High performance liquid chromatography mixer

Abstract

The utility model relates to the technical field of high performance liquid chromatography, in particular to a high performance liquid chromatography mixer. Comprising a main body, a second pressing cap and a connecting assembly, the upper end of the main body is connected with the second pressing cap, a liquid inlet and a liquid outlet are formed in the second pressing cap, the main body is of a hollow structure with the upper end open, one end of the liquid inlet is communicated with the outside of the second pressing cap, and the other end of the liquid inlet is communicated with the inside of the main body; the other end of the liquid outlet is communicated with the interior of the main body, the liquid inlet and the liquid outlet are each provided with a connecting assembly, a filter pad is arranged at the upper end in the main body and covers an opening in the upper end of the main body, a plurality of mixing spaces are formed in the main body, a plurality of mixing beads are arranged in each mixing space, and every two adjacent mixing spaces are communicated; a liquid flow path is arranged in the main body and is W-shaped; the mixing effect of high performance liquid chromatography is improved, the mixing uniformity in the shortest time is realized by using a small space, and the repeatability of a liquid chromatography system is optimal.

Description

Technical Field

[0001] The utility model relates to the technical field of high performance liquid chromatography, in particular to a high performance liquid chromatography mixer. Background Technique

[0002] With the development of modern chemical technology and the application of new materials and new technologies, the importance of petrochemical industry, organic synthesis, physiology and biochemistry, medicine and healthcare and other fields in people's daily life has become more prominent. As an important technical means for inspection, detection and verification of facts, instrumental analytical chemistry has also been developed and improved. High performance liquid chromatography included therein has high separation efficiency, fast analysis ability and convenient application method, and occupies an important position in instrumental analytical chemistry.

[0003] In recent years, people's attention to medicine and healthcare has been continuously deepened, the sensitivity to drugs and the self-protection awareness have been continuously strengthened, and the requirements for drug research and development and preparation in the pharmaceutical industry have become more stringent. Therefore, for the use of analytical instruments, which are inspection tools for verifying medicine, more strict requirements will be imposed, and more strict requirements will also be imposed on high performance liquid chromatography. Improving the mixing effect of the mobile phase, enhancing the analysis ability of liquid chromatography and strengthening the analysis effect of liquid chromatography are the current directions in the improvement research of high performance liquid chromatography.

[0004] The existing patent CN115608199A discloses a passive dynamic mixer for liquid chromatography, including a mixer body, a mixer cover and a runner assembly; the runner assembly includes runner blades, a blade shaft and a spacer ring. One end of the blade shaft is sequentially sleeved with a plurality of runner blades, and the runner blades are separated by spacer rings. The runner blade is integrally a sheet-shaped circle, and a central shaft hole for the blade shaft to pass through is provided in the center, and a diversion hole is also provided around the central shaft hole. Although the above mixer adds a blade shaft structure and can achieve dynamic stirring to a certain extent, it has a large space and cannot avoid the scraping damage between the runner blade and the cavity.

[0005] The existing patent CN202052482U discloses a static mixer, which is composed of a connection valve, a hollow screw, a pressing ring, a mixer cavity, a mixer screw, a mixer sealing gasket, a mixer distributor, a shunt ball, multiple liquid inlet pipes, a connecting pipe, an outlet pipe, etc. At least two solvents enter the mixer cavity after being connected by the connection valve. In the mixer cavity, multi-component shunt balls are filled in the through holes separated by two mixer distributors. Four shunt balls of equal size are in a group, and the centers of these four shunt balls are connected to form a regular tetrahedron. The mixed liquid is continuously separated and polymerized due to the obstruction of the shunt balls and is fully mixed in the cavity. According to the actual flow rate, 2 or more mixer cavities can be connected in series using a series pipe to obtain a more reasonable mixer volume. However, the above mixer is a multi-cavity series connection and is placed side by side. Since the mixer cavities are connected by stainless steel pipes, the mixer is relatively large both horizontally and vertically, requires a large installation space, is not convenient for installation and disassembly. At the same time, due to the lack of filtration in the design, corresponding impurities are mixed into the mixer during use, which is very likely to cause the pressure of the mixer to gradually increase and is relatively troublesome to clean.

[0006] Therefore, there is an urgent need to provide a high-performance liquid chromatography mixer, which, compared with the prior art, improves the mixing effect of high-performance liquid chromatography, realizes the mixing uniformity performance in the shortest time using a smaller space, and achieves the optimal repeatability of the liquid chromatography system. Summary of the Utility Model

[0007] The utility model solves the technical problems existing in the prior art, and provides a high-performance liquid chromatography mixer.

[0008] To achieve the above object, the technical solution adopted by the utility model is as follows:

[0009] A high-performance liquid chromatography mixer includes a main body, a second compression cap, and a connection assembly. The upper end of the main body is connected to the second compression cap. The second compression cap is internally provided with a liquid inlet and a liquid outlet. The main body is a hollow structure with an open upper end. One end of the liquid inlet is communicated with the outside of the second compression cap, and the other end of the liquid inlet is communicated with the inside of the main body. One end of the liquid outlet is communicated with the outside of the second compression cap, and the other end of the liquid outlet is communicated with the inside of the main body. A connection assembly is installed at both the liquid inlet and the liquid outlet. A filter pad is provided at the upper end inside the main body, and the filter pad covers the open upper end of the main body. Multiple mixing spaces are provided inside the main body, and multiple mixing beads are provided in each mixing space. Adjacent two mixing spaces are communicated. A liquid flow path is provided inside the main body, and the liquid flow path is in a W shape.

[0010] Furthermore, a plurality of partition plates are provided inside the main body, and the partition plates divide the inside of the main body into a plurality of mixing spaces.

[0011] Further, a plurality of honeycomb holes are provided at only one end of the side wall of the partition plate, and the honeycomb holes vertically penetrate through the partition plate.

[0012] Further, the honeycomb holes on two adjacent partition plates are arranged at different ends and are embedded in the groove in an inverted pattern.

[0013] Further, the honeycomb holes provided on the partition plate closest to the liquid inlet are arranged away from the liquid inlet, and the honeycomb holes provided on the partition plate closest to the liquid outlet are arranged away from the liquid outlet.

[0014] Further, a plurality of embedding grooves are provided inside the main body, and a partition plate is installed inside each embedding groove.

[0015] Further, filtering parts are provided at both ends of the filter pad, and the two filtering parts respectively correspond to the liquid inlet and the liquid outlet; the filter pad is made of PEEK material.

[0016] Further, a plurality of filtering holes are provided in each filtering part.

[0017] Further, the connection assembly includes a first compression cap, a connection screw and a blade ring. A first compression cap is installed in each of the liquid inlet and the liquid outlet. The blade ring is arranged inside the first compression cap, and the upper part of the blade ring is connected to the connection screw; the first compression cap, the connection screw, the blade ring and the mixing beads are all made of stainless steel.

[0018] Further, the second compression cap is connected to the main body through a fixing screw, and the fixing screw acts on the filter pad for pressing and sealing.

[0019] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0020] (1) In the present utility model, the liquid is filtered and then mixed in the mixing space filled with mixing beads in a form of changing direction, and partition plates are provided inside the main body, so that the liquid moves along a W-shaped flow path, increasing the mixing path, improving the mixing effect of high performance liquid chromatography, realizing the mixing uniformity performance in the shortest time by using a smaller space, and achieving the optimal repeatability of the liquid chromatography system.

[0021] (2) In the present utility model, a filter pad is provided between the second compression cap and the partition plate, and filtering holes are provided at both ends of the filter pad, so that the filtering holes only correspond to the liquid inlet and the liquid outlet, which can not only filter the liquid but also play a sealing role, ensuring the sealing effect of the mixer.

[0022] (3) In the present utility model, honeycomb holes are provided at one end of each partition plate, enhancing the mixing effect of the mixer and being more beneficial to the mixing uniformity of the liquid. Description of the Drawings

[0023] Figure 1 This is a schematic diagram of the overall structure of the present utility model.

[0024] Figure 2 This is a sectional view showing the internal structure of the present utility model.

[0025] Figure 3 This is an installation schematic diagram of the first compression cap and the second compression cap of the present utility model.

[0026] Figure 4 This is a schematic diagram showing the installation structure of the partition plate in the main body of the present utility model.

[0027] Figure 5 This is a schematic diagram of the structure of the partition plate of the present utility model.

[0028] Figure 6 This is a schematic diagram of the structure of the filter pad of the present utility model.

[0029] Explanation of reference numerals:

[0030] 1. Connecting screw; 2. Blade ring; 3. First compression cap; 4. Second compression cap; 5. Main body; 6. Filter pad; 7. Filter hole; 8. Mixing beads; 9. Fixing screw; 10. Embedding groove; 11. Partition plate; 12. Honeycomb holes; 13. Screw hole. Detailed implementation manners

[0031] The technical solutions of the present utility model will be clearly described below in conjunction with the accompanying drawings. Obviously, the described embodiments are not all the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model. It should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model.

[0032] Such as Figure 1 、 Figure 2 、 Figure 3As shown in the figure, the present utility model provides a high performance liquid chromatography mixer, which includes a main body 5, a second compression cap 4 and a connection assembly. The upper end of the main body 5 is connected to the second compression cap 4. The second compression cap 4 and the main body 5 are connected by fixing screws 9. The second compression cap 4 is provided with a liquid inlet and a liquid outlet, both of which penetrate through the second compression cap 4. Connection assemblies are connected to both the liquid inlet and the liquid outlet. The connection assembly includes a connection screw 1, a blade ring 2 and a first compression cap 3. The first compression cap 3 is threadedly connected to the inside of the liquid inlet and the liquid outlet. A blade ring 2 is arranged inside each first compression cap 3. The upper part of each blade ring 2 is connected to the connection screw 1. The connection screw 1 and the blade ring 2 are used to connect the external pipeline to the first compression cap 3.

[0033] The main body 5 is a hollow structure with an open upper end. Filter pads 6 are installed inside the main body 5 near the liquid inlet and the liquid outlet. The filter pads 6 are made of PEEK material. A plurality of partition plates 11 are arranged inside the main body 5. Preferably, three partition plates 11 are provided. The partition plates 11 are arranged in parallel. The partition plates 11 are perpendicular to the filter pads 6. The upper ends of the partition plates 11 are in contact with the lower wall of the filter pads 6. Embedding grooves 10 are provided on the side walls of the main body 5. The partition plates 11 are installed inside the embedding grooves 10. The partition plates 11 divide the interior of the main body 5 into a plurality of mixing spaces. A plurality of mixing beads 8 are arranged inside each mixing space. The specifications of the mixing beads 8 in each mixing space are the same or different. The specifications of the mixing beads 8 in different mixing spaces are the same or different. A plurality of mixing beads 8 are arranged inside the mixing space to change the flow direction and mix the fluid after it enters the mixing space. The fixing screws 9 press the filter pads 6 tightly between the second compression cap 4 and the partition plates 11 to play a role in sealing the mixer. The blade ring 2, the first compression cap 3, the connection screw 1 and the mixing beads 8 are all made of stainless steel.

[0034] As Figure 4 , Figure 5 As shown in the figure, one end of the side wall of the partition plate 11 is provided with honeycomb holes 12, which penetrate through the partition plate 11. The honeycomb holes 12 provided on adjacent two partition plates 11 are arranged at different ends. They are installed in a "one positive and one negative" sequence in turn and are embedded in the embedding grooves 10 in an inverted manner. That is, if the honeycomb holes 12 provided on one of the adjacent two partition plates 11 are located at the upper end, then the honeycomb holes 12 of the adjacent partition plate 11 are located at the lower end. The honeycomb holes 12 of the partition plate 11 closest to the liquid inlet are arranged at the end far from the liquid inlet, and the honeycomb holes 12 of the partition plate 11 closest to the liquid outlet are arranged at the end far from the liquid outlet. Two screw holes 13 are provided on the upper wall of the main body 5. Two fixing screws 9 are also provided. Each fixing screw 9 passes through the second compression cap 4 and is connected to the screw hole 13 to realize the installation of the second compression cap 4 and the main body 5. The flow path inside the main body 5 is in a W shape. The honeycomb holes 12 serve as the only communication channel between adjacent two mixing spaces, which can change the flow direction of the liquid inside the mixer. At the same time, better mixing can be achieved because the volume of the space before and after the liquid passes through the honeycomb holes 12 changes.

[0035] AsFigure 6 As shown, both ends of the filter pad 6 are provided with filtering parts, and the two filtering parts correspond to the liquid inlet and the liquid outlet respectively. Each filtering part is provided with a plurality of filtering holes 7 to mix and filter the liquid flowing into the main body 5 and the liquid flowing out of the main body 5. At the same time, the filter pad 6 is pressed tightly between the second pressing cap 4 and the partition plate 11 by the fixing screw 9, and can also play a sealing role to ensure the sealing effect of the mixer.

[0036] The working principle of the high-performance liquid chromatography mixer provided by the present utility model: The high-performance liquid chromatography mixer provided by the present utility model is connected to the application system through the connecting component. The liquid flows in through the liquid inlet, passes through the filter pad 6 and enters the inside of the main body 5. The liquid first flows into the mixing space opposite to the liquid inlet, and the liquid flows downward through the mixing beads 8 arranged in the mixing space, and flows into the adjacent mixing space of the mixing space through the honeycomb holes 12. The liquid flows along the W-shaped flow path inside the main body 5 and finally flows out through the liquid outlet. The liquid is mixed by changing the path by the mixing beads 8 in the W-shaped flow path. The liquid is restricted by the partition plate 11 and can only move in one direction. When the liquid passes through the honeycomb holes 12, due to the change of the front and rear spaces, the liquid mixing is promoted, so that the liquid enters another mixing space separated by the partition plate 11 and continues to have its path changed by the mixing beads 8 therein for sufficient mixing.

[0037] The high-performance liquid chromatography mixer provided by the present utility model is provided with a filter pad 6 below the second pressing cap 4 to play a sealing role. At the same time, the filter pad 6 is provided with filtering holes 7 to filter the mixed liquid; after being filtered, the liquid is mixed in the form of changing directions inside the mixing space filled with the mixing beads 8, and a partition plate 11 is also provided inside the main body 5, so that the liquid moves along the W-shaped flow path, increasing the mixing path, improving the mixing effect of the high-performance liquid chromatography, realizing the mixing uniformity performance in the shortest time by using a smaller space, and achieving the optimal repeatability of the liquid chromatography system; honeycomb holes 12 are provided at one end of each partition plate 11 to enhance the mixing effect of the mixer and be more conducive to the mixing uniformity of the liquid.

[0038] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present utility model, rather than a limitation on the protection scope of the present utility model. Any simple modification or equivalent replacement made by those of ordinary skill in the art to the technical solution of the present utility model does not depart from the essence and scope of the technical solution of the present utility model.

Claims

1. An efficient liquid chromatography mixer, characterized in that, It includes a main body, a second compression cap and a connection component. The upper end of the main body is connected to the second compression cap. The second compression cap is internally provided with a liquid inlet and a liquid outlet. The main body is a hollow structure with an open upper end. One end of the liquid inlet is communicated with the outside of the second compression cap, and the other end of the liquid inlet is communicated with the inside of the main body. One end of the liquid outlet is communicated with the outside of the second compression cap, and the other end of the liquid outlet is communicated with the inside of the main body. A connection component is installed at both the liquid inlet and the liquid outlet. A filter pad is provided at the upper end inside the main body, and the filter pad covers the open upper end of the main body. A plurality of mixing spaces are provided inside the main body, and a plurality of mixing beads are provided in each mixing space. Adjacent two mixing spaces are communicated. A liquid flow path is provided inside the main body, and the liquid flow path is in a W shape.

2. The high-performance liquid chromatography mixer according to claim 1, characterized in that, A plurality of partition plates are provided inside the main body, and the partition plates divide the inside of the main body into a plurality of mixing spaces.

3. The high-performance liquid chromatography mixer according to claim 2, characterized in that, Only one end of the side wall of the partition plate is provided with a plurality of honeycomb holes, and the honeycomb holes penetrate through the partition plate vertically.

4. The high-performance liquid chromatography mixer according to claim 3, wherein, The honeycomb holes on adjacent two partition plates are arranged at different ends.

5. An efficient liquid chromatography mixer according to claim 4, characterized in that, The honeycomb holes provided on the partition plate closest to the liquid inlet are arranged away from the liquid inlet, and the honeycomb holes provided on the partition plate closest to the liquid outlet are arranged away from the liquid outlet.

6. The high-performance liquid chromatography mixer according to claim 2, characterized in that, A plurality of embedding grooves are provided inside the main body, and a partition plate is installed inside each embedding groove.

7. An efficient liquid chromatography mixer according to claim 1, characterized in that, Both ends of the filter pad are provided with filtering parts, and the two filtering parts correspond to the liquid inlet and the liquid outlet respectively; the filter pad is made of PEEK material.

8. An efficient liquid chromatography mixer according to claim 7, characterized in that, Each filtering part is provided with a plurality of filtering holes.

9. The high-performance liquid chromatography mixer according to claim 1, characterized in that, The connection component includes a first compression cap, a connection screw and a blade ring. A first compression cap is installed inside both the liquid inlet and the liquid outlet. The blade ring is arranged inside the first compression cap, and the upper part of the blade ring is connected to the connection screw; the first compression cap, the connection screw, the blade ring and the mixing beads are all made of stainless steel material.

10. An efficient liquid chromatography mixer according to claim 1, characterized in that, The second compression cap and the main body are connected by fixing screws, and the fixing screws act on the filter pad for pressing and sealing.

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