Drug-loaded collagen plug
By installing a drug-loading part in the collagen plug and enhancing the stent structure, the problem of losing elastic structure after the collagen plug is wetted is solved, and better wound sealing and healing effects are achieved.
Patent Information
- Application Number
- CN202421406920.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-19
- Publication Date
- 2025-07-11
- Estimated Expiration
- 2034-06-19
AI Technical Summary
The existing collagen plugs lose their elastic structure when used because they are wetted, making it difficult to effectively seal the wound, which is prone to infection.
A drug-loading collagen plug is designed, with a drug-loading part inside and a stent structure to enhance strength, and the drug-loading space is reasonably filled to improve the wound recovery effect.
By filling the drug with the drug-loading part, the stent structure enhances the support effect of the collagen plug, expands its use and improves the wound sealing and healing effect.
Smart Images
Figure CN223081785U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the technical field of medical supplies, and particularly relates to a drug-loaded collagen plug. Background Art
[0002] Currently, a collagen plug, also known as a collagen sponge, is prepared by a freeze-drying process. It is a white, porous, absorbable oral collagen sponge provided in a sterile state and is widely used for packing wounds. Therefore, the collagen plug has a certain elasticity when dry and can maintain its volume and structure under light pressure. However, when in use, due to being wetted by liquids such as normal saline, saliva, and blood, the hardness of the collagen plug drops sharply and it also loses its elastic structure. It can often fill the dead space during implantation, but then loses its shape and cannot close the wound, easily causing wound contamination and bringing about infection.
[0003] Based on this, there is an urgent need for a drug-loaded collagen plug to solve the above problems. Summary of the Utility Model
[0004] To have a basic understanding of some aspects of the disclosed embodiments, a simple summary is given below. This summary is not a general review, nor is it intended to identify key / important constituent elements or delineate the protection scope of these embodiments, but rather serves as a preface to the subsequent detailed description.
[0005] In view of the deficiencies of the prior art, the embodiments of the present disclosure provide a drug-loaded collagen plug, which is provided with a drug-loading part for filling drugs, and adopts a stent structure to enhance its own strength and designs a reasonable drug-filling space to improve the wound recovery effect.
[0006] The embodiments of the present disclosure provide a drug-loaded collagen plug, which includes a main body part and a drug-loading part. The main body part is composed of collagen to form a structure that can be extruded and deformed; the drug-loading part is opened inside the main body part and opens on one surface of the main body part.
[0007] In the preferred technical solution of the above drug-loaded collagen plug, the size of the drug-loaded collagen plug is adapted to the size of the area where the drug is to be placed.
[0008] In the preferred technical solution of the above drug-loaded collagen plug, the main body part includes a frustum region and a transition region. The frustum region includes a top surface and a bottom surface, where the diameter of the top surface is smaller than that of the bottom surface. The transition region is located at the upper part of the frustum region and smoothly transitions along the peripheral arc of the top surface to form a partial spherical arc shape.
[0009] In the preferred technical solution of the above drug-loaded collagen plug, the diameter of the bottom surface of the frustum region is 1.4 mm, and the height of the main body part is 2.4 mm.
[0010] In the preferred technical solution of the above drug-loaded collagen plug, the drug-loading part opens on the bottom surface and extends inward to form a concave part for containing drugs.
[0011] In the preferred technical solution of the above drug-loaded collagen plug, the main body part has a cube structure and includes an upper surface and a lower surface.
[0012] In the preferred technical solution of the above drug-loaded collagen plug, the side length of the main body part is 1 mm, the drug-loading part opens on the lower surface and extends inward to form a concave part for containing drugs.
[0013] In the preferred technical solution of the above drug-loaded collagen plug, the ratio range of the volume of the drug-loading part to the volume of the main body part is 1 / 5 to 1 / 3.
[0014] In the preferred technical solution of the above drug-loaded collagen plug, the main body part has a sponge-like structure and can form a jelly-like structure by infiltrating hydrogel after loading drugs.
[0015] In the preferred technical solution of the above drug-loaded collagen plug, the drug-loaded collagen plug further includes a collagen scaffold part with a strength greater than that of the main body part, and the collagen scaffold part is arranged between the main body part and the drug-loading part.
[0016] The drug-loaded collagen plug provided by the embodiments of the present disclosure can achieve the following technical effects:
[0017] In the drug-loaded collagen plug of the present application, the main body part is made of collagen to form an extrusion-deformable structure. The drug-loading part is opened inside the main body part and opens on one side surface of the main body part. The drug-loaded collagen plug plays a certain supporting role by filling drugs through opening the drug-loading part on the main body part. At the same time, the drug itself has the effect of treating wounds, so the use of the collagen plug is expanded. In addition, a collagen scaffold part is arranged inside the main body part, and since the strength of the collagen scaffold part is greater than that of the main body part, the strength of the whole collagen plug is further enhanced.
[0018] The above general description and the following description are only exemplary and explanatory and are not used to limit the present application. Description of the Drawings
[0019] One or more embodiments are exemplarily illustrated by the corresponding drawings. These exemplary illustrations and the drawings do not constitute a limitation on the embodiments. Elements with the same reference numerals in the drawings are shown as similar elements. The drawings do not constitute a scale limitation, and among them:
[0020] Figure 1 Shows a schematic diagram of a drug-loaded collagen plug provided by the present utility model;
[0021] Figure 2Shows a schematic diagram of another drug-loaded collagen plug provided by the present utility model.
[0022] Reference numerals:
[0023] 1. Main body; 11. Frustum region; 12. Transition region;
[0024] 2. Drug-loading part. Detailed implementation manners
[0025] In order to understand the features and technical content of the embodiments of the present disclosure in more detail, the implementation of the embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings. The accompanying drawings are only for reference and explanation purposes and are not used to limit the embodiments of the present disclosure. In the following technical description, for the sake of explanation, multiple details are provided to fully understand the disclosed embodiments. However, one or more embodiments can still be implemented without these details. In other cases, well-known structures and devices can be shown in a simplified manner to simplify the drawings.
[0026] In the embodiments of the present disclosure, terms such as "first", "second", etc. in the specification and claims of the embodiments of the present disclosure and the above-mentioned accompanying drawings are used to distinguish similar objects and do not have to be used to describe a specific order or sequence. It should be understood that such terms can be interchanged under appropriate circumstances so as to implement the embodiments of the present disclosure described herein. In addition, the terms "comprising" and "having" and any variations thereof are intended to cover non-exclusive inclusion.
[0027] In the embodiments of the present disclosure, the orientation or positional relationship indicated by terms such as "upper", "lower", "inner", "middle", "outer", "front", "rear", etc. is based on the orientation or positional relationship shown in the accompanying drawings. These terms are mainly used to better describe the embodiments of the present disclosure and their embodiments and are not used to limit that the indicated devices, elements or components must have a specific orientation or be constructed and operated in a specific orientation. And, in addition to being able to represent an orientation or positional relationship, some of the above terms may also be used to represent other meanings. For example, the term "upper" may also be used to represent a certain attachment relationship or connection relationship in some cases. For those of ordinary skill in the art, the specific meanings of these terms in the embodiments of the present disclosure can be understood according to specific circumstances.
[0028] In addition, the terms "arranged", "connected", "fixed" should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, or there can be internal communication between two devices, elements or components. For those of ordinary skill in the art, the specific meanings of the above terms in the embodiments of the present disclosure can be understood according to specific circumstances.
[0029] Unless otherwise specified, the term "plurality" means two or more.
[0030] It should be noted that, without conflict, the embodiments in the present disclosure and the features in the embodiments can be combined with each other.
[0031] Preferably, the drug-loaded collagen plug is applied in dental surgery for patients with insufficient soft tissues. It helps to reduce the risk of postoperative rebleeding in tooth extraction patients. It helps the healing of difficult-to-heal wounds, etc. The microscopic spatial structure of medical biomaterials plays a very important role in biological activity. The collagen plug is supported by collagen molecules and designed with a multi-layer three-dimensional spatial structure with uniform pore size. Collagen is the main constituent protein of the extracellular matrix. Collagen is a natural high-molecular protein, mainly distributed in tissues such as bones, tendons, ligaments, skin, and corneas of animals, and is the most abundant protein in animals. Collagen has the functions of hemostasis, promoting tissue hyperplasia, and accelerating wound healing. The collagen sponge made of collagen also has the same functions. Since the collagen sponge placed in the tooth extraction socket can promote tissue hyperplasia in the tooth extraction socket and accelerate wound healing, the collagen sponge is widely used in the field of tooth extraction. However, the density of the collagen sponge is relatively large and it can be absorbed by the human body relatively quickly. When the wound in the tooth extraction socket has not completely healed, the collagen sponge protein has been completely absorbed, affecting the wound healing effect. And the collagen sponge is likely to fall out of the tooth extraction socket after being placed in the upper tooth extraction socket, resulting in relatively difficult operation in the subsequent treatment process. Moreover, the tooth extraction sockets of different people vary in size, and the collagen sponge plugs are generally made in several standard sizes, and these collagen sponge plugs cannot fit everyone. Based on this, in order to improve the strength of the collagen plug, improve its structural rationality, and adjust its size to adapt to more patients, the present application has made the following improvements.
[0032] As Figures 1 to 2 shown, an embodiment of the present disclosure provides a drug-loaded collagen plug. The drug-loaded collagen plug includes a main body part 1 and a drug-loading part 2. The main body part 1 is made of collagen to form an extrusion deformation structure; the drug-loading part 2 is opened inside the main body part 1 and opens on one surface of the main body part 1.
[0033] Specifically, the drug-loaded collagen plug can be a collagen sponge-like plug, which is used to fill the wound when there is a wound on the body. To facilitate the filling of the collagen plug into the wound, the drug-loaded collagen plug is generally designed in shapes such as a wedge, a cube, or a cuboid. The bottom of the wedge-shaped drug-loaded collagen plug is in the shape of a frustum of a cone, and the top is a part of a sphere, forming an approximately inverted frustum of a cone with a smooth top transition. Therefore, the main body 1 is also in the above shape. Then, an inner cavity is excavated in the main body 1 to form the drug-loading part 2. The proportion of the drug-loading part 2 should consider both the overall strength and the drug efficacy. This drug-loaded collagen plug has good tissue compatibility and complete absorbability, and has a typical porous structure, which is beneficial to the absorption of exudate from damaged tissues. The product can degrade and absorb itself in the body.
[0034] Particularly, the main body 1 can also be in an irregular shape. Using the main body 1 in an irregular shape can, to a certain extent, adapt to various wounds.
[0035] As Figures 1 to 2 shown, in the preferred technical solution of this application, the size of the drug-loaded collagen plug is adapted to the size of the area where the drug is to be placed.
[0036] Specifically, the size of the drug-loaded collagen plug is also the size of the main body 1. It should have various sizes to adapt to the diversification of wound sizes.
[0037] In addition, to adapt to different wound sizes, multiple drug-loaded collagen plugs can also be used in combination, which is also an effective method to adapt to various wounds. This is equivalent to designing a model block to be used in combination when there is a larger wound.
[0038] As Figure 1 shown, in the preferred technical solution of this application, the main body 1 includes a frustum of a cone area 11 and a transition area 12. The frustum of a cone area 11 includes a top surface and a bottom surface, where the diameter of the top surface is smaller than that of the bottom surface. The transition area 12 is located in the upper part of the frustum of a cone area 11 and smoothly transitions along the peripheral arc of the top surface to form a partial spherical arc shape.
[0039] Specifically, although the main body 1 includes the frustum of a cone area 11 and the transition area 12, its overall shape is still approximately that of a frustum of a cone. The transition area 12 is relatively small compared to the frustum of a cone area 11, only adding some curvature to the upper transition of the frustum of a cone area 11. The top surface of the frustum of a cone area 11 contacts the transition area 12. An opening for the drug-loading part 2 is provided on the bottom surface of the frustum of a cone area 11.
[0040] As Figure 1 shown, in the preferred technical solution of this application, the diameter of the bottom surface of the frustum of a cone area 11 is 1.4 mm, and the height of the main body 1 is 2.4 mm.
[0041] Specifically, the height of the main body 1 includes the height of the frustum region 11 plus the height of the transition region 12. As a preferred example, the height of the main body 1 is taken as 2.4 mm. The diameter of the bottom surface of the corresponding frustum region 11 is set to 1.4 mm. Obviously, the height of the main body 1 is greater than the diameter of the bottom surface of the frustum region 11. In addition, the height of the main body 1 can also be less than or equal to the diameter of the bottom surface of the frustum region 11 to meet the diverse needs of the wound.
[0042] As Figure 1 shown, in the preferred technical solution of the present application, the drug-carrying part 2 opens on the bottom surface and extends inward to form a concave part for containing drugs.
[0043] Specifically, the cavity inside the main body 1 is the drug-carrying part 2. The drug-carrying part 2 opens on the bottom surface to facilitate filling of drugs.
[0044] As Figure 2 shown, in the preferred technical solution of the present application, the main body 1 is a cube structure and includes an upper surface and a lower surface. The drug-carrying part 2 opens on the lower surface and extends inward to form a concave part for containing drugs.
[0045] Specifically, the main body 1 with a cube structure is also a common drug-carrying collagen plug. It can adapt to various types of wounds. The drug-carrying collagen plug with a cube structure also has good tissue compatibility and complete absorbability, and has a typical porous structure, which is beneficial to the absorption of exudate from damaged tissues. The product can degrade and absorb itself in the body. Similar to the drug-carrying collagen plug with an approximately frustum shape above, the drug-carrying collagen plug with a cube structure also has a cavity inside, that is, the drug-carrying part 2, and the opening of the drug-carrying part 2 is on the lower surface.
[0046] As Figure 2 shown, in the preferred technical solution of the present application, the side lengths of the main body 1 are all 1 mm.
[0047] Specifically, the preferred side length of the main body 1 with a cube structure is 1 mm. In addition, side lengths of other sizes also exist to adapt to different wound sizes.
[0048] As Figures 1 - 2 shown, in the preferred technical solution of the present application, the ratio range of the volume of the drug-carrying part 2 to the volume of the main body 1 is from 1 / 5 to 1 / 3.
[0049] Specifically, for the main body portion 1 of any shape and size, the volume ratio of the drug-carrying portion 2 located inside it to the main body portion 1 itself preferably ranges from 1 / 5 to 1 / 3. This can ensure that the amount of drug inside the drug-carrying portion 2 is sufficient to heal the wound, and at the same time, it will not affect the supporting effect of the main body portion 1. In addition, when there are other requirements, the volume ratio range can also be changed. After the drug is gradually absorbed, its supporting effect decreases. At this time, due to other structural designs of the present application, such as the supporting effect of the following collagen scaffold portion, it can still play a good supporting role.
[0050] In a preferred technical solution of the present application, the main body portion 1 is a sponge-like structure, which can form a jelly-like structure after being infiltrated with hydrogel after loading the drug.
[0051] Specifically, after the drug-carrying collagen plug of the present application is filled with the drug, it is infiltrated at a low temperature, and then placed at the wound and solidified and fixed.
[0052] In a preferred technical solution of the present application, the drug-carrying collagen plug further includes a collagen scaffold portion with a strength greater than that of the main body portion 1, and the collagen scaffold portion is arranged between the main body portion 1 and the drug-carrying portion 2.
[0053] Specifically, through separation and purification techniques, the collagen extracted from animal tissues is woven into a reticular collagen scaffold with a specific spatial configuration through a cross-linking process. The drug-carrying collagen plug itself is a porous structure. A part of the space is opened in the porous structure for placing the collagen scaffold portion, and the collagen scaffold portion is closely attached to the wall of this part of the space. Since the strength of the collagen scaffold portion is relatively large, it can play a good supporting role. Moreover, although the strength of the collagen scaffold portion is higher than that of the drug-carrying collagen plug, it itself is still a porous structure made of collagen, but only has a lower pore density, a larger thickness of the wall between the pores, and a larger number. Therefore, it can still have good tissue compatibility and complete absorbability, which is beneficial to the absorption of exudate from damaged tissues, and the product can be degraded and absorbed in the body by itself.
[0054] The main body portion 1 of the drug-carrying collagen plug of the present application is composed of collagen to form an extrusion-deformed structure. The drug-carrying portion 2 is opened inside the main body portion 1 and opens on one surface of the main body portion 1, such as the bottom surface or the lower surface. The drug-carrying collagen plug plays a certain supporting role by filling the drug through opening the drug-carrying portion 2 on the main body portion 1. At the same time, the drug itself has the effect of treating the wound, so the use of the collagen plug is expanded. In addition, setting the collagen scaffold portion inside the main body portion 1 further strengthens the strength of the entire collagen plug because the strength of the collagen scaffold portion is greater than that of the main body portion 1.
[0055] In addition to the typical frustum-like shape, cube, cuboid and other shapes, the drug-loaded collagen plug is designed with other shapes suitable for various wounds, which is simple and easy to use and has a wide range of applications.
[0056] The volume ratio of the drug-loading part 2 to the volume of the main body part 1 ranges from 1 / 5 to 1 / 3. This can not only ensure the dosage of the drug, but also play a good supporting role and play an active role in the recovery of the wound.
[0057] The above description and the drawings fully illustrate the embodiments of the present disclosure so that those skilled in the art can practice them. Other embodiments may include structural and other changes. The embodiments represent only possible variations. Unless explicitly required, the individual components and functions are optional, and the order of operations may vary. Parts and features of some embodiments may be included in or replace parts and features of other embodiments. The embodiments of the present disclosure are not limited to the structures already described and shown in the drawings, and various modifications and changes can be made without departing from its scope. The scope of the present disclosure is limited only by the appended claims.
Claims
1. A drug-loaded collagen plug, characterized in that, Comprising: A main body part, which is made of collagen and formed into an extrusion-deformable structure; And A drug-loading part, which is provided inside the main body part and opens on one surface of the main body part; Wherein, the main body part includes: A frustum region, which includes a top surface and a bottom surface, and the diameter of the top surface is smaller than that of the bottom surface; and A transition region, which is located at the upper part of the frustum region and smoothly transitions along the peripheral arc of the top surface to form a partial spherical arc shape.
2. The drug-loaded collagen plug according to claim 1, characterized in that, The size of the drug-loading collagen plug is adapted to the size of the area where the drug is to be placed.
3. The drug-loaded collagen plug according to claim 1, wherein, The diameter of the bottom surface of the frustum region is 1.4 mm, and the height of the main body part is 2.4 mm.
4. The drug-loaded collagen plug according to claim 3, wherein The drug-loading part opens on the bottom surface and extends inward to form a concave part for containing the drug.
5. The drug-loaded collagen plug according to claim 2, wherein, The main body part is a cube structure and includes an upper surface and a lower surface.
6. The drug-loaded collagen plug according to claim 5, wherein, The side length of the main body part is 1 mm, the drug-loading part opens on the lower surface and extends inward to form a concave part for containing the drug.
7. The drug-loaded collagen plug according to claim 6, wherein The ratio range of the volume of the drug-loading part to the volume of the main body part is 1 / 5 to 1 / 3.
8. The drug-loaded collagen plug according to claim 1, characterized in that, The main body part is a sponge-like structure and can form a jelly-like structure by infiltrating with hydrogel after loading the drug.
9. The drug-loaded collagen plug according to any one of claims 1 to 8, characterized in that, Further comprising: A collagen support part with a strength greater than that of the main body part, and the collagen support part is arranged between the main body part and the drug-loading part.