Respiratory function parameter calibration device

Abstract

The utility model relates to the technical field of instrument calibration, in particular to a respiratory function parameter calibration device which comprises a guide pipe, a piston pump and an electric control assembly, the guide pipe is provided with an air inlet end and an air outlet end, and the air outlet end of the guide pipe is communicated with the air inlet end of a respiratory function detector to be calibrated; the air outlet end of the piston pump is connected with the air inlet end of the guide pipe; the control end of the electric control assembly is electrically connected with the control end of the piston pump. Calibration parameters are set through the display operation module, the reciprocating frequency and amplitude of the piston are controlled through the main control circuit board, and accurate control over the breathing frequency, the tidal volume and the ventilation volume per minute is achieved; the device can simulate standard breathing parameters of different experimental animals and collect the simulated data through the breathing function detection instrument, so that the accuracy and consistency of detection results are ensured, and the reliability of non-clinical research data and the experimental efficiency are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of instrument calibration, and particularly relates to a calibration device for respiratory function parameters. Background Art

[0002] In non-clinical drug research, the impact of drugs on respiratory system function is directly related to the life safety of clinical patients. Whole Body Plethysmography technology is one of the most widely used technologies in non-clinical respiratory function detection. By evaluating the impact of drugs on main respiratory function parameters such as respiratory rate, tidal volume, and minute ventilation volume of experimental animals, the safety and effectiveness of drugs are ensured.

[0003] According to the requirements of Good Laboratory Practice, respiratory function detection instruments need to be calibrated regularly. However, there is a lack of dedicated calibration devices for respiratory function parameters in the current market. Existing methods mainly rely on manual operations, such as using syringes of specific specifications for calibration. However, this method can only calibrate the respiratory rate and cannot accurately calibrate the tidal volume and minute ventilation volume. Moreover, manual operations bring large errors, which do not meet the requirements of the "Technical Guidelines for Drug Safety Pharmacology Research". Summary of the Utility Model

[0004] The technical problem to be solved by the utility model is that the calibration method of existing respiratory function detection instruments cannot accurately calibrate the tidal volume and minute ventilation volume, and the errors brought by manual operations are relatively large and cannot meet the requirements. The purpose is to provide a calibration device for respiratory function parameters, which realizes the accurate calibration of respiratory rate, tidal volume, and minute ventilation volume, simulates the standard respiratory parameters of different experimental animals, and ensures the accuracy and consistency of respiratory function detection instruments.

[0005] The utility model is realized through the following technical solutions:

[0006] A calibration device for respiratory function parameters, comprising:

[0007] A catheter, which has an air inlet end and an air outlet end, and the air outlet end of the catheter is communicated with the air inlet end of the respiratory function detector to be calibrated;

[0008] A piston pump, whose air outlet end is connected to the air inlet end of the catheter;

[0009] An electronic control component, whose control end is electrically connected to the control end of the piston pump.

[0010] Specifically, the electronic control component includes: a power module, a main control circuit board, a display operation module, and a control module. The power module, the display operation module, and the control module are all electrically connected to the main control circuit board, and the control end of the control module is electrically connected to the control end of the piston motor.

[0011] Optionally, the piston pump includes:

[0012] A gas piston, whose air outlet end is communicated with the air inlet end of the conduit;

[0013] A piston motor, whose power end is connected to the gas piston and drives the gas piston to move.

[0014] Optionally, the gas piston includes a housing, a plug body, and a reciprocating push rod. The plug body is arranged inside the housing, the outer side surface of the plug body is in dynamic seal with the inner side surface of the housing, the moving end of the reciprocating push rod is connected to the plug body and pushes the plug body to move inside the housing, and the power end of the reciprocating push rod is connected to the power end of the piston motor;

[0015] An air inlet and an air outlet are arranged on the housing. The air outlet of the housing is communicated with the air inlet end of the conduit, and the air inlet of the housing is communicated with the atmosphere.

[0016] Specifically, an air outlet check valve is arranged at the air outlet of the housing, and an air inlet check valve is arranged at the air inlet of the housing.

[0017] Optionally, the calibration device further includes a resin housing. The display operation module is arranged outside the resin housing. The air inlet end of the conduit is arranged inside the resin housing, and the air outlet end of the conduit extends outside the resin housing. The piston pump, the power module, the main control circuit board, and the control module are all arranged inside the resin housing.

[0018] Optionally, a power indicator light and a power switch connected to the main control circuit board are further arranged on the resin housing.

[0019] A usage method of a respiratory function parameter calibration device, based on a respiratory function parameter calibration device as described in any one of the above, the usage method includes:

[0020] Turn on the power. The display operation module detects whether there is a touch instruction. If not, continue to standby; if so, wait for the input of an operation instruction;

[0021] The main control circuit board receives the operation instruction and determines the propulsion rate and single working duration of the piston pump according to the operation instruction;

[0022] Wait for the input of a start instruction; after receiving the start instruction, control the piston pump to work through the control module;

[0023] Detect whether the single working duration is reached. If the single working duration is not reached, control the piston pump to continue working; if the single working duration is reached, control the piston pump to stop working.

[0024] Specifically, the operation instruction includes the gas supply speed, and the propulsion rate of the piston pump is calculated through the gas supply speed. The calculation method includes: obtaining the gas supply speed V t and the gas chamber volume L1, and calculating the reciprocating frequency

[0025] Determine the propulsion rate of the piston pump where θ is the stepping angle.

[0026] Specifically, the operation instruction also includes the gas supply volume. The single working duration of the piston pump is calculated through the gas supply speed and the gas supply volume. The calculation formula for the single working duration is where V1 is the gas supply volume.

[0027] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0028] The present invention sets calibration parameters through the display operation module, and controls the reciprocating frequency and amplitude of the piston through the main control circuit board, so as to achieve precise control of the breathing frequency, tidal volume and minute ventilation volume; the device can simulate the standard breathing parameters of different experimental animals, and collect these simulated data through a breathing function detection instrument to ensure the accuracy and consistency of the detection results, and improve the reliability of non-clinical research data and experimental efficiency.

[0029] Using this device for calibration, researchers can intuitively set and adjust parameters, compare the data collected by the breathing function detection instrument with the set values to ensure the accuracy of the instrument measurement. The device reduces the errors caused by manual operation through automatic control, improves the reliability of data and the repeatability of experiments. And through the regular calibration of this device, the accuracy and reliability of the breathing function detection instrument in non-clinical drug research can be ensured, which helps to accurately identify and screen the respiratory system function risks caused by drugs, thus ensuring the medication safety of clinical patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] The drawings illustrate exemplary embodiments of the present invention and, together with the description thereof, are used to explain the principles of the present invention. These drawings are included to provide a further understanding of the present invention, and the drawings are included in this specification and form a part of this specification, and do not constitute a limitation on the embodiments of the present invention.

[0031] Figure 1 It is a schematic structural diagram of a breathing function parameter calibration device according to the present invention.

[0032] Figure 2 It is a schematic flow chart of the usage method of a respiratory function parameter calibration device according to the present utility model.

[0033] Reference numerals: 1 - catheter, 2 - gas piston, 3 - piston motor, 4 - main control circuit board, 5 - power supply module, 6 - control module, 7 - display operation module. Specific embodiments

[0034] To make the purpose, technical solutions and advantages of the present utility model clearer and more understandable, the present utility model will be further described in detail below with reference to the drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the relevant content and do not limit the present utility model.

[0035] In addition, it should be noted that for the sake of convenience of description, only the parts related to the present utility model are shown in the drawings.

[0036] Without conflict, the embodiments in the present utility model and the features in the embodiments can be combined with each other. The present utility model will be described in detail below with reference to the drawings and embodiments.

[0037] Embodiment 1

[0038] As Figure 1 shown, a respiratory function parameter calibration device is provided, including: a catheter 1, a piston pump and an electric control component. The catheter 1 has an air inlet end and an air outlet end, and the air outlet end of the catheter 1 is communicated with the air inlet end of the respiratory function detector to be calibrated; the air outlet end of the piston pump is connected to the air inlet end of the catheter 1; the control end of the electric control component is electrically connected to the control end of the piston pump.

[0039] The piston pump pushes gas through the reciprocating motion of the piston. The air outlet end of the piston pump is connected to the air inlet end of the catheter 1, so as to press the gas into the catheter 1 to simulate different respiratory parameters. The air outlet end of the catheter 1 is connected to the air inlet end of the respiratory function detector to be calibrated, and the gas can flow from the catheter 1 into the detector to simulate the breathing of an animal.

[0040] The electric control component is responsible for controlling the working state of the piston pump. The electric control component includes: a power supply module 5, a main control circuit board 4, a display operation module 7 and a control module 6. The power supply module 5, the display operation module 7 and the control module 6 are all electrically connected to the main control circuit board 4, and the control end of the control module 6 is electrically connected to the control end of the piston motor 3.

[0041] The power supply module 5 provides the power supply for the entire device, ensuring the normal operation of each component. The main control circuit board 4 coordinates the work of each module, executes the preset control program through the processor, and manages the operation of the entire system. The display and operation module 7 provides a user interface, usually a touch display screen, through which users can set and adjust various parameters, such as respiratory rate, tidal volume, etc. The control module 6 is responsible for specifically executing the control commands issued by the main control circuit board 4, directly controlling the working state of the piston motor 3, and ensuring that the piston pump works according to the set parameters.

[0042] Embodiment 2

[0043] The piston pump includes: a gas piston 2 and a piston motor 3,

[0044] The gas outlet end of the gas piston 2 is communicated with the gas inlet end of the conduit 1; the driving end of the piston motor 3 is connected to the gas piston 2 and drives the gas piston 2 to move. The gas flow during the breathing process is simulated by the piston pump. The piston motor 3 is connected to the gas piston 2 through its driving end and drives the reciprocating motion of the gas piston 2, thereby generating a gas flow to simulate the breathing of experimental animals.

[0045] The gas piston 2 includes a housing, a plug body and a reciprocating push rod. The plug body is arranged inside the housing. The outer side surface of the plug body is in dynamic seal with the inner side surface of the housing. The moving end of the reciprocating push rod is connected to the plug body and pushes the plug body to move inside the housing. The driving end of the reciprocating push rod is connected to the driving end of the piston motor 3; the dynamic seal refers to the sealing state between the plug body and the inner side surface of the housing, which allows the plug body to move while ensuring the sealing performance.

[0046] An air inlet and an air outlet are provided on the housing. The air outlet of the housing is communicated with the air inlet end of the conduit 1, and the air inlet of the housing is communicated with the atmosphere. An air outlet check valve is provided at the air outlet of the housing, and an air inlet check valve is provided at the air inlet of the housing.

[0047] The design of the air inlet and the air outlet ensures that gas can freely enter and exit the housing, thereby simulating the gas flow during the breathing process. The air inlet is communicated with the atmosphere, allowing fresh air to enter the housing; the air outlet is communicated with the air inlet end of the conduit 1, allowing gas to flow from the housing to the conduit 1 and finally enter the respiratory function detector. The function of the check valve is to ensure the unidirectionality of gas flow, that is, gas can only enter from the air inlet and discharge from the air outlet, preventing gas from flowing back. The air inlet check valve is installed at the air inlet of the housing to ensure that gas can only enter the housing from the atmosphere and prevent the gas inside the housing from flowing back to the atmosphere. The air outlet check valve is installed at the air outlet of the housing to ensure that gas can only be discharged from the housing into the conduit 1 and prevent the gas in the conduit 1 from flowing back into the housing.

[0048] In summary, driven by the piston motor 3, the gas piston 2 can accurately simulate the gas flow during breathing through the movement of the reciprocating push rod, ensuring that the gas can only flow in a predetermined direction, thereby achieving precise calibration of the respiratory function detector.

[0049] Embodiment 3

[0050] To integrate all core components into a portable, compact, and easy-to-operate device, the calibration device further includes a resin housing. The display operation module 7 is arranged outside the resin housing. The intake end of the conduit 1 is arranged inside the resin housing, and the outlet end of the conduit 1 extends outside the resin housing. The piston pump, the power module 5, the main control circuit board 4, and the control module 6 are all arranged inside the resin housing.

[0051] The resin housing effectively protects the internal piston pump, power module 5, main control circuit board 4, and control module 6 from damage by the external environment, such as dust, moisture, and physical shock. The display operation module 7 is arranged outside the resin housing, enabling users to conveniently view and set various parameters without opening the housing.

[0052] The resin housing is also provided with a power indicator light and a power switch connected to the main control circuit board 4. Through the power indicator light, users can intuitively see the power status of the device and confirm whether the device is normally powered on and operating. The power switch facilitates users to control the opening and closing of the device, with simple and quick operation.

[0053] Embodiment 4

[0054] A usage method of a respiratory function parameter calibration device, based on the above-mentioned respiratory function parameter calibration device, the usage method includes:

[0055] Connect the power supply. Power on the device.

[0056] The display operation module detects whether there is a touch instruction. If not, it continues to standby; if so, it waits for the input of an operation instruction. That is, after power on, the display operation module starts to detect whether there is a touch instruction. If no touch instruction is detected, the device will continue to remain in the standby state to save energy and extend the device life. If a touch instruction is detected, the display operation module enters the state of waiting for the input of an operation instruction.

[0057] During the process of waiting for the input of an operation instruction, the user inputs the corresponding operation instruction through the display operation module (usually a touch screen). The main control circuit board receives the operation instruction and determines the propulsion rate and single working duration of the piston pump according to the operation instruction; the propulsion rate refers to the moving speed of the piston during the operation of the piston pump, and the single working duration refers to the continuous working time of the piston pump after each start.

[0058] Wait for the input of a start instruction;

[0059] After receiving the start instruction, the piston pump is controlled by the control module to work; the piston pump starts to work according to the set propulsion rate and single working duration.

[0060] Detect whether the single working duration is reached. If the single working duration is not reached, control the piston pump to continue working; if the single working duration is reached, control the piston pump to stop working.

[0061] Embodiment Five

[0062] The operation instruction includes the gas supply speed (referring to the speed at which gas flows through the conduit per unit time, usually in milliliters per second). The propulsion rate of the piston pump is calculated based on the gas supply speed. The calculation method includes: (obtaining the gas supply speed V t and the gas chamber volume L1, calculating the reciprocating frequency

[0063] Determine the propulsion rate of the piston pump where θ is the stepping angle.

[0064] The operation instruction also includes the gas supply volume. The single working duration of the piston pump is calculated based on the gas supply speed and the gas supply volume. The calculation method includes: (supplement how to calculate the single working duration through the gas supply speed and the gas supply volume. If there is a calculation formula, please provide the calculation formula and explain the parameters).

[0065] The gas supply volume refers to the total gas volume that the piston pump needs to transfer in one operation cycle, usually in milliliters (mL).

[0066] The single working duration refers to the time required for the piston pump to complete one set working cycle, usually in seconds (s).

[0067] The calculation formula for the single working duration is where V1 is the gas supply volume.

[0068] In the description of this specification, the description referring to terms such as "one embodiment / way", "some embodiments / ways", "example", "specific example", or "some examples", etc. means that the specific features, structures, materials, or characteristics described in connection with that embodiment / way or example are included in at least one embodiment / way or example of this application. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment / way or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments / ways or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments / ways or examples described in this specification and the features of different embodiments / ways or examples.

[0069] In addition, the terms "first" and "second" are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In the description of the present application, "a plurality of" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0070] Those skilled in the art should understand that the above embodiments are merely for clearly explaining the present utility model and are not intended to limit the scope of the present utility model. For those skilled in the art, other changes or modifications can be made based on the above utility model, and these changes or modifications are still within the scope of the present utility model.

Claims

1. A respiratory function parameter calibration device, characterized in that Comprising: A conduit (1) having an air inlet end and an air outlet end, the air outlet end of the conduit (1) being in communication with the air inlet end of a respiratory function detector to be calibrated; A piston pump, its air outlet end being connected to the air inlet end of the conduit (1); An electric control assembly, its control end being electrically connected to the control end of the piston pump.

2. The calibration device for respiratory function parameters according to claim 1, characterized in that The electric control assembly includes: a power supply module (5), a main control circuit board (4), a display operation module (7) and a control module (6). The power supply module (5), the display operation module (7) and the control module (6) are all electrically connected to the main control circuit board (4). The control end of the control module (6) is electrically connected to the control end of the piston motor (3) of the piston pump.

3. The calibration device for respiratory function parameters according to claim 2, characterized in that, The piston pump includes: A gas piston (2), its air outlet end being in communication with the air inlet end of the conduit (1); A piston motor (3), its power end being connected to the gas piston (2) and driving the gas piston (2) to move.

4. A respiratory function parameter calibration device according to claim 3, characterized in that, The gas piston (2) includes a housing, a plug body and a reciprocating push rod. The plug body is arranged inside the housing. The outer side surface of the plug body is in dynamic seal with the inner side surface of the housing. The moving end of the reciprocating push rod is connected to the plug body and pushes the plug body to move inside the housing. The power end of the reciprocating push rod is connected to the power end of the piston motor (3); An air inlet and an air outlet are provided on the housing. The air outlet of the housing is in communication with the air inlet end of the conduit (1). The air inlet of the housing is in communication with the atmosphere.

5. A respiratory function parameter calibration device according to claim 4, characterized in that, An air outlet check valve is provided at the air outlet of the housing, and an air inlet check valve is provided at the air inlet of the housing.

6. The calibration device for respiratory function parameters according to claim 2, characterized in that The calibration device further includes a resin housing. The display operation module (7) is arranged outside the resin housing. The air inlet end of the conduit (1) is arranged inside the resin housing. The air outlet end of the conduit (1) extends outside the resin housing. The piston pump, the power supply module (5), the main control circuit board (4) and the control module (6) are all arranged inside the resin housing.

7. The calibration device for respiratory function parameters according to claim 6, characterized in that, A power indicator light and a power switch connected to the main control circuit board (4) are further provided on the resin housing.

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