Pressure-controllable solid-phase extraction device convenient for batch treatment

Abstract

The utility model relates to the technical field of solid-phase extraction, and discloses a pressure-controllable solid-phase extraction device convenient for batch treatment, which comprises a box body, a liquid box is fixedly connected to the upper surface of the box body, a sealing cover is arranged on the upper surface of the liquid box, a conveying pipe is arranged in the box body, a liquid guide head is arranged on the side wall of the conveying pipe, and a liquid outlet is formed in the side wall of the liquid guide head. A mounting plate is fixedly connected to the interior of the box body, an extraction column is fixedly connected to the interior of the mounting plate, a first adjusting valve is arranged on the side wall of the extraction column, a fixing frame is arranged in the box body, and an auxiliary assembly is arranged on the side wall of the fixing frame and used for assisting sliding of the fixing frame. According to the device, the rotating block is rotated, then the pressing block is pressed, the first fixing block slides into the groove, the rotating strip is attached to the side wall of the fixing shell, the first fixing column slides downwards, the spring is squeezed and contracted, then the fixing shell is taken out of the mounting plate, the quick dismounting effect is achieved, and the practicability of the device is improved through the structure.

Description

Technical Field

[0001] The utility model relates to the technical field of solid-phase extraction, in particular to a controllable-pressure solid-phase extraction device convenient for batch processing. Background Art

[0002] A solid-phase extraction device is a technique commonly used for sample pretreatment. It uses a solid adsorbent to adsorb target compounds in a liquid sample, thereby achieving separation from the sample matrix and interfering compounds. Subsequently, through elution with an eluent or thermal desorption, the purpose of separating and enriching the target compounds is achieved. A controllable-pressure solid-phase extraction device aims to process multiple samples and ensure the stability and controllability of pressure during the operation. Such devices usually include an automated sample processing and injection system that can precisely control the loading and flow rate of the sample. The pressure control part ensures the uniformity and stability inside the solid-phase column during the extraction process, thereby improving the consistency and efficiency of sample processing.

[0003] A traditional controllable-pressure solid-phase extraction device convenient for batch processing consists of parts such as an extraction unit, a pump control system, and an elution unit. The sample solution is slowly passed through a small column fixed with solid-phase extraction material by the pump control system under a constant negative pressure, so that the target analyte in the sample is adsorbed onto the solid-phase material. The system pressure is changed, and a positive pressure elution is performed on the small column using another solvent or solvent mixture to release the target analyte from the solid-phase material. The eluate is collected through the elution unit for subsequent analysis and detection.

[0004] For a traditional controllable-pressure solid-phase extraction device convenient for batch processing, since it is an integrated design, it is rather troublesome to take and place the collection tube, and it is inconvenient to clean its interior. Therefore, a controllable-pressure solid-phase extraction device convenient for batch processing is proposed to solve the above problems. Content of the Utility Model

[0005] In order to make up for the above deficiencies, the utility model provides a controllable-pressure solid-phase extraction device convenient for batch processing, aiming to improve the problems in the prior art that due to the integrated design, it is rather troublesome to take and place the collection tube and it is inconvenient to clean its interior.

[0006] In order to achieve the above purpose, the utility model adopts the following technical scheme:

[0007] A solid-phase extraction device with controllable pressure for facilitating batch processing, comprising a box body. A liquid box is fixedly connected to the upper surface of the box body. A sealing cover is arranged on the upper surface of the liquid box. A conveying pipe is arranged inside the box body. A liquid guiding head is arranged on the side wall of the conveying pipe. An installation plate is fixedly connected inside the box body. An extraction column is fixedly connected inside the installation plate. A regulating valve I is arranged on the side wall of the extraction column. A fixing frame is arranged inside the box body. An auxiliary component is arranged on the side wall of the fixing frame for assisting in sliding and fixing the fixing frame. A collecting pipe is arranged inside the fixing frame. A fixing outer shell is slidably connected inside the installation plate. A rotating block is threadedly connected to the side wall of the fixing outer shell. The side wall of the rotating block fits the upper surface of the installation plate. A pressing block is slidably connected inside the fixing outer shell. A fixing block I is fixedly connected to the side wall of the pressing block. The side wall of the fixing block I is slidably connected inside the fixing outer shell. A rotating bar is rotatably connected to the side wall of the fixing block I. The side wall of the rotating bar fits the side wall of the box body. A conical head is fixedly connected to the lower surface of the fixing outer shell. A groove is opened inside the conical head. The side wall of the fixing block I is slidably connected inside the groove. A fixing column I is fixedly connected to the lower surface of the pressing block. A spring is sleeved on the side wall of the fixing column I. One end of the spring is fixedly connected inside the conical head, and the other end of the spring is fixedly connected to the side wall of the pressing block;

[0008] As a further description of the above technical solution:

[0009] A fixing column II is arranged inside the box body. A rack column is slidably connected inside the fixing column II. One end of the rack column is fixedly connected to the bottom of the fixing frame;

[0010] As a further description of the above technical solution:

[0011] The auxiliary component includes a slider. The side wall of the slider is fixedly connected to the side wall of the fixing frame. The side wall of the slider is slidably connected to the inner wall of the box body;

[0012] As a further description of the above technical solution:

[0013] A vacuum pump is fixedly connected to the side wall of the box body. A connecting pipe is fixedly connected to the upper surface of the vacuum pump. One end of the connecting pipe is fixedly connected inside the box body. A regulating valve II is arranged on the side wall of the connecting pipe;

[0014] As a further description of the above technical solution:

[0015] A push rod is fixedly connected inside the box body. A rack block is fixedly connected to the output end of the push rod;

[0016] As a further description of the above technical solution:

[0017] A fixed block two is fixedly connected inside the box body, and a rotating column is rotatably connected inside the fixed block two;

[0018] As a further description of the above technical solution:

[0019] A driving gear is fixedly connected to the side wall of the rotating column, and the driving gear meshes with the rack block;

[0020] As a further description of the above technical solution:

[0021] A driven gear is fixedly connected to the side wall of the rotating column, and the driven gear meshes with the rack column.

[0022] The utility model has the following beneficial effects:

[0023] 1. In the utility model, by rotating the rotating block and then pressing the pressing block, the fixed block one slides into the groove, making the rotating bar fit against the side wall of the fixed shell, causing the fixed column one to slide down, squeezing and contracting the spring, and then taking out the fixed shell from the installation plate to achieve a quick disassembly effect, solving the problem that for some controllable pressure solid phase extraction devices that are convenient for batch processing and are integrally designed, it is rather troublesome to take and place the collection tube and it is inconvenient to clean the inside. Through the above structure, the practicability of the equipment is improved.

[0024] 2. In the utility model, by starting the push rod to push the rack block, the driving gear rotates, and then drives the driven gear to rotate, causing the rack column to slide, achieving the effect of adjusting the height of the fixed frame, solving the problem that for some controllable pressure solid phase extraction devices that are convenient for batch processing, the distance between the collection tube and the extraction column cannot be adjusted according to the length of the collection tube. Through the above structure, the practicability of the equipment is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 is a three-dimensional schematic diagram of a controllable pressure solid phase extraction device convenient for batch processing proposed by the utility model;

[0026] Figure 2 is a schematic structural diagram of a cross-section of a controllable pressure solid phase extraction device convenient for batch processing proposed by the utility model;

[0027] Figure 3 is a schematic structural diagram of a fixed shell part of a controllable pressure solid phase extraction device convenient for batch processing proposed by the utility model;

[0028] Figure 4 is a schematic structural diagram of the bottom of a fixed frame of a controllable pressure solid phase extraction device convenient for batch processing proposed by the utility model.

[0029] Legend Explanation:

[0030] 1. Box body; 2. Liquid tank; 3. Sealing cover; 4. Mounting plate; 5. Delivery pipe; 6. Liquid guide head; 7. Extraction column; 8. First regulating valve; 9. Vacuum pump; 10. Connecting pipe; 11. Second regulating valve; 12. Fixed bracket; 13. Collection pipe; 14. Fixed housing; 15. Rotating block; 16. Pressing block; 17. Conical head; 18. Groove; 19. First fixing block; 20. Rotating bar; 21. First fixing column; 22. Spring; 23. Slide block; 24. Second fixing block; 25. Rotating column; 26. Driving gear; 27. Driven gear; 28. Second fixing column; 29. Rack column; 30. Rack block; 31. Push rod. Detailed implementation manner

[0031] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0032] Refer to Figures 1 - 3, an embodiment provided by the present utility model: a solid-phase extraction device with controllable pressure for facilitating batch processing, comprising a box body 1, a liquid box 2 fixedly connected to the upper surface of the box body 1, a sealing cover 3 arranged on the upper surface of the liquid box 2, a conveying pipe 5 arranged inside the box body 1, a liquid guiding head 6 arranged on the side wall of the conveying pipe 5, a mounting plate 4 fixedly connected inside the box body 1, an extraction column 7 fixedly connected inside the mounting plate 4, a first regulating valve 8 arranged on the side wall of the extraction column 7, a fixing frame 12 arranged inside the box body 1, an auxiliary component arranged on the side wall of the fixing frame 12 for assisting in sliding and fixing the fixing frame 12, a collecting pipe 13 arranged inside the fixing frame 12, a fixing outer shell 14 slidably connected inside the mounting plate 4, a rotating block 15 threadedly connected to the side wall of the fixing outer shell 14, the side wall of the rotating block 15 being attached to the upper surface of the mounting plate 4, a pressing block 16 slidably connected inside the fixing outer shell 14, a first fixing block 19 fixedly connected to the side wall of the pressing block 16, the side wall of the first fixing block 19 being slidably connected inside the fixing outer shell 14, a rotating bar 20 rotatably connected to the side wall of the first fixing block 19, the side wall of the rotating bar 20 being attached to the side wall of the box body 1, a conical head 17 fixedly connected to the lower surface of the fixing outer shell 14, a groove 18 opened inside the conical head 17, the side wall of the first fixing block 19 being slidably connected inside the groove 18, a first fixing column 21 fixedly connected to the lower surface of the pressing block 16, a spring 22 sleeved on the side wall of the first fixing column 21, one end of the spring 22 being fixedly connected inside the conical head 17 and the other end of the spring 22 being fixedly connected to the side wall of the pressing block 16, the auxiliary component comprising a slider 23, the side wall of the slider 23 being fixedly connected to the side wall of the fixing frame 12, the side wall of the slider 23 being slidably connected to the inner wall of the box body 1, a vacuum pump 9 fixedly connected to the side wall of the box body 1, a connecting pipe 10 fixedly connected to the upper surface of the vacuum pump 9, one end of the connecting pipe 10 being fixedly connected inside the box body 1, and a second regulating valve 11 arranged on the side wall of the connecting pipe 10;

[0033] During the solid-phase extraction operation, first, the liquid in the liquid tank 2 is introduced through the delivery pipe 5, then guided through the liquid guide head 6 and enters the extraction column 7 respectively. Next, the vacuum pump 9 is started, and the pressure inside the box 1 is adjusted by adjusting the second regulating valve 11. After the adjustment is completed, the liquid that has completed the extraction in the extraction column 7 is slowly discharged by adjusting the first regulating valve 8 and finally flows into the collection pipe 13. After the extraction operation is completed, the vacuum pump 9 needs to be turned off, and the collection pipe 13 is taken out for the next operation. When the box 1 needs to be disassembled, first operate the rotating block 15 to separate it from the mounting plate 4. Then, press the pressing block 16, which will cause the pressing block 16 together with the first fixing column 21 to enter the inside of the conical head 17 under the sliding action of the fixed housing 14. This action will deform and contract the spring 22, and at the same time, the rotating bar 20 will also be squeezed and rotated, and then enter the inside of the groove 18. At this time, the side wall of the rotating bar 20 is closely attached to the side wall of the fixed housing 14, so that the fixed housing 14 can be safely taken out to realize the separation of the box 1. When installing the box 1, first ensure that the box 1 is aligned, then press the pressing block 16, so that the pressing block 16 together with the first fixing column 21 slides through the fixed housing 14 and enters the inside of the conical head 17. Once again, the spring 22 is deformed and contracted, and at the same time, the rotating bar 20 is squeezed and rotated and enters the inside of the groove 18, so that the side wall of the rotating bar 20 can closely adhere to the side wall of the fixed housing 14. At this time, the conical head 17 is passed through the mounting plate 4 and through the side wall of the box 1. After releasing the pressing block 16, due to the spring 22 returning to its original state, it will push the pressing block 16 upward, causing the rotating bar 20 to disengage from the groove 18 and unfold. At this time, the side wall of the rotating bar 20 is closely attached to the side wall of the box 1. Finally, by rotating the rotating block 15, it is rotated to the surface of the mounting plate 4 and closely attached to it, completing the installation work between the boxes 1.

[0034] Referring to Figure 4 , a second fixing column 28 is arranged inside the box 1. A rack column 29 is slidably connected inside the second fixing column 28. One end of the rack column 29 is fixedly connected to the bottom of the fixing frame 12. A push rod 31 is fixedly connected inside the box 1. The output end of the push rod 31 is fixedly connected to a rack block 30. A second fixing block 24 is fixedly connected inside the box 1. A rotating column 25 is rotatably connected inside the second fixing block 24. A driving gear 26 is fixedly connected to the side wall of the rotating column 25. The driving gear 26 meshes with the rack block 30. A driven gear 27 is fixedly connected to the side wall of the rotating column 25. The driven gear 27 meshes with the rack column 29.

[0035] In the situation where the height of different collection tubes 13 needs to be adjusted, the operator will first activate the push rod 31. By starting the push rod 31, the rack block 30 will start to slide. The sliding of the rack block 30 is driven by the pushing force of the push rod 31. The rack block 30 is meshed with the driving gear 26. Therefore, when the rack block 30 slides, the driving gear 26 will also rotate accordingly. The rotation of the driving gear 26 will transmit power to the rotating column 25, causing the rotating column 25 to also start rotating. The rotating column 25 is connected to the driven gear 27. Therefore, the driven gear 27 will also rotate with the rotation of the rotating column 25. The driven gear 27 is meshed with the rack column 29. Therefore, when the driven gear 27 rotates, the rack column 29 will also slide accordingly. The sliding of the rack column 29 will drive the fixing frame 12 to slide inside the box body 1. In this way, the height of the collection tube 13 can be adjusted to meet different usage requirements.

[0036] Working principle: When performing solid-phase extraction using this device, first, the liquid inside the liquid tank 2 flows into the inside of the conveying pipe 5, and then flows into the inside of the extraction column 7 through the liquid guiding head 6 respectively. By starting the vacuum pump 9 and then adjusting the pressure inside the box body 1 through the regulating valve II 11, subsequently, by adjusting the regulating valve I 8, the liquid that has completed extraction inside the extraction column 7 slowly flows down and finally falls into the inside of the collection pipe 13. After the extraction is completed, turn off the vacuum pump 9, and finally take out the collection pipe 13. When it is necessary to disassemble the box body 1, first rotate the rotating block 15 to separate it from the mounting plate 4, then press the pressing block 16, so that the pressing block 16 drives the fixing column I 21 to slide into the inside of the conical head 17 through the fixing housing 14, causing the spring 22 to deform and contract. At the same time, the rotating bar 20 is squeezed and rotated into the inside of the groove 18, making the side wall of the rotating bar 20 fit the side wall of the fixing housing 14. At this time, the fixing housing 14 can be taken out, and then the box body 1 can be separated. When it is necessary to install the box body 1, first align the box body 1, and then press the pressing block 16. Press the pressing block 16, so that the pressing block 16 drives the fixing column I 21 to slide into the inside of the conical head 17 through the fixing housing 14, causing the spring 22 to deform and contract. At the same time, the rotating bar 20 is squeezed and rotated into the inside of the groove 18, making the side wall of the rotating bar 20 fit the side wall of the fixing housing 14. At this time, then pass the conical head 17 through the mounting plate 4 and then through the side wall of the box body 1, and then release the pressed pressing block 16. At this time, since the spring 22 loses pressure and resumes its original shape, it pushes the pressing block 16 upward, causing the rotating bar 20 to disengage from the groove 18 and expand, making the side wall of the rotating bar 20 fit the side wall of the box body 1. At this time, by rotating the rotating block 15 and rotating it to the surface of the mounting plate 4 to fit with it, the installation between the box bodies 1 is completed. When it is necessary to adjust the height of different collection pipes 13, first start the push rod 31 to make it push the rack block 30 to slide, thereby causing the driving gear 26 meshing with it to rotate. By the rotation of the driving gear 26, the rotating column 25 rotates, thereby driving the driven gear 27 to rotate, causing the rack column 29 meshing with it to slide, and then driving the fixing frame 12 to slide inside the box body 1 to achieve the effect of adjusting its height.

[0037] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A pressure-controlled solid phase extraction device for batch processing, comprising a housing (1), characterized in that: The upper surface of the box body (1) is fixedly connected to a liquid box (2), the upper surface of the liquid box (2) is provided with a sealing cover (3), the interior of the box body (1) is provided with a delivery pipe (5), the side wall of the delivery pipe (5) is provided with a liquid guide head (6), the interior of the box body (1) is fixedly connected to a mounting plate (4), the interior of the mounting plate (4) is fixedly connected to an extraction column (7), the side wall of the extraction column (7) is provided with a regulating valve (8), the interior of the box body (1) is provided with a fixed frame (12), the side wall of the fixed frame (12) is provided with an auxiliary component for assisting the sliding of the fixed frame (12), the interior of the fixed frame (12) is provided with a collecting pipe (13), the interior of the mounting plate (4) is slidably connected to a fixed outer shell (14), the side wall of the fixed outer shell (14) is threadedly connected to a rotating block (15), the side wall of the rotating block (15) is in contact with the upper surface of the mounting plate (4), and the fixed outer shell (14) is threadedly connected to a rotating block (15), the side wall of the rotating block (15) is in contact with the upper surface of the mounting plate (4), and the fixed outer shell (14) is threadedly connected to a rotating block (15). A pressing block (16) is slidably connected inside the shell (14); a fixed block (19) is fixedly connected to the side wall of the pressing block (16); the side wall of the fixed block (19) is slidably connected inside the fixed shell (14); a rotating bar (20) is rotatably connected to the side wall of the fixed block (19); the side wall of the rotating bar (20) fits the side wall of the box body (1); a conical head (17) is fixedly connected to the lower surface of the fixed shell (14); a groove (18) is provided inside the conical head (17); the side wall of the fixed block (19) is slidably connected inside the groove (18); a fixed column (21) is fixedly connected to the lower surface of the pressing block (16); a spring (22) is sleeved on the side wall of the fixed column (21); one end of the spring (22) is fixedly connected to the inside of the conical head (17); the other end of the spring (22) is fixedly connected to the side wall of the pressing block (16).

2. A pressure-controlled solid phase extraction device convenient for batch processing according to claim 1, characterized in that: A second fixing column (28) is arranged inside the box body (1), a rack column (29) is slidably connected inside the second fixing column (28), and one end of the rack column (29) is fixedly connected to the bottom of the fixing frame (12).

3. The pressure-controlled solid phase extraction device for batch processing according to claim 1, characterized in that: The auxiliary component comprises a slider (23), the side wall of the slider (23) being fixedly connected to the side wall of the fixing frame (12), and the side wall of the slider (23) being slidably connected to the inner wall of the box body (1).

4. The pressure-controlled solid phase extraction device for batch processing according to claim 1, characterized in that: A vacuum pump (9) is fixedly connected to the side wall of the box body (1), a connecting pipe (10) is fixedly connected to the upper surface of the vacuum pump (9), one end of the connecting pipe (10) is fixedly connected to the inside of the box body (1), and a regulating valve 2 (11) is provided on the side wall of the connecting pipe (10).

5. The pressure-controlled solid phase extraction device for batch processing according to claim 1, characterized in that: A push rod (31) is fixedly connected inside the box body (1), and a rack block (30) is fixedly connected to the output end of the push rod (31).

6. The pressure-controlled solid phase extraction device for batch processing according to claim 5, characterized in that: A second fixing block (24) is fixedly connected inside the box body (1), and a rotating column (25) is rotatably connected inside the second fixing block (24).

7. A pressure-controlled solid phase extraction device for batch processing according to claim 6, characterized in that: A driving gear (26) is fixedly connected to the side wall of the rotating column (25), and the driving gear (26) is meshed with the rack block (30).

8. The pressure-controlled solid phase extraction device for batch processing according to claim 7, characterized in that: A driven gear (27) is fixedly connected to the side wall of the rotating column (25), and the driven gear (27) is meshed with the rack column (29).

Images