Suspension production filling device

Abstract

The utility model provides a suspension producing and filling device, and belongs to the field of medicine producing and filling equipment. The suspension producing and filling device comprises a tank body, a disperser, a stirring device and a peristaltic pump, and is provided with a feed port and a tank body discharge port positioned at the bottom of the tank body; the disperser is arranged in the tank body and is positioned at the bottom of the tank body; the stirring device is arranged in the tank body and is positioned above the disperser; and the peristaltic pump is communicated with the discharge hole of the tank body and is used for quantitatively subpackaging materials. The suspension producing and filling device provided by the utility model can be used for quantitatively subpackaging suspension medicines with uniform mass.

Description

Technical Field

[0001] The utility model belongs to the field of pharmaceutical production filling equipment, and particularly relates to a suspension production filling device. Background Art

[0002] A suspension refers to a non-uniform liquid preparation in which insoluble solid drugs are dispersed in a dispersion medium in the form of fine particles. The drug particles in a suspension are generally between 0.5 and 10 μm, the smaller ones can be 0.1 μm, and the larger ones can reach 50 μm or more.

[0003] The preparation process of a suspension includes processes such as weighing, dispersion, dilution, stirring, volume fixing, and sub-packaging. Since a suspension belongs to a thermodynamically unstable coarse dispersion system, its particles are prone to sedimentation, making the distribution of solid drug particles in the dispersion medium uneven, resulting in different solid drug doses in each bottle of the medicament after sub-packaging. Therefore, continuous stirring is required during the preparation and sub-packaging of a suspension to maintain a uniform distribution of solid drug particles. Existing production devices can discharge and sub-package while stirring, but there is no integrated device for preparation, dispersion, stirring, and sub-packaging. Moreover, their sub-packaging usually uses components such as ordinary valves, pistons, or rubber stoppers for manual liquid discharge, with a large filling deviation, unable to perform quantitative sub-packaging, uncontrollable quality, and inconvenient operation. Summary of the Utility Model

[0004] The utility model provides a suspension production filling device capable of uniformly weighing and quantitatively sub-packaging solid drugs in a suspension.

[0005] To achieve the above object, the utility model adopts the following technical solutions:

[0006] The utility model provides a suspension production filling device, comprising:

[0007] A tank body, having a feeding port and a tank body discharge port located at the bottom of the tank body;

[0008] A disperser, disposed inside the tank body and located at the bottom of the tank body;

[0009] A stirring device, disposed inside the tank body and located above the disperser; and

[0010] A peristaltic pump, communicating with the tank body discharge port for quantitatively sub-packaging materials.

[0011] According to some embodiments of the utility model, the stirring device includes an anchor agitator, the anchor agitator includes a rotating shaft and a U-shaped paddle disposed on the rotating shaft, the bottom of the U-shaped paddle is provided with a concave opening, and the top end of the disperser extends into the concave opening.

[0012] According to some embodiments of the utility model, a scraper is provided on the outer side of the U-shaped paddle.

[0013] According to some embodiments of the present utility model, a connecting piece is further provided on the rotating shaft, one end of the connecting piece is connected to the rotating shaft, and the other end is connected to the U-shaped paddle.

[0014] According to some embodiments of the present utility model, a bird wing-shaped paddle is further provided on the rotating shaft.

[0015] According to some embodiments of the present utility model, it further includes a material pipe and a top-bottom valve. The material pipe is provided with a feed port and a discharge port; the feed port of the material pipe is connected to the discharge port of the tank body through the top-bottom valve, and the discharge port of the material pipe is connected to a peristaltic pump.

[0016] In some embodiments, the rotation speed of the disperser can be 0 - 1440 rpm. In some other embodiments, it can also be 0 - 3000 rpm. The appropriate rotation speed of the disperser can be selected according to the properties of the material.

[0017] Furthermore, the discharge port of the material pipe is connected to the peristaltic pump through a chuck.

[0018] According to some embodiments of the present utility model, the production and filling device further includes an explosion-proof electric control box.

[0019] According to some embodiments of the present utility model, a temperature detector is provided at the bottom of the tank body.

[0020] According to some embodiments of the present utility model, the tank body is provided with a liquid level gauge.

[0021] Compared with the prior art, the beneficial effects of the present utility model are:

[0022] The suspension production and filling device of the present utility model utilizes a slow stirring device and a high-speed disperser. The bottom discharge port is a top-bottom valve, which avoids stirring dead corners and realizes the uniform preparation of the suspension in all directions. The peristaltic pump is used for accurate quantitative filling, realizing automatic filling with stirring during filling, so as to achieve the consistency of the filling amount and drug content of the suspension. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0024] Figure 1 It is a front view schematic diagram of the suspension production and filling device provided by the embodiment of the present utility model;

[0025] Figure 2It is an enlarged view of the A area in the front view schematic diagram of the suspension production and filling device provided by the embodiment of the present utility model;

[0026] Figure 3 It is a top view schematic diagram of the suspension production and filling device provided by the embodiment of the present utility model.

[0027] Each reference numeral in the figure is as follows:

[0028] 1. Tank body; 11. Feeding port; 12. Outlet of the tank body; 13. Lid;

[0029] 2. Stirring device; 20. First motor; 21. Rotating shaft; 22. U-shaped paddle; 23. Bird-wing paddle; 24. Connector;

[0030] 3. Disperser; 30. Second motor; 31. Concave opening;

[0031] 4. Peristaltic pump; 41. Material pipe; 411. Outlet of the material pipe; 412. Chuck; 42. Top and bottom valve; 421. Clamp; 422. Opening and closing knob of the top and bottom valve;

[0032] 5. Explosion-proof electric control box; 51. Liquid level gauge; 52. Temperature detector; 53. Scraper; 54. Pulley. Specific embodiments

[0033] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0034] The terms used here are only for the purpose of describing specific example embodiments, and are not restrictive. For example, unless otherwise clearly stated in the context, the singular forms "a", "an" and "the" used here may also include the plural forms. When used in this specification, the terms "comprising", "including" and / or "containing" mean that the associated integers, steps, operations, elements and / or components exist, but do not exclude the existence of one or more other features, integers, steps, operations, elements, components and / or groups, or the addition of other features, integers, steps, operations, elements, components and / or groups in this system / method.

[0035] In the present utility model, terms such as "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "vertical", "horizontal", "lateral", "longitudinal", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. These terms are mainly used to better describe the present application and its embodiments, and are not intended to limit that the indicated device, element or component must have a specific orientation, or be constructed and operated in a specific orientation.

[0036] In addition, terms such as "installed", "set", "provided with", "connected", "linked" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, or there can be internal communication between two devices, elements or components. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0037] In view of the following description, these features of the present specification and other features, as well as the operation and functions of the relevant elements of the structure, and the combination and manufacturing economy of the components can be significantly improved. Referring to the drawings, all of these form a part of the present specification. However, it should be clearly understood that the drawings are only for the purpose of illustration and description, and are not intended to limit the scope of the present specification. It should also be understood that the drawings are not drawn to scale.

[0038] Figure 1 It is a schematic structural diagram of a suspension production and filling device. The suspension production and filling device includes a tank, the tank has a cylindrical tank body 1 and a lid 13 provided on the top of the tank body 1. After the lid 13 is opened, a feeding port 11 can be formed. A tank body discharge port 12 is also opened on the side of the tank body 1. A peristaltic pump 4 is connected to the tank body discharge port 12. The peristaltic pump 4 can accurately control the transportation of materials to ensure that the volume of the suspension poured into the dispensing bottle is consistent. A disperser 3 is arranged at the center of the inner bottom of the tank body 1. The disperser 3 has a high rotation speed to cause the solvent to form convection, which can help the solute to disperse in the solvent. In this embodiment, the rotation speed of the disperser 3 can be 0 - 3000 rpm. In some other embodiments, the rotation speed can also be 0 - 1440 rpm. The disperser 3 is electrically connected to a second motor 30, and through high-frequency reciprocation to achieve uniform and fine dispersion of the materials. A stirring device 2 is also arranged inside the tank. The stirring device 2 can continuously stir the liquid material to prevent the formation of sediment of the material particles. The stirring device 2 is located above the disperser 3 so as to fully stir and disperse the materials dispersed by the disperser 3 in the overall tank body 1 to improve the stirring efficiency.

[0039] The stirring device 2 can select various different types of stirrers, such as a propeller stirrer, a turbine stirrer, a ribbon stirrer, etc., as long as the requirement of continuous low-speed stirring is met. To adapt to the cylindrical structure of the tank body 1 and maximize the stirring effect, as Figure 1 shown, the stirring device 2 selects an anchor stirrer, and the anchor stirrer includes a rotating shaft 21 and a U-shaped blade 22 arranged on the rotating shaft 21. One end of the rotating shaft 21 of the anchor stirrer passes through the lid 13 and is electrically connected to the first motor 20, and the U-shaped blade 22 at the other end of the rotating shaft 21 extends deep into the tank body 1 for stirring.

[0040] As Figure 2 shown is an enlarged view of area A of the structure of the suspension production and filling device. Since the material after high-speed dispersion by the disperser 3 is affected by a strong centrifugal force and will adhere to the tank wall, a large amount of solid deposition will form on the tank wall. The bottom of the U-shaped blade 22 is recessed inward to form an inward recess 31. The inward recess 31 can form a cavity suitable for accommodating the disperser 3 during rotation, and the disperser 3 is arranged in this cavity, so that the anchor stirrer can work in cooperation with the disperser 3. Since the top end of the disperser 3 extends into the inward recess 31, after the material is dispersed by the disperser 3, the rotation of the U-shaped blade 22 will depolymerize the material and reduce the material deposited on the tank wall.

[0041] To improve the uniformity of the suspension in the tank body 1, a bird-wing blade 23 is arranged at a position on the rotating shaft 21 close to the lid 13. The bird-wing blade 23 can rotate synchronously with the anchor stirrer, which can improve the convection of the solvent in the tank and accelerate the distribution of the material throughout the liquid medium. At the same time, to stabilize the anchor stirrer and assist in stirring, a connecting piece 24 is arranged between the U-shaped blade 22 and the rotating shaft 21. The connecting piece 24 forms a cross structure with the rotating shaft 21, and both ends of the connecting piece 24 are connected to the U-shaped blade 22, which can maintain the structural stability of the anchor stirrer and play a role in disturbing the flow.

[0042] Four scraping plates 53 are arranged on the outer side of the U-shaped blade 22 to scrape off the material adhering to the inner wall of the tank body 1. The four scraping plates 53 are distributed on the U-shaped blade 22. When the U-shaped blade 22 rotates, the scraping positions of the four scraping plates 53 can cover the inner wall of the tank body 1 as much as possible. It can be understood that in other embodiments, the number of the scraping plates 53 can be two, three or others, as long as the material deposited on the tank wall can be scraped off.

[0043] The material is added through the feed inlet 11, is dispersed evenly by the disperser 3 at the bottom of the tank body 1, and is stirred by the bird-wing blade 23 at the top of the tank body 1 and the anchor stirrer inside after adding the diluting solvent. After being fully mixed evenly, under the condition of maintaining slow stirring, through the peristaltic pump 4 at the tank body discharge port 12, the liquid material is quantitatively filled into the packaging bottles.

[0044] As Figure 3The figure shows a top view of the structure of a suspension production and filling device. When preparing preparations containing flammable and explosive substances such as ethanol, the production equipment for preparations containing ethanol must be explosion-proof designed to ensure safe production. To improve safety, the production and filling device can also use an explosion-proof electric control box 5 to prevent explosions caused by electrical sparks or high temperatures in a flammable and explosive environment. At the same time, the first motor 20 electrically connected to the stirring device 2 and the second motor 30 electrically connected to the disperser 3 can both be selected as explosion-proof motors. Similarly, the peristaltic pump 4 can also be selected as an explosion-proof peristaltic pump.

[0045] To facilitate the control of the liquid output volume of the suspension, as Figure 2 shown, the discharge port 12 of the tank body is connected with a material pipe 41 and a top and bottom valve 42. The top and bottom valve 42 has good sealing effect and can effectively avoid material backflow and dead corners of material stirring. The material pipe 41 is provided with a feed port (not marked in the figure) and a discharge port 411 of the material pipe. The feed port of the material pipe is connected to the discharge port 12 of the tank body through the top and bottom valve 42. The discharge port 411 of the material pipe is connected to the peristaltic pump 4 through a chuck 412. By replacing different models of chucks 412, it is possible to achieve matching connection with peristaltic pumps 4 of different pipe diameters. The top and bottom valve 42 is a swing-type top and bottom valve, and is provided with a top and bottom valve opening and closing knob 422 to control the opening and closing of the valve. To facilitate the connection and fixation of the valve and the pipeline, a clamp 421 is also provided on the top and bottom valve opening and closing knob 422. The structure of the device is simple, and it is convenient to install and disassemble.

[0046] At the same time, a temperature detector 52 can be set on the side wall of the tank body 1, and a thermocouple temperature sensor can be specifically selected to detect the temperature of the suspension in the tank to facilitate the control of the rotation speeds of the anchor agitator and the disperser 3. Similarly, a liquid level gauge 51 can be set on the tank wall of the tank body 1, specifically a glass tube water level gauge, to detect the amount of the suspension and timely add or discharge materials. At the bottom of the tank body 1, a bracket and four pulleys 54 are also provided to facilitate the movement of the entire device and improve the portability of the device.

[0047] The above is only the specific implementation manner of the present utility model, but the protection scope of the present utility model is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present utility model can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should all be covered within the protection scope of the present utility model. Therefore, the protection scope of the present utility model should be subject to the protection scope of the claims.

Claims

1. A suspension production and filling device, characterized in that, Comprising: A tank body, having a feeding port and a tank body discharge port located at the bottom of the tank body; A disperser, arranged inside the tank body and located at the bottom of the tank body; A stirring device, arranged inside the tank body and located above the disperser; And A peristaltic pump, communicated with the tank body discharge port and used for quantitatively dispensing materials.

2. The production filling device according to claim 1, characterized in that, The stirring device includes an anchor agitator, the anchor agitator includes a rotating shaft and a U-shaped paddle arranged on the rotating shaft, the bottom of the U-shaped paddle is provided with a concave notch, and the top end of the disperser extends into the concave notch.

3. The production and filling device according to claim 2, characterized in that, A scraper is arranged on the outer side of the U-shaped paddle.

4. The production and filling device according to claim 3, characterized in that, A connecting piece is further arranged on the rotating shaft, one end of the connecting piece is connected to the rotating shaft, and the other end is connected to the U-shaped paddle.

5. The production and filling device according to claim 3, characterized in that, A bird-wing type paddle is further arranged on the rotating shaft.

6. The production and filling device according to claim 1, characterized in that, It further includes a material pipe and a top and bottom valve, the material pipe is provided with a feed port and a discharge port; the feed port of the material pipe is connected to the tank body discharge port through the top and bottom valve, and the discharge port of the material pipe is connected to the peristaltic pump.

7. The production filling device according to claim 6, characterized in that, The discharge port of the material pipe is connected to the peristaltic pump through a chuck.

8. The production filling device according to claim 1, characterized in that, The production and filling device further includes an explosion-proof electric control box.

9. The production and filling device according to claim 1, characterized in that, A temperature detector is arranged at the bottom of the tank body.

10. The production filling device according to claim 1, characterized in that, A liquid level gauge is arranged on the tank body.

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