Integrated gel delivery device and medical equipment thereof

Abstract

The utility model relates to an integrated gel delivery device and medical equipment thereof. The integrated gel delivery device comprises an injector, the injector is used for injecting the photosensitive hydrogel; an air injection device and an ultraviolet device are respectively arranged on one side of the injector; the gas spraying device is used for spraying gas so as to drive the photosensitive hydrogel pushed and injected by the injector to be sprayed forwards; and the ultraviolet device is used for applying ultraviolet light to the photosensitive hydrogel sprayed by the air spraying device so as to carry out light curing on the photosensitive hydrogel. According to the device, the photosensitive hydrogel needing to be delivered is driven by air pressure, the air pressure of the air injection device is controllable, the effective delivery distance is long, the delivery range is large, delivery is uniform, the delivery angle is large, and the operability is high, so that compared with a traditional mode of delivering the hydrogel by using an injector, the efficiency is higher; the application range of the hydrogel material in medical environments such as laparoscopes is greatly widened.

Description

Technical Field

[0001] The utility model relates to the technical field of clinical medical devices, in particular to an integrated gel delivery device and a medical device thereof. Background Technique

[0002] With the continuous progress of medical technology, laparoscopic surgery has become the first choice for medical staff and patients in the field of surgical operations due to its advantages of minimal invasiveness and rapid recovery. Laparoscopic surgery is performed through laparoscopic trocars and special long-handled surgical instruments. In this process, one end of the laparoscopic trocar is inserted into the skin, and the other end is exposed on the skin surface, thereby establishing a dedicated channel for surgical instruments such as slender surgical forceps, electrocautery hooks, ultrasonic scalpels, and endoscopic lenses to enter the abdominal cavity through the laparoscopic trocar for surgical operations. However, during laparoscopic surgery, surgical suturing still faces limitations of the suture itself, such as cutting injuries caused by high suture tension, easy local ischemia affecting healing, and long suture operation time. To solve these problems, research on seamless repair strategies mainly based on hydrogel materials has been widely carried out in multiple clinical disciplines, and using hydrogel materials for wound repair under laparoscopic surgery has gradually become a research hotspot.

[0003] In 2022, a team from Southern Medical University disclosed a patented technology - an in-vivo minimally invasive in-situ gel-forming ultraviolet light source type endoscope and its curing injection mechanism. The curing injection mechanism is provided with a syringe for loading photosensitive hydrogel and placing the photosensitive hydrogel at the action point, and a light guide part for conducting ultraviolet light to the action point; the light guide part is sleeved on the injection needle of the syringe; the light guide part and the injection needle are integrally inserted and assembled into the laparoscopic trocar. This technology provides a simple and integrated minimally invasive instrument for using gel to repair wounds under laparoscopy, reducing the operation difficulty of the gel repair treatment strategy.

[0004] However, this technology directly injects hydrogel into the target action point (such as a wound) using a traditional syringe, and this delivery method has many deficiencies, such as short delivery distance, small delivery range, uneven delivery, and limited delivery angle. These deficiencies are further amplified in the operation-limited environment of laparoscopic surgery, severely restricting the application of hydrogel materials in the laparoscopic environment. Content of the Utility Model

[0005] Aiming at the problems existing in the prior art, the purpose of the utility model is to provide an integrated gel delivery device and a medical device thereof, which can improve the delivery efficiency of photosensitive hydrogel and broaden the application of hydrogel materials in the medical environment.

[0006] In order to achieve the above purpose, the utility model adopts the following technical scheme:

[0007] An integrated gel delivery device, comprising a syringe for injecting a photosensitive hydrogel;

[0008] On one side of the syringe, an air jet device and an ultraviolet device are respectively provided;

[0009] The air jet device is used to eject gas to drive the photosensitive hydrogel injected by the syringe to jet forward;

[0010] The ultraviolet device is used to apply ultraviolet light to the photosensitive hydrogel jetted by the air jet device to cure it by light.

[0011] Furthermore, at the front end of the syringe, an outer tube and an inner tube are coaxially arranged. The outer tube is sleeved on the inner tube needle to form a coaxial needle. The inner tube is a photosensitive hydrogel channel, and a gas channel is formed between the outer tube and the inner tube. The air jet device includes an air pump, and the air pump is connected to the gas channel.

[0012] Furthermore, the ultraviolet device includes an ultraviolet light source and a light guiding device. The light guiding device is arranged on one side of the coaxial needle and is connected to the ultraviolet light source.

[0013] Furthermore, the number of the light guiding devices is multiple, and the multiple light guiding devices are arranged in a ring outside the coaxial needle.

[0014] Furthermore, a coaxial sleeve is sleeved outside the coaxial needle, and the multiple light guiding devices are wrapped in the sleeve.

[0015] Furthermore, the front end of the coaxial needle protrudes between the multiple light guiding devices.

[0016] Furthermore, the sleeve includes a heat shrinkable tube.

[0017] Furthermore, the light guiding device is an optical fiber, and a black rubber layer is provided outside each optical fiber.

[0018] A medical device, comprising the above-mentioned integrated gel delivery device.

[0019] A delivery method of an integrated gel delivery device, comprising the following steps,

[0020] Turn on the air jet device and eject gas from the air jet device;

[0021] Orient the syringe towards the action point, push the syringe, and eject the photosensitive hydrogel from the syringe;

[0022] The gas ejected by the air jet device drives the photosensitive hydrogel ejected from the syringe to jet forward onto the action point;

[0023] Use the ultraviolet device to apply ultraviolet light to the photosensitive hydrogel jetted onto the action point to cure it by light.

[0024] Generally speaking, the present utility model has the following advantages:

[0025] In use, first turn on the jet device to eject gas from it; then push the syringe towards the action point (such as a wound to be repaired) to inject the photosensitive hydrogel out of the syringe. The gas ejected by the jet device drives the photosensitive hydrogel pushed out by the syringe to be jetted forward onto the action point. At the same time, the ultraviolet device is used to apply ultraviolet light to the photosensitive hydrogel jetted onto the action point to make it photocured for wound repair. The device of the present utility model uses air pressure to drive the photosensitive hydrogel to be delivered. Since the air pressure of the jet device is controllable, the effective delivery distance is far, the delivery range is large, the delivery is uniform, the delivery angle is large, and the operability is strong. Therefore, compared with the traditional method of using a syringe to deliver gel, the efficiency is higher, which greatly broadens the application of hydrogel materials in medical environments such as laparoscopy. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 is a schematic structural diagram of the integrated gel delivery device in Embodiment 1 of the present utility model.

[0027] Figure 2 is a schematic cross-sectional structural diagram of the light guiding device and the coaxial needle in Embodiment 2 of the present utility model.

[0028] Figure 3 is a schematic diagram of the relative position relationship between the front end of the coaxial needle and the front end of the light guiding device in Embodiment 3 of the present utility model.

[0029] Figure 4 is a schematic cross-sectional view of the integrated gel delivery device in Embodiment 4 of the present utility model.

[0030] Figure 5 is a schematic diagram of the demonstration effect of jetting the target at different inclination angles in Embodiment 5 of the present utility model.

[0031] In the figure:

[0032] 100 - syringe, 110 - coaxial needle, 120 - syringe barrel, 130 - syringe piston push rod, 200 - light guiding device, 210 - rubber sleeve, 220 - optical fiber, 221 - black rubber layer, 230 - optical fiber connection port, 300 - ultraviolet light source, 400 - air pump, 410 - air pump connection port. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0033] The following will further elaborate on the present utility model in detail.

[0034] Embodiment 1

[0035] A spray-type in-situ crosslinked integrated gel delivery device, as Figure 1 shown, is provided with a syringe 100 for storing and injecting the photosensitive hydrogel, an ultraviolet device for photocuring the hydrogel, and a jet device for driving the hydrogel to be jetted.

[0036] The front end of the syringe 100 is provided with an inner tube and an outer tube. The outer tube is sleeved outside the inner tube, and the outer tube and the inner tube are coaxially arranged to form a coaxial needle 110.

[0037] The syringe barrel 120 is arranged in the middle section of the syringe 100 and is used for storing the photosensitive hydrogel. The inner tube is connected to the syringe barrel 120 and is used for forwardly conveying the photosensitive hydrogel. The syringe piston push rod 130 is arranged at the rear end of the syringe 100. When the syringe piston push rod 130 is pushed forward, the photosensitive hydrogel in the syringe barrel 120 can be pushed forward into the inner tube.

[0038] The air jet device includes an air pump 400. A gas channel is formed between the outer tube and the inner tube of the syringe 100. The air pump 400 is connected to the gas channel, and the gas ejected by the air pump 400 is jetted forward through the gas channel.

[0039] The ultraviolet device includes an ultraviolet light source 300 and a light guiding device 200. The light guiding device 200 is arranged on one side of the coaxial needle 110.

[0040] The light guiding device 200 is connected to the ultraviolet light source 300 and can conduct the ultraviolet light of the ultraviolet light source 300 to the front of the coaxial needle 110.

[0041] In this embodiment, the application of spraying the photosensitive hydrogel to repair abdominal wounds under laparoscopic conditions is demonstrated.

[0042] The photosensitive hydrogel is pre-loaded in the syringe barrel 120 of the syringe 100. The coaxial needle 110 and the light guiding part 200 enter the abdominal cavity through the laparoscopic trocar hole. The tip of the coaxial needle 110 aims at the target wound position and keeps a distance of 2-20 cm from the target wound. The air pump 400 is turned on, and the air flow generated by the air pump 400 will enter the gas channel between the outer tube and the inner tube. Then, the syringe 100 is pushed to inject the photosensitive hydrogel out of the inner tube of the coaxial needle 110. At this time, the photosensitive hydrogel will be affected by the outer layer of air flow and be jetted forward, evenly covering the target wound. Then, the injection is ended and the air pump 400 is turned off, the ultraviolet light source 300 is turned on, the tip aims at the photosensitive hydrogel on the wound, and the light guiding device 200 can conduct the ultraviolet light source 300 to the front of the tip. After the photosensitive hydrogel is irradiated by ultraviolet light, a cross-linking reaction occurs and it is converted into a solid state, forming a gel barrier at the wound.

[0043] The device uses air pressure to push the photosensitive hydrogel, with a long effective delivery distance, a large delivery range, a fast delivery speed, strong operability, and higher efficiency than the traditional method of using a syringe 100 to deliver the gel. The overall device has a small volume and high integration, and can be adapted to the laparoscopic environment.

[0044] Example 2

[0045] A spray-type in-situ crosslinked integrated gel delivery device, as Figure 2 shown. The other structures are the same as those in Embodiment 2, except that: the light guiding device 200 is composed of several optical fibers 220 arranged in a circular pattern outside the coaxial needle 110. There is a layer of black rubber layer 221 outside each optical fiber 220, and all the optical fibers 220 are wrapped and fixed by the outermost rubber sleeve 210.

[0046] The arrangement of a layer of black rubber layer 221 outside the optical fiber 220 is beneficial to the conduction of ultraviolet light. The regular circular arrangement structure formed by several optical fibers 220 around the coaxial needle 110 has a high space utilization rate. The front ends of all the optical fibers 220 are aligned and perpendicular to the axis of the coaxial needle 110, so that the direction of the ultraviolet light transmitted is parallel to the axis direction of the coaxial needle 110. All the optical fibers 220 are wrapped and fixed by the outermost rubber sleeve 210, which plays a protective role in maintaining the arrangement structure of the optical fibers 220.

[0047] Compared with Embodiment 1, the spray-type in-situ crosslinked integrated gel delivery device of this embodiment has the characteristics of small loss, concentrated light, and high space utilization rate in the conduction of ultraviolet light.

[0048] Embodiment 3

[0049] A spray-type in-situ crosslinked integrated gel delivery device, as Figure 3 shown. The other structures are the same as those in Embodiment 2, except that: the front end of the coaxial needle 110 exceeds the front end plane position of the optical fiber 220.

[0050] The front end of the coaxial needle 110 exceeds the front end plane of the optical fiber 220 by about 5 cm, which can effectively prevent the photosensitive hydrogel from splashing and blocking the mouth of the optical fiber 220. It should be noted that the distance by which the front end of the coaxial needle 110 exceeds the front end plane of the optical fiber 220 can also be selected as 2 mm to 15 mm according to needs.

[0051] Compared with Embodiment 1, the spray-type in-situ crosslinked integrated gel delivery device of this embodiment can be used continuously for multiple times without repeatedly cleaning the needle and the mouth of the optical fiber 220.

[0052] Embodiment 4

[0053] A spray-type in-situ crosslinked integrated gel delivery device, as Figure 4 shown. The other structures are the same as those in Embodiment 3, except that: the air pump 400 is connected to the side port of the coaxial needle 110 through the air pump connection port 410, and the light guiding device 200 is connected to the ultraviolet light source 300 through the optical fiber connection port 230.

[0054] The rear end of the optical fiber 220 leaves the coaxial needle 110 at the tail end of the coaxial needle 110 and bends to the side. The rear end of the optical fiber 220 is fixed in the optical fiber connection port 230, and the rear end openings of all optical fibers 220 are kept in the same plane, which can reduce the energy conduction loss of ultraviolet light during the switching process. The air pump connection port 410 is used to connect the outer channel of the coaxial needle 110 and the air pump 400, and the air pump connection port 410 can be adjusted to control the air intake.

[0055] Compared with Example 1, the spray-type in-situ cross-linked integrated gel delivery device of this embodiment is provided with a connection port for an ultraviolet light source 300 and an air pump connection port 410, which provide connection stability and ease of assembly and disassembly.

[0056] Example 5

[0057] A spray-type in-situ cross-linked integrated gel delivery device, such as Figure 5 As shown, its structure is the same as that of Example 1, except that: this embodiment demonstrates spraying different targets at different inclination angles.

[0058] like Figure 5 As shown, the angle between the needle tip direction of the spray-type in-situ cross-linked integrated gel delivery device and the gravity direction is A, and the distance between the needle tip and the target plane is D. We tested three representative situations: Figure 5 In the figure, (a) is tested vertically downward along the direction of gravity (A=0°), (b) is tested horizontally (A=90°), and (c) is tested vertically upward along the direction of gravity (A=180°). The test distance D ranges from 4 cm to 14 cm. According to the gel traces collected on the target plane paper, the spray-type in-situ cross-linked integrated gel delivery device can achieve vertical upward and horizontal spray delivery, and the distribution of the gel within the spray distance of 14 cm is a uniformly distributed circular range. It can be inferred that the spray-type in-situ cross-linked integrated gel delivery device can spray at any angle between 0 and 180°, and the spraying is uniform and effective within a distance of 14 cm.

[0059] When the conventional syringe 100 delivers the hydrogel upward, the hydrogel liquid will flow directly down from the needle tip due to gravity, resulting in the inability to smoothly complete the injection process and a narrow scope of use. The spray-type in-situ cross-linked integrated gel delivery device of this embodiment demonstrates that the device can spray and deliver the gel from a variety of angles without being affected by gravity, and has a wider scope of use than the conventional syringe 100.

[0060] Example 6

[0061] A spray-type in-situ crosslinked integrated gel delivery device has the same structure as that of Example 1, except that: in this example, the application of spraying a photocurable hydrogel to repair wounds under open conditions is demonstrated.

[0062] The spray-type in-situ crosslinked integrated gel delivery device can be used not only under laparoscopic conditions but also in open environments, such as open surgeries or skin surface wounds. Taking skin surface wounds as an example, the usage method of this example is described. After the skin wound is basically cleaned, the repair gel is loaded into the device. Turn on the air pump 400, align the needle tip with the wound, and keep a distance of 4 - 8 cm from the wound. Slowly squeeze the syringe 100, and the gel is evenly sprayed out and covers the wound. After completely covering the wound, turn off the air pump 400, turn on the external ultraviolet light source 300, and the ultraviolet light is guided along the optical fiber 220 to the front. Align the ultraviolet light with the gel on the wound and irradiate for about 5 seconds. The hydrogel is completely crosslinked and cured, and stably adheres to the wound to protect the wound.

[0063] Compared with Example 1, the spray-type in-situ crosslinked integrated gel delivery device of this example demonstrates an example of the device's use in a general open environment, indicating that the application scope of the device is compatible with ordinary open scenarios in addition to laparoscopic scenarios.

[0064] Example 7

[0065] This example provides a medical device, such as a laparoscope or endoscope device, including an integrated gel delivery device as described above.

[0066] Since the medical device adopts the above-mentioned integrated gel delivery device, the effective delivery distance of the photosensitive hydrogel is far, the delivery range is large, the delivery is uniform, the delivery angle is large, and the operability is strong. Therefore, compared with the traditional method of using a syringe 100 to deliver the gel, the efficiency is higher, the working efficiency of the medical device is improved, and the application of hydrogel materials in the medical environment is greatly broadened.

[0067] Example 8

[0068] A delivery method of an integrated gel delivery device includes the following steps.

[0069] Load the photosensitive hydrogel into the syringe 100 of the device, turn on the switch of the air pump 400, align the needle tip of the syringe 100 with the wound, and keep a certain distance from the wound. Slowly squeeze the syringe 100. The photosensitive hydrogel is evenly sprayed out and covers the wound. After the photosensitive hydrogel completely covers the wound, turn off the air pump 400, turn on the external ultraviolet light source 300, and the ultraviolet light is guided along the optical fiber 220 to the front of the needle tip. Align the ultraviolet light with the photosensitive hydrogel on the wound and irradiate for several seconds. The hydrogel undergoes complete crosslinking and curing and stably adheres to the wound to protect the wound.

[0070] The above embodiments are preferred embodiments of the present utility model, but the embodiments of the present utility model are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications made without departing from the spirit and principle of the present utility model shall be equivalent replacement methods and are all included in the protection scope of the present utility model.

Claims

1. An integrated gel delivery device, characterized in that: Comprising a syringe; The syringe is used for injecting a photosensitive hydrogel; A jetting device and an ultraviolet device are respectively arranged on one side of the syringe; The jetting device is used for jetting gas to drive the photosensitive hydrogel injected by the syringe to jet forward; The ultraviolet device is used for applying ultraviolet light to the photosensitive hydrogel jetted by the jetting device to cure it by light.

2. The one-piece gel delivery device according to claim 1, wherein: The front end of the syringe is provided with an outer tube and an inner tube which are coaxially arranged. The outer tube is sleeved on the needle of the inner tube to form a coaxial needle. The inner tube is a photosensitive hydrogel channel, and a gas channel is formed between the outer tube and the inner tube. The jetting device includes an air pump, and the air pump is connected to the gas channel.

3. The one-piece gel delivery device according to claim 2, characterized in that: The ultraviolet device includes an ultraviolet light source and a light guiding device. The light guiding device is arranged on one side of the coaxial needle and connected to the ultraviolet light source.

4. The one-piece gel delivery device according to claim 3, wherein: The number of the light guiding devices is multiple, and the multiple light guiding devices are annularly arranged outside the coaxial needle.

5. The one-piece gel delivery device according to claim 4, characterized in that: A coaxial sleeve is sleeved outside the coaxial needle, and the multiple light guiding devices are wrapped in the sleeve.

6. The one-piece gel delivery device according to claim 4, wherein: The front end of the coaxial needle protrudes between the multiple light guiding devices.

7. An integrated gel delivery device according to claim 5, wherein: The sleeve includes a heat shrinkable tube.

8. The one-piece gel delivery device according to claim 4, wherein: The light guiding device is an optical fiber, and a black rubber layer is arranged outside each optical fiber.

9. A medical device, characterized in that: Comprising an integrated gel delivery device according to any one of claims 1 to 8.

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