electrode, and the third electrode 4 is the counter electrode. Optionally, the first electrode 2 is the working electrode, the second electrode 3 is the counter electrode, and the third electrode 4 is the reference electrode. Optionally, the first electrode 2 is the counter electrode, the second electrode 3 is the reference electrode, and the third electrode 4 is the working electrode. Optionally, the first electrode 2 is the counter electrode, the second electrode 3 is the working electrode, and the third electrode 4 is the reference electrode.
[0041] In an alternative embodiment, as Figure 2 shown, at least one positioning bayonet 6 may be provided at the edge of the substrate 1, and the positioning bayonet 6 is used to connect to the inside of the transmitter base for positioning and fixing. The top view shape of the positioning bayonet 6 may be rectangular, semi-circular, triangular, or any other shape.
[0042] In an alternative embodiment, as Figures 4-5 shown, the first end of the electrode may be rectangular, circular, triangular, polygonal, etc. The choice of the shape of the first end of the electrode may be determined according to the electrode function, the sensor design requirements, and the manufacturing technology. The above description of the electrode shape is only an example and is not intended to limit the possible shapes, layouts, or configurations.
[0043] In an alternative embodiment, as Figure 2 shown, a guiding portion 7 protruding outward may be provided on the emitting end of the substrate 1, and the guiding portion 7 is configured to guide the half-wall needle.
[0044] In an alternative embodiment, the electrode and the conductive connection line are printed in one pass by screen printing.
[0045] In an alternative embodiment, the conductive connection lines are overprinted or printed in parallel. Optionally, when multiple conductive connection lines are on the same layer, the parallel printing method may be used, and the multiple conductive connection lines will not cross / overlap on this layer. Optionally, when multiple conductive connection lines are on different layers, the overprinting method may be used. At this time, when viewed from the top, the conductive connection lines may cross / overlap or may not cross / overlap.
[0046] To better understand the technical solution of the present application, several specific examples will be described below. The details listed in this example are mainly for easy understanding and do not limit the protection scope of the present application.
[0047] Example 1
[0048] This embodiment provides an electrochemical biosensor, which includes three electrodes: a working electrode, a reference electrode, and a counter electrode.
[0049] In this embodiment, the working electrode and the reference electrode are both distributed on the first side (front side) of the sensor substrate 1. Effective interlayer insulation is achieved by providing an insulating layer 5 between these two electrodes. The counter electrode is arranged on the second side (back side) of the sensor substrate 1. The working electrode, the reference electrode, and the counter electrode all have two ends, and the two ends of each electrode are connected by a conductive connection wire. The first ends, second ends of all electrodes, and the conductive wires (conductive connection wires) connected thereto are all on the same layer and the same side of the substrate 1, corresponding to their respective electrodes, and can be completed by screen printing process at one time.
[0050] Embodiment 2
[0051] This embodiment provides an electrochemical biosensor, which includes four electrodes: two working electrodes (a first working electrode and a second working electrode), a reference electrode, and an auxiliary electrode.
[0052] In this embodiment, the first working electrode and the second working electrode are distributed on the first side (front side) of the sensor substrate 1, and the working electrode and the reference electrode are distributed on the second side (back side) of the sensor substrate 1. Effective interlayer insulation is achieved by providing an insulating layer 5 between the first working electrode and the second working electrode, and effective interlayer insulation is also achieved by providing an insulating layer 5 between the working electrode and the reference electrode. Each electrode has two ends, and the two ends of each electrode are connected by a conductive connection wire. The first ends, second ends of all electrodes, and the conductive wires (conductive connection wires) connected thereto are all on the same layer and the same side of the substrate 1, corresponding to their respective electrodes, and can be completed by screen printing process at one time.
[0053] In Embodiment 1 and Embodiment 2, positioning notches 6 can be provided on the substrate 1. The positioning notches 6 match the protruding parts on the inner wall of the base, so as to guide the sensor into the corresponding position of the base and fix the sensor in the base, ensuring that the electrode PADs printed on both sides of the substrate 1 are fixedly connected to the connection positions of the electrical connectors respectively.
[0054] Through this design, the electrochemical biosensor of the present invention not only has cost-effectiveness in manufacturing, but also can provide high-performance electrochemical detection technically, and is suitable for wide applications in biomedical fields such as continuous glucose monitoring.
[0055] It should be noted that in the application documents of this patent, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising one" does not exclude the presence of additional identical elements in the process, method, article or device comprising said element. In the application documents of this patent, if it is mentioned that a certain act is performed according to a certain element, it means that the act is performed at least according to that element, including two cases: the act is performed only according to that element, and the act is performed according to that element and other elements. Expressions such as multiple, many times, various, etc. include 2, 2 times, 2 kinds, and more than 2, more than 2 times, more than 2 kinds.
[0056] All documents mentioned in this application are considered to be integrally included in the disclosure of this application so as to be used as a basis for modification if necessary. In addition, it should be understood that after reading the above disclosure of this application, those skilled in the art can make various changes or modifications to this application, and these equivalent forms also fall within the scope claimed by this application.
Claims
1. An electrochemical biosensor, characterized in that: include: A substrate (1), a first electrode (2) and a second electrode (3); The substrate (1) is L-shaped, the first end of the substrate (1) is a test end, and the second end of the substrate (1) is a transmitting end; At least one of the first electrodes (2) is arranged on the first surface of the substrate (1), the first end of the first electrode (2) is arranged on the emitting end, the second end of the first electrode (2) is arranged on the testing end, the first end and the second end of the first electrode (2) are connected via a first conductive connecting line, and the first end of the first electrode (2), the second end of the first electrode (2) and the first conductive connecting line are located on the same surface; At least one of the second electrodes (3) is arranged on the second surface of the substrate (1); the first end of the second electrode (3) is arranged on the transmitting end; the second end of the second electrode (3) is arranged on the testing end; the first end and the second end of the second electrode (3) are connected via a second conductive connecting line; the first end of the second electrode (3), the second end of the second electrode (3) and the second conductive connecting line are located on the same surface.
2. The electrochemical biosensor according to claim 1, characterized in that The invention also comprises at least one third electrode (4), wherein the third electrode (4) is arranged on the first surface or the second surface of the substrate (1), the first end of the third electrode (4) is arranged on the transmitting end, the second end of the third electrode (4) is arranged on the testing end, the first end and the second end of the third electrode (4) are connected via a third conductive connecting line, and the first end of the third electrode (4), the second end of the third electrode (4) and the third conductive connecting line are located on the same surface.
3. The electrochemical biosensor according to claim 1, characterized in that At least one positioning bayonet (6) is provided at the edge of the substrate (1), and the positioning bayonet (6) is used to connect with the inside of the transmitter base for positioning and fixing.
4. The electrochemical biosensor according to claim 2, characterized in that An insulating layer (5) is sandwiched between the third electrode (4), the third conductive connecting line and the first electrode (2), the first conductive connecting line.
5. The electrochemical biosensor according to claim 2, characterized in that: An insulating layer (5) is sandwiched between the third electrode (4), the third conductive connecting line and the second electrode (3), the second conductive connecting line.
6. The electrochemical biosensor according to claim 2, characterized in that: The first electrode (2), the second electrode (3), and the third electrode (4) are respectively a reference electrode, a working electrode, and a counter electrode.
7. The electrochemical biosensor according to claim 1, characterized in that The first end of the electrode is rectangular, circular, triangular or polygonal.
8. The electrochemical biosensor according to claim 1, characterized in that A guide portion (7) protruding outward is provided on the emitting end of the substrate (1), and the guide portion (7) is configured to guide the half-wall needle.
9. The electrochemical biosensor according to claim 2, characterized in that: The electrodes and the conductive connecting wires are printed at one time by screen printing.
10. The electrochemical biosensor according to claim 2, characterized in that: The conductive connecting lines are printed in overlapping or parallel manner.