Sample treatment device for mass spectrometry detection

Abstract

The utility model relates to the technical field of medical equipment, in particular to a sample processing device for mass spectrometry detection, which comprises an extraction cylinder, the upper end of the extraction cylinder is in threaded connection with a sealing cover, and the front surface of the sealing cover is provided with an internal threaded hole. Through the arrangement of the extraction barrel, a fructus aurantii material needing to be crushed is placed in the grinding seat in the extraction barrel, then the sealing cover is screwed into the upper end of the extraction barrel, when the grinding body enters the grinding seat, the fructus aurantii material can be extruded, and then after quantitative extraction liquid is sucked into the extraction liquid suction rubber head, the fructus aurantii material can be crushed. The method comprises the following steps: driving an external thread connecting sleeve to be screwed into an internal thread hole, then driving a rotating shaft and a grinding body to rotate through a rotating ball head, quickly crushing and grinding a fructus aurantii material, then extruding an extraction liquid suction rubber head to enable quantitative extraction liquid to enter an extraction barrel through a liquid suction pipe, and quickly soaking the ground and crushed fructus aurantii material. The capability of quickly obtaining the standard sample is realized.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, and particularly relates to a sample processing device for mass spectrometry detection. Background Technique

[0002] Mass spectrometry analysis technology features fast analysis speed, strong specificity, and high sensitivity. In recent years, with the continuous innovation and improvement of mass spectrometry ionization technology and mass analyzers, mass spectrometry analysis technology has demonstrated excellent qualitative and quantitative capabilities at the molecular level.

[0003] Currently, a patent document with the publication number CN219870574U discloses a sample processing device for mass spectrometry detection. This sample processing device for mass spectrometry detection includes a sampling component and an extraction component arranged below the sampling component. The extraction component includes a shielding outer sleeve, an extraction needle arranged inside the shielding outer sleeve. The extraction needle includes a connection block, an extraction vertical tube arranged on the connection block, and an extraction horizontal tube arranged on the side of the connection block. The extraction vertical tube is communicated with the extraction horizontal tube. The shielding outer sleeve is provided with a through hole adapted to the extraction horizontal tube. The sampling component includes a sealing cover sleeved outside the shielding outer sleeve, a pressing rod arranged on the sealing cover, and a liquid leakage quantitative tube arranged below the sealing cover. The liquid leakage quantitative tube is sleeved outside the connection block and has a cutting slope at the bottom. The sample processing device for mass spectrometry detection in the utility model solves the problems in the prior art that during the detection of the active ingredients of Chinese herbal medicine Fructus Aurantii, too many pretreatment processes are cumbersome and time-consuming, and cause losses and contamination to the samples.

[0004] However, when the above-mentioned existing sample processing device for mass spectrometry detection processes Chinese herbal medicine Fructus Aurantii, by cutting the Fructus Aurantii and placing the central part of the Fructus Aurantii in the liquid leakage quantitative tube, and then injecting an extraction solution for soaking treatment to obtain an extraction sample. However, when the Fructus Aurantii is not completely crushed, the process of soaking treatment with the extraction solution requires a long time to obtain a standard sample, which easily causes the detection data of the sample to be unrepresentative. Therefore, we propose a sample processing device for mass spectrometry detection. Content of the Utility Model

[0005] The purpose of the utility model is to provide a sample processing device for mass spectrometry detection, which has the advantage of good sample detection effect, and solves the problem that when the Fructus Aurantii is not completely crushed, the process of soaking treatment with the extraction solution requires a long time to obtain a standard sample, which easily causes the detection data of the sample to be unrepresentative.

[0006] To achieve the above object, the present utility model provides the following technical solutions: A sample processing device for mass spectrometry detection, including an extraction cylinder, the upper end of the extraction cylinder is threadedly connected with a sealing cover, the front surface of the sealing cover is provided with an internal thread hole, the inner side of the internal thread hole is threadedly connected with an external thread connecting sleeve, the inner side of the external thread connecting sleeve is fixedly connected with a liquid passing straw, the right end of the liquid passing straw is communicated with an extraction liquid suction rubber head, the middle end of the top of the sealing cover is movably connected with a rotating shaft through a bearing, the bottom of the rotating shaft is fixedly connected with a grinding body, the outer surface of the grinding body is provided with grinding bumps, the top of the rotating shaft is provided with a rotating ball head, and the inner cavity of the extraction cylinder is fixedly connected with a grinding seat and a liquid collecting hopper from top to bottom in sequence, and the inner surface of the grinding seat is provided with filtering holes.

[0007] Preferably, a pressure supply device is provided at the lower end of the rear side of the extraction cylinder, an ionization needle is provided on the inner surface of the lower end of the liquid collecting hopper, and a through hole is provided at the upper end of the ionization needle.

[0008] Preferably, the grinding body and the grinding seat are adapted to each other, and the lower end of the grinding body is in a hemispherical structure.

[0009] Preferably, the extraction liquid suction rubber head is made of transparent silica gel, and the liquid passing straw is made of polycarbonate.

[0010] Preferably, the number of the grinding bumps is multiple, and the grinding bumps are in a hemispherical structure.

[0011] Preferably, the number of the filtering holes is multiple, and the included angle between two adjacent filtering holes is equal.

[0012] Preferably, the lower end of the extraction cylinder is fixedly connected with support legs, and the bottom of the support legs is fixedly connected with a support bottom plate.

[0013] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0014] 1. Through the setting of the extraction cylinder, the Fructus Aurantii materials to be broken are placed in the grinding seat inside it. Then, the sealing cover is screwed into the upper end of the extraction cylinder. When the grinding body enters the grinding seat, it can squeeze the Fructus Aurantii materials. Then, after a certain amount of extraction liquid is inhaled into the extraction liquid suction rubber head, the external thread connecting sleeve is driven to be screwed into the internal thread hole. Then, the rotating shaft and the grinding body are driven to rotate through the rotating ball head. And with the cooperation of the grinding bumps and the grinding seat, the Fructus Aurantii materials can be quickly broken and ground. Then, the extraction liquid suction rubber head is squeezed so that a certain amount of extraction liquid enters the extraction cylinder through the liquid passing straw, and the ground and broken Fructus Aurantii materials are quickly soaked, realizing the ability to quickly obtain standard samples.

[0015] 2. By providing the supporting legs and the supporting base plate, the present utility model enables the device to be stably placed when not in use, facilitating people's use. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic structural view of the first perspective of the present utility model;

[0017] Figure 2 is a schematic cross-sectional structural view of the second perspective of the present utility model;

[0018] Figure 3 is a schematic structural view of the grinding seat of the present utility model;

[0019] Figure 4 is a schematic structural view of the sealing cover of the present utility model;

[0020] Figure 5 is a schematic structural view of the external thread connecting sleeve of the present utility model.

[0021] In the figures: 1, extraction cylinder; 2, sealing cover; 3, rotating shaft; 4, grinding body; 5, grinding convex block; 6, internal thread hole; 7, rotating ball head; 8, supporting leg; 9, supporting base plate; 10, pressure supply device; 11, liquid collecting hopper; 12, grinding seat; 13, extraction liquid suction rubber head; 14, through hole; 15, ionization needle; 16, filter hole; 17, external thread connecting sleeve; 18, liquid passing suction pipe. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0022] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present utility model.

[0023] In the description of the present utility model, unless otherwise specified, "a plurality of" means two or more; the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be construed as a limitation of the present utility model. In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0024] In the description of the present utility model, it should be noted that unless otherwise clearly specified and defined, the terms "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0025] It should be noted that the extraction cylinder 1, the sealing cover 2, the rotating shaft 3, the grinding body 4, the grinding bump 5, the internal thread hole 6, the rotating ball head 7, the support leg 8, the support bottom plate 9, the pressure supply device 10, the liquid collecting hopper 11, the grinding seat 12, the extraction liquid suction rubber head 13, the through hole 14, the ionization needle 15, the filter hole 16, the external thread connecting sleeve 17 and the liquid passing suction pipe 18 of the present application are all common standard parts or parts known to those skilled in the art. Their structures and principles can all be known by those skilled in the art through technical manuals or obtained through conventional experimental methods, and the connection with the power supply circuit adopts the conventional connection method in the prior art, which will not be elaborated here.

[0026] Embodiment 1

[0027] Please refer to Figures 1-5 As shown in the figure, the present utility model provides a technical solution: a sample processing device for mass spectrometry detection, including an extraction cylinder 1. The upper end of the extraction cylinder 1 is threadedly connected with a sealing cover 2. An internal thread hole 6 is opened on the front surface of the sealing cover 2. An external thread connecting sleeve 17 is threadedly connected to the inner side of the internal thread hole 6. A liquid passing suction pipe 18 is fixedly connected to the inner side of the external thread connecting sleeve 17. The right end of the liquid passing suction pipe 18 is communicated with an extraction liquid suction rubber head 13. The middle end of the top of the sealing cover 2 is movably connected with a rotating shaft 3 through a bearing. A grinding body 4 is fixedly connected to the bottom of the rotating shaft 3. Grinding bumps 5 are arranged on the outer surface of the grinding body 4. A rotating ball head 7 is arranged on the top of the rotating shaft 3. A grinding seat 12 and a liquid collecting hopper 11 are fixedly connected to the inner cavity of the extraction cylinder 1 in sequence from top to bottom. Filter holes 16 are opened on the inner surface of the grinding seat 12;

[0028] Among them, a pressure supply device 10 is arranged at the lower end of the rear side of the extraction cylinder 1. An ionization needle 15 is arranged on the inner surface of the lower end of the liquid collecting hopper 11. A through hole 14 is arranged at the upper end of the ionization needle 15;

[0029] Through the above technical solution as Figure 2 shown, it is ionized under the action of the ionization needle 15, and under the action of the external pressure supply device 10, it is ionized and atomized, and is ejected from the ionization needle 15 to the mass spectrometer for detection.

[0030] Among them, the grinding body 4 and the grinding seat 12 are adapted to each other, and the lower end of the grinding body 4 is in a hemispherical structure;

[0031] Through the above technical solutions, such as Figures 2-4 shown, through the settings of the grinding body 4 and the grinding seat 12, the quick grinding and crushing of the Fructus Aurantii Immaturus materials can be achieved, the acquisition time of the extraction liquid is reduced, and the standardization of the samples can be ensured.

[0032] Among them, the material of the extraction liquid suction rubber head 13 is transparent silica gel, and the material of the liquid passing straw 18 is polycarbonate;

[0033] Through the above technical solutions, such as Figure 1 and Figure 3 as well as Figure 5 shown, through the settings of the extraction liquid suction rubber head 13 and the liquid passing straw 18, a quantitative extraction liquid can be injected to ensure the standardization of the samples.

[0034] Among them, the number of the grinding bumps 5 is multiple, and the grinding bumps 5 are hemispherical structures;

[0035] Through the above technical solutions, such as Figure 2 and Figure 4 shown, through the setting of the grinding bumps 5, when the grinding body 4 rotates in the grinding seat 12, the crushing efficiency of the Fructus Aurantii Immaturus materials can be accelerated.

[0036] Among them, the number of the filter holes 16 is multiple, and the included angle between two adjacent filter holes 16 is equal.

[0037] Through the above technical solutions, such as Figure 3 shown, through the setting of the filter holes 16, the soaked extraction liquid can be filtered.

[0038] In this technical solution, through the setting of the extraction cylinder 1, the Fructus Aurantii Immaturus materials to be crushed are placed in the grinding seat 12 inside it. Then, the sealing cover 2 is screwed into the upper end of the extraction cylinder 1. When the grinding body 4 enters the grinding seat 12, it can cause extrusion on the Fructus Aurantii Immaturus materials. Then, after a quantitative extraction liquid is inhaled into the extraction liquid suction rubber head 13, the external thread connecting sleeve 17 is driven to be screwed into the internal thread hole 6. Then, the rotating shaft 3 and the grinding body 4 are driven to rotate by the rotating ball head 7. And with the cooperation of the grinding bumps 5 and the grinding seat 12, the Fructus Aurantii Immaturus materials can be quickly crushed and ground. Then, the extraction liquid suction rubber head 13 is squeezed so that a quantitative extraction liquid enters the extraction cylinder 1 through the liquid passing straw 18, and the crushed and ground Fructus Aurantii Immaturus materials are quickly soaked. And the soaked extraction liquid can pass through the filter holes 16 and be filtered into the liquid collecting hopper 11. And with the assistance of the through hole 14, it is ionized under the action of the ionization needle 15, and under the action of the external pressure supply device 10, it is ionized and atomized and sprayed out through the ionization needle 15 for detection by the mass spectrometer.

[0039] Embodiment 2

[0040] On the basis of Embodiment 1, the present utility model is as Figures 1-2As shown, the lower end of the extraction cylinder 1 is fixedly connected to the support leg 8, and the bottom of the support leg 8 is fixedly connected to the support bottom plate 9.

[0041] Through the arrangement of the support leg 8 and the support bottom plate 9 in this technical solution, the device can be stably placed when not in use, which facilitates people's use.

[0042] Working principle: Through the setting of the extraction cylinder 1, the Fructus Aurantii materials to be broken are placed in the grinding seat 12 inside it. Then, the sealing cover 2 is screwed into the upper end of the extraction cylinder 1. When the grinding body 4 enters the grinding seat 12, it can exert pressure on the Fructus Aurantii materials. Then, after the extraction liquid suction rubber head 13 sucks in a certain amount of extraction liquid, the external thread connecting sleeve 17 is driven to be screwed into the internal thread hole 6. Then, the rotating shaft 3 and the grinding body 4 are driven to rotate by the rotating ball head 7. And with the cooperation of the grinding convex block 5 and the grinding seat 12, the Fructus Aurantii materials can be quickly broken and ground. Then, the extraction liquid suction rubber head 13 is squeezed so that a certain amount of extraction liquid enters the extraction cylinder 1 through the liquid passing suction pipe 18, and quickly soaks the ground and broken Fructus Aurantii materials. The soaked extraction liquid can pass through the filter holes 16 and enter the liquid collecting hopper 11, and with the assistance of the through hole 14, it is ionized under the action of the ionization needle 15, and under the action of the external pressure supply device 10, it is ionized and atomized, and is sprayed out through the ionization needle 15 to the mass spectrometer for detection. Through the arrangement of the support leg 8 and the support bottom plate 9, the device can be stably placed when not in use, which facilitates people's use.

[0043] Importantly, it should be noted that the construction and arrangement of the present application shown in multiple different exemplary embodiments are merely illustrative. Although only a few embodiments are described in detail in this disclosure, those who refer to this disclosure should easily understand that many modifications are possible without materially departing from the novel teachings and advantages of the subject matter described in this application (e.g., changes in the dimensions, scales, structures, shapes and proportions of various elements, as well as parameter values (such as temperature, pressure, etc.), installation arrangements, use of materials, colors, orientations, etc.). For example, an element shown as integrally formed may be composed of multiple parts or elements, the position of the element may be inverted or otherwise changed, and the nature, number or position of discrete elements may be altered or changed. Accordingly, all such modifications are intended to be included within the scope of the present utility model. The order or sequence of any process or method steps may be changed or reordered according to alternative embodiments. In the claims, any clause of "means-plus-function" is intended to cover the structures that perform the recited function herein, and not only structural equivalents but also equivalent structures. Other substitutions, modifications, changes and omissions may be made in the design, operating conditions and arrangement of the exemplary embodiments without departing from the scope of the present utility model. Therefore, the present utility model is not limited to a particular embodiment, but extends to various modifications that still fall within the scope of the appended claims.

[0044] In addition, in order to provide a concise description of the exemplary embodiments, all features of the actual embodiments may not be described (i.e., those features that are not relevant to the currently contemplated best mode of carrying out the present utility model or those features that are not relevant to the implementation of the present utility model).

[0045] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present utility model, rather than to limit the protection scope of the present utility model. Although the present utility model has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present utility model can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present utility model.

Claims

1. A sample processing device for mass spectrometry detection, comprising an extraction cartridge (1), characterized in that: The upper end of the extraction cylinder (1) is threadedly connected to a sealing cover (2); an internal threaded hole (6) is provided on the front of the sealing cover (2); an external threaded connection sleeve (17) is threadedly connected to the inner side of the internal threaded hole (6); a liquid-passing suction tube (18) is fixedly connected to the inner side of the external threaded connection sleeve (17); the right end of the liquid-passing suction tube (18) is connected to an extraction liquid suction rubber head (13); the middle end of the top of the sealing cover (2) is movably connected to a rotating shaft (3) through a bearing; the bottom of the rotating shaft (3) is fixedly connected to a grinding body (4); a grinding protrusion (5) is provided on the outer surface of the grinding body (4); a rotating ball head (7) is provided on the top of the rotating shaft (3); the inner cavity of the extraction cylinder (1) is fixedly connected to a grinding seat (12) and a liquid collecting bucket (11) in sequence from top to bottom; a filtering hole (16) is provided on the inner surface of the grinding seat (12).

2. A sample processing device for mass spectrometry detection according to claim 1, characterized in that: A pressure supply device (10) is provided at the lower end of the rear side of the extraction cylinder (1), an ionization needle (15) is provided on the inner surface of the lower end of the liquid collecting bucket (11), and a through hole (14) is provided at the upper end of the ionization needle (15).

3. A sample processing device for mass spectrometry detection according to claim 1, characterized in that: The grinding body (4) and the grinding seat (12) are matched, and the lower end of the grinding body (4) is in a hemispherical structure.

4. A sample processing device for mass spectrometry detection according to claim 1, characterized in that: The material of the extraction liquid suction rubber head (13) is transparent silica gel, and the material of the liquid passing straw (18) is polycarbonate.

5. The sample processing device for mass spectrometry detection according to claim 1, characterized in that: The number of the grinding protrusions (5) is plural, and the grinding protrusions (5) are of a hemispherical structure.

6. A sample processing device for mass spectrometry detection according to claim 1, characterized in that: The number of the filter holes (16) is multiple, and the angles between two adjacent filter holes (16) are equal.

7. A sample processing device for mass spectrometry detection according to claim 1, characterized in that: The lower end of the extraction cylinder (1) is fixedly connected to a support leg (8), and the bottom of the support leg (8) is fixedly connected to a support base plate (9).

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