Fixator of mouse aerosolization device and mouse aerosolization device

Abstract

The embodiment of the utility model relates to a fixing device of a mouse aerosolization device and the mouse aerosolization device, a mouse can be easily induced to enter the inlet end of a tube body through the tube body, and meanwhile, due to the fact that the thickness of the tube body conforms to the shape of the mouse, the mouse can be prevented from returning to the inlet end, and it is guaranteed that the head of the mouse faces the administration end of the tube body; a through hole is formed in the medicine feeding end of the tube body, atomized medicine can be injected through the through hole, and the diameter of the through hole is designed to enable most atomizers to be inserted, but mice cannot pass through the through hole easily. Therefore, the mouse fixer and the mouse aerosolization device provided by the embodiment of the utility model can facilitate the operation of an aerosolization experiment of the mouse, and are simple in structure, low in cost and easy to industrialize.

Description

Technical Field

[0001] The present application relates to the technical field of scientific research auxiliary equipment, and in particular to a fixer for a mouse atomization drug delivery device and a mouse atomization drug delivery device. Background Art

[0002] Nebulizer drug delivery is an emerging drug delivery method. After being atomized, the drug can reach the micron level and be inhaled into the lungs through the nasal cavity to take effect. The nasal cavity and lungs are rich in capillaries, and the drug utilization rate is high, which is close to the efficiency of intravenous injection. In addition, this drug delivery method is active inhalation, which avoids physiological pain and does not have the risk of secondary infection caused by repeated use of drug delivery equipment. Nebulizer drug delivery can directly act on the bronchi and alveoli and is used to treat various respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), bronchitis, etc. In the field of prevention of infectious diseases, vaccines can activate the mucosal immune system of the nasal cavity and lungs through this route of administration, enhance the first barrier of immunity, and have a significant preventive effect on pathogens transmitted through the respiratory tract, such as influenza virus and respiratory syncytial virus.

[0003] Although the research on nebulizer drug delivery devices for clinical trials has been in-depth and has made great breakthroughs, nebulizer drug delivery devices for preclinical mouse experiments are still rare. The nebulizer devices used for aerosol exposure infection tests on the market have disadvantages such as high instrument cost, large device size, and large amount of drug filling before nebulization. When these nebulizer devices are used to administer drugs to mice, the drug delivery efficiency is low and the dosage is difficult to accurately control; cross-contamination is easy to occur between different drug delivery groups, affecting the accuracy of animal experiments. When small portable nebulizers for humans are used to administer drugs to mice, the nebulized drugs spread quickly, the mouse inhalation efficiency is low, and there is no effective device to receive the nebulized gas and fix the mice. Utility Model Content

[0004] In view of this, the embodiments of the present application provide a fixer for a mouse aerosol drug administration device and a mouse aerosol drug administration device to solve the problem of difficulty in mouse aerosol drug administration experiments in the background technology.

[0005] In a first aspect, an embodiment of the present application provides a fixer for a mouse aerosol drug delivery device, comprising:

[0006] A tube body, wherein two ends of the tube body are respectively an inlet end and a drug delivery end, the inlet end of the tube body has an inlet for mice to drill into, and the drug delivery end of the tube body has a through hole for the spray end of the nebulizer to be inserted;

[0007] A cover body, detachably connected to the inlet end of the tube body, for closing the inlet;

[0008] The length of the tube body is greater than or equal to the body length of the mouse, the inner diameter of the tube body is greater than or equal to the body width of the mouse but less than the body length of the mouse, and the diameter of the through hole is less than the body width of the mouse.

[0009] Combined with the first aspect of the present application, in an alternative embodiment, the diameter of the tube body is 20 mm to 40 mm; the diameter of the through hole is 5 mm to 10 mm.

[0010] Combined with the first aspect of the present application, in an alternative embodiment, the drug delivery end is a conical drug delivery end, and the through hole is located at the tip of the conical drug delivery end.

[0011] Combined with the first aspect of the present application, in an alternative embodiment, the side wall of the inlet end has an external thread, the inner wall of the cover body has an internal thread, and the cover body is threadedly connected to the side wall of the inlet end.

[0012] Combined with the first aspect of the present application, in an alternative embodiment, the outer side wall of the cover body has anti-slip textures.

[0013] Combined with the first aspect of the present application, in an alternative embodiment, the drug delivery end corresponds to the head position of the mouse, and at least the material of the drug delivery end of the tube body is a transparent or semi-transparent material.

[0014] Combined with the first aspect of the present application, in an alternative embodiment, all the materials of the tube body are transparent or semi-transparent materials.

[0015] Combined with the first aspect of the present application, in an alternative embodiment, a number of protruding points are distributed on the inner wall of the tube body.

[0016] Combined with the first aspect of the present application, in an alternative embodiment, a number of recessed points are distributed on the inner wall of the tube body.

[0017] In a second aspect, an embodiment of the present application provides a mouse atomization drug delivery device, including a holder of the mouse atomization drug delivery device described in the first aspect, and an atomizer; the spray end of the atomizer can be inserted into the through hole.

[0018] The holder of the mouse atomization drug delivery device and the mouse atomization drug delivery device provided by the embodiments of the present application can easily induce a mouse to drill into the inlet end of the tube body through the tube body. At the same time, since the thickness of the tube body conforms to the body shape of the mouse, it can prevent the mouse from returning to the inlet end and ensure that the mouse's head faces the drug delivery end of the tube body; a through hole is opened at the drug delivery end of the tube body, and an atomized medicament can be injected through the through hole. The diameter of the through hole is designed so that most atomizers can be inserted, but it is difficult for the mouse to pass through. Therefore, the mouse holder and the mouse atomization drug delivery device provided by the embodiments of the present application can facilitate the experimental operation of mouse atomization drug delivery, and have a simple structure, low cost, and are easy to industrialize.

[0019] Additional aspects and advantages of the present application will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The drawings described herein are used to provide a further understanding of the present application and form a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation of the present application. In the drawings:

[0021] Figure 1 Schematic structural diagram of the holder of the mouse atomization drug delivery device provided in Embodiment 1 of the present application;

[0022] Figure 2 Schematic diagram of the component composition of the holder of the mouse atomization drug delivery device provided in Embodiment 1 of the present application;

[0023] Figure 3 Schematic diagram of a partial cross-section of the usage state of the holder of the mouse atomization drug delivery device provided in Embodiment 1 of the present application;

[0024] Figure 4 Schematic diagram of the inner wall structure of the tube of the holder of the mouse atomization drug delivery device provided in Embodiment 2 of the present application.

[0025] The reference numerals in the drawings are:

[0026] Tube body 1; cover body 2; inlet end 11; drug delivery end 12; through hole 13; protruding point 14. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0027] In order to make the technical solutions and beneficial effects of the present utility model more obvious and understandable, the following will be described in detail by way of specific embodiments. Among them, the drawings are not necessarily drawn to scale, and local features may be enlarged or reduced to more clearly show the details of the local features; unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical and scientific fields to which the present application belongs.

[0028] In the description of the present utility model, the orientation or positional relationship indicated by terms such as "center", "longitudinal", "lateral", "length", "width", "thickness", "height", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of simplifying the description of the present utility model, rather than indicating that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, that is, it cannot be understood as a limitation of the present utility model.

[0029] In the present utility model, the terms "first" and "second" are only used for the purpose of clear description, and cannot be understood as the relative importance of the indicated features or the quantity of the indicated technical features. Therefore, the features defined with "first" and "second" may clearly include at least one such feature. In the description of the present utility model, the meaning of "a plurality of" is at least two, such as two, three, etc.; the meaning of "several" is at least one, such as one, two, three, etc., unless otherwise clearly and specifically defined.

[0030] In the present utility model, unless otherwise clearly defined, terms such as "installed", "connected", "joined", "fixed", "set", etc. shall be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and can also be the communication inside two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0031] In the present utility model, unless otherwise clearly defined, the first feature being "on", "above", "over", "upward", "above", "below", "beneath", "downward", or "under" the second feature can be that the first feature is in direct contact with the second feature, or the first feature and the second feature are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "over", or "upward" the second feature can be that the first feature is directly above or obliquely above the second feature, or merely indicates that the horizontal height of the first feature is higher than the horizontal height of the second feature. The first feature being "below", "beneath", or "downward" the second feature can be that the first feature is directly below or obliquely below the second feature, or merely indicates that the horizontal height of the first feature is lower than the horizontal height of the second feature.

[0032] In order to thoroughly understand the present application, detailed steps and detailed structures will be presented in the following description to explain the technical solution of the present application. The preferred embodiments of the present application are described in detail as follows. However, in addition to these detailed descriptions, the present application may also have other implementation manners.

[0033] This embodiment provides a holder for a mouse atomization drug delivery device, as Figure 1 , Figure 2As shown in the figure, it includes a tube body 1 and a cover body 2. The two ends of the tube body 1 are respectively an inlet end 11 and a drug administration end 12. There is an inlet at the inlet end 11 of the tube body 1 for a mouse to drill into, and the drug administration end 12 of the tube body 1 has a through hole 13 for the spray end of the nebulizer 3 to be inserted. The cover body 2 is detachably connected to the inlet end 11 of the tube body 1 for closing the inlet. Among them, the tube body 1 refers to a tubular and hollow member, and the space inside the tube body 1 can accommodate a mouse. The length of the tube body 1 is greater than or equal to the body length of the mouse, the inner diameter of the tube body 1 is greater than or equal to the body width of the mouse but less than the body length of the mouse, and the diameter of the through hole 13 is less than the body width of the mouse.

[0034] The fixer of the mouse atomization drug administration device provided by the embodiment of the present application can easily induce the mouse to drill into the inlet end 11 of the tube body 1 through the tube body 1. At the same time, since the thickness of the tube body 1 conforms to the body shape of the mouse, it can prevent the mouse from returning to the inlet end 11 and ensure that the mouse's head faces the drug administration end 12 of the tube body 1. A through hole 13 is opened at the drug administration end 12 of the tube body 1, and atomized medicine can be injected through the through hole 13. The diameter of the through hole 13 is designed so that most nebulizers can be inserted, but it is difficult for the mouse to pass through. Therefore, the mouse fixer provided by the embodiment of the present application can facilitate the atomization drug administration experiment operation of the mouse, and has a simple structure, low cost and is easy to industrialize.

[0035] The embodiment of the present application provides an operation method for the fixer, including the following steps:

[0036] Take the mouse fixer, open the cover body 2, hold the tube body 1 by hand, send the head of the mouse into the inlet end 11 of the tube body 1, and make the mouse drill into the inlet;

[0037] When the mouse drills in a sufficient distance, close the cover body 2 at the inlet end 11 of the tube body 1;

[0038] Take the pre-prepared nebulizer 3 filled with medicine, as Figure 3 shown, hold the tube body 1 with the mouse by one hand, at this time the head of the mouse faces the drug administration end 12, hold the nebulizer 3 with the other hand, insert the spray end of the nebulizer 3 into the through hole 13, and then press the start key of the nebulizer 3 to complete the drug administration;

[0039] The volume of the tube body 1 is small, and the mouse can inhale enough atomized gas in the tube body 1 in a short time, and the time required for the experiment is less, which improves the experimental efficiency.

[0040] In an alternative embodiment, the diameter of the tube body 1 is 20 mm to 40 mm. Within this diameter range, mice of normal body size can all drill into the tube body 1, and it is not overly spacious, preventing the mice from turning around. The volume of the tube body 1 is also appropriate, avoiding excessive demand for atomized drugs and reducing experimental efficiency. The diameter of the through hole 13 is 5 mm to 10 mm. At this diameter, mice of normal body size cannot pass through the through hole 13, and most atomizers 3 on the market can insert their spray ends, with good adaptability.

[0041] In an alternative embodiment, as Figure 1 、 Figure 2 shown, the drug delivery end 12 is a conical drug delivery end, and the through hole 13 is located at the tip of the conical drug delivery end. In this solution, the conical drug delivery end 12 facilitates the processing of the through hole 13. For example, when manufacturing the tube body 1, the through hole is not directly processed at the drug delivery end 12, but the tube body is manufactured as a complete cone. Before subsequent experiments, a tip is cut off from the conical end of the tube body with a cutter or scissors, creating a through hole 13 at the conical drug delivery end 12. Therefore, designing the drug delivery end as conical can reduce manufacturing costs. In other embodiments, the tube body 1 can directly purchase a centrifuge tube, such as a 50 ml centrifuge tube, and cut off a tip from the conical end of the centrifuge tube to obtain the tube body 1 required in this embodiment, which can reduce procurement costs.

[0042] In an alternative embodiment, as Figure 1 、 Figure 2 shown, the side wall of the inlet end 11 has an external thread, the inner wall of the cover 2 has an internal thread, and the cover 2 is threadedly connected to the side wall of the inlet end 11. The threaded connection structure has good sealing performance, is convenient and reliable for disassembly and assembly, and is conducive to the operation of experimental personnel.

[0043] In an alternative embodiment, as Figure 1 、 Figure 2 shown, the outer side wall of the cover 2 has anti-slip texture, facilitating experimental personnel to tighten or loosen the cover 2 by hand.

[0044] In an alternative embodiment, the material of the tube body 1 is a transparent or semi-transparent material, so that experimental personnel can see the activity state of the mice and the diffusion state of the drug while administering the drug, and understand the drug administration effect. The material can be, for example: glass, polypropylene, polyethylene, polystyrene, polycarbonate, etc. It can be understood that in other embodiments, at least the material of the drug delivery end 12 of the tube body 1 can be a transparent or semi-transparent material.

[0045] This embodiment also provides a mouse atomized drug delivery device, as Figure 3 shown, including the mouse fixator described above, and an atomizer 3; the spray end of the atomizer 3 can be inserted into the through hole 13.

[0046] The mouse atomization drug delivery device provided by the embodiment of the present application can easily induce a mouse to drill into the inlet end 11 of the tube body 1 through the tube body 1. At the same time, since the thickness of the tube body 1 conforms to the body shape of the mouse, it can prevent the mouse from returning to the inlet end 11 and ensure that the mouse's head faces the drug delivery end 12 of the tube body 1. A through hole 13 is opened at the drug delivery end 12 of the tube body 1, and an atomized medicament can be injected through the through hole 13. The diameter of the through hole 13 is designed such that most atomizers can be inserted, but it is difficult for the mouse to pass through. Therefore, the mouse atomization drug delivery device provided by the embodiment of the present application is convenient for the atomization drug delivery experiment operation of the mouse, has a simple structure, low cost, and is easy to industrialize. The internal space of the tube body 1 of the device is relatively compact, the utilization rate of the drug inhaled by the mouse is high, and there is no need for excessive atomized drug, which is beneficial to the control of the atomization drug dosage. In addition, the tube body 1 and the cover body 2 of this embodiment can be produced or obtained at low cost. During the mouse experiment process, the tube body 1 and the cover body 2 can be frequently replaced between different experimental groups to avoid cross-contamination between different drug experimental groups and affect the experimental accuracy.

[0047] In an alternative embodiment, for the mouse atomization drug delivery device of this embodiment, the atomizer 3 is small and portable for manual operation.

[0048] In an alternative embodiment, for the mouse atomization drug delivery device of this embodiment, the inner wall contour of the through hole 13 is the same as the outer edge contour of the spray end of the atomizer 3, so that after the spray end of the atomizer 3 is inserted into the through hole 13, the connection stability and sealing performance between the tube body 1 and the atomizer 3 are better.

[0049] Embodiment 2

[0050] This embodiment provides a fixator for a mouse atomization drug delivery device, as Figure 4 shown. The difference between it and the fixator provided in Embodiment 1 is that a number of protruding points 14 are distributed on the inner wall of the tube body 1. The arrangement of the protruding points 14 can prompt the mouse to continue crawling deeper into the tube body 1 after drilling into the tube body 1, and the protruding points 14 can facilitate the mouse's claws to climb.

[0051] It can be understood that in other embodiments, as an alternative to the protruding points 14, a number of concave points can also be distributed on the inner wall of the tube body 1, and the arrangement of the concave points can also facilitate the mouse's claws to climb.

[0052] It can be understood that in other embodiments, the inner wall of the tube body 1 can also be subjected to frosted treatment, which can also facilitate the mouse's claws to climb.

[0053] It should be understood that the above embodiments are all exemplary and do not cover all possible implementation manners included in the claims. Without departing from the scope of the present disclosure, various deformations and changes can be made based on the above embodiments. Similarly, the technical features of the above embodiments can be arbitrarily combined to form additional embodiments of the present application that may not be explicitly described. Therefore, the above embodiments only represent several implementation manners of the present application and do not limit the protection scope of the patent of the present application.

Claims

1. A fixer for a mouse aerosol drug delivery device, characterized in that: include: A tube body (1), wherein two ends of the tube body (1) are an inlet end (11) and a drug delivery end (12), respectively; the inlet end (11) of the tube body (1) is provided with an inlet for a mouse to enter, and the drug delivery end (12) of the tube body (1) is provided with a through hole (13) for the spray end of an atomizer (3) to be inserted; A cover body (2) detachably connected to the inlet end (11) of the tube body (1) and used to close the inlet; The length of the tube body (1) is greater than or equal to the body length of the mouse, the inner diameter of the tube body (1) is greater than or equal to the body width of the mouse but smaller than the body length of the mouse, and the diameter of the through hole (13) is smaller than the body width of the mouse.

2. The fastener according to claim 1, characterized in that: The diameter of the tube body (1) is 20 mm to 40 mm; The diameter of the through hole (13) is 5 mm to 10 mm.

3. The fastener according to claim 1, characterized in that: The drug delivery end (12) is a conical drug delivery end, and the through hole (13) is located at the tip of the conical drug delivery end.

4. The fastener according to claim 1, characterized in that: The side wall of the inlet end (11) has an external thread, the inner wall of the cover body (2) has an internal thread, and the cover body (2) is threadedly connected to the side wall of the inlet end (11).

5. The fastener according to claim 1, characterized in that: The outer side wall of the cover body (2) has an anti-slip texture.

6. The fastener according to claim 1, characterized in that: The drug delivery end (12) corresponds to the position of the mouse's head, and the material of at least the drug delivery end (12) of the tube body (1) is a transparent or translucent material.

7. The fastener according to claim 6, characterized in that: The entire material of the tube body (1) is transparent or translucent material.

8. The fastener according to any one of claims 1 to 7, characterized in that: The inner wall of the tube body (1) is provided with a plurality of protruding points (14).

9. The fastener according to any one of claims 1 to 7, characterized in that: The inner wall of the tube body (1) is provided with a plurality of depressions.

10. A mouse atomization drug delivery device, characterized in that: It comprises a holder of the mouse aerosol drug delivery device as described in any one of claims 1 to 9, and a nebulizer (3); the spray end of the nebulizer (3) can be inserted into the through hole (13).

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