Biochip packaging equipment

Abstract

The utility model discloses biological chip packaging equipment, and relates to the technical field of biological chips, the biological chip packaging equipment comprises a biological chip 1, a sealing rubber ring 2, a cover plate 3, a base 4, a pressing rubber ring 5 and a gland 6, the base 4 is in a groove shape, the bottom of the base 4 is hollow, the biological chip 1 is placed in the base 4, and the sealing rubber ring 2 is added between the biological chip 1 and the cover plate 3 to form a closed detection area; the gland 6 is in a groove shape, the bottom of the gland 6 is hollow, the gland 6 is matched with the base 4, used for being tightly connected with the base 4 and buckled on the base 4, and a pressing rubber ring 5 is additionally arranged between the gland 6 and the cover plate 3. The cover plate 3 is provided with a liquid adding channel 7 which is used for adding a detection reagent into the detection area of the biological chip 1. By adopting the biological chip packaging equipment, the use convenience of the biological chip is improved.

Description

Technical Field

[0001] This application relates to the field of biochip technology, and in particular, to a biochip encapsulation device. Background Art

[0002] Biochip technology originated from nucleic acid molecular hybridization. Generally, a biochip refers to a microarray hybridization chip (micro-arrays) of bioinformatics molecules (such as gene fragments, DNA fragments, or polypeptides, proteins, 10 sugar molecules, tissues, etc.) that are densely fixed on a mutually supporting medium. The sequence and position of each molecule in the array are known and are pre-set sequence lattices. Currently, the biochips on the market are often mainly naked gene chips without encapsulation. When in use, it generally requires adding a fence and a cover glass for hybridization, and special brackets and containers are also needed for the cleaning after hybridization, resulting in a relatively complex detection process of the biochip and not meeting the requirements of convenient and fast POCT (point-of-care testing), which restricts the application of biochips in the POCT field to a certain extent. Utility Model Content

[0003] The embodiments of this application provide a biochip encapsulation device to solve the technical problem of the inconvenient use of biochips in the prior art.

[0004] The embodiments of this application provide a biochip encapsulation device, which is characterized by including: a biochip 1, a sealing rubber ring 2, a cover plate 3, a base 4, a pressing rubber ring 5, and a pressing cover 6, wherein:

[0005] The base 4 is in a groove shape and has a hollow bottom for placing the biochip 1 inside. A sealed detection area is formed between the biochip 1 and the cover plate 3 by adding the sealing rubber ring 2.

[0006] The pressing cover 6 is in a groove shape and has a hollow bottom, which is matched with the base 4 for tightly connecting with the base 4 and buckling on the base 4. A pressing rubber ring 5 is added between the pressing cover 6 and the cover plate 3.

[0007] The cover plate 3 has a liquid adding channel 7 for adding a detection reagent to the detection area of the biochip 1.

[0008] Further, it further includes: a Luer connector 8 for hermetically sealing the channel opening of the liquid adding channel 7 by means of a thread.

[0009] Further, the periphery of the base 4 has a plurality of upper buckles 41, and the periphery of the pressing cover 6 has a plurality of lower buckles 61 that correspond to and match the plurality of upper buckles 41 one by one. The pressing cover 6 and the base 4 are interlocked and clamped through the upper buckles 41 and the lower buckles 61.

[0010] Further, the sealing rubber ring 2 includes rubber ring protrusions 21 around the perimeter, a rubber ring body 22, and a pressing ring 23 that forms a detection area in the middle. The thickness of the pressing ring 23 is greater than the thickness of the rubber ring body 22.

[0011] Further, the cover plate 3 has a cover plate boss 31 that matches the thickness of the sealing rubber ring 2, and the thick edge of the sealing rubber ring 2 is mounted on the cover plate boss 31.

[0012] Further, the outlet of the liquid adding channel 7 of the cover plate 3 on the side facing the biochip 1 is a sampling hole 71, and the sampling hole 71 has a concave structure in the shape of a flared opening.

[0013] Further, the taper of the channel 72 of the liquid adding channel 7 connected to the sampling hole 71 is smaller than the taper of a pipette tip.

[0014] Further, the outer surface of the cover plate 3 has a cover plate protrusion 32 along the long axis direction.

[0015] Further, the pressing cover 6 has an arc-shaped protrusion 62.

[0016] The beneficial effects of the present application include:

[0017] The biochip encapsulation device provided by the embodiment of the present application includes a biochip 1, a sealing rubber ring 2, a cover plate 3, a base 4, a pressing rubber ring 5, and a pressing cover 6, wherein: the base 4 is in the shape of a groove and has a hollow bottom for placing the biochip 1 inside. A sealed detection area is formed between the biochip 1 and the cover plate 3 by adding the sealing rubber ring 2; the pressing cover 6 is in the shape of a groove and has a hollow bottom, which matches the base 4 and is used to be tightly connected to the base 4 and buckle on the base 4. A pressing rubber ring 5 is added between the pressing cover 6 and the cover plate 3; the cover plate 3 has a liquid adding channel 7 for adding a detection reagent to the detection area of the biochip 1. Through this encapsulation device, the biochip 1 can be encapsulated in a sealed space, and through the sealing rubber ring 2 and the pressing rubber ring 5, the biochip 1 can be better pressed in the encapsulation device, so that it is not easy to fall off during use. The test solution can be directly added to the detection area of the biochip 1 through the liquid adding channel 7. Compared with the prior art, the complexity of installing related components during the use of the biochip 1 is reduced, and the convenience of use is improved.

[0018] Other features and advantages of the present application will be described in the following specification, and, in part, will be obvious from the specification, or will be understood by implementing the present application. The objectives and other advantages of the present application can be realized and obtained by the structures specifically pointed out in the written specification, claims, and drawings. Description of the Drawings

[0019] The accompanying drawings are used to provide further understanding of the present application and form a part of the specification. Together with the embodiments of the present application, they are used to explain the present application and do not constitute a limitation to the present application. In the accompanying drawings:

[0020] Figure 1 is a schematic three-dimensional structure diagram of a biochip encapsulation device provided by an embodiment of the present application;

[0021] Figure 2 is a schematic cross-sectional diagram of a biochip encapsulation device provided by an embodiment of the present application;

[0022] Figure 3 is a schematic cross-sectional diagram of a biochip encapsulation device provided by an embodiment of the present application;

[0023] Figure 4 is a schematic structure diagram of the base of a biochip encapsulation device provided by an embodiment of the present application;

[0024] Figure 5 is a schematic structure diagram of the gland of a biochip encapsulation device provided by an embodiment of the present application;

[0025] Figure 6 is a schematic structure diagram of the sealing rubber ring of a biochip encapsulation device provided by an embodiment of the present application;

[0026] Figure 7 is a schematic structure diagram of the cover plate of a biochip encapsulation device provided by an embodiment of the present application;

[0027] Figure 8 is a schematic structure diagram of the liquid adding channel of a biochip encapsulation device provided by an embodiment of the present application;

[0028] Figure 9 is a schematic structure diagram of the cover plate of a biochip encapsulation device provided by an embodiment of the present application. Detailed Embodiments

[0029] In order to provide an implementation solution for improving the convenience of using a biochip, an embodiment of the present application provides a biochip encapsulation device. The following describes the preferred embodiments of the present application with reference to the accompanying drawings of the specification. It should be understood that the preferred embodiments described herein are only used to explain and illustrate the present application and are not used to limit the present application. And without conflict, the embodiments in the present application and the features in the embodiments can be combined with each other.

[0030] An embodiment of the present application provides one, which is characterized in that, as Figures 1 to 3 shown, it includes: a biochip 1, a sealing rubber ring 2, a cover plate 3, a base 4, a pressing rubber ring 5, and a gland 6, wherein:

[0031] The base 4 is in the shape of a groove and hollow at the bottom, and is used to place the biochip 1 inside. A sealed detection area is formed between the biochip 1 and the cover plate 3 by adding a sealing rubber ring 2.

[0032] The gland 6 is in the shape of a groove and hollow at the bottom, and is matched with the base 4 for tightly connecting with the base 4 and buckling on the base 4. A pressing rubber ring 5 is added between the gland 6 and the cover plate 3.

[0033] The cover plate 3 has a liquid adding channel 7 for adding a detection reagent to the detection area of the biochip 1.

[0034] By using the above-mentioned encapsulation device provided by the embodiment of the present application, the biochip 1 can be encapsulated in a sealed space, and through the sealing rubber ring 2 and the pressing rubber ring 5, the biochip 1 can be better pressed in the encapsulation device, so that it is not easy to fall off during use. The test solution can be directly added to the detection area of the biochip 1 through the liquid adding channel 7. Compared with the prior art, the complexity of installing related components during the use of the biochip 1 is reduced, and the convenience of use is improved.

[0035] In an embodiment of the present application, further, as Figures 2 to 3 shown, it may further include: a Luer connector 8 for thread-sealing at the channel opening of the liquid adding channel 7.

[0036] The Luer connector 8 can be understood as a plug for tightly sealing the channel opening of the liquid adding channel 7. When the biochip 1 is to be used, the Luer connector 8 is removed.

[0037] In an embodiment of the present application, further, as Figure 4 、 Figure 5 shown, the four sides of the base 4 may have a plurality of upper buckles 41, and the four sides of the gland 6 may have a plurality of lower buckles 61 that correspond to and match the plurality of upper buckles 41 one by one. The gland 6 and the base 4 are interlocked and clamped through the upper buckles 41 and the lower buckles 61.

[0038] Through the interlocking and clamping of the plurality of corresponding upper buckles 41 and lower buckles 61 one by one, the components inside the encapsulation device, including the biochip 1, the sealing rubber ring 2, the cover plate 3, and the pressing rubber ring 5, can be more tightly pressed, and it can be ensured that the encapsulation device cannot be opened without the buckles being damaged, so that the encapsulation device and the biochip 1 therein cannot be reused, improving the safety of using the biochip 1.

[0039] In an embodiment of the present application, further, as Figure 6 shown, the sealing rubber ring 2 may include a rubber ring protrusion 21 around, a rubber ring body 22, and a pressing ring 23 that forms a detection area in the middle. The thickness of the pressing ring 23 is greater than the thickness of the rubber ring body 22.

[0040] Specifically, the thickness of the rubber ring body 22 can generally be 0.1 mm. A rubber ring protrusion 21 is provided around the rubber ring body 22, which can generally enhance the hardness of the entire sealing rubber ring 2. The thickness of the pressing ring 23 forming the detection area in the middle can be 0.12 - 0.14 mm, so that the sealing rubber ring 2 provides a greater pressing force when being pressed.

[0041] Figure 7 The shown sealing rubber ring 2 includes two annular regions, and each annular region corresponds to a detection area.

[0042] In an embodiment of the present application, further, as Figure 7 shown, the cover plate 3 has a cover plate boss 31 matching the thickness of the sealing rubber ring 2. The thick edge of the sealing rubber ring 2 can be installed on the cover plate boss 31, and the thick edge of the sealing rubber ring 2 is the outermost circle of rubber ring protrusions 21.

[0043] When installing the sealing rubber ring 2, clamping the thick edges around the sealing rubber ring 2 onto the cover plate boss 31 of the cover plate 3 can make the sealing rubber ring 2 flat and fitting even if it is relatively thin, and can ensure that the sealing performance of the sealing rubber ring 2 is not affected after being pressed.

[0044] In an embodiment of the present application, further, as Figure 8 shown, the outlet of the liquid adding channel 7 of the cover plate 3 on the side facing the biochip 1 is a sampling hole 71. The sampling hole 71 has a concave structure with a flared shape, so that the test solution in the biochip 1 can easily flow out.

[0045] Further, as Figure 9 shown, the taper of the channel 72 of the liquid adding channel 7 connected to the sampling hole 71 is smaller than the taper of the pipette tip 73, that is, the channel 72 is a conical surface with a smaller conical degree than the pipette tip 73, so that when using a pipette for sampling and removing the test solution in the biochip, a better sealing effect can be ensured through pressure.

[0046] In an embodiment of the present application, further, as Figure 9 shown, the outer surface of the cover plate 3 has a cover plate protrusion 32 along the long axis direction, which can improve the overall strength of the cover plate 3. The outer surface of the cover plate 3 is the side facing the Luer connector 8 and has a liquid adding port on it;

[0047] Further, as Figure 5 shown, the gland 6 has an arc-shaped protrusion 62, which can strengthen the strength of the lower buckle to reduce deformation and enhance the sealing effect on the entire biochip.

[0048] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising a..." does not exclude the existence of additional identical elements in the process, method, article or device comprising the said element.

[0049] Obviously, those skilled in the art can make various changes and modifications to this application without departing from the spirit and scope of this application. Thus, if these modifications and variations of this application fall within the scope of the claims of this application and their equivalent technologies, this application is also intended to include these modifications and variations.

Claims

1. A biochip encapsulation device, characterized in that, Comprising: A biochip (1), a sealing rubber ring (2), a cover plate (3), a base (4), a pressing rubber ring (5) and a gland (6), wherein: The base (4) is in a groove shape and has a hollow bottom for placing the biochip (1) inside. A sealed detection area is formed between the biochip (1) and the cover plate (3) by adding the sealing rubber ring (2). The gland (6) is in a groove shape and has a hollow bottom, which is matched with the base (4) for tightly connecting with the base (4) and buckling on the base (4). A pressing rubber ring (5) is added between the gland (6) and the cover plate (3). The cover plate (3) has a liquid adding channel (7) for adding a detection reagent to the detection area of the biochip (1).

2. The biochip packaging device according to claim 1, characterized in that, Also comprising: A Luer connector (8) for thread-sealing at the orifice of the liquid adding channel (7).

3. The biochip packaging device according to claim 1 or 2, characterized in that, There are a plurality of upper buckles (41) around the base (4), and a plurality of lower buckles (61) corresponding to and matching with the plurality of upper buckles (41) around the gland (6). The gland (6) and the base (4) are interlocked and clamped through the upper buckles (41) and the lower buckles (61).

4. The biochip packaging device according to claim 1 or 2, characterized in that The sealing rubber ring (2) includes a rubber ring bulge (21) around the periphery, a rubber ring body (22) and a pressing ring (23) forming a detection area in the middle. The thickness of the pressing ring (23) is greater than the thickness of the rubber ring body (22).

5. The biochip packaging device according to claim 1 or 2, characterized in that, The cover plate (3) has a cover plate boss (31) matching the thickness of the sealing rubber ring (2), and the thick edge of the sealing rubber ring (2) is installed on the cover plate boss (31).

6. The biochip packaging device according to claim 1 or 2, characterized in that, The outlet of the liquid adding channel (7) of the cover plate (3) on the side facing the biochip (1) is a sampling hole (71), and the sampling hole (71) has a concave structure in a flared shape.

7. The biochip packaging device according to claim 6, wherein, The taper of the channel (72) of the liquid adding channel (7) connected to the sampling hole (71) is smaller than the taper of a pipette tip.

8. The biochip packaging device according to claim 1 or 2, characterized in that, The outer surface of the cover plate (3) has a cover plate bulge (32) along the long axis direction.

9. The biochip packaging device according to claim 1 or 2, characterized in that, The gland (6) has an arc-shaped bulge (62).

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