Non-GLP toxicology experiment device

Abstract

The utility model discloses a non-GLP toxicological experimental device, which relates to the technical field of experimental devices and comprises a container for accommodating a mouse. The container is provided with a plurality of cavities with upward openings for accommodating mice, the upper sides of the cavities are provided with conical cylinder covers for shielding the openings of the cavities, the upper sides of the conical cylinder covers are connected with cylindrical mouse cages, the upper ends of the mouse cages are closed, and the lower ends of the mouse cages are communicated with the interiors of the conical cylinder covers; according to the non-GLP toxicological experimental cage, all experimental mice can penetrate through the conical barrel cover to enter the barrel-shaped mouse cage through inversion, the activity space of the experimental mice is reduced, the mice are limited through the mouse cage, the tail of the mice can penetrate through the mouse cage, then tail intravenous injection administration can be conducted, and the convenience of the non-GLP toxicological experiment is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental devices, and particularly relates to a non-GLP toxicology experimental device. Background Art

[0002] Non-GLP refers to non-good laboratory practice, non-Good Laboratory Practice or exploratory toxicity experiments on the network. It is opposite to GLP (Good Laboratory Practice). Non-GLP experiments are usually used for exploratory toxicity experiments. Compared with GLP, it is more flexible, not restricted by strict specification requirements, and more suitable for preliminary and exploratory research.

[0003] The selection between GLP and non-GLP needs to comprehensively consider multiple factors, such as the purpose of experimental analysis, the technical strength conditions of the laboratory, cost, etc.; GLP experiments are relatively more costly than non-GLP experiments.

[0004] In the process of providing non-GLP toxicology evaluation for new drug developers, single-dose toxicity tests and repeated-dose toxicity tests need to be carried out on experimental mice. Tail vein injection of mice is a commonly used drug administration method. However, staff need to fix the position of each mouse one by one and then perform tail vein injection. The operation of fixing the position one by one is cumbersome and inefficient. Therefore, a non-GLP toxicology experimental device that facilitates rapid tail vein injection drug administration to mice is provided. Content of the Utility Model

[0005] The purpose of the utility model is to solve the above problems in the prior art and provide a non-GLP toxicology experimental device.

[0006] To achieve the above purpose, the utility model provides the following technical solutions:

[0007] A non-GLP toxicology experimental device includes a container for accommodating mice; the container has a number of cavities for accommodating mice with openings upward, and conical cylinder covers for blocking the openings of the cavities are provided on the upper sides of the cavities. Cylindrical mouse cages are connected to the upper sides of the conical cylinder covers. The upper ends of the mouse cages are closed, and the lower ends of the mouse cages communicate with the interiors of the conical cylinder covers.

[0008] Further, the shape of the container is circular ring-shaped; the cavities are evenly distributed along the circumference of the container.

[0009] Further, the lower ends of the conical cylinder covers are connected end to end.

[0010] Further, first handles are provided on both sides of the container.

[0011] Further, a number of doors are provided on the side wall of the container, and ventilation holes are provided on the doors.

[0012] Further, a pull-out baffle is provided at the upper port of the conical cylinder cover.

[0013] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0014] By being inverted, all the experimental mice of the present utility model can pass through the conical cylinder cover and enter the cylindrical mouse cage, reducing their activity space. The mouse cage realizes the limitation of the mice, enabling the mouse tails to pass through the mouse cage, and thus facilitating the tail vein injection and administration, improving the convenience of non-GLP toxicology experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic structural diagram of the present utility model.

[0016] Figure 2 It is a schematic diagram of the interior of the container of the present utility model.

[0017] Figure 3 It is a schematic diagram of the bottom of the conical cylinder cover of the present utility model.

[0018] Figure 4 is Figure 1 a partially enlarged schematic diagram.

[0019] Figure 5 It is a schematic diagram of the mouse cage and the pull-out baffle of the present utility model.

[0020] In the figure: 1. Container; 2. Cavity; 3. Conical cylinder cover; 4. Mouse cage; 5. First handle; 6. Door; 7. Ventilation hole; 8. Fixed rod; 9. Rotating rod; 10. Pull-out baffle; 11. Second handle. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0021] In order to make the objectives, technical solutions and advantages of the present utility model more clearly understood, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model, that is, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Usually, the components of the embodiments of the present utility model described and shown in the accompanying drawings herein can be arranged and designed in various different configurations.

[0022] In the description of the present utility model, unless otherwise clearly defined and limited, the terms "installation", "connection" and "connection" that may appear should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection or an electrical connection; it may be a direct connection or an indirect connection through an intermediate medium, and it may be the communication inside two elements. For those skilled in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0023] It should be noted that relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, such that a process, method, article or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or device.

[0024] In the description of the present utility model, it should be noted that unless otherwise clearly specified and defined, the term "provided with" that may appear should be understood in a broad sense. For example, the object of "provided with" can be a part of the body, or can be arranged separately from the body and connected to the body, and this connection can be a detachable connection or a non-detachable connection. For those skilled in the art, the specific meaning of the above terms in the present utility model can be understood through specific circumstances.

[0025] The following further describes the present utility model in detail with reference to embodiments.

[0026] Specific embodiments of the non-GLP toxicology experiment device provided by the present utility model:

[0027] Please refer to Figures 1-5 , a non-GLP toxicology experiment device, including a container 1 for accommodating mice; the container 1 has a number of cavities 2 for accommodating mice with openings facing upward, and the shape of the container 1 is circular ring-shaped; the cavities 2 are evenly distributed along the circumference of the container 1 and can accommodate a plurality of experimental mice, so that the experimental mice are placed in each independent cavity 2; the container 1 is preferably made of transparent acrylic material with a smooth inner wall.

[0028] A number of doors 6 are provided on the side wall of the container 1, and the number of doors 6 is the same as and corresponds one-to-one to the number of cavities 2. Ventilation holes 7 are provided on the doors 6, and the ventilation holes 7 play a role in ventilation and air permeability to ensure the needs of experimental mice.

[0029] In this embodiment, the door 6 is hinged to the container 1, and a number of fixing rods 8 are provided on the outer side of the side wall of the container 1. The shape of the fixing rods 8 is L-shaped, and the number of fixing rods 8 is the same as and corresponds one-to-one to the number of doors 6. A rotating rod 9 is rotatably connected to the outer side of one end of the door 6 away from the hinged end, and the rotating rod 9 can be rotated to the inner side of the fixing rod 8 and between the outer side of the container 1 to realize the rotational limit of the door 6.

[0030] Conical tube covers 3 for blocking the openings of the cavities 2 are provided on the upper sides of the cavities 2, and the lower ends and the large ends of the conical tube covers 3 are connected end to end to form a ring. The conical tube covers 3 are connected to the upper side of the container 1, and the conical tube covers 3 are preferably made of transparent acrylic material with a smooth inner wall, which is convenient for observing the situation of experimental mice in the container 1.

[0031] On the upper side of the conical barrel cover 3, a cylindrical squirrel cage 4 is connected. The upper end of the squirrel cage 4 is closed, and the lower end of the squirrel cage 4 communicates with the inside of the conical barrel cover 3; the squirrel cage 4 forms a relatively small space capable of accommodating a mouse, restricting the movement of the mouse. When the mouse enters the squirrel cage 4, the mouse clings to the inner side of the squirrel cage 4, and its movement and flipping are restricted; the cage gaps of the squirrel cage 4 allow the mouse's tail to pass through, facilitating tail vein injection.

[0032] On both sides of the container 1, U-shaped first handles 5 are provided, which facilitate the flipping of the device through the first handles 5.

[0033] A pull baffle 10 is provided at the upper port of the conical barrel cover 3. The pull baffle 10 has a first state of blocking the upper port of the conical barrel cover 3 and a second state of not blocking the upper port of the conical barrel cover 3; specifically, a through hole is provided on one side of the upper end of the conical barrel cover 3, the pull baffle 10 slides through the through hole and has friction with the inner wall of the through hole. Limit plates are provided at both ends of the pull baffle 10 to prevent the pull baffle 10 from falling off; a U-shaped second handle 11 is connected to the outside of the limit plate at the outer end of the pull baffle 10 to make the pulling convenient.

[0034] The process of drug administration in the toxicity test: Move all the pull baffles 10 to the second state, invert the device through the first handle 5, and the mouse passes through the inside of the conical barrel cover 3 from the cavity 2 and enters the squirrel cage 4 where its movement is restricted; move all the pull baffles 10 to the first state; flip the device to make it upright, and the pull baffle 10 supports under the mouse to prevent the mouse from falling into the cavity 2, realizing the limitation of all mice. Pull out the mouse's tail outside the squirrel cage 4 one by one for tail vein drug injection. After completion, invert the device, then move all the pull baffles 10 to the second state, and slowly flip the device to let the mouse return to its original cavity 2.

[0035] Finally, it should be noted that the above are only the preferred embodiments of the present utility model and are not used to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still make modifications to the technical solutions recorded in the foregoing embodiments without creative efforts, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A non-GLP toxicology experiment device, comprising a container (1) for accommodating mice; characterized in that: The container (1) has a number of cavities (2) for accommodating mice with openings facing upwards. Conical cylinder covers (3) that block the openings of the cavities (2) are provided on the upper sides of the cavities (2). Cylindrical mouse cages (4) are connected to the upper sides of the conical cylinder covers (3). The upper ends of the mouse cages (4) are closed, and the lower ends of the mouse cages (4) communicate with the interiors of the conical cylinder covers (3).

2. The non-GLP toxicology experiment device according to claim 1, wherein: The container (1) is circular ring-shaped; the cavities (2) are evenly distributed along the circumference of the container (1).

3. The non-GLP toxicology experiment device according to claim 1 or 2, characterized in that: The lower ends of the conical cylinder covers (3) are connected end to end.

4. The non-GLP toxicological experiment device according to claim 1, wherein: First handles (5) are provided on both sides of the container (1).

5. The non-GLP toxicology experiment device according to claim 1, characterized in that: A number of doors (6) are provided on the side wall of the container (1), and ventilation holes (7) are provided on the doors (6).

6. The non-GLP toxicological experiment device according to claim 1, characterized in that: A pull baffle (10) is provided at the upper port of the conical cylinder cover (3).

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