Composite column mounting assembly

Abstract

The utility model relates to a composite column installation assembly which comprises an installation base. The composite column limiting plate is arranged on the mounting base and used for allowing the multiple composite columns to penetrate through, the composite column supporting plate is located below the composite column limiting plate and used for supporting the composite columns, and the composite column supporting plate is configured to be capable of being close to or away from the composite column limiting plate so as to adjust the height of the multiple composite columns stretching out of the composite column limiting plate.

Description

Technical Field

[0001] The utility model relates to the technical field of compound synthesis, in particular to a synthesis column installation component. Background Art

[0002] A compound synthesizer is a chemical instrument capable of performing chemical synthesis. There can be various types of compound synthesizers, for example, nucleic acid synthesizers, polypeptide synthesizers, etc. Taking a nucleic acid synthesizer as an example, during the experiment, liquid is injected into the synthesis column installed in the synthesis column installation component through a liquid separation tube, so as to perform nucleic acid synthesis with the substances in the synthesis column.

[0003] Among them, the injection accuracy is an important link in the experiment process, which may directly affect the result of nucleic acid synthesis. In addition, according to different experimental scenarios, the types of synthesis columns required may be different. Therefore, how to be compatible with different types of synthesis columns and improve the injection accuracy is a topic that needs to be studied currently. Summary of the Utility Model

[0004] In order to overcome the deficiencies of the above prior art, the utility model provides a synthesis column installation component, which can be compatible with different types of synthesis columns and can adapt to the heights of different types of synthesis columns, thereby being beneficial to improving the injection accuracy.

[0005] An object of the utility model is to provide a synthesis column installation component, including: a mounting base; a synthesis column limiting plate disposed on the mounting base for allowing a plurality of synthesis columns to pass through; a synthesis column supporting plate located below the synthesis column limiting plate for supporting the synthesis column, and the synthesis column supporting plate is configured to be able to approach or move away from the synthesis column limiting plate to adjust the heights of the plurality of synthesis columns protruding from the synthesis column limiting plate.

[0006] In some embodiments, the synthesis column installation component further includes a support, the support is connected between the synthesis column supporting plate and the synthesis column limiting plate, and the support is configured to be able to make the synthesis column supporting plate approach or move away from the synthesis column limiting plate.

[0007] In some embodiments, one end of the support is detachably connected to the synthesis column limiting plate, and the other end of the support is detachably connected to the synthesis column supporting plate.

[0008] In some embodiments, the support has a first length or a second length between the synthesis column limiting plate and the synthesis column supporting plate, and the sizes of the first length and the second length are different.

[0009] In some embodiments, the support is provided with adjustment holes extending in a direction in which the synthesis column tray moves closer to or away from the synthesis column limiting plate. Fasteners are inserted through the adjustment holes, and the synthesis column tray is fixed to the support by the fasteners. The distance between the synthesis column tray and the synthesis column limiting plate is adjusted by adjusting the position of the fasteners in the adjustment holes.

[0010] In some embodiments, the synthesis column limiting plate is detachably connected to the mounting base.

[0011] In some embodiments, the mounting base includes a bottom plate and a vertical plate connected to the bottom plate. The vertical plate is provided with a locking sleeve, and the synthesis column limiting plate is fixed to the vertical plate by a locking device in cooperation with the locking sleeve.

[0012] In some embodiments, the synthesis column limiting plate is provided with a plurality of limiting holes for respectively allowing the synthesis columns to pass through. The synthesis column tray is provided with a plurality of supporting portions corresponding to the plurality of limiting holes. Each supporting portion includes a groove and a through hole penetrating the bottom surface of the groove. The diameter of the through hole is smaller than the diameter of the limiting hole. The groove is used to accommodate part of the synthesis column and the bottom surface of the groove is used to support the synthesis column. The through hole is used to allow the end interface of the synthesis column to pass through.

[0013] The utility model can adjust the height of the synthesis column with different lengths extending out of the synthesis column limiting plate by enabling the synthesis column tray to be close to or away from the synthesis column limiting plate, so as to keep a proper distance between the top ports of the synthesis columns with different lengths and the liquid distribution tubes in the synthesizer, thereby improving compatibility and also being beneficial to improving the liquid injection precision, and further reducing the experimental defect rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The drawings described herein are used to provide a further understanding of the present disclosure and form a part of the present disclosure. The illustrative embodiments and descriptions thereof of the present disclosure are used to explain the present disclosure and do not constitute an improper limitation of the present disclosure. In the drawings:

[0015] Figure 1 shows a schematic structural diagram of a synthesis column carrying device provided by some embodiments of the present application;

[0016] Figure 2 shows a schematic structural diagram of a synthesis column mounting assembly provided by some embodiments of the present application;

[0017] Figure 3 shows a schematic structural diagram of a joint mounting assembly provided by some embodiments of the present application;

[0018] Figure 4 shows a schematic structural diagram of a sliding assembly provided by some embodiments of the present application;

[0019] Figure 5 Shows a schematic structural diagram of a positioning component provided by some embodiments of the present application;

[0020] Figure 6 Shows a schematic diagram of the operation process of a positioning component provided by some embodiments of the present application;

[0021] Figure 7 Shows a schematic structural diagram of a joint mounting plate provided by some embodiments of the present application;

[0022] Figure 8 Shows a top view schematic diagram of a joint mounted on a mounting plate provided by some embodiments of the present application;

[0023] Figure 9 Shows a cross-sectional view schematic diagram of a joint mounted on a mounting plate provided by some embodiments of the present application;

[0024] Figure 10 Shows a cooperation schematic diagram of a joint mounting plate and a joint pressing plate provided by some embodiments of the present application;

[0025] Figure 11 Shows a comparison schematic diagram of adjusting the extended height of a synthetic column by supports with different sizes provided by some embodiments of the present application;

[0026] Figure 12 Shows a comparison schematic diagram of adjusting the extended height of a synthetic column through support adjustment holes provided by some embodiments of the present application.

[0027] Figure 13 Shows a comparison schematic diagram of a bearing device in a synthesizer supporting different types of synthetic columns provided by some embodiments of the present application. Detailed implementation manners

[0028] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are some but not all of the embodiments of the present application.

[0029] Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed utility model, but merely represents selected embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without creative efforts fall within the scope of protection of the present application.

[0030] It should be noted that like reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0031] A compound synthesizer is a chemical instrument capable of performing chemical synthesis. There can be various types of compound synthesizers. For example, nucleic acid synthesizers, polypeptide synthesizers, etc. Taking the nucleic acid synthesizer as an example, a nucleic acid synthesizer is an experimental device capable of efficiently synthesizing nucleic acid molecules (such as DNA or RNA). It injects liquid into the synthesis column on the carrier device through a liquid separation tube, thereby performing nucleic acid synthesis with the substances in the synthesis column.

[0032] Generally, the required liquid injection volume in the synthesis column is very small. If the liquid drops are to be accurately injected into the synthesis column, the distance between the synthesis column and the liquid separation tube needs to meet certain requirements. In addition, depending on the different experimental scenarios, the types of synthesis columns required may also be different. The inventor found that when replacing different types of synthesis columns, due to certain differences in the length (height) of the synthesis columns, the distance between the top port of the synthesis column and the liquid injection port at the end of the liquid separation tube is different. Usually, the position of the liquid separation tube in the nucleic acid synthesizer is relatively fixed. When the distance between the top port of the synthesis column and the liquid injection port of the liquid separation tube is large, there may be a risk that the liquid drops cannot be accurately injected, resulting in an error in the liquid injection volume, and further leading to poor experimental results.

[0033] In response to this, the present application provides a synthesis column installation assembly, which can be compatible with different types of synthesis columns, and make the top ports of different types of synthesis columns generally at the same height, thereby improving compatibility while also being conducive to improving the liquid injection accuracy, and further reducing the experimental defect rate.

[0034] In the following description, the synthesis column installation assembly 20 is described by taking its application in a nucleic acid synthesizer as an example. It can be understood that the synthesizer is not limited to a nucleic acid synthesizer, but can also be a polypeptide synthesizer or other compound synthesizers. Thus, the synthesis column carried by the synthesis column carrier device can be a nucleic acid synthesis column, a polypeptide synthesis column or other compound synthesis columns.

[0035] Refer to Figures 1 to 13 , the synthesis column installation assembly 20 provided by the present application can be applied to a nucleic acid synthesizer 200. The synthesis column installation assembly 20 includes: a mounting base 10, a synthesis column limiting plate 21, and a synthesis column support plate 22.

[0036] The mounting base 10 can provide support for the synthesis column limiting plate 21 and the synthesis column support plate 22. As an example, the mounting base 10 can include a bottom plate 11 and a vertical plate 12 provided on the bottom plate 11. The bottom plate 11 can be installed on the internal support component of the nucleic acid synthesizer 200, and the vertical plate 12 can support the synthesis column limiting plate 21. Optionally, the bottom plate 11 and the vertical plate 12 are detachably connected.

[0037] The synthesis column limiting plate 21 is arranged on the mounting seat 10 and is used for multiple synthesis columns T to pass through. The synthesis column supporting plate 22 is located below the synthesis column limiting plate 21 and is used to support the synthesis column T. The synthesis column supporting plate 22 is configured to be able to approach or move away from the synthesis column limiting plate 21 to adjust the height of the multiple synthesis columns T protruding from the synthesis column limiting plate 21.

[0038] That the synthesis column supporting plate 22 is configured to be able to approach or move away from the synthesis column limiting plate 21 can be understood as that when the position of the synthesis column supporting plate 22 relative to the synthesis column limiting plate 21 changes, the position of the synthesis column supporting plate 22 relative to the synthesis column limiting plate 21 can change, so that the distance between the synthesis column supporting plate 22 and the synthesis column limiting plate 21 changes. Thus, for synthesis columns T of different lengths, the height of the synthesis columns T protruding from the synthesis column limiting plate 21 can be made substantially the same.

[0039] Exemplarily, referring to Figure 1 and Figure 2 and, for a relatively short synthesis column T, the synthesis column supporting plate 22 supports the relatively short synthesis column T to approach the synthesis column limiting plate 21, so that the distance between the synthesis column supporting plate 22 and the synthesis column limiting plate 21 becomes smaller, thereby keeping a proper distance between the top port of the relatively short synthesis column T and the liquid distribution pipe in the nucleic acid synthesizer 200; for a relatively long synthesis column T, the synthesis column supporting plate 22 supports the relatively long synthesis column T to move away from the synthesis column limiting plate 21, so that the distance between the synthesis column supporting plate 22 and the synthesis column limiting plate 21 becomes larger, thereby keeping the proper distance between the top port of the relatively long synthesis column T and the liquid distribution pipe in the nucleic acid synthesizer 200.

[0040] By enabling the synthesis column supporting plate 22 to approach or move away from the synthesis column limiting plate 21, the height of the synthesis columns T of different lengths protruding from the synthesis column limiting plate 21 can be adjusted, so as to keep a proper distance between the top ports of the synthesis columns T of different lengths and the liquid distribution pipe in the nucleic acid synthesizer 200. Thus, while improving compatibility, it is also beneficial to improve the liquid injection accuracy and further reduce the experimental defect rate.

[0041] In some embodiments, the synthesis column mounting assembly 20 further includes a support 23. The support 23 is connected between the synthesis column supporting plate 22 and the synthesis column limiting plate 21. The support 23 is configured to be able to make the synthesis column supporting plate 22 approach or move away from the synthesis column limiting plate 21.

[0042] In one example, the support 23 can be made to approach or move away from the synthesis column limiting plate 21 by changing the length (which can also be called the height) of the support 23 located between the synthesis column limiting plate 21 and the synthesis column supporting plate 22, so as to adjust the distance between the synthesis column supporting plate 22 and the synthesis column limiting plate 21, and further make the height of the synthesis columns T of different lengths protruding from the synthesis column limiting plate 21 substantially the same.

[0043] Specifically, referring toFigure 11 One end of the support 23 is detachably connected to the synthetic column limit plate 21, and the other end of the support 23 is detachably connected to the synthetic column support plate 22. Thus, by replacing the support 23 with different lengths, the distance between the synthetic column support plate 22 and the synthetic column limit plate 21 is changed, and further the height of different synthetic columns T protruding from the synthetic column limit plate 21 is adjusted, so that the heights of different lengths of synthetic columns T protruding from the synthetic column limit plate 21 are substantially the same.

[0044] Exemplarily, the support 23 has a first length L1 or a second length L2 located between the synthetic column limit plate 21 and the synthetic column support plate 22, and the sizes of the first length L1 and the second length L2 are different.

[0045] For example, for a shorter synthetic column T, the support 23 with the second length L2 can be replaced ( Figure 11 as shown in b in), to reduce the distance between the synthetic column support plate 22 and the synthetic column limit plate 21. For a longer synthetic column T, the support 23 with the first length L1 longer than the second length L2 can be replaced ( Figure 11 as shown in a in), to increase the distance between the synthetic column support plate 22 and the synthetic column limit plate 21. Thus, the heights of the shorter synthetic column T and the longer synthetic column T protruding from the synthetic column limit plate 21 are substantially the same.

[0046] In another example, referring to Figure 12 , the support 23 is provided with an adjustment hole 231 extending in the direction in which the synthetic column support plate 22 moves closer to or away from the synthetic column limit plate 21. A fastener 24 is inserted through the adjustment hole 231, and the synthetic column support plate 22 is fixed to the support 23 by the fastener 24. The distance between the synthetic column limit plate 21 and the synthetic column support plate 22 is adjusted by adjusting the position of the fastener 24 in the adjustment hole 231.

[0047] For example, for a shorter synthetic column T, the position of the fastener 24 at the highest point in the adjustment hole 231 can be adjusted ( Figure 12 as shown in b in), and the synthetic column support plate 22 is fixed to the support 23 by the fastener 24 to reduce the distance between the synthetic column support plate 22 and the synthetic column limit plate 21; for a longer synthetic column T, the position of the fastener 24 at the lowest point in the adjustment hole 231 can be adjusted ( Figure 12 as shown in a in), and the synthetic column support plate 22 is fixed to the support 23 by the fastener 24 to increase the distance between the synthetic column support plate 22 and the synthetic column limit plate 21. Thus, the heights of the shorter synthetic column T and the longer synthetic column T protruding from the synthetic column limit plate 21 can be substantially the same.

[0048] It should be noted that in the above solution, by replacing the supports 23 with different lengths or by providing adjustment holes 231 in the supports 23, the synthetic column support plate 22 is moved closer to or farther away from the synthetic column limiting plate 21 to adjust the distance between the synthetic column support plate 22 and the synthetic column limiting plate 21, so that the heights of synthetic columns T with different lengths extending out of the synthetic column limiting plate 21 can be generally the same. However, this is not limited to this. The synthetic column support plate 22 can also be moved closer to or farther away from the synthetic column limiting plate 21 in other possible ways. For example, the synthetic column support plate 22 is slidably arranged on the mounting base 10 and is moved closer to or farther away from the synthetic column limiting plate 21 by sliding.

[0049] In some embodiments, the synthetic column limiting plate 21 is detachably connected to the mounting base 10.

[0050] Exemplarily, the synthetic column limiting plate 21 can be detachably connected to the vertical plate 12 of the mounting base 10 through a fastener 24.

[0051] The detachable connection between the synthetic column limiting plate 21 and the mounting base 10 enables the synthetic column mounting assembly 20 to be modular and disassembled from the device, facilitating the cleaning of the synthetic column T. At the same time, the synthetic column T can be batch-mounted outside the device, reducing the waiting time for replacing the synthetic column T.

[0052] In some embodiments, the mounting base 10 includes a bottom plate 11 and a vertical plate 12 connected to the bottom plate 11. The vertical plate 12 is provided with a locking sleeve, and the synthetic column limiting plate 21 is fixed to the vertical plate 12 through a quick-release fastener 25 in cooperation with the locking sleeve. Thus, the quick disassembly and assembly of the synthetic column limiting plate 21 and the mounting base 10 are realized.

[0053] In some embodiments, referring to Figure 11 , the synthetic column limiting plate 21 is provided with a plurality of limiting holes 211 for the synthetic column T to pass through respectively. The synthetic column support plate 22 is provided with a plurality of support portions 221 corresponding to the plurality of limiting holes 211. Each support portion 221 includes a groove 221a and a through hole 221b penetrating the bottom surface of the groove 221a. The aperture of the through hole 221b is smaller than the aperture of the limiting hole 211. The groove 221a is used to accommodate a part of the synthetic column T, and the bottom surface of the groove 221a is used to support the lower end surface of the synthetic column T. The through hole 221b is used for the end interface of the synthetic column T to pass through, and the end interface of the synthetic column T is used to connect to a joint S, and the joint S can be, for example, a Luer joint.

[0054] The end interface of the synthetic column T is used to connect to the joint S. The plurality of limiting holes 211 on the synthetic column limiting plate 21 can be arranged in one row, two rows, three rows or more rows.

[0055] In use, the synthesis column limiting plate 21 is detached from the mounting base 10, so that the synthesis column mounting assembly 20 is detached from the device 100. Then, a plurality of synthesis columns T are installed. Finally, the synthesis column mounting assembly 20 equipped with a plurality of synthesis columns T is installed on the mounting base 10.

[0056] In some embodiments, the embodiment of the present application further provides a nucleic acid synthesis column carrying device 100. The nucleic acid synthesis column carrying device 100 includes the above-mentioned synthesis column mounting assembly 20, and further includes a connector mounting plate 31. The connector mounting assembly 30 includes the connector mounting plate 31. The connector mounting plate 31 is disposed on the mounting base 10 and below the synthesis column support plate 22 for supporting a plurality of connectors S. The connector mounting plate 31 is configured to be able to approach or move away from the synthesis column support plate 22, so that the plurality of connectors S supported by the connector mounting plate 31 are respectively installed on the plurality of synthesis columns T supported by the synthesis column support plate 22.

[0057] That the connector mounting plate 31 is configured to be able to approach or move away from the synthesis column support plate 22 can be understood as follows: when the position of the synthesis column support plate 22 relative to the synthesis column limiting plate 21 changes, the connector mounting plate 31 can follow the synthesis column support plate 22 to approach or move away from the synthesis column limiting plate 21, so as to enable the plurality of connectors S supported by the connector mounting plate 31 to be respectively installed on the plurality of synthesis columns T supported by the synthesis column support plate 22 for synthesis columns T of different lengths. It can be understood that the plurality of connectors S supported by the connector mounting plate 31 and the plurality of synthesis columns T supported by the synthesis column support plate 22 are in one-to-one correspondence.

[0058] Exemplarily, referring to Figure 1 and Figure 2 For a shorter synthesis column T, the synthesis column support plate 22 supports the shorter synthesis column T to approach the synthesis column limiting plate 21, so that the distance between the synthesis column support plate 22 and the synthesis column limiting plate 21 becomes smaller, so that a suitable distance is maintained between the top port of the shorter synthesis column T and the liquid distribution tube in the nucleic acid synthesizer 200. At the same time, the connector mounting plate 31 supports the connector S to follow the synthesis column support plate 22 to approach the synthesis column limiting plate 21, so that the plurality of connectors S supported by the connector mounting plate 31 are respectively installed on the plurality of shorter synthesis columns T supported by the synthesis column support plate 22. For a longer synthesis column T, the synthesis column support plate 22 supports the longer synthesis column T to move away from the synthesis column limiting plate 21, so that the distance between the synthesis column support plate 22 and the synthesis column limiting plate 21 becomes larger, so that a suitable distance is maintained between the top port of the longer synthesis column T and the liquid distribution tube in the nucleic acid synthesizer 200. At the same time, the connector mounting plate 31 supports the connector S to follow the synthesis column support plate 22 to move away from the synthesis column limiting plate 21, so that the plurality of connectors S supported by the connector mounting plate 31 are respectively installed on the plurality of longer synthesis columns T supported by the synthesis column support plate 22.

[0059] The joint mounting plate 31 is configured to be able to approach or move away from the synthetic column support plate 22, enabling batch installation and disassembly of the joint S and the synthetic column T, and improving the installation efficiency. In the prior art, it was necessary to install the joint S on the synthetic column T one by one, which was time-consuming and laborious with low efficiency.

[0060] In some embodiments, the nucleic acid synthesis column carrier device 100 further includes a sliding assembly 13 disposed on the mounting base 10. The joint mounting plate 31 is slidably connected to the mounting base 10 through the sliding assembly 13, so that the joint mounting plate 31 can slide closer to or away from the synthetic column support plate 22.

[0061] The joint mounting plate 31 approaches or moves away from the synthetic column support plate 22 in a sliding manner, and the movement process is smoother, so that a plurality of joints S supported by the joint mounting plate 31 can be reliably installed on a plurality of synthetic columns T supported by the synthetic column support plate 22.

[0062] In some embodiments, the nucleic acid synthesis column carrier device 100 further includes a positioning assembly 14 disposed on the mounting base 10. The positioning assembly 14 is configured to be able to limit the sliding of the joint mounting plate 31, so that the joint mounting plate 31 keeps the joint S and the synthetic column T in an installed state.

[0063] As an example, referring to Figure 3 , the sliding assembly 13 includes a first slide rail 131, a second slide rail 132, a first slider 133 and a second slider 134. The first slide rail 131 and the second slide rail 132 are respectively disposed on the mounting base 10 and on the left and right sides of the joint mounting plate 31. The first slider 133 is slidably connected to the first slide rail 131, the second slider 134 is slidably connected to the second slide rail 132, and the joint mounting plate 31 is connected to the first slider 133 and the second slider 134, so that it can slide along the first slide rail 131 and the second slide rail 132 following the first slider 133 and the second slider 134. For example, the first slide rail 131 and the second slide rail 132 can be respectively disposed on two vertical plates 12 of the mounting base 10.

[0064] As an example, referring to Figures 4 to 6 , at least one of the first slider 133 and the second slider 134 is provided with a plurality of positioning holes 135 in the sliding direction of the joint mounting plate 31. The positioning assembly 14 includes two left and right plunger mounting blocks 141 corresponding to the first slider 133 and the second slider 134 and a knob plunger 142 installed on the plunger mounting blocks 141. The knob plunger 142 is used to cooperate with the positioning holes 135 of the first slider 133 and the second slider 134 to limit the sliding of the joint mounting plate 31.

[0065] The knob plunger 142 is an example of the positioning component 14 and can quickly cooperate with the positioning hole 135 to limit the sliding of the joint mounting plate 31. Of course, other components such as bolts and pins can also be used as the positioning component 14 to cooperate with the positioning hole 135 to limit the sliding of the joint mounting plate 31.

[0066] For example, for the shorter synthesis column T, the knob plunger 142 is located in the lowest one of the plurality of positioning holes 135 ( Figure 13 h2 shown in b), to limit the sliding of the joint mounting plate 31. For the longer synthesis column T, the knob plunger 142 is located in the highest one of the plurality of positioning holes 135 ( Figure 13 h1 shown in a), to limit the sliding of the joint mounting plate 31.

[0067] In some embodiments, the joint mounting plate 31 is detachably connected to the first slider 133 and the second slider 134. For example, the joint mounting plate 31 is detachably connected to the first slider 133 and the second slider 134 through fasteners. The fasteners are not limited to screws, snap connectors, etc.

[0068] By detachably connecting the joint mounting plate 31 to the first slider 133 and the second slider 134, the joint mounting plate 31 can be detached, which is convenient for cleaning the joint S. At the same time, the joints S can be batch-mounted outside the device, reducing the waiting time for replacing the joints S.

[0069] It should be noted that in the implementation of this application, according to different types (specifications) of the synthesis column, such as different lengths, different numbers of positioning holes 15 can be provided on the first slider 133 slidably connected to the first slide rail 131, and different numbers of positioning holes 15 can be provided on the second slider 134 slidably connected to the second slide rail 132.

[0070] In addition, in the embodiments of this application, the specifications and dimensions of the support 23 and the synthesis column T shown in the figure are only exemplary. It can be understood that the specifications and dimensions of the support 23 and the synthesis column T can also be any other possible specifications and dimensions.

[0071] In some embodiments, referring to Figure 7 、 Figure 8 and Figure 9 , the joint mounting plate 31 is provided with a plurality of first joint holes 311 corresponding to the through holes 221b respectively. The support surface of the joint mounting plate 31 facing the synthesis column support plate 22 is provided with a positioning groove 312 communicating with the first joint holes 311. The first joint holes 311 are used for the body S1 of the joint S to pass through, and the positioning groove 312 is used for accommodating and supporting the flank S2 of the joint S to limit the rotation of the joint S.

[0072] The multiple first joint holes 311 on the joint mounting plate 31 can also be formed in one row, two rows, three rows or more rows, and the multiple first joint holes 311, the multiple through holes 221b and the multiple limiting holes 211 correspond to each other one by one. In each row of the first joint holes 311, the first joint holes 311 can be communicated with each other through the positioning grooves 312, which is convenient for processing.

[0073] In some embodiments, referring to Figure 10 , the joint mounting assembly 30 further includes a joint pressing plate 32. The joint pressing plate 32 includes multiple second joint holes 321 corresponding to the first joint holes 311 respectively. The second joint holes 321 are used for allowing only the part of the body S1 of the joint S above the flank S2 to pass through while keeping the flank S2 in the positioning groove 312. The joint pressing plate 32 is arranged on the supporting surface of the joint mounting plate 31 to prevent the joint S from detaching from the joint mounting plate 31. Thus, the joint mounting plate 31 supports the joint S more firmly.

[0074] During use, in the first step, the joint mounting plate 31 can be detached from the first slider 133 and the second slider 134, so that the whole joint mounting assembly 300 can be detached from the device 100. Then, multiple joints S are installed, and finally, the joint mounting assembly 300 with multiple joints S installed is mounted on the first slider 133 and the second slider 134 through the joint mounting plate 31;

[0075] In the second step, the synthetic column limiting plate 21 is detached from the mounting seat 10, so that the synthetic column mounting assembly 20 can be detached from the device 100. Then, multiple synthetic columns T are installed, and finally, the synthetic column mounting assembly 20 with multiple synthetic columns T installed is mounted on the mounting seat 10;

[0076] In the third step, the height of the joint mounting plate 31 is adjusted so that multiple joints S are batch-mounted on the synthetic column T.

[0077] It can be imagined that the order of the above second step and the third step can be swapped, that is, first, according to the length of the synthetic column to be installed, the slider slides up and down along the sliding assembly to a set height to adjust the height of the joint mounting plate 31, and the slider is positioned through the knob plunger;

[0078] However, when the synthetic column mounting assembly 20 with multiple synthetic columns T installed is placed on the assembly on which the joint mounting assembly 30 (such as Figure 3 ) has been installed, at this time, the end interface of the synthetic column T and the upper edge of the joint S are only in a contact state. It is necessary to press the top port of the synthetic column T so that its end interface is tightly pressed and inserted into the joint S to complete the installation of the joint S and the synthetic column T.

[0079] Referring to Figure 13, an embodiment of the present application further provides a synthesizer 200, including: a synthesizer housing 210, the synthesizer housing 210 is provided with a plurality of liquid distribution tubes 220; the synthesis column carrying device 100 as mentioned above, the synthesis column carrying device 100 is arranged inside the synthesizer housing 210, and the liquid distribution tubes 220 are located above the synthesis column carrying device 100, and are used for injecting liquid into the top ports of a plurality of synthesis columns T. Among them, by moving the synthesis column support plate 22 closer to or away from the synthesis column limiting plate 21, the distance between the top ports of the plurality of synthesis columns T and the liquid injection ports of the liquid distribution tubes 220 is kept at a preset distance.

[0080] In some embodiments, the synthesis column carrying device 100 is detachably arranged inside the synthesizer housing 210 through the mounting seat 10. Thus, the whole synthesis column carrying device 100 can be detached from the synthesizer 200, which is convenient for replacement and maintenance. The synthesizer 200 can be a nucleic acid synthesizer, a polypeptide synthesizer or other compound synthesizers.

[0081] It should be noted that in this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including a..." does not exclude the existence of another identical element in the process, method, article or device including the said element.

Claims

1. A synthetic column installation component, characterized in that, Comprising: Mounting base; Synthesis column limiting plate, which is arranged on the mounting base and is used for multiple synthesis columns to pass through; And Synthesis column support plate, which is located below the synthesis column limiting plate and is used for supporting the synthesis column. The synthesis column support plate is configured to be able to approach or move away from the synthesis column limiting plate to adjust the height of multiple synthesis columns extending out of the synthesis column limiting plate.

2. The synthesis column mounting assembly according to claim 1, wherein The synthesis column mounting assembly further includes a support, the support is connected between the synthesis column support plate and the synthesis column limiting plate, and the support is configured to be able to make the synthesis column support plate approach or move away from the synthesis column limiting plate.

3. The synthesis column mounting assembly according to claim 2, wherein One end of the support is detachably connected to the synthesis column limiting plate, and the other end of the support is detachably connected to the synthesis column support plate.

4. The synthesis column mounting assembly according to claim 3, wherein The support has a first length or a second length between the synthesis column limiting plate and the synthesis column support plate, and the sizes of the first length and the second length are different.

5. The synthesis column mounting assembly according to claim 2, wherein The support is provided with an adjustment hole extending in the direction in which the synthesis column support plate approaches or moves away from the synthesis column limiting plate. A fastener is inserted through the adjustment hole, and the synthesis column support plate is fixed to the support through the fastener. The distance between the synthesis column support plate and the synthesis column limiting plate is adjusted by adjusting the position of the fastener in the adjustment hole.

6. The synthesis column mounting assembly according to any one of claims 1 to 5, wherein The synthesis column limiting plate is detachably connected to the mounting base.

7. The synthesis column mounting assembly according to claim 6, wherein The mounting base includes a bottom plate and a vertical plate connected to the bottom plate. The vertical plate is provided with a locking sleeve, and the synthesis column limiting plate is fixed to the vertical plate through the cooperation of a lock and the locking sleeve.

8. The synthesis column mounting assembly according to any one of claims 1 to 5, wherein The synthesis column limiting plate is provided with a plurality of limiting holes for the synthesis columns to pass through respectively, The synthesis column support plate is provided with a plurality of support portions corresponding to the plurality of limiting holes. Each support portion includes a groove and a through hole penetrating the bottom surface of the groove. The aperture of the through hole is smaller than the aperture of the limiting hole. The groove is used for accommodating part of the synthesis column and the bottom surface of the groove is used for supporting the synthesis column, and the through hole is used for the end interface of the synthesis column to pass through.

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