Automatic dry distillation device for radionuclide I-124

Abstract

The utility model discloses an automatic dry distillation device for radionuclide I-124, which comprises a shell, and a target shuttle conveying pipe, a grabbing manipulator, a main heating table, a movable bracket, an air cylinder, a secondary heating table, a condensing container, an iodine conveying pipe, a peristaltic pump, a raw material liquid bottle, a recycling bottle, a cleaning bottle and a controller which are arranged on the shell, the grabbing mechanical arm is located above the target shuttle conveying pipe, the movable support is connected with a vertical push rod of the air cylinder, the main heating table is connected with the movable support, the secondary heating table is located below the condensation container and located above the movable support, the upper end of the iodine conveying pipe is communicated with the lower end of the condensation container, and the lower end of the iodine conveying pipe penetrates through the secondary heating table. The peristaltic pump is respectively connected with the raw material liquid bottle and the condensing container. According to the utility model, the integration level is obviously improved, the product volume is reduced, the automatic control is realized, the automation degree is improved, the production efficiency is improved, the potential safety hazard is avoided or reduced, the structure is simpler, the cost is lower, and the popularization is facilitated.

Description

Technical Field

[0001] The utility model relates to a preparation device for radioactive nuclide I-124, in particular to an automatic dry distillation device for radioactive nuclide I-124. Background Technique

[0002] I-124 is 124 I, which is an iodine radioactive nuclide with a physical half-life of 4.176 d and a biological metabolic half-life in the body of 120 - 138 d. It decays through positron emission (23.3%) and electron capture (76.7%). The main uptake organ is the thyroid gland. The high-energy positrons it emits can be used for PET / CT disease diagnosis to obtain high-quality detection images. At the same time, it can also emit Auger electrons through the electron capture method, directly causing damage to the DNA of tumor cells to achieve a therapeutic effect. Therefore, I-124 is a nuclide with dual diagnostic and therapeutic uses.

[0003] Using a medical cyclotron to generate high-speed protons to bombard an iodine target to produce iodine nuclides has received increasing attention. After the bombardment, other impurities in the target are generally removed through a dry distillation device to obtain high-purity I-124. Traditional dry distillation devices are either complex in structure and high in cost, making it difficult to popularize and apply, or have low integration and low automation, requiring manual operation, resulting in low efficiency and potential safety hazards. Content of the Utility Model

[0004] The purpose of the utility model is to provide an automatic dry distillation device for radioactive nuclide I-124 with high integration, high automation, high efficiency, low cost, and easy to popularize in order to solve the above problems.

[0005] The utility model realizes the above purpose through the following technical solutions:

[0006] An automatic dry distillation device for radioactive nuclide I-124, including a housing, further including a target shuttle conveying pipe, a grasping manipulator, a main heating table, a moving bracket, a cylinder, a secondary heating table, a condensation container, an iodine conveying pipe, a peristaltic pump, a raw material liquid bottle, a recovery bottle, a cleaning bottle and a controller installed on the housing. The grasping manipulator capable of grasping and releasing the target shuttle is connected to a manipulator driver and can move vertically. The grasping manipulator is located above the vertically arranged target shuttle conveying pipe. The cylinder is connected to a cylinder driver and can move horizontally. The moving bracket is connected to the upper end of the vertical push rod of the cylinder. The main heating table with a main heater inside is connected to the moving bracket. The secondary heating table with a secondary heater inside is located below the condensation container and above the moving bracket. A condensation pipe is provided inside the condensation container connected to a condenser vacuum pump. The upper end of the vertically arranged iodine conveying pipe is connected to the lower end of the condensation container. The lower end of the iodine conveying pipe passes through the secondary heating table. The inlet of the peristaltic pump is connected to the raw material liquid bottle, and the outlet of the peristaltic pump is connected to the upper part of the condensation container. The recovery bottle and the cleaning bottle are respectively installed on the moving bracket and are arranged horizontally with the main heating table. The control input ends of the manipulator driver, the grasping manipulator, the cylinder driver, the cylinder, the main heater, the secondary heater, the condenser vacuum pump and the peristaltic pump are respectively correspondingly connected to the control output end of the controller. The above-mentioned target shuttle refers to a target material container used for placing the target material after target shooting, which is convenient for transferring the target material.

[0007] Preferably, for the convenience of operation and to improve the integration degree, the target shuttle conveying pipe, the grasping manipulator, the main heating table, the moving bracket, the cylinder, the secondary heating table, the condensation container, the iodine conveying pipe, the peristaltic pump, the raw material liquid bottle, the recovery bottle and the cleaning bottle are all installed on the outer wall of the housing, and the manipulator driver, the cylinder driver, the condenser vacuum pump and the controller are all placed inside the housing.

[0008] Preferably, for the convenience of precisely controlling the vertical movement of the grasping manipulator, the manipulator driver is a manipulator driving motor, and the rotating shaft of the manipulator driving motor is connected to the grasping manipulator through a manipulator transmission device.

[0009] Preferably, for the convenience of precisely controlling the horizontal movement of the cylinder, the cylinder driver is a cylinder driving motor, and the rotating shaft of the cylinder driving motor is connected to the cylinder through a cylinder transmission device.

[0010] Preferably, in order to facilitate the precise grasping and releasing of the target shuttle, the grasping manipulator is a vacuum seat with an inner cavity. The vacuum seat is connected to a manipulator vacuum pump. The lower end of the vacuum seat is provided with a clamping groove corresponding to the upper end of the target shuttle. The clamping groove communicates with the inner cavity of the vacuum seat. The manipulator vacuum pump is correspondingly connected to the control output end of the controller.

[0011] Preferably, in order to improve the integration degree, the manipulator vacuum pump is placed inside the housing.

[0012] The beneficial effects of the present utility model are as follows:

[0013] By integrally installing the target shuttle delivery pipe, manipulator driver, grasping manipulator, main heating table, moving bracket, cylinder driver, cylinder, secondary heating table, condensation container, condenser vacuum pump, iodine delivery pipe, peristaltic pump, raw material liquid bottle, recovery bottle, cleaning bottle and controller on the housing, the present utility model significantly improves the integration degree, reduces the product volume, realizes automatic control, improves the automation level, improves the production efficiency, avoids or reduces the potential safety hazard of I-124 to human body. The whole device has a relatively simple structure, low cost, and is conducive to popularization. Description of the Drawings

[0014] Figure 1 is a perspective view of the automatic dry distillation device for radioactive nuclide I-124 of the present utility model during application;

[0015] Figure 2 is a front view of the automatic dry distillation device for radioactive nuclide I-124 of the present utility model during application. Detailed Embodiments

[0016] The present utility model will be further described below in conjunction with the drawings:

[0017] As Figure 1 and Figure 2As shown in the figure, the automatic dry distillation device for radioactive nuclide I-124 of the present utility model includes a housing 1, and further includes a target shuttle conveying pipe 6, a grasping manipulator 2, a main heating table 5, a moving bracket 8, a cylinder 15, a secondary heating table 10, a condensation container 7, an iodine conveying pipe 12, a peristaltic pump 14, a raw material liquid bottle 16, a recovery bottle 9, a cleaning bottle 13 and a controller (not visible in the figure) installed on the housing 1. The grasping manipulator 2 capable of grasping and releasing the target shuttle 4 is connected to a manipulator driver (not visible in the figure) and can move vertically. The grasping manipulator 2 is located above the vertical target shuttle conveying pipe 6. The cylinder 15 is connected to a cylinder driver (not visible in the figure) and can move horizontally. The moving bracket 8 is connected to the upper end of the vertical push rod of the cylinder 15. The main heating table 5 with a built-in main heater (not visible in the figure) is connected to the moving bracket 8. The secondary heating table 10 with a built-in secondary heater (not visible in the figure) is located below the condensation container 7 and above the moving bracket 8. A spiral condensation pipe (not visible in the figure) is provided in the condensation container 7 connected to a condenser vacuum pump (not visible in the figure). The upper end of the vertical iodine conveying pipe 12 communicates with the lower end of the condensation container 7. The lower end of the iodine conveying pipe 12 passes through the secondary heating table 10. The inlet of the peristaltic pump 14 is respectively connected to a plurality of raw material liquid bottles 16 through a plurality of three-way valves 11. The outlet of the peristaltic pump 14 is connected to the upper part of the condensation container 7. The recovery bottle 9 and the cleaning bottle 13 are respectively installed on the moving bracket 8 and are arranged horizontally with the main heating table 5. The control input ends of the manipulator driver, the grasping manipulator 2, the cylinder driver, the cylinder 15, the main heater, the secondary heater, the condenser vacuum pump and the peristaltic pump 14 are respectively correspondingly connected to the control output end of the controller.

[0018] As Figure 1 and Figure 2 shown in the figure, the present utility model also discloses the following various more optimized specific structures:

[0019] For the convenience of operation and to improve the integration degree, the target shuttle conveying pipe 6, the grasping manipulator 2, the main heating table 5, the moving bracket 8, the cylinder 15, the secondary heating table 10, the condensation container 7, the iodine conveying pipe 12, the peristaltic pump 14, the raw material liquid bottle 16, the recovery bottle 9 and the cleaning bottle 13 are all installed on the outer wall of the housing 1. The manipulator driver, the cylinder driver, the condenser vacuum pump and the controller are all placed inside the housing 1.

[0020] For the convenience of precisely controlling the vertical movement of the grasping manipulator 2, the manipulator driver is a manipulator driving motor, and the rotating shaft of the manipulator driving motor is connected to the grasping manipulator 2 through a manipulator transmission device. The manipulator transmission device here can be easily realized by adopting the conventional structure of the existing technology according to actual needs, such as a transmission device using the connection of a screw rod and a nut.

[0021] In order to precisely control the lateral movement of the cylinder 15, the cylinder driver is a cylinder drive motor, and the rotating shaft of the cylinder drive motor is connected to the cylinder 15 through a cylinder transmission device. The cylinder transmission device here can be easily implemented by using conventional structures in the prior art according to actual needs, such as a transmission device connected by a screw and a nut.

[0022] In order to facilitate accurate grasping and releasing of the target shuttle 4, the grasping manipulator 2 is a vacuum seat (cylindrical in shape in the figure) with an inner cavity, the vacuum seat is connected to the manipulator vacuum pump (not visible in the figure), the lower end of the vacuum seat is provided with a clamping groove 3 corresponding to the upper end of the target shuttle 4, the clamping groove 3 is communicated with the inner cavity of the vacuum seat, and the manipulator vacuum pump is correspondingly connected to the control output end of the controller.

[0023] In order to improve the integration, the robot vacuum pump is placed in the housing 1.

[0024] like Figure 1 and Figure 2 As shown, when used, the lower end of the target shuttle conveying pipe 6 is first connected to the target shooting device (not shown in the figure), and the target shuttle 4 after the target shooting can enter the target shuttle conveying pipe 6 through the lower end of the target shuttle conveying pipe 6 and be sent out from the upper end of the target shuttle conveying pipe 6; before formal work, the grabbing manipulator 2 is first moved to the uppermost position through the controller, and the cylinder 15 is moved to the position where the main heating table 5 is not between the target shuttle conveying pipe 6 and the grabbing manipulator 2; then the grabbing manipulator 2 is moved downward until the clamping groove 3 is located above the upper end of the target shuttle conveying pipe 6 and is in contact with or close to it, and the manipulator vacuum pump is turned on to evacuate the interior of the grabbing manipulator 2, so that the condenser tube in the condensation container 7 is in a condensed state (according to the actual situation, it can be achieved by filling it with condensate or connecting it to a compressor and starting the compressor, etc., which are all existing technologies, and the specific structure and implementation method are not mentioned here). As a limitation), make preparations before work; then the target shuttle 4 is blown out from the upper end of the target shuttle conveying pipe 6 through the relevant control structure, and the upper end of the target shuttle 4 is placed in the clamping groove 3 of the grabbing manipulator 2, and the grabbing manipulator 2 sucks the target shuttle 4 with vacuum negative pressure to fix it; then the grabbing manipulator 2 is controlled to move upward to the limit position, and then the cylinder 15 is moved to the position where the main heating platform 5 is located below the target shuttle 4, and then the cylinder 15 is started so that its push rod drives the movable bracket 8 and the main heating platform 5 to move upward, so that the upper part of the main heating platform 5 and the lower end of the target shuttle 4 are in contact (or docking) with each other, and the cylinder 15 stops running, and then the manipulator vacuum pump is turned off, the grabbing manipulator 2 releases the target shuttle 4, and then the cylinder 15 is started so that its push rod drives the movable bracket 8 and the main heating platform 5 to move downward. After the target shuttle 4 is completely separated from the clamping groove 3 of the grabbing manipulator 2, the cylinder 15 stops running, and the state at this time is as follows Figure 1 and Figure 2As shown; then control the cylinder 15 to drive the moving bracket 8 and the main heating table 5 to move horizontally until the target shuttle 4 is directly below the secondary heating table 10, the cylinder 15 stops moving, and then start the cylinder 15 to make its push rod drive the moving bracket 8 and the main heating table 5 to move upward until the upper end of the target shuttle 4 comes into contact (or docks) with the lower surface of the secondary heating table 10. At this time, the iodine target material on the target shuttle 4 corresponds to the lower end of the target shuttle delivery pipe 6, and the cylinder 15 stops running; then turn on the main heater in the main heating table 5 and the secondary heater in the secondary heating table 10, and turn on the condenser vacuum pump to evacuate the condensation container 7; after the temperature of the target shuttle 4 rises to a certain level, I-124 begins to sublime. Under the action of the vacuum in the condensation container 7 and the target shuttle delivery pipe 6, the I-124 vapor enters the condensation container 7 from the target shuttle 4 through the target shuttle delivery pipe 6 and adsorbs on the outer wall of the condenser tube; after the sublimation of I-124 is completed and the iodine adheres to the wall, turn off the condenser vacuum pump, start the cylinder 15 to make its push rod drive the moving bracket 8 and the main heating table 5 to move downward. After completely separating from the secondary heating table 10, the cylinder 15 stops running, and then control the cylinder 15 to drive the moving bracket 8 to move horizontally so that the recovery bottle 9 is directly below the target shuttle delivery pipe 6; start the cylinder 15 to make its push rod drive the moving bracket 8 to move upward until the lower end of the target shuttle delivery pipe 6 is inside (or docked) the upper mouth of the recovery bottle 9, and the cylinder 15 stops running; start the peristaltic pump 14 to pump the elution liquid (such as NaOH solution) in the required raw material liquid bottle 16 into the upper part of the condensation container 7. This elution liquid elutes the I-124 attached to the outer wall of the condenser tube and flows into the recovery bottle 9 through the target shuttle delivery pipe 6. The pH value of the liquid in the recovery bottle 9 can also be fine-tuned by extracting the corresponding liquid through the peristaltic pump 14 as needed; then start the cylinder 15 to make its push rod drive the moving bracket 8 to move downward. After completely separating from the target shuttle delivery pipe 6, the cylinder 15 stops running, and then control the cylinder 15 to drive the moving bracket 8 to move horizontally so that the cleaning bottle 13 is directly below the target shuttle delivery pipe 6; start the cylinder 15 to make its push rod drive the moving bracket 8 to move upward until the lower end of the target shuttle delivery pipe 6 is inside (or docked) the upper mouth of the cleaning bottle 13, and the cylinder 15 stops running; start the peristaltic pump 14 to pump the cleaning liquid (such as water, buffer solution, alcohol, etc.) in the required raw material liquid bottle 16 into the upper part of the condensation container 7. Use this cleaning liquid to wash the outer wall of the condenser tube and the inner wall of the condensation container 7, and flow into the cleaning bottle 13 through the target shuttle delivery pipe 6; then reset all components to complete the automated dry distillation process of I-124 this time and prepare for the next dry distillation.

[0025] The above embodiments are only the preferred embodiments of the present invention and do not limit the technical solutions of the present invention. As long as the technical solutions can be achieved on the basis of the above embodiments without creative labor, they shall be regarded as falling within the scope of the patent rights of the present invention.

Claims

1. An automatic dry distillation device for radioactive nuclide I-124, comprising a housing, characterized in that: It further includes a target shuttle delivery pipe, a grasping manipulator, a main heating table, a moving bracket, a cylinder, a secondary heating table, a condensation container, an iodine delivery pipe, a peristaltic pump, a raw material liquid bottle, a recovery bottle, a cleaning bottle and a controller installed on the outer shell. The grasping manipulator capable of grasping and releasing the target shuttle is connected to a manipulator driver and can move vertically. The grasping manipulator is located above the vertically arranged target shuttle delivery pipe. The cylinder is connected to a cylinder driver and can move horizontally. The moving bracket is connected to the upper end of the vertical push rod of the cylinder. The main heating table with a built-in main heater is connected to the moving bracket. The secondary heating table with a built-in secondary heater is located below the condensation container and above the moving bracket. A condensation pipe is provided in the condensation container connected to a condenser vacuum pump. The upper end of the vertically arranged iodine delivery pipe communicates with the lower end of the condensation container. The lower end of the iodine delivery pipe passes through the secondary heating table. The inlet of the peristaltic pump is connected to the raw material liquid bottle, and the outlet of the peristaltic pump is connected to the upper part of the condensation container. The recovery bottle and the cleaning bottle are respectively installed on the moving bracket and are arranged horizontally with the main heating table. The control input ends of the manipulator driver, the grasping manipulator, the cylinder driver, the cylinder, the main heater, the secondary heater, the condenser vacuum pump and the peristaltic pump are respectively correspondingly connected to the control output end of the controller.

2. The automatic dry distillation device for the radionuclide I-124 according to claim 1, characterized in that: The target shuttle delivery pipe, the grasping manipulator, the main heating table, the moving bracket, the cylinder, the secondary heating table, the condensation container, the iodine delivery pipe, the peristaltic pump, the raw material liquid bottle, the recovery bottle and the cleaning bottle are all installed on the outer wall of the outer shell. The manipulator driver, the cylinder driver, the condenser vacuum pump and the controller are all placed inside the outer shell.

3. The automatic dry distillation device for the radionuclide I-124 according to claim 1 or 2, characterized in that: The manipulator driver is a manipulator drive motor, and the rotating shaft of the manipulator drive motor is connected to the grasping manipulator through a manipulator transmission device.

4. The automatic dry distillation device for radioactive nuclide I-124 according to claim 1 or 2, characterized in that: The cylinder driver is a cylinder drive motor, and the rotating shaft of the cylinder drive motor is connected to the cylinder through a cylinder transmission device.

5. The automatic dry distillation device for radionuclide I-124 according to claim 1 or 2, characterized in that: The grasping manipulator is a vacuum seat with an inner cavity. The vacuum seat is connected to a manipulator vacuum pump. A clamping groove corresponding to the upper end of the target shuttle is provided at the lower end of the vacuum seat. The clamping groove communicates with the inner cavity of the vacuum seat. The manipulator vacuum pump is correspondingly connected to the control output end of the controller.

6. The automatic dry distillation device for the radionuclide I-124 according to claim 5, characterized in that: The manipulator vacuum pump is placed inside the outer shell.

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