Nose inhalation administration system for mice
By designing a mouse nasal inhalation delivery system, the problems of fixation and oral closure during nasal inhalation delivery in mice were solved, and the administration accuracy and experimental accuracy were improved.
Patent Information
- Application Number
- CN202421704877.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-18
- Publication Date
- 2025-07-11
- Estimated Expiration
- 2034-07-18
AI Technical Summary
In the existing nasal inhalation dosing methods of mice, the experimenter needs to manually fix the mice, resulting in oral opening, increased loss of drug liquid, inaccurate dosage, affecting the accuracy of the experiment.
A mouse nasal inhalation drug delivery system is designed, including a fixing device, an oral closure device and a drug delivery channel jamming device to fix and close the oral cavity of the mouse to ensure that the drug delivery channel outlet is located directly above the nasal cavity.
The stable fixation and oral closure of mice were achieved, reducing drug loss, and improving drug administration accuracy and experimental accuracy.
Smart Images
Figure CN223081794U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of animal experiment instruments, and particularly relates to a nasal inhalation drug delivery system for mice. Background Art
[0002] At present, mouse models are mostly used in the research of lung diseases. Direct or indirect intervention on lung tissue is a common scientific research method. The direct intervention methods for the lungs mainly include tracheal intubation, tracheotomy, and nasal inhalation drug delivery. Among them, tracheotomy exposes the trachea through an invasive method, and the tissue is closed layer by layer after drug delivery, which first causes trauma to the mice; tracheal intubation injects drugs into the mouse airway under the guidance of a tracheal intubation needle through the oral cavity and naturally diffuses to the lungs. At present, tracheal intubation mostly uses the blind intubation method, which cannot guarantee the intubation success rate. Repeated attempts at intubation will cause laryngeal edema and lead to asphyxiation and death of the mice; nasal inhalation drug delivery is to drop the drug into the mouse nasal cavity and let the mouse inhale the liquid medicine naturally to reach the lungs. Therefore, the nasal inhalation method is currently the drug delivery method that causes the least stress response and trauma to the mice.
[0003] At present, mouse nasal inhalation drug delivery mainly involves anesthetizing the mouse. The experimenter fixes the mouse with one hand and slowly drops the liquid medicine into the mouse nasal cavity with a pipette gun in the other hand. Since the mouse's mouth automatically opens when it is fixed during drug delivery, the mouse reflexively swallows some of the liquid medicine that enters the mouth into the stomach, resulting in a reduction in the actual drug delivery amount to the lungs, an increase in loss, and inaccurate drug delivery amount causing experimental errors.
[0004] Therefore, there is an urgent need for a new mouse nasal inhalation drug delivery device that can fix the mouse and liberate the experimenter's hand for fixing the mouse, and can close the mouse's mouth to reduce drug loss, improve drug delivery accuracy, and increase experimental accuracy. Summary of the Utility Model
[0005] The utility model is made to solve the above problems, and its purpose is to provide a nasal inhalation drug delivery system for mice.
[0006] The utility model provides a nasal inhalation drug delivery system for mice, which has the following characteristics: a fixing device for placing and fixing the mouse; a mouse oral cavity closing device arranged on the fixing device for restraining and closing the oral cavity of the mouse on the fixing device; and a drug delivery channel clamping device arranged on the fixing device for clamping and fixing the drug delivery channel. When the mouse is fixed on the fixing device and the drug delivery channel is clamped and fixed on the drug delivery channel clamping device, the liquid medicine outlet of the drug delivery channel is located directly above the mouse nasal cavity.
[0007] In the mouse nasal inhalation administration system provided by the present utility model, it may further have the following features: wherein, the fixing device includes: a base, which is a horizontally arranged plate-like structure; a clamping groove, recessed on the base and opening upwards; a fixing platform, which is a rectangular plate-like structure, the bottom edge of which is rotatably connected to the base, and the front surface of the fixing platform is used to place and fix the mouse; and a clamping plate, one end of which is connected to the back surface of the fixing platform, and the other end of which can be matched and inserted into the clamping groove, so that the planes of the base and the fixing platform are fixed at an angle.
[0008] In the mouse nasal inhalation administration system provided by the present utility model, it may further have the following features: wherein, the number of clamping grooves is several, and the several clamping grooves are arranged in an array, and the arrangement direction thereof is perpendicular to the bottom edge of the fixing platform. One end of the clamping plate is rotatably connected to the back surface of the fixing platform and its relative rotation direction is perpendicular to the bottom edge of the fixing platform. When the other end of the clamping plate is inserted into different clamping grooves, different angles are formed between the planes of the base and the fixing platform and are fixed.
[0009] In the mouse nasal inhalation administration system provided by the present utility model, it may further have the following features: wherein, the fixing device further includes a support plate, which protrudes from the front surface of the fixing platform and is used to support the lower limbs of the mouse.
[0010] In the mouse nasal inhalation administration system provided by the present utility model, it may further have the following features: wherein, the number of fixing grooves is 2, which are opened on both sides of the rectangular fixing platform and the opening directions thereof face the outside of both sides of the fixing platform. When the experimenter places the mouse on the front surface of the fixing platform, after tying the upper limbs of the mouse with a thin line and then winding it around the two fixing grooves and tying it tightly on the back surface of the fixing platform, the mouse can be fixed on the front surface of the fixing platform.
[0011] In the mouse nasal inhalation administration system provided by the present utility model, it may further have the following features: wherein, the mouse oral cavity closing device includes: two screws, rotatably arranged at both ends of the other bottom edge of the fixing platform; and a restraint belt, both ends of which are wound around the screws. When the mouse is fixed on the front surface of the fixing platform, the lower jaw of the mouse is lifted by the restraint belt, and the screws are rotated to tighten the restraint belt wound thereon, so as to apply an upward force to the lower jaw of the mouse to close the oral cavity of the mouse.
[0012] In the mouse nasal inhalation administration system provided by the present utility model, it may further have the following features: wherein, the administration channel clamping device includes: a support back plate, arranged on the other bottom edge of the fixing platform and coplanar with the fixing platform; and two clamping blocks, protruding from the support back plate or the fixing platform, and the extending direction thereof faces the front surface of the fixing platform. There is a certain distance between the two clamping blocks, which is used to clamp into the administration channel. The support back plate and the two clamping blocks cooperate together to clamp the administration channel above the nasal cavity of the mouse.
[0013] In the mouse nasal inhalation drug delivery system provided by the present utility model, it may further have the following features: wherein, the snap block includes: a first extension section protruding from the support backplate or the fixing platform, and the extending direction thereof is towards the front of the fixing platform, and the protruding direction of the first extension section is perpendicular to the plane where the fixing platform is located; and a second extension section disposed on the first extension section and facing upwards.
[0014] In the mouse nasal inhalation drug delivery system provided by the present utility model, it may further have the following features: wherein, the support backplate and the fixing platform are integrally formed, the first extension section is integrally formed with the support backplate or the fixing platform, and the first extension section and the second extension section are integrally formed.
[0015] Functions and effects of the utility model
[0016] According to a mouse nasal inhalation drug delivery system related to the present utility model, because it includes: a fixing device for placing and fixing a mouse; a mouse oral cavity closing device disposed on the fixing device for binding and closing the oral cavity of the mouse on the fixing device; and a drug delivery channel snap connection device disposed on the fixing device for snap-connecting and fixing the drug delivery channel. Wherein, when the mouse is fixed on the fixing device and the drug delivery channel is snap-connected and fixed on the drug delivery channel snap connection device, the liquid medicine outlet of the drug delivery channel is located directly above the mouse's nasal cavity.
[0017] Therefore, the mouse nasal inhalation drug delivery system of the present utility model can fix the mouse, liberate the hands of the experimenter for fixing the mouse, and can close the oral cavity of the mouse to reduce drug loss, improve the drug delivery accuracy, and increase the experiment accuracy. Brief description of the drawings
[0018] Figure 1 is a schematic structural diagram of a mouse nasal inhalation drug delivery system according to an embodiment of the present utility model;
[0019] Figure 2 is Figure 1 an enlarged view of part A in
[0020] Figure 3 is a schematic structural diagram of a mouse nasal inhalation drug delivery system according to an embodiment of the present utility model in another direction. Detailed implementation manners
[0021] In order to make the technical means, creative features, achieved purposes and effects realized by the present utility model easy to understand, the following embodiments will specifically describe a mouse nasal inhalation drug delivery system of the present utility model in conjunction with the drawings.
[0022] <Embodiment>
[0023] Figure 1 is a schematic structural diagram of a mouse nasal inhalation drug delivery system according to an embodiment of the present utility model; Figure 2Yes Figure 1 An enlarged view of part A in the figure.
[0024] As Figure 1 and 2 shown, this embodiment provides a mouse nasal inhalation drug delivery system 100, including a fixing device 10, a mouse oral cavity closing device 20, and a drug delivery channel clamping device 30.
[0025] The fixing device 10 includes a base 11, a clamping groove 12, a fixing platform 13, a clamping plate 14, a fixing groove 15, and a support plate 16.
[0026] The base 11 is a horizontally arranged rectangular plate-like structure.
[0027] Figure 3 It is a schematic structural diagram of another direction of a mouse nasal inhalation drug delivery system according to an embodiment of the present invention.
[0028] As Figures 1 to 3 shown, the clamping groove 12 is recessed in the base 11 and has an upward opening. The number of clamping grooves 12 is several and they are arranged in an array parallel to each other (arranged along the x-axis direction).
[0029] The fixing platform 13 is a rectangular plate-like structure, and its bottom edge is rotatably connected to the base 11 through a hinge.
[0030] One end of the clamping plate 14 is rotatably connected to the back surface of the fixing platform 13 and its relative rotation direction is along the xoz plane, and the other end is matchably embedded in the clamping groove 12. When the other end of the clamping plate 14 is embedded in different clamping grooves 12, different angles are formed between the respective planes of the base 11 and the fixing platform 13 and are fixed.
[0031] The number of fixing grooves 15 is 2, which are opened on both sides of the rectangular fixing platform 13 and their opening directions face the outside of both sides of the fixing platform 13. When the experimenter places the mouse 1 on the front surface of the fixing platform 13, binds the upper limbs of the mouse 1 with a thin wire and then bypasses the two fixing grooves 15 and ties the thin wire tightly on the back surface of the fixing platform 13, the mouse 1 can be fixed on the front surface of the fixing platform 13.
[0032] The support plate 16 protrudes from the front surface of the fixing platform 13 and is used to support the lower limbs of the mouse 1.
[0033] The mouse oral cavity closing device 20 includes screws 21 and a restraint strap 22.
[0034] The number of screws 21 is 2, and they are rotatably arranged at both ends of the other bottom edge of the fixing platform 13.
[0035] Both ends of the restraint strap 22 are respectively wound around two different screws 21. When the mouse 1 is fixed to the front of the fixing platform 13, the restraint strap 22 is used to lift the lower jaw of the mouse 1, and the two screws 21 are rotated to tighten the restraint strap 22 wound around them, so as to apply an upward force to the lower jaw of the mouse 1 to close the oral cavity 2 of the mouse 1.
[0036] The drug delivery channel clamping device 30 includes a support backplate 31 and a clamping block 32.
[0037] The support backplate 31 is integrally formed and protrudes from the other bottom edge of the fixing platform 13 and is coplanar with the fixing platform 13. Among them, the support backplate 31 and the screw 21 are on the same side.
[0038] The number of the clamping blocks 32 is 2, including a first extension section 321 and a second extension section 322.
[0039] The first extension section 321 is integrally formed and protrudes from the support backplate 31, and its extending direction faces the front of the fixing platform 13. The protruding direction of the first extension section 321 is perpendicular to the plane where the fixing platform 13 is located.
[0040] The second extension section 322 is integrally arranged on the first extension section 321 and faces upward.
[0041] The two clamping blocks 32 composed of the first extension section 321 and the second extension section 322 are mirror-symmetrical, and there is a gap between the two clamping blocks 32 for the drug delivery channel 1 to pass through.
[0042] When the mouse 1 is fixed on the fixing platform 13 and the drug delivery channel 3 is clamped and fixed on the drug delivery channel clamping device 30, the liquid medicine outlet 4 of the drug delivery channel 3 is directly above the nasal cavity 5 of the mouse 1.
[0043] The mouse nasal inhalation drug delivery system 100 in this embodiment can be applied to the research of various small rodents.
[0044] The using process of the mouse nasal inhalation drug delivery system 100:
[0045] S01, by adjusting one end of the clamping plate 14 to be embedded in a suitable clamping groove 12, an appropriate angle is formed between the fixing platform 13 and the base 11.
[0046] S02, place the mouse 1 on the front of the fixing platform 13, and its lower limbs are supported by the support plate 16. Subsequently, use thin wires to tie the upper limbs of the mouse 1 with two thin wires respectively, and then bypass the two ends of the thin wires around the two fixing grooves 15 and tie them tightly on the back of the fixing platform 13, so that the mouse 1 is fixed to the front of the fixing platform 13.
[0047] S03, wrap the restraint strap 22 around the mandible of the mouse 1, and tighten the restraint strap 22 by adjusting the two screws 21, so as to apply an upward force to the mandible of the mouse 1, and finally close the oral cavity 2 of the mouse 1.
[0048] S03, place the drug delivery channel 3 in the space formed by the support backboard 31, the first extension section 321 and the second extension section 322, and the liquid medicine outlet 4 of the drug delivery channel 3 is located directly above the nasal cavity 5 of the mouse 1, then the drug administration can be started.
[0049] Functions and effects of the embodiment
[0050] According to a mouse nasal inhalation drug delivery system provided by this embodiment, because it includes: a fixing device for placing and fixing a mouse; a mouse oral cavity closing device arranged on the fixing device for restraining and closing the oral cavity of the mouse on the fixing device; and a drug delivery channel clamping device arranged on the fixing device for clamping and fixing the drug delivery channel. Among them, when the mouse is fixed on the fixing device and the drug delivery channel is clamped and fixed on the drug delivery channel clamping device, the liquid medicine outlet of the drug delivery channel is located directly above the nasal cavity of the mouse.
[0051] Therefore, the mouse nasal inhalation drug delivery system of this embodiment can fix the mouse, liberate the hands of the experimenter for fixing the mouse, and can close the oral cavity of the mouse to reduce drug loss, improve the drug delivery accuracy, and increase the experimental accuracy.
[0052] Furthermore, the fixing device includes: a base, which is a horizontally arranged plate-like structure; a clamping groove recessed on the base with an upward opening; a fixing table, which is a rectangular plate-like structure, the bottom edge of which is rotatably connected to the base, and the front surface of the fixing table is used for placing and fixing the mouse; and a clamping plate, one end of which is connected to the back surface of the fixing table, and the other end of which can be matched and embedded in the clamping groove, so that the planes of the base and the fixing table are fixed at an angle. Such a setting makes the structure of the fixing device for fixing the mouse more reliable.
[0053] Furthermore, the number of clamping grooves is several, the several clamping grooves are arranged in an array, and the arrangement direction is perpendicular to the bottom edge of the fixing table. One end of the clamping plate is rotatably connected to the back surface of the fixing table and its relative rotation direction is perpendicular to the bottom edge of the fixing table. When the other end of the clamping plate is embedded in different clamping grooves, different angles are formed between the planes of the base and the fixing table and are fixed. Such a setting makes the pitch angle of the fixing device for fixing the mouse adjustable, reducing the cervical fatigue of the operator.
[0054] Furthermore, the fixing device further includes a support plate convexly arranged on the front surface of the fixing table for supporting the lower limbs of the mouse. Such a setting can provide a certain support for the lower limbs of the mouse, reducing the risk of the mouse dying from neck dislocation due to the influence of its own gravity.
[0055] Furthermore, the fixing device further includes fixing grooves. The number of the fixing grooves is 2, which are opened on both sides of the rectangular fixing platform, and their opening directions face the outside of both sides of the fixing platform. When the experimenter places the mouse on the front of the fixing platform, ties the upper limb of the mouse with a thin thread, then bypasses the two fixing grooves and ties them tightly on the back of the fixing platform, the mouse can be fixed on the front of the fixing platform. With such a setting, the mouse can be fixed on the fixing platform conveniently and quickly.
[0056] Furthermore, the mouse oral cavity closing device includes: two screws rotatably arranged at both ends of the other bottom edge of the fixing platform; and a restraint band, both ends of which are wound around the screws. When the mouse is fixed on the front of the fixing platform, the lower jaw of the mouse is lifted by the restraint band, and the screws are rotated to tighten the restraint band wound around them, so as to apply an upward force to the lower jaw of the mouse to close the oral cavity of the mouse. With such a setting, the oral cavity of the mouse can be controlled to close, and it can adapt to different mice and the tightness of controlling the closing of the mouse oral cavity is adjustable.
[0057] Furthermore, the drug delivery channel clamping device includes: a support back plate arranged on the other bottom edge of the fixing platform and coplanar with the fixing platform; and two clamping blocks protruding from the support back plate or the fixing platform, and their extending directions face the front of the fixing platform. There is a certain distance between the two clamping blocks for clamping the drug delivery channel. The support back plate and the two clamping blocks cooperate together to clamp the drug delivery channel above the nasal cavity of the mouse. With such a setting, the drug delivery channel can be fixed and located above the nasal cavity of the mouse, thus freeing both hands and facilitating automatic nasal inhalation drug delivery to the mouse.
[0058] Furthermore, the clamping block includes: a first extension section protruding from the support back plate or the fixing platform and its extending direction faces the front of the fixing platform, and the protruding direction of the first extension section is perpendicular to the plane where the fixing platform is located; and a second extension section arranged on the first extension section and facing upward. With such a setting, when the clamping block clamps the drug delivery channel, the drug delivery channel is not easily detached.
[0059] Furthermore, the support back plate and the fixing platform are integrally formed, the first extension section and the support back plate or the fixing platform are integrally formed, and the first extension section and the second extension section are integrally formed. With such a setting, the firmness of the whole device is increased and it is not easily damaged.
[0060] Those skilled in the art should understand that the present utility model is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principle of the present utility model. Without departing from the spirit and scope of the present utility model, the present utility model will have various changes and improvements, and these changes and improvements all fall within the scope of the present utility model claimed. The scope of protection claimed by the present utility model is defined by the appended claims and their equivalents.
Claims
1. A mouse nasal inhalation drug delivery system, characterized in that, Comprising: A fixing device for placing and fixing a mouse; A mouse oral cavity closing device arranged on the fixing device for binding and closing the oral cavity of the mouse on the fixing device; and A drug delivery channel clamping device arranged on the fixing device for clamping and fixing the drug delivery channel, wherein when the mouse is fixed on the fixing device and the drug delivery channel is clamped and fixed on the drug delivery channel clamping device, the liquid medicine outlet of the drug delivery channel is located directly above the nasal cavity of the mouse.
2. The mouse nasal inhalation drug delivery system according to claim 1, Characterized in that: Wherein, The fixing device includes: A base, which is a horizontally arranged plate-like structure; A clamping groove recessed on the base and opening upward; A fixing platform, which is a rectangular plate-like structure, the bottom edge of which is rotatably connected to the base, and the front surface of the fixing platform is used for placing and fixing a mouse; and A clamping plate, one end of which is connected to the back surface of the fixing platform, and the other end of which can be fitted and embedded into the clamping groove, so that the planes of the base and the fixing platform are fixed at an angle.
3. The mouse nasal inhalation drug delivery system according to claim 2, characterized in that: Among them, The number of the clamping grooves is several, and several of the clamping grooves are arranged in an array, and the arrangement direction thereof is perpendicular to the bottom edge of the fixing platform, One end of the clamping plate is rotatably connected to the back surface of the fixing platform and its relative rotation direction is perpendicular to the bottom edge of the fixing platform. When the other end of the clamping plate is embedded into different clamping grooves, different angles are formed between the planes of the base and the fixing platform and are fixed.
4. The mouse nasal inhalation drug delivery system according to claim 2, characterized in that: Among them, The fixing device further includes a support plate, The support plate protrudes from the front surface of the fixing platform and is used for supporting the lower limbs of the mouse.
5. The mouse nasal inhalation drug delivery system according to claim 2, characterized in that: Among them, The fixing device further includes a fixing groove, The number of the fixing grooves is 2, which are opened on both sides of the rectangular fixing platform and the opening directions thereof face the outside of both sides of the fixing platform, When the experimenter places the mouse on the front surface of the fixing platform, binds the upper limbs of the mouse with a thin line, then bypasses the two fixing grooves and ties them tightly on the back surface of the fixing platform, the mouse can be fixed on the front surface of the fixing platform.
6. The mouse nasal inhalation drug delivery system according to claim 2, characterized in that: Among them, The mouse oral cavity closing device includes: Two screws rotatably arranged at both ends of the other bottom edge of the fixing platform; and A binding band, both ends of which are wound around the screws, When the mouse is fixed on the front surface of the fixing platform, the lower jaw of the mouse is lifted by the binding band, and the screws are rotated to tighten the binding band wound thereon, so as to apply an upward force to the lower jaw of the mouse to close the oral cavity of the mouse.
7. The mouse nasal inhalation drug delivery system according to claim 2, Characterized in that: Wherein, The drug delivery channel clamping device includes: A support back plate arranged on the other bottom edge of the fixing platform and coplanar with the fixing platform; And Two clamping blocks protruding from the support back plate or the fixing platform, and the extending direction thereof faces the front surface of the fixing platform. A certain distance is spaced between the two clamping blocks for clamping the drug delivery channel. The supporting backplate and the two clamping blocks cooperate with each other to clamp the drug delivery channel above the nasal cavity of the mouse.
8. The mouse nasal inhalation administration system according to claim 7, It is characterized in that: Wherein, The clamping block includes: A first extension section, protruding from the supporting backplate or the fixing platform and extending towards the front of the fixing platform, and the protruding direction of the first extension section is perpendicular to the plane where the fixing platform is located; And A second extension section, arranged on the first extension section and facing upwards.
9. The mouse nasal inhalation drug delivery system according to claim 8, characterized in that: Among them, The supporting backplate and the fixing platform are integrally formed; The first extension section and the supporting backplate or the fixing platform are integrally formed; The first extension section and the second extension section are integrally formed.