High performance liquid chromatographic column cleaning device

Abstract

The utility model relates to the technical field of liquid chromatographic columns, in particular to a high-performance liquid chromatographic column cleaning device which comprises a liquid storage barrel, a first-stage waste liquid barrel, a second-stage waste liquid barrel, a first flushing head, a second flushing head, a clamping assembly and a transfer mechanism, the liquid storage barrel is provided with a first pump body, and the first-stage waste liquid barrel is provided with a second pump body; the clamping assembly is driven by the transfer mechanism and is provided with a loading and unloading station, a first washing station and a second washing station, the clamping assembly clamps / disassembles the chromatographic column at the loading and unloading station, and when the clamping assembly moves to the first washing station, the clamping assembly is driven by the second washing station; when the clamping assembly moves to the first washing station, the chromatographic column is located above the second-stage waste liquid barrel and is aligned to the second washing head, and when the clamping assembly moves to the second washing station, the chromatographic column is located above the first-stage waste liquid barrel and is aligned to the first washing head. The cleaning device has the effect of improving the problem that the utilization efficiency of the cleaning liquid is low.

Description

Technical Field

[0001] This application relates to the technical field of liquid chromatography columns, and in particular to a high-performance liquid chromatography column cleaning device. Background Art

[0002] Liquid chromatography technology is a high-efficiency separation and purification technology. A liquid chromatography column is an instrument used for liquid chromatography analysis, which is the main place for substance separation and belongs to the core part of liquid chromatography, and can directly affect the performance of separation and purification. After the chromatography column is used, sample molecules will remain in the column, so it needs to be cleaned in time. The correct cleaning method requires flushing with different concentrations of acetonitrile, methanol or other organic solvents according to the composition of the experimental sample.

[0003] In the related art, the cleaning device includes a liquid storage tank, a waste liquid tank, a flushing head and a valve arranged on the liquid storage tank. A lifting mechanism and a clamping mechanism for clamping the chromatography column are arranged on the liquid storage tank. The clamping mechanism arranged below the liquid storage tank clamps the chromatography column, aligns the upper end of the chromatography column with the flushing head of the liquid storage tank, the lifting mechanism drives the liquid storage tank to descend, inserts the lower end of the chromatography column into the waste liquid tank, opens the valve to release the cleaning liquid to clean the chromatography column, and the waste liquid after cleaning is received by the waste liquid tank.

[0004] In view of the above related art, the cleaning liquid in the liquid storage tank can be accurately injected into the chromatography column through a pipeline. This flushing method usually requires a large amount of cleaning liquid to flow through the chromatography column to thoroughly clean the residual substances in the chromatography column. A large amount of cleaning liquid flowing out of the chromatography column is regarded as waste liquid, and the utilization efficiency is low. Utility Model Content

[0005] In order to improve the problem of low utilization efficiency of the cleaning liquid, this application provides a high-performance liquid chromatography column cleaning device.

[0006] The high-performance liquid chromatography column cleaning device provided by this application adopts the following technical solutions:

[0007] A high-performance liquid chromatography column cleaning device includes a liquid storage bucket for holding cleaning liquid, a primary waste liquid bucket for holding primary waste liquid, a secondary waste liquid bucket for holding secondary waste liquid, a first flushing head arranged on the upper side of the primary waste liquid bucket, a second flushing head arranged on the upper side of the secondary waste liquid bucket, a clamping assembly for clamping the chromatography column, and a transfer mechanism for moving the clamping assembly. The liquid storage bucket is provided with a first pump body for lifting the cleaning liquid to the first flushing head, and the primary waste liquid bucket is provided with a second pump body for lifting the primary waste liquid to the second flushing head;

[0008] The clamping assembly is driven by the transfer mechanism and has a loading / unloading station, a first flushing station, and a second flushing station. The clamping assembly clamps / dismounts the chromatographic column at the loading / unloading station. When the clamping assembly moves to the first flushing station, the chromatographic column is located above the secondary waste liquid bucket and aligned with the second flushing head. When the clamping assembly moves to the second flushing station, the chromatographic column is located above the primary waste liquid bucket and aligned with the first flushing head.

[0009] By adopting the above technical solution, part of the cleaning liquid in the primary waste liquid still has a certain cleaning ability and can be lifted by the second pump to the second flushing head to perform a preliminary rough flushing on the chromatographic column at the first flushing station, flushing most of the residual substances. The chromatographic column after rough flushing is transferred to the second flushing station, and the clean cleaning liquid in the liquid storage bucket is lifted by the first pump to the first flushing head to perform a fine flushing on the chromatographic column to remove the remaining small amount of residual substances. Through the primary waste liquid bucket, the secondary waste liquid bucket, and the corresponding first flushing head and second flushing head, the recycling of the cleaning liquid is realized, the waste of the cleaning liquid is reduced, and the utilization efficiency is improved. The transfer mechanism drives the clamping assembly to move between different stations, and the operator only needs to stand at the loading / unloading station to clamp or dismount the chromatographic column, so as to realize the transfer and flushing of the chromatographic column, reduce manual operation, and improve work efficiency and operation convenience.

[0010] Furthermore, the liquid storage bucket, the primary waste liquid bucket, and the secondary waste liquid bucket are arranged adjacent to each other circumferentially. A first installation chamber for arranging the first pump body and pipelines is left between two adjacent outer walls of the liquid storage bucket and the primary waste liquid bucket. A second installation chamber for arranging the second pump body and pipelines is left between two adjacent outer walls of the primary waste liquid bucket and the secondary waste liquid bucket. A third installation chamber is left between two adjacent outer walls of the secondary waste liquid bucket and the liquid storage bucket, and a third pump body for discharging the waste liquid in the secondary waste liquid bucket is arranged in the third installation chamber.

[0011] By adopting the above technical solution, the first pump body and pipelines are arranged in the first installation chamber to lift the cleaning liquid in the liquid storage bucket to the first flushing head for fine flushing; the second pump body and pipelines are arranged in the second installation chamber to lift the waste liquid with remaining utilization value in the primary waste liquid bucket to the second flushing head for rough flushing; the third pump body is arranged in the third installation chamber to discharge the final waste liquid in the secondary waste liquid bucket. The liquid storage bucket, the primary waste liquid bucket, and the secondary waste liquid bucket are arranged adjacent to each other circumferentially. The integrated layout makes the whole device structure compact, reduces the overall occupied area of the device, and also makes the connection between components and the pipeline layout more reasonable, reduces unnecessary pipeline length and complexity, improves the operation efficiency of the whole system, and is convenient for maintenance and management.

[0012] Furthermore, a first mounting plate is provided between the adjacent outer walls of the liquid storage bucket and the primary waste liquid bucket at a position above the first installation chamber. The first flushing head is mounted on the first mounting plate, and the first pump body is in communication with both the first flushing head and the liquid storage bucket.

[0013] A second mounting plate is provided between the adjacent outer walls of the primary waste liquid bucket and the secondary waste liquid bucket at a position above the second installation chamber. The second flushing head is mounted on the second mounting plate, and the second pump body is in communication with both the second flushing head and the primary waste liquid bucket.

[0014] By adopting the above technical solution, a first mounting plate and a second mounting plate are respectively provided at positions above the first installation chamber and the second installation chamber, and the first flushing head and the second flushing head are respectively mounted on the mounting plates, which improves the stability of the flushing heads and reduces the risk of the flushing heads loosening or being damaged due to vibration or external force. Since the flushing heads are directly mounted on the mounting plates and are in communication with the corresponding pump bodies and the liquid storage bucket or waste liquid bucket, the pipeline connection is more simple and direct, making the structure of the entire cleaning system more compact and orderly, reducing unnecessary elbows and joints, reducing pipeline resistance and leakage risk, and also improving the flow efficiency of the cleaning liquid.

[0015] Furthermore, a mounting cylinder is provided vertically at the central position of the circumferential arrangement of the liquid storage bucket, the primary waste liquid bucket, and the secondary waste liquid bucket. The transfer mechanism includes a telescopic driving member and a rotational driving member. The telescopic driving member is arranged inside the mounting cylinder, the rotational driving member is provided above the telescopic driving member and protrudes from the upper opening of the mounting cylinder, and the clamping assembly is provided above the telescopic driving member.

[0016] By adopting the above technical solution, the mounting cylinder enables the transfer mechanism to be located at the central position of the three buckets, thereby reducing the occupied space of the entire device. The combination method of the transfer mechanism and the clamping assembly is more compact, making the entire cleaning device more integrated in structure. The transfer mechanism includes a telescopic driving member and a rotational driving member. The telescopic driving member drives the clamping assembly to expand and contract, and the rotational driving member drives the clamping assembly to rotate axially. The clamping assembly moves and positions in multiple dimensions, that is, it can move to each working station by axial rotation and can be aligned below the flushing head by expansion and contraction, improving operation flexibility and ensuring the smooth progress of the cleaning process.

[0017] Furthermore, the clamping assembly includes a mounting frame body, clamping jaws, and an opening and closing driving member. The mounting frame body is mounted on the rotational driving member, the opening and closing driving member is provided on the mounting frame body, and the clamping jaws are provided on the side of the opening and closing driving member away from the mounting frame body.

[0018] By adopting the above technical solution, the mounting frame is mounted on the rotation driving member, serving as the support structure for the clamping jaws and the opening and closing driving member, ensuring that the clamping assembly remains stable when moving and clamping the chromatographic column, and is not prone to shaking or deformation. The opening and closing driving member makes the opening and closing actions of the clamping jaws more flexible and controllable, and can quickly adjust the clamping force and position according to actual needs, improving the automation degree of the clamping assembly.

[0019] Furthermore, the mounting frame includes a mounting disk for fixedly connecting with the piston rod and a connecting rod fixedly connected to the mounting disk, and the opening and closing driving member is fixedly connected to the connecting rod.

[0020] By adopting the above technical solution, the mounting disk is fixedly connected with the piston rod, providing a support basis for the clamping assembly, making the clamping assembly more stable and reliable during the moving process. The opening and closing driving member is fixedly connected to the connecting rod, ensuring that the opening and closing action is perpendicular to the clamping direction of the clamping jaws, making the opening and closing of the clamping jaws smoother and more precise.

[0021] Furthermore, a closed top plate is provided between the adjacent outer walls of the secondary waste liquid bucket and the liquid storage bucket at the upper position of the third installation chamber.

[0022] By adopting the above technical solution, the closed top plate closes the upper part of the third installation chamber, avoiding the exposure of pipelines and equipment components, preventing waste liquid from splashing into the chamber during the cleaning process, and also reducing the influence of other abnormal situations or external factors on the equipment and pipelines in the chamber, which helps to maintain the cleanliness and stability of the chamber.

[0023] Furthermore, a first closed side plate for closing the first installation chamber is provided between the adjacent outer walls of the liquid storage bucket and the primary waste liquid bucket, and the top side of the first closed side plate is flush with the first installation plate;

[0024] A second closed side plate for closing the second installation chamber is provided between the adjacent outer walls of the primary waste liquid bucket and the secondary waste liquid bucket, and the top side of the second closed side plate is flush with the second installation plate;

[0025] A third closed side plate for closing the third installation chamber is provided between the adjacent outer walls of the secondary waste liquid bucket and the liquid storage bucket, and the top side of the third closed side plate is flush with the closed top plate.

[0026] By adopting the above technical solutions, the first closed side plate, the second closed side plate, and the third closed side plate effectively isolate the first installation chamber, the second installation chamber, and the third installation chamber from the external environment respectively, ensuring the independence and closeness of each chamber, thereby maintaining their respective functionality and cleanliness. The closed side plates provide clear boundaries, enabling operators to more easily identify and locate different chambers. The closed side plates facilitate the maintenance of components within each chamber. The operator can open the closed side plates to inspect, clean, or repair the pump bodies, pipelines, and other components within the chambers.

[0027] Furthermore, a first connecting pipe is penetrated through the barrel wall of the liquid storage barrel on the side close to the primary waste liquid barrel. The first connecting pipe is in communication with both the interior of the liquid storage barrel and the first pump body. A second connecting pipe is penetrated through the barrel wall of the primary waste liquid barrel on the side close to the secondary waste liquid barrel. The second connecting pipe is in communication with both the interior of the secondary waste liquid barrel and the second pump body.

[0028] By adopting the above technical solutions, the connecting pipes directly connect the liquid storage barrel, the primary waste liquid barrel, and the corresponding pump bodies, which can reduce the resistance and time in the fluid transmission process and improve the fluid transmission efficiency. The connecting pipes facilitate the operator to control the flow direction and flow rate of the fluid, thereby meeting different cleaning or treatment requirements. The connecting pipes are directly penetrated through the barrel wall, reducing the number and length of external pipelines, making the structure of the entire cleaning device more compact and concise.

[0029] Furthermore, a drain pipe that is in communication with the third pump body and is used for discharging waste liquid is penetrated through the third closed side plate.

[0030] By adopting the above technical solutions, the drain pipe is used for discharging waste liquid, preventing the accumulation of waste liquid inside the cleaning device and reducing the risk of waste liquid leakage or spillage. The waste liquid is quickly discharged through the third pump body, which helps to reduce the residence time of the waste liquid inside the cleaning device and improves the efficiency of waste liquid treatment. The drain pipe can be connected to different treatment systems or storage containers according to actual needs, facilitating subsequent centralized treatment.

[0031] In summary, the present application includes at least one of the following beneficial technical effects:

[0032] 1. By setting up the primary waste liquid barrel and the secondary waste liquid barrel, the hierarchical utilization of the cleaning liquid is realized. Some of the cleaning liquid in the primary waste liquid still has the cleaning ability and is lifted by the second pump to the second rinsing head for preliminary rough cleaning. The clean cleaning liquid in the liquid storage barrel is lifted by the first pump to the first rinsing head for fine cleaning, ensuring the thorough cleaning of the chromatographic column. The utilization efficiency of the cleaning liquid is improved through the recycling mechanism, effectively reducing the waste of the cleaning liquid;

[0033] 2. The liquid storage bucket, the primary waste liquid bucket, and the secondary waste liquid bucket are arranged adjacent to each other circumferentially. The annular layout improves the integration of the device, making the whole device structure compact and reducing the overall occupied area. The coordinated setting of the first installation chamber, the second installation chamber, the third installation chamber, and the corresponding first installation plate, second installation plate, and closed top plate makes the connection between components and the pipeline layout more reasonable, reduces the unnecessary pipeline length and complexity, and improves the operating efficiency of the system;

[0034] 3. The combination method of the transfer mechanism and the clamping component is compact, realizing the automatic transfer and flushing of the chromatographic column between different workstations, reducing manual operation, and improving work efficiency and operation convenience. The flushing head is installed on the installation plate and is interconnected with the corresponding pump body and the liquid storage bucket or waste liquid bucket, improving the stability of the flushing head and reducing the risk of loosening or damage due to vibration or external force. Description of the Drawings

[0035] Figure 1 is the overall structural schematic diagram of an efficient liquid chromatography column cleaning device according to an embodiment of the present application Figure 1 。

[0036] Figure 2 is the overall structural schematic diagram of an efficient liquid chromatography column cleaning device according to an embodiment of the present application Figure 2 。

[0037] Figure 3 is the overall structural schematic diagram of the base, liquid storage bucket, primary waste liquid bucket, secondary waste liquid bucket, and installation cylinder in an embodiment of the present application.

[0038] Figure 4 is the overall structural schematic diagram of the second flushing head and the second pump body in an embodiment of the present application.

[0039] Figure 5 is the overall structural schematic diagram of the clamping component and the transfer mechanism in an embodiment of the present application.

[0040] Description of reference numerals: 0, chromatographic column; 1, liquid storage barrel; 11, first installation chamber; 12, first pump body; 13, first mounting plate; 14, first closed side plate; 15, first connecting pipe; 2, primary waste liquid barrel; 21, second installation chamber; 22, second pump body; 23, second mounting plate; 24, second closed side plate; 25, second connecting pipe; 3, secondary waste liquid barrel; 31, third installation chamber; 32, third pump body; 33, closed top plate; 34, third closed side plate; 35, drain pipe; 4, first flushing head; 5, second flushing head; 6, clamping assembly; 61, loading and unloading station; 62, first flushing station; 63, second flushing station; 64, mounting frame; 641, mounting disc; 642, connecting rod; 65, jaw; 66, opening and closing drive member; 7, transfer mechanism; 71, telescopic drive member; 72, rotational drive member; 8, valve body; 9, mounting cylinder; 10, base. Detailed implementation manners

[0041] In order to make the objectives, technical solutions and advantages of the present application clearer and more understandable, the present application will be further described in detail below with reference to the Figures 1-5 accompanying drawings and embodiments.

[0042] The embodiment of the present application discloses a high-performance liquid chromatography column cleaning device. In this embodiment, words used to express positional relationships such as "upper" and "lower" are determined with reference to the placement and installation positions of the high-performance liquid chromatography column cleaning device in its normal use state.

[0043] Referring to Figure 1 and Figure 2 , the high-performance liquid chromatography column cleaning device includes a base 10, a liquid storage barrel 1, a primary waste liquid barrel 2, a secondary waste liquid barrel 3, a mounting cylinder 9, a first flushing head 4, a second flushing head 5, a first pump body 12, a second pump body 22, a third pump body 32, a clamping assembly 6 and a transfer mechanism 7.

[0044] Combining Figure 3 , the base 10 is horizontally arranged in a disc shape, the mounting cylinder 9 is vertically fixedly connected to the center position of the base 10, and the liquid storage barrel 1, the primary waste liquid barrel 2 and the secondary waste liquid barrel 3 are circumferentially arranged at intervals along the outer wall of the mounting cylinder 9. The liquid storage barrel 1, the primary waste liquid barrel 2 and the secondary waste liquid barrel 3 are arranged in a ring and are all fixedly connected to the base 10.

[0045] A first installation chamber 11 is jointly formed between the opposite outer walls of the liquid storage barrel 1 and the primary waste liquid barrel 2 and the base 10. The first pump body 12 is communicatively provided with a first connecting pipe 15. The first connecting pipe 15 vertically penetrates through the side wall of the liquid storage barrel 1 and is communicatively connected to the inside of the liquid storage barrel 1. The first pump body 12 is arranged in the first installation chamber 11 and is communicatively connected to the inside of the liquid storage barrel 1 through the first connecting pipe 15. The first flushing head 4 is communicatively connected to the first pump body 12 and is located above the primary waste liquid barrel 2.

[0046] A second installation chamber 21 is jointly formed between the opposite outer walls of the first waste liquid bucket 2 and the second waste liquid bucket 3 and the base 10. A second connecting pipe 25 is communicated with the second pump body 22. The second connecting pipe 25 vertically penetrates through the side wall of the first waste liquid bucket 2 and is communicated with the inside of the first waste liquid bucket 2. The second pump body 22 is arranged in the second installation chamber 21 and is communicated with the inside of the first waste liquid bucket 2 through the second connecting pipe 25. The second flushing head 5 is communicated with the second pump body 22 and is located above the second waste liquid bucket 3.

[0047] A third installation chamber 31 is jointly formed between the opposite outer walls of the second waste liquid bucket 3 and the liquid storage bucket 1 and the base 10. A drain pipe 35 is communicated with the third pump body 32. The drain pipe 35 vertically penetrates through the side wall of the second waste liquid bucket 3 and is communicated with the inside of the second waste liquid bucket 3. Both the third pump body 32 and the drain pipe 35 are arranged in the third installation chamber 31. The waste liquid in the second waste liquid bucket 3 is discharged through the third pump body 32 and the drain pipe 35 for centralized treatment.

[0048] Refer to Figure 1 and Figure 3 Above the first installation chamber 11, a first installation plate 13 is provided between the opposite outer walls of the liquid storage bucket 1 and the first waste liquid bucket 2. The pipeline connected to the first flushing head 4 vertically penetrates through and is fixedly connected to the first installation plate 13. The liquid storage bucket 1 and the first waste liquid bucket 2 are provided with a first closed side plate 14 for closing the first installation chamber 11. The first closed side plate 14 is perpendicular to the first installation plate 13.

[0049] Above the second installation chamber 21, a second installation plate 23 is provided between the opposite outer walls of the first waste liquid bucket 2 and the second waste liquid bucket 3. The pipeline connected to the second flushing head 5 vertically penetrates through and is fixedly connected to the second installation plate 23. The first waste liquid bucket 2 and the second waste liquid bucket 3 are provided with a second closed side plate 24 for closing the second installation chamber 21. The second closed side plate 24 is perpendicular to the second installation plate 23.

[0050] Above the third installation chamber 31, a closed top plate 33 is provided between the opposite outer walls of the second waste liquid bucket 3 and the liquid storage bucket 1. The second waste liquid bucket 3 and the liquid storage bucket 1 are provided with a third closed side plate 34 for closing the third installation chamber 31. The third closed side plate 34 is perpendicular to the closed top plate 33. One end of the drain pipe 35 far from the third pump body 32 penetrates through the third closed side plate 34 and is located outside the third installation chamber 31.

[0051] Refer to Figure 2 and Figure 4 On the pipeline for connecting the first pump body 12 and the first flushing head 4, on the pipeline for connecting the second pump body 22 and the second flushing head 5, and on the first drain pipe 35, valves 8 for controlling opening and closing are respectively provided.

[0052] Refer to Figure 1 and Figure 5 Figure 5 , the clamping assembly 6 includes a mounting frame 64, clamping jaws 65 and an opening / closing driving member 66. The mounting frame 64 has a mounting disk 641 for connecting with the transfer mechanism 7 and connecting rods 642 circumferentially and uniformly arranged on the side wall of the mounting disk 641. The opening / closing driving member 66 is installed at one end of the connecting rod 642 away from the mounting disk 641. The clamping jaws 65 are installed on the opening / closing driving member 66 and are driven by the opening / closing driving member 66 to clamp the outer wall of the chromatographic column 0. In this embodiment, the number of the clamping jaws 65 is preferably three, and the numbers of the opening / closing driving member 66 and the mounting rods correspond to three. Each clamping jaw 65 is respectively aligned above the liquid storage barrel 1, the primary waste liquid barrel 2 and the secondary waste liquid barrel 3.

[0053] The transfer mechanism 7 includes a telescopic driving member 71 and a rotating driving member 72. In this embodiment, the telescopic driving member 71 is preferably a hydraulic cylinder with a certain jacking ability, and the rotating driving member 72 is preferably a servo motor that can rotate arbitrarily. The telescopic driving member 71 is installed in the installation cylinder 9. The telescopic driving member 71 has a cylinder body and a piston rod. The rotating driving member 72 is installed at one end of the piston rod of the telescopic driving member 71 away from the cylinder body. The rotating driving member 72 has a machine body and an output shaft. The mounting disk 641 of the mounting frame 64 is coaxially and fixedly connected to the output shaft of the rotating driving member 72. The clamping assembly 6 is driven by the transfer mechanism 7 to realize lifting and rotation, so as to facilitate aligning the chromatographic column 0 below the first flushing head 4 or the second flushing head 5.

[0054] The clamping jaws 65 are driven by the transfer mechanism 7, so as to have a loading / unloading station 61, a first flushing station 62 and a second flushing station 63. When the clamping jaws 65 are at the loading / unloading station 61, an operator loads or unloads the chromatographic column 0 at the position of the liquid storage barrel 1. When the clamping jaws 65 are at the first flushing station 62, the clamping jaws 65 clamp the chromatographic column 0 and are aligned below the second flushing head 5. When the clamping jaws 65 are at the second flushing station 63, the clamping jaws 65 clamp the chromatographic column 0 and are aligned below the first flushing head 4.

[0055] The implementation principle of the high performance liquid chromatography column cleaning device in the embodiment of the present application is as follows: The liquid storage barrel 1, the primary waste liquid barrel 2 and the secondary waste liquid barrel 3 are circumferentially arranged at intervals along the outer wall of the installation cylinder 9, forming three independent functional areas: a liquid storage area, a primary flushing waste liquid area and a fine flushing waste liquid area. The clean cleaning liquid in the liquid storage barrel 1 is lifted to the first flushing head 4 through the first pump body 12 and the first connecting pipe 15 for fine flushing the chromatographic column 0. The waste liquid with certain cleaning ability collected in the primary waste liquid barrel 2 is lifted to the second flushing head 5 through the second pump body 22 and the second connecting pipe 25 for preliminary rough flushing of the chromatographic column 0. The waste liquid without utilization value after rough flushing enters the secondary waste liquid barrel 3 and is finally discharged from the device through the third pump body 32 and the drain pipe 35 for centralized treatment.

[0056] The clamping assembly 6 clamps the chromatographic column 0, and the transfer mechanism 7 drives the clamping assembly 6 to lift and rotate, so as to realize the transfer of the chromatographic column 0 between different workstations. The transfer process of the chromatographic column 0 includes a loading and unloading station 61 (where an operator clamps or unloads the chromatographic column 0), a first flushing station 62 (aligning with the second flushing head 5 for rough flushing), and a second flushing station 63 (aligning with the first flushing head 4 for fine flushing). The operator only needs to clamp or disassemble the chromatographic column 0 at the loading and unloading station 61, and the transfer mechanism 7 and the clamping assembly 6 automatically complete the transfer and cleaning process of the chromatographic column 0, improving work efficiency and operation convenience. The cleaning device realizes efficient and convenient cleaning operation of the chromatographic column 0 through reasonable structural layout, recycling and hierarchical utilization of the cleaning liquid, and automatic transfer and cleaning process of the chromatographic column 0.

[0057] The above are all preferred embodiments of the present application, and do not limit the protection scope of the present application accordingly. Therefore, all equivalent changes made according to the structure, shape, and principle of the present application should be covered within the protection scope of the present application.

Claims

1. An efficient liquid chromatography column cleaning device, characterized in that: It includes a liquid storage bucket (1) for containing cleaning liquid, a primary waste liquid bucket (2) for containing primary waste liquid, a secondary waste liquid bucket (3) for containing secondary waste liquid, a first rinsing head (4) arranged above the primary waste liquid bucket (2), a second rinsing head (5) arranged above the secondary waste liquid bucket (3), a clamping assembly (6) for clamping a chromatographic column, and a transfer mechanism (7) for moving the clamping assembly (6). The liquid storage bucket (1) is provided with a first pump body (12) for lifting the cleaning liquid to the first rinsing head (4), and the primary waste liquid bucket (2) is provided with a second pump body (22) for lifting the primary waste liquid to the second rinsing head (5). The clamping assembly (6) is driven by the transfer mechanism (7) and has a loading / unloading station (61), a first rinsing station (62), and a second rinsing station (63). The clamping assembly (6) clamps / dismounts the chromatographic column at the loading / unloading station (61). When the clamping assembly (6) moves to the first rinsing station (62), the chromatographic column is located above the secondary waste liquid bucket (3) and aligned with the second rinsing head (5). When the clamping assembly (6) moves to the second rinsing station (63), the chromatographic column is located above the primary waste liquid bucket (2) and aligned with the first rinsing head (4).

2. An efficient liquid chromatography column cleaning device according to claim 1, characterized in that: The liquid storage bucket (1) is circumferentially adjacent to the primary waste liquid bucket (2) and the secondary waste liquid bucket (3). A first installation chamber (11) for arranging the first pump body (12) and pipelines is left between two adjacent outer walls of the liquid storage bucket (1) and the primary waste liquid bucket (2). A second installation chamber (21) for arranging the second pump body (22) and pipelines is left between two adjacent outer walls of the primary waste liquid bucket (2) and the secondary waste liquid bucket (3). A third installation chamber (31) is left between two adjacent outer walls of the secondary waste liquid bucket (3) and the liquid storage bucket (1). A third pump body (32) for discharging the waste liquid in the secondary waste liquid bucket (3) is arranged in the third installation chamber (31).

3. An efficient liquid chromatography column cleaning device according to claim 2, characterized in that: A first installation plate (13) is provided between the adjacent outer walls of the liquid storage bucket (1) and the primary waste liquid bucket (2) at a position above the first installation chamber (11). The first rinsing head (4) is installed on the first installation plate (13). The first pump body (12) is in communication with both the first rinsing head (4) and the liquid storage bucket (1). A second installation plate (23) is provided between the adjacent outer walls of the primary waste liquid bucket (2) and the secondary waste liquid bucket (3) at a position above the second installation chamber (21). The second rinsing head (5) is installed on the second installation plate (23). The second pump body (22) is in communication with both the second rinsing head (5) and the primary waste liquid bucket (2). Valves (8) for controlling opening and closing are respectively provided on the first rinsing head (4) and the second rinsing head (5).

4. An efficient liquid chromatography column cleaning device according to claim 2, characterized in that: At the central position in the circumferential arrangement of the liquid storage bucket (1), the primary waste liquid bucket (2), and the secondary waste liquid bucket (3), an installation cylinder (9) is provided along the vertical direction. The transfer mechanism (7) includes a telescopic driving member (71) and a rotational driving member (72). The telescopic driving member (71) is arranged inside the installation cylinder (9), and the rotational driving member (72) is provided above the telescopic driving member (71) and protrudes from the upper opening of the installation cylinder (9). The clamping assembly (6) is provided above the telescopic driving member (71).

5. The high-performance liquid chromatography column cleaning device according to claim 4, wherein: The clamping assembly (6) includes a mounting frame body (64), clamping jaws (65), and an opening and closing driving member (66). The mounting frame body (64) is mounted on the rotational driving member (72), the opening and closing driving member (66) is provided on the mounting frame body (64), and the clamping jaws (65) are provided on the side of the opening and closing driving member (66) away from the mounting frame body (64).

6. The high-performance liquid chromatography column cleaning device according to claim 5, characterized in that: The mounting frame body (64) includes a mounting disk (641) for connecting with the rotational driving member (72) and a connecting rod (642) fixedly connected to the mounting disk (641). The opening and closing driving member (66) is fixedly connected to the connecting rod (642).

7. An efficient liquid chromatography column cleaning device according to claim 3, characterized in that: A closed top plate (33) is provided at the upper position of the third installation chamber (31) between the adjacent outer walls of the secondary waste liquid bucket (3) and the liquid storage bucket (1).

8. An efficient liquid chromatography column cleaning device according to claim 7, characterized in that: A first closed side plate (14) for closing the first installation chamber (11) is provided between the adjacent outer walls of the liquid storage bucket (1) and the primary waste liquid bucket (2). The top side of the first closed side plate (14) is flush with the first installation plate (13). A second closed side plate (24) for closing the second installation chamber (21) is provided between the adjacent outer walls of the primary waste liquid bucket (2) and the secondary waste liquid bucket (3). The top side of the second closed side plate (24) is flush with the second installation plate (23). A third closed side plate (34) for closing the third installation chamber (31) is provided between the adjacent outer walls of the secondary waste liquid bucket (3) and the liquid storage bucket (1). The top side of the third closed side plate (34) is flush with the closed top plate (33).

9. An efficient liquid chromatography column cleaning device according to claim 1, characterized in that: A first connecting pipe (15) is penetrated through the barrel wall of the liquid storage bucket (1) on the side close to the primary waste liquid bucket (2). The first connecting pipe (15) is communicated with both the inside of the liquid storage bucket (1) and the first pump body (12). A second connecting pipe (25) is penetrated through the barrel wall of the primary waste liquid bucket (2) on the side close to the secondary waste liquid bucket (3). The second connecting pipe (25) is communicated with both the inside of the secondary waste liquid bucket (3) and the second pump body (22).

10. An efficient liquid chromatography column cleaning device according to claim 8, characterized in that: A drain pipe (35) communicating with the third pump body (32) and used for discharging waste liquid is penetrated through the third closed side plate (34).

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